Article
Biotechnology & Applied Microbiology
Tao Zhang, Haoyuan Yu, Manita Aryal, Jing Yang, Maolin Li, Shuxian Li, Na Zhang, Han Shi, Baoyu Li, Guangliang Liu, Yuguang Fu
Summary: This study successfully prepared two monoclonal antibodies against porcine CD103 protein and demonstrated their applicability in vivo experiments. This provides the basis for the study of porcine mucosal immunity.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Immunology
Tomas Blanco, Rohan Bir Singh, Hayate Nakagawa, Yukako Taketani, Thomas H. Dohlman, Yihe Chen, Sunil K. Chauhan, Jia Yin, Reza Dana
Summary: This study assesses the role of CD103+DC1 in suppressing Th1 alloreactivity in transplanted corneal allografts and finds that CD103+DC1 plays a critical role in regulating host alloimmune responses.
MUCOSAL IMMUNOLOGY
(2023)
Article
Immunology
Wei Zhang, Eun-Koung An, So-Jung Kim, Hae-Bin Park, Peter C. W. Lee, Jun-O Jin
Summary: This study demonstrated the side effects of FimH and indicated that the use of FimH can aggravate the disease in patients with colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Gabriela Peron, Janine Oliveira, Fabricio Freitas Fernandes, Liana Verinaud
Summary: DC subsets expressing alpha E integrin have antagonistic functions in driving T cells towards inflammatory or immunosuppressive phenotypes depending on tissue microenvironment factors. Lung CD103(+) DCs in a pulmonary P. brasiliensis infection model contribute to Treg differentiation, suggesting an immunosuppressive effect similar to that observed in PCM patients.
MICROBIAL PATHOGENESIS
(2021)
Article
Oncology
Kaikai Zhao, Liyang Jiang, Youjiao Si, Shujie Zhou, Zhaoqin Huang, Xiangjiao Meng
Summary: This study explores the synergistic effects of radiotherapy (RT) combined with anti-TIGIT therapy and the underlying mechanism. The results show that TIGIT is upregulated in immune cells after RT. The administration of anti-TIGIT antibody enhances the efficacy of RT through a CD8+ T cell-dependent mechanism. The combination of RT and anti-TIGIT antibody promotes the accumulation of tumor-infiltrating dendritic cells (DCs), leading to the activation of CD8+ T cells. CD103+ DCs play a critical role in promoting the anti-tumor effects of the combination therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Qifeng Zhong, Yong Lu, Wenlong Xu, Zhien Rong, Xu Chang, Li Qin, Xiaoping Chen, Fang Zhou
Summary: NSCLC cells have a modulating effect on the protein expression of CD86 and HLA-DR on CD303(+) pDCs, as well as on the production of cytokines like IL-12, IL-23, IL-27, and TGF-beta by these cells. Additionally, NSCLC cells regulate the development of CD303(+) pDC subsets expressing CD205 and/or CD103 through the modulation of protein expression on these cells. This may ultimately contribute to the creation of an immune-suppressive microenvironment induced by NSCLC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shuai Wang, Qinchuan Wu, Tianchi Chen, Rong Su, Caixu Pan, Junjie Qian, Hechen Huang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: In addition to the classical DC-T cell axis, CD47 blockade significantly enhances the ability of CD103(+) DCs to take up tumor DNA, resulting in the stimulation of the cGAS-STING pathway and the promotion of NK cell infiltration and activation in liver cancer.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Lynn Mes, Ulrike Steffen, Hung-Jen Chen, Jennifer Veth, Willianne Hoepel, Guillermo Romeo Griffith, Georg Schett, Jeroen den Dunnen
Summary: While IgA is known for its neutralizing and anti-inflammatory function, little is known about the inflammatory role of IgA subclasses, IgA1 and IgA2. This study demonstrates that both IgA subclasses amplify pro-inflammatory cytokine production in human myeloid immune cell subsets, with IgA2 inducing significantly more inflammation in CD103(+) dendritic cells. These findings have implications for understanding the role of IgA subclasses in inflammatory disorders and chronic intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Mallory Paynich Murray, Catherine M. Crosby, Paola Marcovecchio, Nadine Hartmann, Shilpi Chandra, Meng Zhao, Archana Khurana, Sonja P. Zahner, Bjorn E. Clausen, Fadie T. Coleman, Joseph P. Mizgerd, Zbigniew Mikulski, Mitchell Kronenberg
Summary: This study investigates the roles of innate-like T cells during pulmonary pneumococcal infection. The researchers found that these T cells rapidly increase in the lung tissue following infection and participate in the immune response. Specifically, interleukin-17-producing NKT17 and gamma delta T cells play a major role in the infection, with NKT17 cells being preferentially located in lung tissue prior to infection and interacting with CD103(+) dendritic cells. These studies demonstrate the importance of specific cellular interactions and functional subsets of innate-like T cells in protecting against lung infection.
Article
Biochemistry & Molecular Biology
Karin Egusa, Shusaku Shibutani, Hiroyuki Iwata
Summary: In this study, the regulatory mechanism of endocytosis in THP-1 cells was investigated. It was found that IgG and insulin enhance endocytic activity in THP-1 cells by activating PI3K. These findings indicate the importance of IgG and insulin in maintaining cellular endocytic activity and antigen presentation and nutrient uptake.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Zora Modrusan, Jacqueline McBride, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Marcin Kowanetz, Wei Zou, Mark McCleland, Patrick Caplazi, Shadi Toghi Eshgi, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, W. Rodney Mathews, Thomas Powles, Sanjeev Mariathasan, Jane Grogan, William E. O'Gorman
Summary: CD8+ tissue-resident memory T (T-RM) cells expressing CD103 (ITGAE) are believed to actively suppress cancer progression, and their presence in tumors may predict response to immunotherapy. This study found that in inflamed tumors, CD103+ CD8+ T-RM cells exhibit a complex phenotype characterized by increased clonal expansion, expression of checkpoint regulators, and cytotoxic proteins, suggesting their involvement in antitumor response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Kyungtaek Im, Yun Jung Choi, Dong Ha Kim, Da -Som Kim, Kyosun Ban, Wonjun Ji, In-Jeoung Baek, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Summary: This study reveals that AXL inhibits the clonal expansion of tumor-specific CD8+ T cells through the regulation of CD8+ T cell and DC migration in the tumor microenvironment. AXL knockout suppresses tumor growth and induces an increased population of tumor-infiltrating CD8+ T cells and CD103+ DCs. Anti-PD-1 treatment shows synergistic anti-cancer effects in AXL-/- mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Manami Tanaka, Masato Yasui, Mariko Hara-Chikuma
Summary: Inhibition of AQP3 can suppress the growth of multiple myeloma cells and tumor growth, suggesting that AQP3 inhibition may be an effective therapeutic strategy for multiple myeloma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Shota Shimizu, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa
Summary: PI3K-C2 alpha is essential for clathrin-mediated endocytosis of the gamma-secretase complex, facilitating the cleavage of endocytosed Notch1 by the gamma-secretase complex to generate NICD1 in ECs.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Wei Pan, Nie Hui, Hongmei Wang, Hongbin He
Summary: Bovine parainfluenza virus 3 enters MDBK cells via macropinocytosis and clathrin-mediated endocytosis, requiring acid-dependent entry and cathepsin L. Additionally, macropinocytosis is dependent on actin dynamics during BPIV3 infection.
VETERINARY MICROBIOLOGY
(2021)