Review
Immunology
Afreen Shadan, Avik Pathak, Ying Ma, Ranjana Pathania, Rajnish Prakash Singh
Summary: This article reviews the mechanisms, virulence factors, and other factors associated with the pathogenesis of A. baumannii infection. Additionally, it discusses the role of innate and adaptive immune response, as well as the current progress in developing innovative strategies to combat this multidrug-resistant pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Fisheries
Yuanmei Li, Xue Qiao, Zhaoqun Liu, Lingling Wang, Linsheng Song
Summary: The research identified an Mx homologue named CgMx1 in the oyster Crassostrea gigas, which encodes a 562-amino acid peptide. CgMx1 showed abundant expression in tissues and exhibited significant responses to poly (I:C) and recombinant IFN-like protein stimulation. CgMx1 was involved in the immune response of C. gigas through a signal pathway mediated by CgIFNLP and CgSTAT.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
D. Jaramillo, B. P. Busby, M. Bestbier, P. Bennett, Z. Waddington
Summary: This study demonstrates the protective effect of an autogenous vaccine against NZ-RLO1 in preventing severe disease and death in Chinook salmon juveniles. It also highlights the importance of the route of administration and dose in evaluating pathogenicity and vaccine efficacy.
JOURNAL OF FISH DISEASES
(2023)
Article
Biology
Daniel A. Phillips, Lori A. Zacharoff, Cheri M. Hampton, Grace W. Chong, Anthony P. Malanoski, Lauren Ann Metskas, Shuai Xu, Lina J. Bird, Brian J. Eddie, Aleksandr E. Miklos, Grant J. Jensen, Lawrence F. Drummy, Mohamed Y. El-Naggar, Sarah M. Glaven
Summary: BAR domain proteins are a superfamily of coiled-coil proteins that influence membrane curvature in eukaryotes, and a bacterial protein BdpA with BAR domain-like activity has been discovered to impact the formation of membrane vesicles and outer membrane extensions. BdpA is essential for the uniform size distribution of membrane vesicles and the scaffolding of consistent diameter and curvature in OMEs, influencing the morphology of these structures. Overexpression of BdpA can promote the formation of OMEs in bacterial species where it is not typically observed, suggesting a new class of bacterial BAR domain-like proteins.
Article
Chemistry, Multidisciplinary
Jingmei Pan, Xilin Li, Binfen Shao, Funeng Xu, Xuehui Huang, Xing Guo, Shaobing Zhou
Summary: A nanocarrier that achieves self-blockade of PD-L1 in tumor cells and a detection kit to quantitatively measure the binding rate of PD-1/PD-L1 have been developed, improving the efficacy of PD-1/PD-L1 self-blocking therapy.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Thomas E. Hall, Nicholas Ariotti, Harriet P. Lo, James Rae, Charles Ferguson, Nick Martel, Ye-Wheen Lim, Jean Giacomotto, Robert G. Parton
Summary: Plasma membrane rupture can lead to cell death. This study uses an active trapping model to investigate the structural changes of sarcolemma, showing the essential role of caveolae in maintaining sarcolemmal integrity and quantifying the contribution of caveolar-derived membrane to surface expansion.
Article
Multidisciplinary Sciences
Jiaxin Li, Rui Zhang, Changwan Wang, Junyan Zhu, Miao Ren, Yingbo Jiang, Xianteng Hou, Yangting Du, Qing Wu, Shishi Qi, Lin Li, She Chen, Hui Yang, Fajian Hou
Summary: The RIG-I-MAVS signaling pathway is essential for defense against viral infection and maintaining immune balance. The protein WDR77 has been identified as a negative regulator of MAVS aggregation, which helps prevent harmful inflammation and downregulate the immune response.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Gina M. Mohammed, Heba ElSayed ElZorkany, Khaled Y. Farroh, Wafaa R. Abd El-Aziz, Hisham A. Elshoky
Summary: The study aimed to produce an efficient vaccine using CS and AsCS nanoparticles from E. coli O1 and O78 serogroups to control colibacillosis in chicken. Adding chitosan nanoparticles can improve vaccine efficacy by inducing strong immunity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Hao Qin, Hejia Li, Jin Zhu, Yuting Qin, Nan Li, Jian Shi, Guangjun Nie, Ruifang Zhao
Summary: Cancer vaccines need to effectively deliver antigens and trigger immune reactions. This study presents a strategy to assemble tumor antigens into bacterial outer membrane vesicles (OMVs) via electrostatic interaction. The OMV-delivered vaccine (OMVax) stimulates immune responses and inhibits metastasis, but immune response activation decreases with increased positive surface charge. These findings highlight the importance of optimizing vaccine formulations.
Review
Infectious Diseases
Yun Tang, Yingjie Zhou, Bisha He, Ting Cao, Xiangping Zhou, Lichang Ning, En Chen, Yumeng Li, Xiaoping Xie, Binfeng Peng, Yibao Hu, Shuangquan Liu
Summary: This review systematically summarizes the host's immune responses to T. pallidum infection and the escape mechanisms of T. pallidum, providing a foundation for studying the pathogenic mechanism and prevention and treatment of syphilis.
Article
Immunology
Anatoli Slepenkin, Sukumar Pal, Steven Hoang-Phou, Abisola Abisoye-Ogunniyan, Amy Rasley, Patrik D'haeseleer, Matthew A. Coleman, Luis M. de la Maza
Summary: Chlamydia trachomatis is a common sexually transmitted pathogen, and a safer and more effective vaccine is urgently needed. This study found that the antigens PmpG and Pgp3, alone or in combination with MOMP, elicited weaker immune responses, while vaccination with MOMP induced a robust immune response and protected against a respiratory challenge with C. muridarum. Pgp3 antagonized the protection induced by MOMP.
Article
Immunology
Chang-Ung Kim, Sukyeong Eo, Pureum Lee, Sang-Hyun Kim, Young Sang Kim, Doo-Jin Kim
Summary: This study demonstrates that consecutive administration of modified outer membrane vesicle (fmOMV) and influenza virus can induce broad and long-lasting protective immunity against various virus subtypes.
MICROBES AND INFECTION
(2022)
Article
Immunology
Jingjing Sun, Xuansheng Lin, Yige He, Baozhong Zhang, Nan Zhou, Jian-dong Huang
Summary: In this study, engineered bacterial outer membrane vesicles (OMVs) were used to develop a multitargeting S. aureus click vaccine. The click vaccine, decorated with surface exposed SpyCatcher, can flexibly bind with various SpyTag-fused S. aureus antigens. Compared with antigens mixed with alum adjuvant, the click vaccine induced more potent antigen-specific humoral and Th1-based cellular immune response, providing protection against S. aureus infection in a mouse model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis David Ginez, Aurora Osorio, Ricardo Vazquez-Ramirez, Thelma Arenas, Luis Mendoza, Laura Camarena, Sebastian Poggio
Summary: The outer membrane (OM) is crucial for Gram-negative bacterial cell envelope, with restricted diffusion of OM proteins and LPS creating a semi-crystalline state. The low fluidity of OM contributes to cell rigidity, with LPS characteristics strongly influencing OM properties and fluidity. Measurement of LPS fluidity can be challenging but important for understanding membrane dynamics.
Review
Microbiology
Matthew Thomas Doyle, Harris D. Bernstein
Summary: The Omp85 protein superfamily is a group of proteins found in the outer membrane of gram-negative bacteria and bacterial-origin eukaryotic organelles. These proteins are involved in both membrane insertion and translocation of proteins across the outer membrane. Recent studies have uncovered new insights into the functions of these proteins, particularly the well-studied member BamA, which is essential for bacterial barrel assembly and has potential implications for antibiotic development.
ANNUAL REVIEW OF MICROBIOLOGY
(2022)
