Article
Biochemistry & Molecular Biology
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Giulia Recchia Luciani, Maurizio Soli, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: The purpose of this study was to investigate the impact of the JAK-STAT inhibitor baricitinib on the inflammatory response caused by the spike S1 protein from SARS-CoV-2. The research findings indicate that baricitinib can inhibit the phosphorylation of STAT1 and STAT3 in MDM, and decrease the release of IL-6 and TNF alpha. However, its effectiveness on endothelial cell activation is limited.
Article
Developmental Biology
Si Chen, Kira L. Lathrop, Takaaki Kuwajima, Jeffrey M. Gross
Summary: The study identifies the essential role of JAK/STAT pathway activity in the survival of retinal ganglion cells (RGCs) after optic nerve injury, showing that immune responses directly contribute to RGC death. Blocking neuroinflammation or depleting macrophages/microglia rescues RGC survival post-injury.
Review
Microbiology
Rui Zhang, Jun Tang
Summary: This review highlights the importance of IFN-I mediated innate immunity in defense against viral infection, focusing on the strategies employed by the alphaherpesvirus Pseudorabies virus (PRV) to counteract IFN-I mediated immunity, particularly through inhibition of IFN-I induced gene transcription via the JAK-STAT pathway. Knowledge gained from PRV contributes to understanding alphaherpesviral immune evasion mechanisms and aids in vaccine development for PRV control.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang
Summary: Innate immunity serves as the initial defense against viral infections, but viruses like PRRSV have evolved various strategies to evade it. PRRSV, a highly destructive virus in the global swine industry, utilizes multiple strategies to avoid porcine innate immune responses. Understanding the evasion mechanisms employed by PRRSV can aid in developing more effective methods to control and eliminate the virus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabio Sarais, Sophia Kummerow, Ruth Montero, Henrike Rebl, Bernd Koellner, Tom Goldammer, Bertrand Collet, Alexander Rebl
Summary: The study revealed the existence of eight pias genes in the rainbow trout genome, each showing differential expression in tissues and cells. Three structurally different Pias protein variants were found to suppress the activity of the NF-kappa B promoter in a dose-dependent manner, with potential different immune gene regulation in ifn γ-expressing cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiao-qin Ran, Lin Gao, Meng Yan, Cui-jie Kang
Summary: The discovery of a new ligand, Prx4, in the JAK/STAT pathway of shrimp has provided insights into its role in anti-bacterial immune response and activation of antimicrobial peptides.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Shina Lu, Xiaojue Peng, Shanshan Zeng, Hang Deng, Zhiqing Feng, Qing Zeng, Xining Cheng, Jihuan Hu, Zuocheng Ye, Meifeng Li, Xiaowen Xu, Gang Lin, Chengyu Hu
Summary: Two mammalian PIAS1 orthologs, CiPIAS1a and CiPIAS1b, were identified in Ctenopharyngodon idellus. They are suggested to participate in IFN-mediated antiviral and antibacterial immune response by interacting with STAT1 to inhibit its phosphorylation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dhiraj Gurjar, Sananda Kumar Patra, Neelam Bodhale, Nibedita Lenka, Bhaskar Saha
Summary: IFN-gamma plays a critical role in both innate and adaptive immunity, and its responsiveness in infected macrophages determines the efficacy of anti-Leishmania function. Impaired IFN-gamma responsiveness is caused by altered expression and heterodimerization of IFN-gamma receptors, as well as reduced signaling molecule phosphorylation and increased degradation. The parasite load is not only influenced by the production of IFN-gamma but also by its responsiveness.
Article
Immunology
Jiali Wang, Jia Liu, Mingyang Wang, Fei Zhao, Meili Ge, Li Liu, Erlie Jiang, Sizhou Feng, Mingzhe Han, Xiaolei Pei, Yizhou Zheng
Summary: This study investigated the immunoregulatory mechanism of levamisole (LMS) in the treatment of aplastic anemia (AA) and confirmed its effectiveness through clinical retrospective study and animal models. The results showed that LMS can improve AA by inhibiting T-cell activation and regulating related molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saima Kausar, Isma Gul, Ruochen Liu, Xiao-Xue Ke, Zhen Dong, Muhammad Nadeem Abbas, Hongjuan Cui
Summary: The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in physiological processes like immune responses, hematopoiesis, cell growth, and differentiation. In this study, researchers investigated the function of suppressors of cytokine signaling (SOCS) proteins in lepidopteran insects, particularly the Chinese oak silkworm. They identified the full-length sequence of a SOCS-2 protein called ApSOCS-2 and studied its role in the immune response through the JAK-STAT pathway. The results showed that ApSOCS-2 negatively regulates the transcription of antimicrobial peptide genes and plays a key role in the immune function of the insect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rui Shen, Kewei Zheng, Yu Zhou, Xiaofeng Chi, Huimin Pan, Chengfang Wu, Yinan Yang, Yonggang Zheng, Duojia Pan, Bo Liu
Summary: This study identifies the important role of RASSF in antiviral immunity in fruit flies and elucidates the signaling pathway it regulates. The study also reveals the involvement of RASSF and the STRIPAK PP2A complex in antiviral response in human cell lines.
Review
Pharmacology & Pharmacy
Hong-Tai Tzeng, I-Tsu Chyuan, Jenn-Haung Lai
Summary: The JAK/STAT signaling pathway plays a crucial role in immune regulation, affecting cell proliferation, survival, inflammation, and immune tolerance. Aberrant activation of this pathway can lead to autoimmune diseases and cancer progression, while targeting JAK/STAT has shown efficacy in suppressing inflammation. The success of small-molecule JAK inhibitors in treating rheumatologic diseases highlights their therapeutic potential in other conditions.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Aliva Prity Minz, Debasish Mohapatra, Madhuri Dutta, Manisha Sethi, Deepti Parida, Amlan Priyadarshee Mohapatra, Swayambara Mishra, Salona Kar, Prakash K. Sasmal, Shantibhusan Senapati
Summary: This study investigates the effect of gemcitabine on immune checkpoint protein expression in pancreatic cancer cells. The results show that gemcitabine significantly induces the expression of immune checkpoint proteins in cancer associated fibroblasts and pancreatic cancer cells. In addition, statins can suppress gemcitabine-induced immune checkpoint protein expression and overcome the T-cell inactivation caused by gemcitabine treatment. The combination therapy of simvastatin and gemcitabine results in reduced intra-tumor immune checkpoint protein expression and decreased tumor burden and metastasis incidence in a mouse pancreatic tumor model.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Zongliang Huang, Wei Wang, Pengpeng Xu, Shangyu Gong, Yingshan Hu, Yan Liu, Fang Su, Khalid Mahmood Anjum, Wu-Min Deng, Suping Yang, Jiyong Liu, Renjie Jiao, Jianming Chen
Summary: In this study, it was found that the adaptor protein Ect4 of the Toll pathway contributes to resistance to viral infection and regulates the JAK/STAT signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Wen-Rui He, Jin Yuan, Yu-He Ma, Cheng-Yan Zhao, Zhong-Yuan Yang, Yuhang Zhang, Shichong Han, Bo Wan, Gai-Ping Zhang
Summary: The regulation of host inflammatory and innate immune responses by ASFV has been summarized, providing insights into the development of ASFV vaccines and antiviral drugs. The understanding of viral proteins involved in immune evasion is crucial for the development of effective vaccines for African swine fever.