Article
Medicine, Research & Experimental
Rehab M. El-Sayed, Rehab E. Abo El Gheit, Ghada A. Badawi
Summary: The study revealed that vincamine has a protective effect against cisplatin-induced nephrotoxicity by reducing kidney damage through various mechanisms, including antioxidant, anti-inflammatory, and anti-apoptotic activities.
Article
Immunology
Kang Li, Jiaqi Li, Xiumei Wei, Junya Wang, Ming Geng, Kete Ai, Wei Liang, Jiansong Zhang, Kunming Li, Haiyou Gao, Jialong Yang
Summary: The study investigated the suppression of T cell immunity by IL-10 in a Nile tilapia model. The findings reveal that IL-10 inhibits T cell activation and differentiation through the activation of JAK1/STAT3 axis and suppression of NF-KB and MAPK/ERK signaling pathways.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Siqi Liu, Junfu Guo, Xianda Cheng, Wenna Li, Shuangyu Lyu, Xuanyi Chen, Qingwei Li, Hao Wang
Summary: This study identifies TGF-beta homologs in jawless vertebrates and reveals the origin and evolution of the TGF-beta subfamily. The findings suggest that TGF-beta s play important roles in immune regulation in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiao Yin, Xiansheng Zhao, Xuejiao Chen, Guanxin Shen
Summary: Emodin regulates M2 polarization through the miR-26a/TGF-beta 1/Akt signaling pathway, inhibiting the growth of hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Jun Li, Ruoshui Li, Izabela Tuleta, Silvia C. Hernandez, Claudio Humeres, Anis Hanna, Bijun Chen, Nikolaos G. Frangogiannis
Summary: The role of macrophage Smad7 in regulating inflammation and repair after myocardial infarction is limited. The anti-inflammatory effects of TGF-beta in macrophages are not restrained by endogenous Smad7 induction.
Article
Chemistry, Medicinal
Eleonora Binatti, Gianni Zoccatelli, Francesca Zanoni, Giulia Dona, Federica Mainente, Roberto Chignola
Summary: The study demonstrates that astaxanthin-loaded microparticles are radiation-resistant, well-tolerated by J774A.1 macrophages, significantly reduce intracellular reactive oxygen species, and inhibit the release of active TGF beta. This indicates that micro-encapsulation of bioactive molecules is a promising strategy to specifically target phagocytic cells and modulate their functions.
Article
Neurosciences
Debora Denardin Luckemeyer, Wenrui Xie, Arthur Silveira Prudente, Katherine A. Qualls, Raquel Tonello, Judith A. Strong, Temugin Berta, Jun-Ming Zhang
Summary: Through experiments, researchers found that the TGF-beta signaling pathway plays an important role in local sympathetic blockade by regulating macrophages in the DRG and its anti-inflammatory actions to alleviate pain behaviors.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Jen-Lung Chen, Yun-Shen Tai, Hsin-Yi Tsai, Chia-Yuan Hsieh, Chun-Lin Chen, Chung-Jung Liu, Deng-Chyang Wu, Yaw-Bin Huang, Ming-Wei Lin
Summary: This study investigated the role of GRP78 in gastric cancer stemness and the regulatory effect of BA on it. The results showed that BA inhibited GRP78-mediated stemness-related protein expression, GRP78-TGF-beta-mediated macrophage polarization into TAMs, and TAM-mediated cancer stemness.
Article
Immunology
Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. In this study, TIM-4 was found to be increased in the sinonasal mucosa of CRSwNP patients, especially in macrophages. TIM-4 was positively correlated with clinical scores and inhibition of TIM-4 reduced polyp formation and EMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Min Yang, Jia Wei Liu, Yu Ting Zhang, Gang Wu
Summary: M2 macrophages, AIM and TGF-beta 1 play important roles in the progression of IgAN fibrosis, and they are interrelated. Their expression levels are positively correlated with serum creatinine, 24-hour proteinuria, and fibrotic area, while negatively correlated with eGFR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Guadalupe Hernandez-Ramirez, Diego Pazos-Castro, Zulema Gonzalez-Klein, Jose Luis Resuela-Gonzalez, Sergio Fernandez-Bravo, Lucia Palacio-Garcia, Vanesa Esteban, Maria Garrido-Arandia, Jaime Tome-Amat, Araceli Diaz-Perales
Summary: This study demonstrated that Alt a 1 can induce asthmatic phenotypes in vivo, promoting tissue remodeling and infiltration of CD45+ cells, particularly eosinophils and macrophages (Siglec F+ and F4/80+). Furthermore, the study revealed that Alt a 1 sensitization is mediated by the TLR4-macrophage axis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Teng Li, Yi Xing, Guoxian Zhang, Yan Wang, Yinsheng Wei, Lingang Cui, Shaojin Zhang, Qingwei Wang
Summary: This study found that circRNA PVT1 regulates bladder wall remodeling caused by BOO and phenotypic changes in hypoxia-induced BMSCs through the miR-203-SOCS3 signaling pathway.
Article
Immunology
Zhijia Li, Muzhou Teng, Yinbo Jiang, Litian Zhang, Xi Luo, Yuhui Liao, Bin Yang
Summary: This study provides the first demonstration of the role of m6A methylation in the pathological process of syphilis and offers new insight into the pathogenesis of TP infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bijun Chen, Ruoshui Li, Silvia C. Hernandez, Anis Hanna, Kai Su, Arti V. Shinde, Nikolaos G. Frangogiannis
Summary: TGF-beta signaling through Smad2/3 regulates macrophage responses in myocardial infarction. Smad3 plays a crucial role in mediating the anti-inflammatory and phagocytic effects of TGF-beta, while the activation of Smad2 does not affect these processes. Smad3, but not Smad2, is the main mediator of transcriptional effects of TGF-beta on macrophages.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Immunology
Shunxian Zhang, Xiaoqin Li, Li Zhu, Siqi Ming, Hongli Wang, Jing Xie, Lu Ren, Jing Huang, Defeng Liang, Liya Xiong, Yuesheng Wang, Dan Zhang, Sitang Gong, Yongjian Wu, Lanlan Geng
Summary: The study revealed that CD163(+)M phi in colorectal polyps may promote polyp progression by inhibiting the local T cell response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)