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A Systematic Nomenclature for the Redox States of High Mobility Group Box (HMGB) Proteins

MOLECULAR MEDICINE (2014)

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MOLECULAR MEDICINE
卷 20, 期 -, 页码 135-137

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FEINSTEIN INST MED RES
DOI: 10.2119/molmed.2014.00022

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Biochemistry & Molecular Biology Cell Biology Medicine, Research & Experimental

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High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

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MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY (2022)

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Article Multidisciplinary Sciences

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Article Astronomy & Astrophysics

Polarization Properties of the Weakly Magnetized Neutron Star X-Ray Binary GS 1826-238 in the High Soft State

Fiamma Capitanio, Sergio Fabiani, Andrea Gnarini, Francesco Ursini, Carlo Ferrigno, Giorgio Matt, Juri Poutanen, Massimo Cocchi, Romana Mikusincova, Ruben Farinelli, Stefano Bianchi, Jari J. E. Kajava, Fabio Muleri, Celia Sanchez-Fernandez, Paolo Soffitta, Kinwah Wu, Ivan Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Niccolo Bucciantini, Simone Castellano, Elisabetta Cavazzuti, Stefano Ciprini, Enrico Costa, Alessandra De Rosa, Ettore Del Monte, Laura Di Gesu, Niccolo Di Lalla, Alessandro Di Marco, Immacolata Donnarumma, Victor Doroshenko, Michal Dovciak, Steven R. Ehlert, Teruaki Enoto, Yuri Evangelista, Riccardo Ferrazzoli, Javier A. Garcia, Shuichi Gunji, Kiyoshi Hayashida, Jeremy Heyl, Wataru Iwakiri, Svetlana G. Jorstad, Vladimir Karas, Takao Kitaguchi, Jeffery J. Kolodziejczak, Henric Krawczynski, Fabio La Monaca, Luca Latronico, Ioannis Liodakis, Simone Maldera, Alberto Manfreda, Frederic Marin, Andrea Marinucci, Alan P. Marscher, Herman L. Marshall, Ikuyuki Mitsuishi, Tsunefumi Mizuno, C. -Y. Ng, Stephen L. O'Dell, Nicola Omodei, Chiara Oppedisano, Alessandro Papitto, George G. Pavlov, Abel L. Peirson, Matteo Perri, Melissa Pesce-Rollins, Pierre-Olivier Petrucci, Maura Pilia, Andrea Possenti, Simonetta Puccetti, Brian D. Ramsey, John Rankin, Ajay Ratheesh, Roger W. Romani, Carmelo Sgro, Patrick Slane, Gloria Spandre, Toru Tamagawa, Fabrizio Tavecchio, Roberto Taverna, Yuzuru Tawara, Allyn F. Tennant, Nicholas E. Thomas, Francesco Tombesi, Alessio Trois, Sergey S. Tsygankov, Roberto Turolla, Jacco Vink, Martin C. Weisskopf, Fei Xie, Silvia Zane

Summary: The launch of IXPE on December 9, 2021 has provided a new perspective in X-ray astronomy. In this study, we present the first observation results of GS 1826-238, a weakly magnetized neutron star, using IXPE on March 29-31, 2022. The upper limit of linear polarization degree (99.73% confidence level) is found to be 1.3% in the energy range of 2-8 keV. Coordinated observations with INTEGRAL and NICER were conducted simultaneously to constrain the geometry and inclination angle of GS 1826-238.

ASTROPHYSICAL JOURNAL (2023)

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Article Astronomy & Astrophysics

X-Ray Polarization Observations of BL Lacertae

Riccardo Middei, Ioannis Liodakis, Matteo Perri, Simonetta Puccetti, Elisabetta Cavazzuti, Laura Di Gesu, Steven R. Ehlert, Grzegorz Madejski, Alan P. Marscher, Herman L. Marshall, Fabio Muleri, Michela Negro, Svetlana G. Jorstad, Beatriz Agis-Gonzalez, Ivan Agudo, Giacomo Bonnoli, Maria Bernardos, Victor Casanova, Maya Garcia-Comas, Cesar Husillos, Alessandro Marchini, Alfredo Sota, Pouya M. Kouch, Elina Lindfors, George A. Borman, Evgenia N. Kopatskaya, Elena G. Larionova, Daria A. Morozova, Sergey S. Savchenko, Andrey A. Vasilyev, Alexey Zhovtan, Carolina Casadio, Juan Escudero, Ioannis Myserlis, Antonio Hales, Seiji Kameno, Ruediger Kneissl, Hugo Messias, Hiroshi Nagai, Dmitry Blinov, Ioakeim G. Bourbah, Sebastian Kiehlmann, Evangelos Kontopodis, Nikos Mandarakas, Stylianos Romanopoulos, Raphael Skalidis, Anna Vervelaki, Joseph R. Masiero, Dimitri Mawet, Maxwell A. Millar-Blanchaer, Georgia Panopoulou, Samaporn Tinyanont, Andrei Berdyugin, Masato Kagitani, Vadim Kravtsov, Takeshi Sakanoi, Ryo Imazawa, Mahito Sasada, Yasushi Fukazawa, Koji S. Kawabata, Makoto Uemura, Tsunefumi Mizuno, Tatsuya Nakaoka, Hiroshi Akitaya, Mark Gurwell, Ramprasad Rao, Niccolo Di Lalla, Nicolo Cibrario, Immacolata Donnarumma, Dawoon E. Kim, Nicola Omodei, Luigi Pacciani, Juri Poutanen, Fabrizio Tavecchio, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Niccolo Bucciantini, Fiamma Capitanio, Simone Castellano, Stefano Ciprini, Enrico Costa, Alessandra De Rosa, Ettore Del Monte, Alessandro Di Marco, Victor Doroshenko, Michal Dovciak, Teruaki Enoto, Yuri Evangelista, Sergio Fabiani, Riccardo Ferrazzoli, Javier A. Garcia, Shuichi Gunji, Kiyoshi Hayashida, Jeremy Heyl, Wataru Iwakiri, Vladimir Karas, Takao Kitaguchi, Jeffery J. Kolodziejczak, Henric Krawczynski, Fabio La Monaca, Luca Latronico, Simone Maldera, Alberto Manfreda, Frederic Marin, Andrea Marinucci, Francesco Massaro, Giorgio Matt, Ikuyuki Mitsuishi, C-Y Ng, Stephen L. O'Dell, Chiara Oppedisano, Alessandro Papitto, George G. Pavlov, Abel L. Peirson, Melissa Pesce-Rollins, Pierre-Olivier Petrucci, Maura Pilia, Andrea Possenti, Brian D. Ramsey, John Rankin, Ajay Ratheesh, Roger W. Romani, Carmelo Sgro, Patrick Slane, Paolo Soffitta, Gloria Spandre, Toru Tamagawa, Roberto Taverna, Yuzuru Tawara, Allyn F. Tennant, Nicholas E. Thomas, Francesco Tombesi, Alessio Trois, Sergey Tsygankov, Roberto Turolla, Jacco Vink, Martin C. Weisskopf, Kinwah Wu, Fei Xie, Silvia Zane

Summary: A multiwavelength polarization analysis of BL Lacertae suggests that proton-synchrotron radiation does not significantly contribute to its X-ray emission, providing support for a leptonic origin.

ASTROPHYSICAL JOURNAL LETTERS (2023)

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Article Nutrition & Dietetics

Glycyrrhizic Acid Inhibits High-Mobility Group Box-1 and Homocysteine-Induced Vascular Dysfunction

Laura Kate Gadanec, Ulf Andersson, Vasso Apostolopoulos, Anthony Zulli

Summary: High levels of HMGB-1 have been found in patients with Hyperhomocysteinemia (HHcy), which worsens cardiovascular outcomes. Targeting HMGB-1 may be a potential therapy for improving HHcy-induced cardiovascular pathologies.

NUTRIENTS (2023)

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Article Medicine, General & Internal

Vagus nerve SARS-CoV-2 infection and inflammatory reflex dysfunction: Is there a causal relationship?

Ulf Andersson, Kevin J. Tracey

Summary: Autonomic dysfunction is a common feature of SARS-CoV-2 infection, but the mechanisms behind it remain unknown. Recent evidence suggests that viral infection and inflammation in the vagus nerve may contribute to dysregulated respiration and impairment of the vagus nerve inflammatory reflex. This reflex is an important mechanism for suppressing cytokine storm, and its dysfunction may contribute to hyperinflammatory pathogenesis in COVID-19 patients.

JOURNAL OF INTERNAL MEDICINE (2023)

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Proceedings Paper Astronomy & Astrophysics

The Small-Sized Telescope of CTAO

G. Tagliaferri, A. Antonelli, T. Arnesen, J. Aschersleben, P. Attina, M. Balbo, S. Bang, M. Barcelo, A. Baryshev, G. Bellassai, D. Berge, C. Bicknell, C. Bigongiari, G. Bonnoli, F. Bouley, A. Brown, A. Bulgarelli, M. Cappi, P. Caraveo, S. Caschera, P. Chadwick, F. Conte, G. Cotter, P. Cristofari, F. De Frondat, E. De Gouveia Dal Pino, N. De Simone, D. Depaoli, J-L Dournaux, C. Duffy, S. Einecke, C. Fermino, S. Funk, C. Gargano, G. Giavitto, A. Giuliani, T. Greenshaw, J. Hinton, J-M Huet, S. Iovenitti, N. La Palombara, J. Lapington, P. Laporte, S. Leach, L. Lessio, G. Leto, S. Lloyd, F. Lucarelli, S. Lombardi, A. Macchi, E. Martinetti, A. Micciche, R. Millul, T. Mineo, T. Mitsunari, A. Nayak, G. Nicotra, A. Okumura, G. Pareschi, M. Penno, H. Prokoph, E. Rebert, C. Righi, C. Rulten, F. Russo, R. Zanmar Sanchez, F. G. Saturni, J. Schaefer, B. Schwab, S. Scuderi, G. Sironi, V Sliusar, H. Sol, S. Spencer, A. Stamerra, H. Tajima, F. Tavecchio, G. Tosti, A. Trois, M. Vecchi, S. Vercellone, J. Vink, R. Walter, J. Watson, R. White, R. Zanin, L. Zampieri, A. Zech, A. Zink

Summary: The Cherenkov Telescope Array Observatory (CTAO) consists of three types of telescopes, distributed in two observation sites. The planned construction of 37 (+5) SST telescopes for the CTA South Alpha Configuration, and potentially up to 70 in future upgrades, will provide advanced optical design and SiPM detectors for a wide field of view.

GROUND-BASED AND AIRBORNE TELESCOPES IX (2022)

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Proceedings Paper Astronomy & Astrophysics

The Data Processing, Simulation, and Archive Systems of the ASTRI Mini-Array Project

Saverio Lombardi, Fabrizio Lucarelli, Ciro Bigongiari, Stefano Gallozzi, Martina Cardillo, Michele Mastropietro, Francesco Gabriele Saturni, Francesco Visconti, Lucio Angelo Antonelli, Andrea Bulgarelli, Milvia Capalbi, Osvaldo Catalano, Antonio Alessio Compagnino, Vito Conforti, Silvia Crestan, Giancarlo Cusumano, Antonino D'Ai, Stefano Germani, Andrea Giuliani, Simone Iovenitti, Valentina La Parola, Maria Concetta Maccarone, Teresa Mineo, Davide Mollica, Antonio Pagliaro, Nicolo Parmiggiani, Matteo Perri, Fabio Pintore, Salvatore Scuderi, Gino Tosti, Stefano Vercellone, Luca Zampieri

Summary: ASTRI Mini-Array is an international project to build and operate a array of nine 4-m class Imaging Atmospheric Cherenkov Telescopes for deep observations of gamma rays. The project aims to achieve effective handling and scientific exploitation of the data through dedicated systems for Data Processing, Simulation, and Archive. The raw data will be processed and analyzed to generate final scientific products, and detailed simulated data will be used for precise reconstruction and background rejection. The Archive System will provide data access at different user levels and for different use cases.

SOFTWARE AND CYBERINFRASTRUCTURE FOR ASTRONOMY VII (2022)

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Proceedings Paper Astronomy & Astrophysics

The Software Architecture and development approach for the ASTRI Mini-Array gamma-ray air-Cherenkov experiment at the Observatorio del Teide

A. Bulgarelli, F. Lucarelli, G. Tosti, V Conforti, N. Parmiggiani, J. H. Schwarz, L. A. Antonelli, L. Baroncelli, C. Bigongiari, M. Capalbi, M. Cardillo, G. A. R. Castillo, O. Catalano, A. A. Compagnino, M. Corpora, A. Costa, S. Crestan, G. Cusumano, A. D'Ai, V Fioretti, S. Gallozzi, S. Germani, F. Gianotti, V Giordano, A. Giuliani, P. G. Bruno, J. G. Green, A. Grillo, F. Incardona, S. Iovenitti, N. La Palombara, V La Parola, M. Landoni, S. Lombardi, M. C. Maccarone, R. Millul, T. Mineo, D. Mollica, A. Pagliaro, G. Pareschi, V Pastore, M. Perri, F. Pintore, P. Romano, F. Russo, P. Sangiorgi, F. G. Saturni, E. Sciacca, S. Scuderi, A. Tacchini, V Testa, M. Trifoglio, A. Tutone, S. Vercellone

Summary: The ASTRI Mini-Array is an international collaboration project focused on very-high gamma-ray astronomy. It utilizes an array of 9 telescopes and high-speed networking connection for remote operations and data processing.

SOFTWARE AND CYBERINFRASTRUCTURE FOR ASTRONOMY VII (2022)

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