Article
Pharmacology & Pharmacy
Tameille Valentine, Lydia Hardowar, Jasmine Elphick-Ross, Richard P. Hulse, Mark Paul-Clark
Summary: Chemotherapy-induced neuropathies cause sensory disturbances and pain in cancer patients, and current analgesic strategies are ineffective due to a lack of understanding of the underlying causes. Research on the immune-neuronal interactions across different cancer therapy drug classes may lead to better pain management for cancer survivors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Zhe LI, Pengbo He, Yuqing Xu, Yuxiao Deng, Yuvan Gao, Sung -liang Chen
Summary: This study demonstrates the noninvasive observation of inflammation-related vascular leakage using photoacoustic microscopy (PAM) in mice. A model combining LPS application and EB injection on mouse ears was developed for the identification and evaluation of early vascular leakage. The results show the potential of PAM in clinical sepsis diagnosis and management.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Critical Care Medicine
Jeremie Joffre, Elliot Lloyd, Erika Wong, Che Chung-Yeh, Nina Nguyen, Fenguyn Xu, Matthieu Legrand, Judith Hellman
Summary: The study showed that epinephrine or norepinephrine significantly reduced endothelial permeability induced by various Toll-like receptor agonists. This effect was mediated by beta 1 and beta 2 adrenergic receptors.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Apple Cortez Vollmers, Sergio Covarrubias, Daisy Kuang, Aaron Shulkin, Justin Iwuagwu, Sol Katzman, Ran Song, Kasthuribai Viswanathan, Christopher Vollmers, Edward Wakeland, Susan Carpenter
Summary: Recent studies have identified a previously unknown function for the lncRNA GAPLINC, which acts as a negative regulator of inflammation in the context of innate immunity, macrophages, and LPS-induced endotoxic shock. Transcriptome analysis in human and mouse macrophages showed that GAPLINC is highly expressed following macrophage differentiation, but rapidly down-regulated upon inflammatory activation. Depletion of GAPLINC leads to enhanced expression of inflammatory genes, while overexpression suppresses this response, ultimately modulating endotoxic shock and multiorgan failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Furong Lu, Yuan Hong, Lizhen Liu, Ning Wei, Yao Lin, Junbing He, Yiming Shao
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of sepsis, with potential implications for diagnosis and management. Further research into lncRNAs could lead to innovative approaches for sepsis treatment.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Keshu Liu, Rongzhang Dou, Chaogang Yang, Ziyang Di, Dongdong Shi, Chunxiao Zhang, Jialin Song, Yan Fang, Sihao Huang, Zhenxian Xiang, Weisong Zhang, Shuyi Wang, Bin Xiong
Summary: Metastasis is the main cause of colorectal cancer treatment failure and death. Communication between endothelium and tumor cells in the tumor microenvironment is crucial for cancer metastasis. Tumor-derived exosomes play a role in increasing vascular permeability, thereby facilitating cancer metastasis. By targeting Kruppel-like factor 4 (KLF4), exosomal miR-29a secreted by EMT-CRC cells decreases the expression of Zonula occlusion 1 (ZO-1), Claudin-5, and Occludin, leading to altered vascular endothelial permeability and promoting the development and metastasis of CRC. Exosomal miR-29a has the potential to be both a predictive marker for tumor metastasis and a therapeutic target for CRC.
Review
Cardiac & Cardiovascular Systems
Ziwei Ou, Elena Dolmatova, Bernard Lassegue, Kathy K. Griendling
Summary: The integrin family, crucial for cell-cell and cell-matrix interactions, plays a significant role in the initiation of acute inflammation by regulating vascular permeability and leukocyte recruitment. Understanding the fine-tuning of integrin signaling during acute inflammation may inspire the development of new drugs for inflammatory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P. Scicluna, W. Joost Wiersinga, Felipe A. Vieira Braga, Tom van der Poll
Summary: This study integrated single-cell data from patients with COVID-19, influenza, and non-infectious controls, revealing unique immune features in CAP patients caused by different pathogens, such as varied levels of NK cells and CD8 T EMRA cells.
Article
Pharmacology & Pharmacy
Pankaj Yadav, Hina Iqbal, Kapil Kumar, Parmanand Kumar, Divya Mishra, Arjun Singh, Anirban Pal, Pradipto Mukhopadhyay, Beena Vamadevan, Dhirendra Singh, Arvind Singh Negi, Debabrata Chanda
Summary: LT-9 exhibited potent biological activity against sepsis in CLP mice by reversing vascular hyporeactivity and enhancing contraction response to norepinephrine through opening of L-type VDCC. Oral administration of LT-9 for 15 days significantly improved survival time, hemodynamic and ECG profile in CLP mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Gillis Greiwe, Eileen Moritz, Katharina Amschler, Annika Poppe, Harun Sarwari, Axel Nierhaus, Stefan Kluge, Hermann Reichenspurner, Christian Zoellner, Edzard Schwedhelm, Guenter Daum, Bjoern Tampe, Martin Sebastian Winkler
Summary: This study found that major cardiac surgery disrupts serum S1P levels, with post-surgery low S1P levels potentially serving as a new marker for evaluating the severity of surgery-induced inflammation. Patients whose S1P levels did not recover to preoperative levels had longer ICU stays and more severe postoperative inflammation. Additionally, the study suggests that high-dose heparin during surgery may have an inhibitory effect on circulating S1P levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
I. P. Shilovskiy, M. S. Sundukova, A. Korneev, A. A. Nikolskii, E. D. Barvinskaya, V. Kovchina, L. Vishniakova, V. N. Turenko, K. Yumashev, M. M. Kaganova, V. E. Brylina, I Sergeev, A. Maerle, D. A. Kudlay, O. Petukhova, M. R. Khaitov
Summary: Bronchial asthma is a common chronic inflammatory disease of airways, and Th2 cytokines IL-4 and IL-13 play a crucial role in its pathogenesis. Experimental data suggest that siRNA targeted to IL-4 and IL-13 can reduce asthma symptoms, attenuate pulmonary inflammation, and inhibit airway hyperreactivity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ye-Chen Han, Zhu-Jun Shen, Yi-Ning Wang, Ruo-Lan Xiang, Hong-Zhi Xie
Summary: The study analyzed the changes in long non-coding RNAs (lncRNAs) and mRNAs in aorta tissue in rats with lipopolysaccharide-induced sepsis using microarrays, and determined the functional networks. The differentially expressed lncRNAs and mRNAs were identified, and further studies on these lncRNAs may help elucidate the genetic mechanism of sepsis and identify potential therapeutic targets.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhu, Xinlin Wang, Tianhao Ying, Xiaoli Li, Yidi Tang, Yanfang Wang, Tao Yu, Mengmeng Sun, Jianing Zhao, Yuan Du, Leiming Zhang
Summary: This study investigated the anti-sepsis effects and mechanisms of kaempferol in a lipopolysaccharide-induced sepsis model. The results demonstrated that kaempferol alleviated inflammatory response and stabilized the endothelial barrier in LPS-induced sepsis by regulating the SphK1/S1P signaling pathway. The study also revealed that kaempferol exhibited cell-specific effects on the regulation of SphK1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Junning Cheng, Chang Ding, Huying Tang, Haonan Zhou, Mingdong Wu, Yikuan Chen
Summary: In sepsis, the ROS-activated MITF-GAS5-miR-23 loop integrates the antioxidant and autophagy systems through MITF-mediated transcription of Nrf2 and p62, dynamically regulating the level and type of autophagy, as well as exerting antioxidant and anti-inflammatory effects.
Article
Nanoscience & Nanotechnology
Nitish Khurana, Bhuvanesh Yathavan, Jolanta Jedrzkiewicz, Amarbir S. Gill, Abigail Pulsipher, Jeremiah A. Alt, Hamidreza Ghandehari
Summary: Research suggests that using nanoscale liposomal carriers can enhance drug accumulation and retention in the sinonasal tissue of patients with chronic rhinosinusitis, ultimately improving patient outcomes.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)