Editorial Material
Multidisciplinary Sciences
Cara West, Neal Silverman
Summary: Studies of the fly Drosophila melanogaster reveal previously unknown details of a defense pathway with similarities to, but also key differences from, a human pathway, especially with the aid of cGas-like receptors.
Article
Immunology
Panagiotis Karagiannis, Isabel Correa, Jitesh Chauhan, Anthony Cheung, Diana Dominguez-Rodriguez, Manuela Terranova-Barberio, Robert J. Harris, Silvia Crescioli, James Spicer, Carsten Bokemeyer, Katie E. Lacy, Sophia N. Karagiannis
Summary: The study found that innate signals can stimulate the survival and antibody production of B cells, which may help identify low-frequency antigen-reactive humoral responses.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Microbiology
Luther A. Bartelt, Alena J. Markmann, Bridget Nelson, Jessica Keys, Heather Root, Heather Henderson, JoAnn Kuruc, Caroline Baker, D. Ryan Bhowmik, Yixuan J. Hou, Lakshmanane Premkumar, Caleb Cornaby, John L. Schmitz, Susan Weiss, Yara Park, Ralph Baric, Aravinda M. de Silva, Anne Lachiewicz, Sonia Napravnik, David van Duin, David M. Margolis
Summary: In this study, it was found that among high-risk patients admitted for COVID-19, those who received CCP with nAb titers of >1:640 had earlier hospital discharge compared to those who received CCP with lower nAb titers, with no CCP-related adverse events. The significance of this research lies in identifying a dose response of CCP and clinical outcomes based on nAb titers. Although limited by a small study size, these findings support further investigation of high-nAb-titer CCP (>1:640) in the treatment of COVID-19.
Editorial Material
Multidisciplinary Sciences
David Enard
Summary: DNA analysis of humans from the Middle Ages reveals that survivors of the bubonic plague experienced rapid natural selection, potentially leading to an increased risk of autoimmune diseases in their descendants.
Review
Immunology
Daniel Michaud, Colleen R. Steward, Bhalchandra Mirlekar, Yuliya Pylayeva-Gupta
Summary: Tumorigenesis involves genetic mutations and changes in the microenvironment, with immune cells in tumors playing a role in promoting tumor growth. Recent studies have shed light on the mechanisms of how B cells regulate immune responses, with negative regulation potentially impacting anti-tumor immune function through cytokine production.
IMMUNOLOGICAL REVIEWS
(2021)
Editorial Material
Multidisciplinary Sciences
Mark A. Travis, Chiara Romagnani
Summary: Active control of the immune system is necessary to prevent inflammatory bowel disease. Cell populations that promote the generation of immunosuppressive regulatory T cells in the gut have been identified.
Article
Cell Biology
Prerna Arora, Anzhalika Sidarovich, Nadine Krueger, Amy Kempf, Inga Nehlmeier, Luise Graichen, Anna-Sophie Moldenhauer, Martin S. Winkler, Sebastian Schulz, Hans-Martin Jaeck, Metodi Stankov, Georg M. N. Behrens, Stefan Poehlmann, Markus Hoffmann
Summary: The Delta variant, B.1.617.2, has spread to over 80 countries, showing evasion of antibodies, resistance to certain therapies, and enhanced transmissibility.
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Immunology
Maya Sangesland, Daniel Lingwood
Summary: This paper discusses the significance of affinity between the B cell receptor and cognate antigen in humoral immunity, and suggests that the BCR can function as an 'innate-like' immune receptor. The concept of evolutionary spandrels in the germline antibody repertoire is also explored, with implications for rational vaccine design to focus humoral immunity on traditionally immune-subdominant targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mehmet Yabas, Ayten Bostanci, Seda Aral
Summary: P4-type ATPases contribute to the asymmetrical distribution of aminophospholipids on plasma membranes in eukaryotes. However, their roles in the immune system are not well understood. By studying ATP11C-deficient pre-B cells, it was found that ATP11C is important for the flippase activity and differentiation of pre-B cells, but not their proliferation in response to IL-7. These findings suggest that ATP11C-mediated lipid asymmetry controls the switch from proliferation to differentiation in pre-B cells.
IMMUNOLOGIC RESEARCH
(2023)
Article
Psychiatry
William W. Eaton, Katrina M. Rodriguez, Mekha A. Thomas, Jeanette Johnson, Monica V. Talor, Curtis Dohan, Clifton O. Bingham III, Rashelle Musci, Kimberly Roth, Deanna L. Kelly, Daniela Cihakova, Erika Darrah
Summary: The relationship between schizophrenia and rheumatoid arthritis has been observed for 85 years, but the mechanisms driving this association are unknown. This study analyzed differences in cytokines, selected genes, and antibodies related to gluten sensitivity, celiac disease, and systemic autoimmunity in patients with schizophrenia, rheumatoid arthritis, and healthy controls. The analysis revealed potential subgroups within schizophrenia patients based on their cytokine profiles, providing new directions for treatment strategies.
PSYCHIATRY RESEARCH
(2022)
Review
Hematology
Anais Roeser, Alan H. Lazarus, Matthieu Mahevas
Summary: Immune thrombocytopenia (ITP) is a bleeding disorder caused by pathogenic autoantibodies secreted by plasma cells. The persistence of long-lived plasma cells in the spleen and bone marrow may explain the failure of rituximab and splenectomy in refractory ITP patients. Reactivation of memory B cells leads to relapses after initial response to rituximab. Strategies targeting B cells and plasma cells include anti-BAFF and rituximab combination therapy, anti-CD38 antibody therapy, and novel monoclonal antibodies and therapies targeting CD20 and CD19. Alternative strategies focus on controlling autoantibody-mediated effects, such as SYK and BTK inhibitors, complement inhibitors, FcRn blockers, and inhibitors of platelet desialylation.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Laura Couloume, Juliette Ferrant, Simon Le Gallou, Marion Mandon, Rachel Jean, Nadege Bescher, Helene Zephir, Gilles Edan, Eric Thouvenot, Aurelie Ruet, Marc Debouverie, Karin Tarte, Patricia Ame, Mikael Roussel, Laure Michel
Summary: This study explored immune response profiles in blood of early MS patients using CyTOF panels, identifying increased abundance of a T-bet-expressing B cell subset and a CD206(+) classical monocyte subset. T-bet-expressing B cells were found to be enriched in aggressive MS patients. Further research is needed to validate these findings and determine the exact role of the identified clusters in neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Qizhi Tang
Summary: Inflammation caused by surgical trauma hinders the survival of transplanted stem-cell-derived neurons in rodent models of Parkinson's disease. However, co-transplanting regulatory T cells enhances the efficacy of the therapy.
Article
Virology
Stephen D. Graham, Huy A. Tu, Benjamin D. McElvany, Nancy R. Graham, Ariadna Grinyo, Edgar Davidson, Benjamin J. Doranz, Sean A. Diehl, Aravinda M. de Silva, Alena Janda Markmann
Summary: The study characterized a strongly neutralizing antibody B11F isolated from a patient who recovered from ZIKV, revealing a new target site on the viral envelope. This is relevant for understanding how antibodies block infection and guiding the design and evaluation of candidate vaccines.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathan Gueguinou, Jeremy Jeandel, Sandra Kaminski, Sarah Baatout, Stephanie Ghislin, Jean-Pol Frippiat
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Corentine Alauzet, Lisiane Cunat, Maxime Wack, Laurence Lanfumey, Christine Legrand-Frossi, Alain Lozniewski, Nelly Agrinier, Catherine Cailliez-Grimal, Jean-Pol Frippiat
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Julie Bonnefoy, Stephanie Ghislin, Jerome Beyrend, Florence Coste, Gaetano Calcagno, Isabelle Lartaud, Guillemette Gauquelin-Koch, Sylvain Poussier, Jean-Pol Frippiat
Summary: The use of rotors to expose animals to hypergravity levels helps understand the effects of altered gravity on physiological functions and animal development. The GEPAM platform, part of ESA's ground-based facilities, studies the impact of altered gravity on aquatic animal models and mice, with rotors for hypergravity exposure and models for simulating microgravity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Tuong Thi Le, Armelle Ropars, Arnaud Aymes, Jean-Pol Frippiat, Romain Kapel
Summary: This study aimed to extract phenolic compounds from liquid effluent of the sunflower protein isolate process using XAD7 resin. Multicriteria optimization showed that the optimal conditions led to production of a fraction containing 76.05% chlorogenic acid with high antioxidant capacity. In vitro assays demonstrated that this fraction was non-toxic to cells and could reduce the production of inflammatory factors, highlighting its potential anti-inflammatory properties.
Article
Fisheries
Yannick Ledore, Anastasia Bestin, Pierrick Haffray, Romain Morvezen, Maud Alix, Berenice Schaerlinger, Pascal Fontaine, Dominique Chardard
Summary: Ultrasound is a rapid, non-invasive, and accurate method for determining the gender of Eurasian perch, with high accuracy rates for both males and females. This method can be highly beneficial for optimal broodstock management and aquaculture research in perch farming.
AQUACULTURE RESEARCH
(2021)
Article
Microbiology
Maurin D'agostino, Nicolas Tesse, Rose Anne Lavergne, Patrice Le Pape, Jean Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: CIN-102 has shown potential as a new class of antifungal drug that is effective against resistant filamentous fungi and inhibits biofilm formation. The study demonstrated the antifungal activity of CIN-102 and its lack of induced resistance in strains, making it a promising candidate for treating invasive fungal infections, especially in cases of resistance.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Microbiology
Jordan Chamarande, Lisiane Cunat, Celine Caillet, Laurence Mathieu, Jerome F. L. Duval, Alain Lozniewski, Jean-Pol Frippiat, Corentine Alauzet, Catherine Cailliez-Grimal
Summary: The gut microbiota is a complex ecosystem crucial for host's well-being, where stress-induced molecules significantly impact the adhesion and biofilm formation capacities of Parabacteroides distasonis. The study provides insights on inter-strain variability and paves the way for further research on stress-molecules' involvement in maintaining P. distasonis within gut microbiota.
Article
Biochemistry & Molecular Biology
Tuong Thi Le, Xavier Framboisier, Arnaud Aymes, Armelle Ropars, Jean-Pol Frippiat, Romain Kapel
Summary: This study identified phenolic compounds in an aqueous protein by-product from rapeseed meal, with sinapine being the main compound. XAD16 resin showed the highest adsorption capacity for phenolic compounds, and ethanol at specific concentrations was effective for their desorption. Antioxidant tests indicated that these compounds can serve as natural antioxidants in the food industry.
Article
Microbiology
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: This study investigated the potential relationship between azole susceptibility and mutations in CYP51 protein sequences in the Fusarium solani species complex (FSSC). The results showed point mutations in FSSC similar to those described in azole-resistant strains. Protein sequence alignments of CYP51 revealed different patterns, and a link between voriconazole susceptibility and protein sequences was observed.
Article
Biochemistry & Molecular Biology
Gaetano Calcagno, Nassima Ouzren, Sandra Kaminski, Stephanie Ghislin, Jean-Pol Frippiat
Summary: Gravity changes during spaceflight affect the immune system and TCR beta repertoire. This study investigates the role of histone modifications in this process, finding that downregulation of H3K27me3 contributes to the regulation of V beta germline transcript expression. The study also suggests the involvement of EZH2 in the regulation of TCR beta locus chromatin structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gaetano Calcagno, Jeremy Jeandel, Jean-Pol Frippiat, Sandra Kaminski
Summary: Different forms of stress in spaceflights impact the immune system and specifically dendritic cells. Hypergravity induces a less mature phenotype in dendritic cells, while simulated microgravity reduces their activation and pro-inflammatory cytokine production. Microgravity also impairs dendritic cells' ability to induce a proper immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marwa Roumani, Armelle Ropars, Christophe Robin, Raphael E. Duval, Jean-Pol Frippiat, Michel Boisbrun, Romain Larbat
Summary: Resistance to conventional treatments calls for the discovery of new therapeutic molecules. Plant specialized metabolites like phenolamides in tomato plants have potential antioxidant, antimicrobial, and anti-inflammatory properties. This study investigated whether three major phenolamides found in Tuta absoluta-infested tomato leaves have antimicrobial, cytotoxic, and/or anti-inflammatory properties. The results showed that these phenolamides exhibited varying degrees of antibacterial activity and were able to counteract the pro-inflammatory effect on cells. Extracts from healthy tomato leaves could also reduce inflammation. These findings suggest that phenolamides from tomato leaves could serve as alternatives to conventional drugs.
Article
Microbiology
Maurine D'Agostino, Anne-Lyse Babin, Marie Zaffino, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: This study investigated the physiological changes of Fusarium solani species complex under simulated microgravity. The results showed increased growth, spore production, and germination, while biofilm production was reduced under microgravity. These findings highlight the importance of further studying this fungus as microgravity may weaken astronauts' immune system.
Article
Biochemistry & Molecular Biology
Rosella Spina, Armelle Ropars, Sihem Bouazzi, Safa Dadi, Pascal Lemiere, Francois Dupire, Afra Khiralla, Sakina Yagi, Jean-Pol Frippiat, Dominique Laurain-Mattar
Summary: Endophytic fungi are a promising research area for the treatment of inflammatory chronic diseases, as they have the potential to possess anti-inflammatory properties. Compounds extracted from endophytic fungi can counteract inflammation and induce an anti-inflammatory state, suggesting their potential as alternatives to conventional anti-inflammatory drugs.
Review
Multidisciplinary Sciences
Pauline Jacob, Christian Oertlin, Bjorn Baselet, Lisa S. Westerberg, Jean-Pol Frippiat, Sarah Baatout
Summary: Despite more than 50 years of sending humans into space, there are still crucial unanswered questions regarding the immune response in space conditions. The complex interactions between the immune system and other physiological systems in the human body make it challenging to study the long-term effects of space stressors such as radiation and microgravity. Exposure to microgravity and cosmic radiation can lead to changes in the immune system at the cellular and molecular levels, as well as in the major physiological systems of the body. Future long-term space missions may face serious health consequences due to abnormal immune responses induced in the space environment, including reduced ability to respond to injuries, infections, and vaccines, and increased risk of chronic diseases.
