期刊
MOLECULAR INFORMATICS
卷 29, 期 1-2, 页码 10-14出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/minf.200900069
关键词
Polypharmacology; Chemogenomics; Drug repurposing; Target profiling; Affinity fingerprint; Drug design; Molecular evolution
Far from the traditional view of selective drug-target interactions, the recent accumulation of large amounts of interaction data for small-molecule drugs and protein targets requires innovative visualisation and analysis tools that are able to deal with what has become a truly complex system. In this context, network theory offers both a robust and illustrative framework to investigate drug-target connections and has been swiftly and widely embraced by the chemical biology and molecular informatics communities. A survey of the most recent applications of drug-target networks to detect cross-pharmacology relationships among targets and to identify new targets for known drugs is provided. Finally, some of the current limitations are also discussed, including the actual completeness of interaction data and the information loss intrinsically associated with the one-mode projection of drug-target networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据