Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

(2015) Sarah M. Schumacher et al.   Science Translational Medicine

Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

(2014) Kristoff T. Homan et al.   ACS Chemical Biology

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

(2014) Elisa Lucas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased  2-Adrenergic Signaling in Hearts

(2014) Q. Fu et al.   DIABETES

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2

(2014) Lucia Garcia-Guerra et al.   Journal of Molecular Cell Biology

Adipose tissues and thyroid hormones

(2014) Maria-Jesus Obregon   Frontiers in Physiology

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors

(2013) Alfonso Carotenuto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Increased Nitric Oxide Bioavailability in Adult GRK2 Hemizygous Mice Protects Against Angiotensin II–Induced Hypertension

(2013) María S. Avendaño et al.   HYPERTENSION

Developmental and tumoral vascularization is regulated by G protein–coupled receptor kinase 2

(2013) Verónica Rivas et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans

(2013) Michiko Itoh et al.   PLoS One

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

(2013) Amandine Girousse et al.   PLOS BIOLOGY

GRK2 at the Control Shaft of Cellular Metabolism

(2012) Michele Ciccarelli et al.   CURRENT PHARMACEUTICAL DESIGN

GRK2 Inhibition in Heart Failure: Something Old, Something New

(2012) Anastasios Lymperopoulos et al.   CURRENT PHARMACEUTICAL DESIGN

G Protein-Coupled Receptor Kinase 2, With  -Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta

(2012) K. Taguchi et al.   DIABETES

GRK2 contribution to the regulation of energy expenditure and brown fat function

(2012) Rocio Vila-Bedmar et al.   FASEB JOURNAL

Peripheral Adrenoceptors: The Impetus Behind Glucose Dysregulation and Insulin Resistance

(2012) H. N. Boyda et al.   JOURNAL OF NEUROENDOCRINOLOGY

Insulin-sensitive obesity in humans – a ‘favorable fat’ phenotype?

(2012) D. Samocha-Bonet et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure

(2012) Sheila Collins   Frontiers in Endocrinology

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

(2011) Briohny W. Smith et al.   Nature Reviews Endocrinology

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia

(2011) Huijing Wang et al.   PAIN

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity

(2011) Kristin Eckardt et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation*

(2011) Rocio Vila-Bedmar et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance

(2011) Federico Mayor et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK

(2010) Mandeep P. Gaidhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The regulation and turnover of mitochondrial uncoupling proteins

(2010) Vian Azzu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

G Protein-Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity

(2010) L. Garcia-Guerra et al.   DIABETES

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

(2010) Rocio Vila-Bedmar et al.   ENDOCRINOLOGY

Determinants of brown adipocyte development and thermogenesis

(2010) D Richard et al.   INTERNATIONAL JOURNAL OF OBESITY

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

(2010) S Collins et al.   INTERNATIONAL JOURNAL OF OBESITY

Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications

(2010) Gavin W. Lambert et al.   PHARMACOLOGY & THERAPEUTICS

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Location, location: protein trafficking and lipolysis in adipocytes

(2008) James G. Granneman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM