期刊
MOLECULAR IMMUNOLOGY
卷 47, 期 10, 页码 1899-1904出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2010.03.013
关键词
Conserved extended haplotype; MHC; HLA; Complotype; family study
资金
- National Office for Research and Technology, Hungary
- Hungarian Research Fund [OTKA T049266, OTKA NF72689, OTKA K 73247]
- Juvenile Diabetes Research Foundation [1-2008-472]
- National Institutes of Health, USA [HL 29583, AM 26844, HD 17461]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD017461] Funding Source: NIH RePORTER
- NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE &KIDNEY DISEASES [R01AM026844] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL029583] Funding Source: NIH RePORTER
Conserved extended haplotypes (CEHs) are large (>= 1 Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasian families in comparison with the previous findings in 2675 normal American Caucasian chromosomes from families in the Boston area. Besides HLA-A, -B and HLA-DRB1/-DQB1 alleles, copy number polymorphism of C4A and C4B genes and several SNPs encoded in the central (class III) MHC region were determined. By comparing 188 Caucasian haplotypes in Hungary to 2675 normal Caucasian chromosomes in Boston, we found that 11 of 12 of the most common CEHs (with a frequency of at least 1%) among the Boston chromosomes also occurred in Hungary. Moreover, there was a significant correlation (R = 0.789: p = 0.0023) in the frequency order of these haplotypes between the two Caucasian populations. Of 10 haplotypes found in >= 2 copies among the Hungarian chromosomes, all but one occurred in one to 14 copies among the Boston haplotypes. These findings indicate that CEHs are commonly shared by distinct European Caucasian populations; however, lower frequency CEHs may differ. (C) 2010 Elsevier Ltd. All rights reserved.
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