Article
Cell Biology
Pina Marotta, Federica Salatiello, Luca Ambrosino, Federica Berruto, Maria Luisa Chiusano, Annamaria Locascio
Summary: The AP-1 transcription factor family is composed of Jun, Fos, Atf3, Atf2/7, and Maf in the tunicate Ciona robusta, where they are mainly expressed in mesenchyme cells during embryonic development, with Fos also showing expression in notochord and neural cells. By ectopic expression in transgenic embryos, the study confirmed functional conservation of the AP-1 complex between Ciona and vertebrates in controlling cell movements and structural organization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Glenn J. Markov, Thach Mai, Surag Nair, Anna Shcherbina, Yu Xin Wang, David M. Burns, Anshul Kundaje, Helen M. Blau
Summary: The AP-1 transcription factor c-Jun plays a critical role in human somatic cell reprogramming by enhancing enhancer accessibility in fibroblasts and repressing OCT4 expression. Through epigenome remodeling, successful reprogramming of human fibroblasts to induced pluripotent stem cells was achieved.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Caiyun Lai, Fan Wu, Yan Wang, Wei Wang, Yueqi Li, Gaoqiang Zhang, Jianji Gao, Zhiliang Zhu, Jianhui Yuan, Jianping Yang, Wenjuan Zhang
Summary: TCE exposure can cause DNA hypomethylation and histone hyperacetylation in cells, leading to increased protein levels of tumor-related genes and inhibiting cell growth. These changes could serve as early biomarkers for TCE-associated diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
James T. Leech, Andrew Brennan, Nicola A. Don, Jody M. Mason, Neil M. Kad
Summary: The AP-1 transcription factor family plays a crucial role in regulating the cell cycle and has various functions in proliferation, differentiation, and stress response. This study shows that cFos can bind to DNA independently of cJun and can interact with DNA as both monomers and dimers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Natalia Ruiz -Molina, Juliana Parsons, Eva L. Decker, Ralf Reski
Summary: Human complement is crucial for defense against pathogens and tissue homeostasis. Factor H (FH) and Factor H-related protein 1 (FHR1) are important complement regulators. The structure of synthetic regulators based on FH and FHR1 were modeled using AlphaFold2, and the interactions between C3 fragments, MAC components (C5, C7, and C9), and various regulators were studied using AlphaFold-Multimer (AFM). The findings provide insights into the molecular mechanisms of complement regulation and can guide the development of complement-based therapies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Immunology
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira
Summary: The complement system plays a crucial role in both innate and adaptive immunity, with three pathways that can be triggered spontaneously or in response to danger. Pathogens often evade this system by hijacking host complement regulators, such as Factor H, to protect themselves from immune attack. Understanding how pathogens interact with complement regulators like Factor H can provide insights into developing treatment strategies to target pathogen evasion mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Brandon Renner, Jennifer Laskowski, Felix Poppelaars, Viviana P. Ferreira, Judith Blaine, Alexandra H. Antonioli, Jonathan P. Hannan, James M. Kovacs, Cees Van Kooten, Zhiying You, Matthew C. Pickering, V. Michael Holers, Joshua M. Thurman
Summary: This study demonstrates that the Factor H-related proteins have unique effects on different cell types within the kidney, with FHR E causing glomerular complement dysregulation in vivo. This has important implications for understanding the pathogenesis of glomerular diseases.
KIDNEY INTERNATIONAL
(2022)
Article
Neurosciences
Ji Won Yoo, Sung-Hwa Sohn, Yeon-Hwa Kim, Too Jae Min
Summary: This study demonstrated that UTI improved learning and memory in zebrafish by enhancing the expression levels of glutamate transporter and cognitive bio-markers. The dose-dependent effect of UTI was observed, indicating that UTI-enhanced learning and memory in zebrafish.
NEUROMOLECULAR MEDICINE
(2021)
Article
Oncology
Milad Soleimani, Alexander Somma, Tamer Kaoud, Ria Goyal, Jorge Bustamante, Dennis C. Wylie, Nisha Holay, Agnieszka Looney, Uma Giri, Todd Triplett, Kevin Dalby, Jeanne Kowalski, S. Gail Eckhardt, Carla Van Den Berg
Summary: JNK-IN-8, a covalent JNK inhibitor, suppresses the growth of triple-negative breast cancer (TNBC) by activating TFEB/TFE3 and inducing lysosome biogenesis and autophagy via mTOR inhibition independently of JNK.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Sung Shin Ahn, Hyunjin Yeo, Euitaek Jung, Yoongho Lim, Young Han Lee, Soon Young Shin
Summary: This study identified the molecular mechanisms by which inflammatory cytokines inhibit the expression of FLG in the skin. It was found that the formation of the FRA1:c-JUN:HDAC1 complex is promoted under TNFa + IFNγ stimulation, leading to the downregulation of FLG expression. This insight into the regulatory pathways of FLG expression provides potential therapeutic strategies for restoring skin barrier function in chronic skin inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Clement Bechtler, Sophia Koutsogiannaki, Ekaterina Umnyakova, Amal Hamid, Avneesh Gautam, Yiannis Sarigiannis, Richard B. Pouw, Christina Lamers, Said Rabbani, Christoph Q. Schmidt, John D. Lambris, Daniel Ricklin
Summary: The use of biomaterials in modern medicine has advanced drug delivery strategies and reduced morbidity and mortality. However, immune reactions remain a serious complication.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag
Summary: Complement dysregulation is a key characteristic of renal diseases like aHUS and C3G, where mutations in proteins like FH and FHRs can lead to complement activation. This study found that 2-O-desulfated heparin derivatives could potentially serve as therapeutics for dysregulated complement diseases by competitively inhibiting FHR1 and FHR5 binding to HSGlx, reducing C3b deposition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yongbing Zhao
Summary: TFSyntax is a database focusing on the arrangement of transcription factor binding sites, providing detailed TF binding maps and syntax information. It contains a large amount of data mapping transcription factor binding motifs, which is valuable for studying the mechanism of transcriptional regulation and the mechanism of regulatory DNA variants causing diseases.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Wei Tang, Hongyang Liu, Lixian Chen, Ke Zhao, Yaoyao Zhang, Ke Zheng, Cheng Zhu, Tiansheng Zheng, Jiahong Liu, Dandan Wang, Lingfang Yu, Xinyu Fang, Chen Zhang, Kuan-Pin Su
Summary: The study revealed that patients with anhedonia in major depressive disorder exhibit different inflammatory characteristics compared to patients without anhedonia. Elevated plasma CFH levels may serve as a potential biomarker for anhedonia in subtyping MDD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Alexandra Gerogianni, Laura M. Baas, Dick J. Sjostrom, Nicole C. A. J. van de Kar, Marit Pullen, Siem J. van de Peppel, Per H. Nilsson, Lambertus P. van den Heuvel
Summary: This study evaluated the functional impact of eight recombinant FI genetic variants found in patients. The results demonstrated that mutations in the FIMAC and SP domains significantly reduced FI's protease activity, while mutations in the LDLRA2 domain did not have a profound effect. Different analytical assays showed a strong positive correlation, and combining different methods and co-factors was necessary to observe activity differences in certain genetic variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
D. Gray Heppner, Tracy L. Kemp, Brian K. Martin, William J. Ramsey, Richard Nichols, Emily J. Dasen, Charles J. Link, Rituparna Das, Zhi Jin Xu, Eric A. Sheldon, Teresa A. Nowak, Thomas P. Monath
LANCET INFECTIOUS DISEASES
(2017)
Article
Medicine, General & Internal
J. A. Regules, J. H. Beigel, K. M. Paolino, J. Voell, A. R. Castellano, Z. Hu, P. Munoz, J. E. Moon, R. C. Ruck, J. W. Bennett, P. S. Twomey, R. L. Gutierrez, S. A. Remich, H. R. Hack, M. L. Wisniewski, M. D. Josleyn, S. A. Kwilas, N. Van Deusen, O. T. Mbaya, Y. Zhou, D. A. Stanley, W. Jing, K. S. Smith, M. Shi, J. E. Ledgerwood, B. S. Graham, N. J. Sullivan, L. L. Jagodzinski, S. A. Peel, J. B. Alimonti, J. W. Hooper, P. M. Silvera, B. K. Martin, T. P. Monath, W. J. Ramsey, C. J. Link, H. C. Lane, N. L. Michael, R. T. Davey, S. J. Thomas
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Article
Multidisciplinary Sciences
Wenlan Alex Chen, Jinjin Zhang, Katie M. Hall, Carol B. Martin, Serguei Kisselev, Emily J. Dasen, Nicholas N. Vahanian, Charles J. Link, Brian K. Martin
Article
Biochemical Research Methods
Robert B. Mandell, Ramesh Koukuntla, Laura J. K. Mogler, Andrea K. Carzoli, Michael R. Holbrook, Brian K. Martin, Nicholas Vahanian, Charles J. Link, Ramon Flick
JOURNAL OF VIROLOGICAL METHODS
(2010)
Article
Biochemistry & Molecular Biology
Sarah A. Ingersoll, Carol B. Martine, Scott R. Barnum, Brian K. Martin
MOLECULAR IMMUNOLOGY
(2010)
Review
Biochemistry & Molecular Biology
Laura A. Fraczek, Brian K. Martin
MOLECULAR IMMUNOLOGY
(2010)
Review
Virology
Robert B. Mandell, Ramesh Koukuntla, Laura J. K. Mogler, Andrea K. Carzoli, Alexander N. Freiberg, Michael R. Holbrook, Brian K. Martin, William R. Staplin, Nicholas N. Vahanian, Charles J. Link, Ramon Flick
Article
Neurosciences
Dustin T. Briggs, Carol B. Martin, Sarah A. Ingersoll, Scott R. Barnum, Brian K. Martin
Article
Biochemistry & Molecular Biology
Carol B. Martin, Sarah A. Ingersoll, Brian K. Martin
MOLECULAR IMMUNOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Carol B. Martin, Sarah A. Ingersoll, Brian K. Martin
MOLECULAR IMMUNOLOGY
(2007)
Article
Neurosciences
R Reiman, AC Torres, BK Martin, JP Ting, LL Campbell, SR Barnum
NEUROSCIENCE LETTERS
(2005)
Article
Oncology
DY Kim, CB Martin, SN Lee, BK Martin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2005)
Article
Immunology
CB Martin, BK Martin
JOURNAL OF IMMUNOLOGY
(2005)
Review
Immunology
Brian K. Martin
IMMUNOLOGIC RESEARCH
(2007)