Article
Fisheries
Xiaomeng Ren, Han Zhang, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: The study found that NOP56 acts as a negative regulator of the MyD88-mediated NF-KB signaling pathway by inhibiting MyD88 protein expression, providing new insights into the regulatory mechanism in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Aleksandra Kusiak, Gareth Brady
Summary: The human innate immune response can be activated by various stimuli, such as PAMPs and DAMPs. These stimuli trigger intracellular signaling pathways that activate transcription factors from the NF-kappa B and IRF families, which play crucial roles in inflammation and antiviral response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Virology
Jinxuan Hong, Xiaojuan Chi, Xu Yuan, Faxin Wen, Kul Raj Rai, Lei Wu, Zhongbao Song, Song Wang, Guijie Guo, Ji-Long Chen
Summary: This study reveals that the ASFV I226R protein impairs the antiviral response by suppressing the activation of NF-kappa B and IRF3, leading to a decrease in interferon expression and interferon-stimulating gene expression.
Article
Immunology
Zebin Zhou, Shaoqing Ding, Yaqian Wang, Janfeng Ren, Xiangyang Zhang, Weiming Li, Qinghua Zhang
Summary: The study identified and characterized LmTLR14d gene in Northeast Chinese lamprey, which was found to be expressed in various tissues and up-regulated during infection. The results suggest that LmTLR14d may play a crucial role in the innate immune signaling of lamprey.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri
Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.
Review
Biochemistry & Molecular Biology
Quanhui Yan, Xiaodi Liu, Yawei Sun, Weijun Zeng, Yuwan Li, Feifan Zhao, Keke Wu, Shuangqi Fan, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Microbiology
Zhaoyao Li, Wenxian Chen, Xiaowen Li, Keke Wu, Xinyan Wang, Weijun Wang, Yuwan Li, Lin Yi, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan, Jinding Chen
Summary: This study analyzed the transcriptomic changes in porcine alveolar macrophages infected with ASFV using RNA-seq technology. The results showed that ASFV infection can activate the NF-kappa B signaling pathway and affect genes related to innate immunity and inflammation.
Article
Virology
Silvia Correia, Pedro Luis Moura, Sonia Ventura, Alexandre Leitao, Robert Michael Evans Parkhouse
Summary: The African Swine Fever Virus (ASFV) is a highly contagious and fatal virus in domestic pigs. No accepted vaccine is available for this virus, but the deletion of virus host evasion gene(s) inhibiting IFN has potential to develop an attenuated virus vaccine. The ASFV ORF I329L gene is a potential candidate for inhibiting Toll-like receptor (TLR) signaling through two different mechanisms.
Review
Pharmacology & Pharmacy
Xuan Huang, Xiaoyong Zhang, Mengji Lu
Summary: TLR7 and TLR8 signaling pathways are favorable drug candidates for the treatment of immune disorders, with agonists and antagonists being used to enhance immune responses or reduce immune overreactions. Optimizing drug safety, efficacy, and specificity, as well as conducting detailed mechanistic studies, will contribute to the development of novel TLR7/8 immunomodulators and therapeutic strategies.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Magda Lewandowska, Ton Sharoni, Yael Admoni, Reuven Aharoni, Yehu Moran
Summary: The study characterized the antiviral immune response of the cnidarian Nematostella vectensis and showed that its RLR paralogs exhibit features distinctive for both vertebrate and invertebrate systems. The functional evidence provided supports the conserved role of RLRs in initiating immune response to dsRNA before the cnidarian-bilaterian split, laying a foundation for further research on the evolution of immune responses to RNA viruses.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson
Summary: LL-37 enhances poly I:C-induced expression of TLR3 mRNA and protein, possibly through enhanced import of poly I:C. Dexamethasone reduces LL-37/poly I:C-induced TLR3 expression by attenuating NF-kappa B activity.
Review
Veterinary Sciences
Mingwei Li, Longjun Guo, Li Feng
Summary: Swine enteric coronavirus causes severe losses in neonatal piglets worldwide. Mixed infections with different members of the virus pose a threat to public health and global security. Studies focus on the effects of viral proteins on apoptosis, autophagy, and innate immunity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
S. Saravanan, Neha Guleria, H. B. Ranjitha, B. P. Sreenivasa, Madhusudan Hosamani, Carlos Prieto, V Umapathi, H. K. Santosh, Subhasmita Behera, V. V. Dhanesh, Gollapalli Sivarama Krishna, Shreya Gopinath, Atul Kolte, Jagadeesh Bayry, Aniket Sanyal, Suresh H. Basagoudanavar
Summary: The study revealed that indigenous cattle, especially Malnad Gidda, exhibit stronger antiviral immune responses against FMDV, limiting virus replication. Innate antiviral immune responses and cell-mediated immunity may play a key role in this process.
Article
Multidisciplinary Sciences
Rui Jiang, Wentao Zhu, Zhiwei Liao, Chunrong Yang, Jianguo Su
Summary: TLR7 plays a crucial role in sensing viral ssRNA and dsRNA, but there are differences in the mechanism of dsRNA sensing between fish and tetrapods.
