Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Immunology
Donghui Bai, Yujie Sun, Qiong Li, Haihua Li, Yuerun Liang, Ximing Xu, Jiejie Hao
Summary: This study found that leonurine, extracted from Herba leonuri, has a protective effect on asthma by regulating the p38 MAPK/NF-κB signaling pathway to reduce inflammation and mucus overproduction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xiaoyu Bao, Jianping Wu
Summary: Ovomucin hydrolysate has been shown to prevent pathogen adhesion to intestinal epithelial cells, and in this study, it was demonstrated to improve intestinal barrier integrity by inhibiting inflammatory responses induced by LPS.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Integrative & Complementary Medicine
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi
Summary: The study found that alpha-mangostin can inhibit the formation and function of osteoclasts and prevent inflammatory osteolysis by inhibiting the activation of the NF-kappa B/mitogen-activated protein kinase signaling pathways. This has potential clinical applications for treating osteoclast-related diseases.
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Plant Sciences
Dong Zhen, Tian-qi Xuan, Boqin Hu, Xue Bai, Dan-ni Fu, Yu Wang, Yun Wu, Jingfeng Yang, Qianqian Ma
Summary: Pteryxin has anti-inflammatory properties by inhibiting NF-kappa B/MAPK signaling pathway and blocking NLRP3 activation, suggesting it as a potential treatment option for inflammatory-related diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Juan Xu, CongMei Xiao, HaiShun Xu, ShengXiang Yang, ZheMing Chen, HongZhen Wang, BingSong Zheng, BiZeng Mao, XueQian Wu
Summary: Ganoderma lucidum sterols (GLS) exhibit anti-inflammatory effects by inhibiting cell polarization and the release of proinflammatory mediators. The anti-inflammatory activity of GLS is mediated through MAPK and NF-kappa B pathways, suggesting a synergistic effect with Ganoderma polysaccharides and triterpenes.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Plant Sciences
Dong Zhen, Chunyan Liu, Tianpeng Huang, Danni Fu, Xue Bai, Qianqian Ma, Mingyang Jiang, Guohua Gong
Summary: Ethanol extracts of Loulu flowers alleviated LPS-induced acute lung injury by suppressing inflammatory response and enhancing antioxidation capacity, which correlated with the MAPK/NF-kappa B and Nrf2/HO-1 signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siqi Tang, Chunying Li, Zongwu Suo, Yi Xu, Kaixin Wei, Lei Zhao, Hao Huang, Xiangqian Liu, Dongxu Liu, Xiaojun Li
Summary: According to traditional Chinese medicine theory, the traditional herb Eleutherococcus henryi Oliv. is commonly used to treat inflammatory conditions. This study aimed to determine whether the natural lignan savinin obtained from the roots of E. henryi can relieve LPS-induced neuroinflammation and the underlying mechanism. The results showed that savinin significantly decreased the levels of neuroinflammatory cytokines and improved the LPS-induced neuroinflammatory response in mice by modulating the MAPK/NF-kappa B and NLRP3 signaling pathways.
Article
Agriculture, Multidisciplinary
Hung-Tse Huang, Chia-Ching Liaw, Chun-Tang Chiou, Yao-Haur Kuo, Kung-Ta Lee
Summary: Five new triterpene acids were isolated from a methanolic extract of Mesona procumbens, showing potential as NO inhibitors. These compounds also demonstrated the ability to inhibit NF-κB activation by interfering with the MAPK signaling pathway, leading to decreased levels of inflammatory proteins.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhouwei Duan, Hui Xie, Shasha Yu, Shiping Wang, Hong Yang
Summary: This study investigates the molecular mechanism of PIPERIN's anti-inflammatory effect in RAW264.7 cells and finds that it may regulate key factors of the NF-kappa B and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Anna C. Beck, Sonia L. Sugg, Ronald J. Weigel, Mary Belding-Schmitt, James R. Howe, Geeta Lal
Summary: Racial disparities exist in patients undergoing thyroidectomy for benign disease, with African American patients showing more pre-operative comorbidities. However, race is not an independent predictor of surgical outcomes.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammed O. Suraju, Nicole Peyton, Brian Mooers, Chris Jensen, Joel Shilyansky
JOURNAL OF CARDIOTHORACIC SURGERY
(2020)
Article
Oncology
Ingrid M. Lizarraga, Amanda R. Kahl, Ellie Jacoby, Mary E. Charlton, Charles F. Lynch, Sonia L. Sugg
Summary: The study found a high proportion of contralateral prophylactic mastectomy in young rural women in Iowa, with travel distance and availability of reconstructive services likely influencing decision-making. Improving access to multidisciplinary care in rural states may help optimize decision-making.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Editorial Material
Surgery
Muneera R. Kapadia, Ian M. Kratzke, Sonia L. Sugg
Article
Oncology
Philip M. Spanheimer, Amani Bashir, Allison W. Lorenzen, Anna C. Beck, Junlin Liao, Ingrid M. Lizarraga, Lillian M. Erdahl, Sonia L. Sugg, Mark W. Karwal, Ronald J. Weigel
Summary: In this study, preoperative vandetanib treatment for two weeks in patients with invasive breast cancer did not show significant differences in markers of proliferation and apoptosis compared to placebo. However, there was a trend towards reduction in p-ERK activation and enhanced effects in Ret-expressing tumors with vandetanib treatment, aligning with the investigational hypothesis.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Surgery
Sarah Kelley, Anna C. Beck, Ronald J. Weigel, James R. Howe, Sonia L. Sugg, Geeta Lal
Summary: This study assessed the impact of an institutional Endocrine MDT, finding that MDT presentations led to a higher rate of management changes, especially for recurrent TC patients, and increased evidenced-based practice among attendees. Attendees reported that the conference exceeded educational expectations, with a growing trend towards using evidence and guideline-based approaches.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Anna C. Beck, Sophia L. Fu, Junlin Liao, Amani Bashir, Sonia L. Sugg, Lillian M. Erdahl, Ronald J. Weigel, Ingrid M. Lizarraga
Summary: The study found that in patients with AH/LCIS, most patients received evaluation from breast surgeons, but only a small percentage accepted all risk management recommendations. MRI screening was more likely recommended in those with strong family history and high risk calculations, but 84% of patients did not receive any risk management recommendations.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Martin L. Blakely, Jon E. Tyson, Kevin P. Lally, Susan R. Hintz, Barry Eggleston, David K. Stevenson, Gail E. Besner, Abhik Das, Robin K. Ohls, William E. Truog, Leif D. Nelin, Brenda B. Poindexter, Claudia Pedroza, Michele C. Walsh, Barbara J. Stoll, Rachel Geller, Kathleen A. Kennedy, Reed A. Dimmitt, Waldemar A. Carlo, C. Michael Cotten, Abbot R. Laptook, Krisa P. Van Meurs, Kara L. Calkins, Gregory M. Sokol, Pablo J. Sanchez, Myra H. Wyckoff, Ravi M. Patel, Ivan D. Frantz, Seetha Shankaran, Carl T. D'Angio, Bradley A. Yoder, Edward F. Bell, Kristi L. Watterberg, Colin A. Martin, Carroll M. Harmon, Henry Rice, Arlet G. Kurkchubasche, Karl Sylvester, James C. Y. Dunn, Troy A. Markel, Diana L. Diesen, Amina M. Bhatia, Alan Flake, Walter J. Chwals, Rebeccah Brown, Kathryn D. Bass, Shawn D. St Peter, Christina M. Shanti, Walter Pegoli, David Skarda, Joel Shilyansky, David G. Lemon, Ricardo A. Mosquera, Myriam Peralta-Carcelen, Ricki F. Goldstein, Betty R. Vohr, Isabell B. Purdy, Abbey C. Hines, Nathalie L. Maitre, Roy J. Heyne, Sara B. DeMauro, Elisabeth C. McGowan, Kimberly Yolton, Howard W. Kilbride, Girija Natarajan, Kelley Yost, Sarah Winter, Tarah T. Colaizy, Matthew M. Laughon, Satyanarayana Lakshminrusimha, Rosemary D. Higgins
Summary: The study found that initial surgical treatment of necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP) did not result in overall differences in death or neurodevelopmental impairment (NDI) rates in premature infants. However, the impact of initial treatment varied depending on the preoperative diagnosis of NEC or IP.
Article
Oncology
Ingrid M. Lizarraga, Mary C. Schroeder, Ismail Jatoi, Sonia L. Sugg, Amy Trentham-Dietz, Laurel Hoeth, Elizabeth A. Chrischilles
Summary: The study found that patients choosing different surgical methods for breast cancer have differences in treatment decision-making goals and roles. However, women in the CPM group are more likely to take a more active role in treatment decision-making and are better able to reduce worries about recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Education, Scientific Disciplines
Megan J. Jensen, Junlin Liao, Barbara Van Gorp, Sonia L. Sugg, Julia Shelton, Claudia Corwin, Geeta Lal
Summary: The study found high rates of musculoskeletal symptoms among surgeon trainees during residency training. However, after receiving lectures on surgical ergonomics, all residents reported increased awareness of their own habits while operating and improved understanding of methods to prevent and treat work-related injuries.
JOURNAL OF SURGICAL EDUCATION
(2021)
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Editorial Material
Oncology
Rebecca A. Uhlmann, Sarah L. Mott, Melissa Curry, Sneha Phadke, Sonia L. Sugg, Lillian M. Erdahl, Ronald J. Weigel, Ingrid M. Lizarraga
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Rebecca A. Uhlmann, Sarah L. Mott, Melissa Curry, Sneha Phadke, Sonia L. Sugg, Lillian M. Erdahl, Ronald J. Weigel, Ingrid M. Lizarraga
Summary: This study examined the worry and knowledge of breast cancer survivors about lymphedema, as well as their willingness to participate in screening and prevention programs. The findings revealed limited knowledge about lymphedema risk factors among the participants, but higher worry levels were associated with advanced clinical stage, axillary lymph node dissection, and employment.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Rachel L. Shrode, Jessica E. Knobbe, Nicole Cady, Meeta Yadav, Jemmie Hoang, Catherine Cherwin, Melissa Curry, Rohan Garje, Praveen Vikas, Sonia Sugg, Sneha Phadke, Edward Filardo, Ashutosh K. Mangalam
Summary: Given the impact of geographical location on the gut microbiome, studying region-specific microbiome signatures of various diseases becomes crucial. This study focused on profiling the gut microbiome of breast cancer patients in the Midwestern region of the United States. The analysis revealed distinct clustering between breast cancer and healthy controls at the species and genera level, suggesting gut dysbiosis in breast cancer. Depletion of SCFA-producing gut bacteria was observed, indicating their potential role in the pathobiology of breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Deborah J. Wessels, Claude Pujol, Nikash Pradhan, Daniel F. Lusche, Luis Gonzalez, Sydney E. Kelly, Elizabeth M. Martin, Edward R. Voss, Yang-Nim Park, Michael Dailey, Sonia L. Sugg, Sneha Phadke, Amani Bashir, David R. Soll
Summary: A computer-assisted platform was developed using laser scanning confocal microscopy to reconstruct interactions between metastatic breast cancer cells and human umbilical vein endothelial cells in real-time. Results showed that an anti-RHAMM antibody blocked filopodium formation and related behaviors.
CELL ADHESION & MIGRATION
(2021)