期刊
MOLECULAR IMMUNOLOGY
卷 45, 期 4, 页码 1126-1135出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2007.07.013
关键词
immune regulation; CD200R; lymphocytes; inhibitory receptors
To ensure an adequate response against pathogens and prevent unwanted self-reactivity, immune cells need to functionally express both activating and inhibitory receptors. CD200R is an inhibitory receptor mainly expressed on myeloid cells that down-modulates cellular activation both in vivo and in vitro. Although previously mainly studied as a regulator of myeloid function, we now show that CD200R is differentially expressed on human and mouse T-cell subsets. In both species, CD4(+) T cells express higher amounts of CD200R than CD8(+) T cells, and memory cells express higher amounts of CD200R than naive or effector cells. CD200R expression is up-regulated on both CD4(+) and CD8(+) T cells after stimulation in vitro. Furthermore, we show CD200R expression on human and mouse B cells. In human tonsils, CD200R is differentially expressed on B cells, with high expression on memory cells and plasmablasts. Mice lacking the ligand for CD200R, CD200(-/-) mice, do not show abnormal composition of the lymphocyte compartment and have normal B cell responses to antigenic challenge. Although the functional implications remain to be elucidated, the expression of CD200R on lymphocytes suggests a much broader role for CD200R-mediated immune regulation than previously anticipated. (c) 2007 Elsevier Ltd. All rights reserved.
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