Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jianxian Ge, Cang Li, Ning Wang, Ruru Zhang, Mohammad Javad Afshari, Can Chen, Dandan Kou, Dandan Zhou, Ling Wen, Jianfeng Zeng, Mingyuan Gao
Summary: Polyethylene glycol (PEG) is commonly used to enhance the biocompatibility and blood circulation time of iron oxide nanoparticles (IONPs) as MRI contrast agents. However, the surface effect induced by PEGylation can impact the relaxometric properties of IONPs and subsequently affect imaging results. In this study, three diphosphonate PEGs with different molecular weights were used to replace the hydrophobic oleate ligands of IONPs, and the relationship between PEG chain length and relaxometric properties of IONPs was investigated.
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Biology
Lei Xia, Xiaowei Song, Guanghai Yan, Jishan Quan, Guangyu Jin
Summary: This study synthesized a targeted magnetic resonance imaging (MRI) contrast agent for liver cancer cells and demonstrated its potential and characteristics in vitro experiments.
OPEN LIFE SCIENCES
(2022)
Article
Oncology
Runze Yang, A. Max Hamilton, Hongfu Sun, Khalil S. Rawji, Susobhan Sarkar, Reza Mirzaei, G. Bruce Pike, V. Wee Yong, Jeff F. Dunn
Summary: This study demonstrates that MRI with USPIO injection can detect therapeutic responses of innate immune stimulating agents, providing a potential imaging technique for monitoring cancer immunotherapies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Sara Nava, Daniela Lisini, Simona Frigerio, Anna Bersano
Summary: DCs vaccines have established safety and the ability to induce anti-tumor responses, and combining with other treatments may improve efficacy. Combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy could be the key to cancer treatment paradigms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kierstin P. Melo, Ashley Makela, Natasha N. Knier, Amanda M. Hamilton, Paula J. Foster
Summary: MPI is a new imaging modality that detects SPIOs sensitively and specifically. MPIO labeled cells were visible in mouse brain images, with signal and iron content measurements increasing with higher numbers of injected cells.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Vassily Vorobiev, Souad Adriouach, Lindsey A. Crowe, Sebastien Lenglet, Aurelien Thomas, Anne-Sophie Chauvin, Eric Allemann
Summary: This study presents mixed micelles as a potential formulation for molecular imaging of atheroma and cancer cells using MRI. The micelles are characterized by their size, zeta potential, stability, relaxivity, and toxicity, and showed promising results in target binding and internalization assays.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Physical
Jie Zeng, Linlin Huo, Zhenyu Wang, Xin Sun, Yu Guo, Muyao Li, Mingya Tan, Shiqi Zhu, Jingqin Fang, Zhenghuan Zhao
Summary: In recent years, great progress has been made in precisely controlling the structures of magnetic nanoparticles to investigate structure-relaxivity relationships. However, the influence of hollow structures with unique interior structures on the relaxation rate of magnetic nanoparticles has been rarely studied. In this work, we obtained a series of hollow manganese-doped iron oxide nanoparticles (MnIONs) with different void and dopant ratios and investigated the influence of hollow structures on the T-1/T-2 relaxation rate. The results showed that hollow MnIO nanoparticles exhibit increased T-1 relaxivity due to the increased surface-to-volume ratio, while they also show increased T-2 relaxivity attributed to the increased number of magnetic cores per unit volume and magnetic field inhomogeneity induced by hollow structures.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Yekkuni L. Balachandran, Wei Wang, Hongyi Yang, Haiyang Tong, Lulu Wang, Feng Liu, Hongsong Chen, Kai Zhong, Ye Liu, Xingyu Jiang
Summary: In this study, small heterogeneous iron oxide/dysprosium oxide nanoparticles were synthesized as a contrast agent for magnetic resonance imaging. These nanoparticles can target the liver and improve image resolution and signal-to-noise ratio at ultrahigh magnetic fields, allowing for precise diagnosis of liver fibrosis stages.
Article
Multidisciplinary Sciences
Juanye Zhang, Yingying Ning, Hua Zhu, Nicholas J. Rotile, He Wei, Himashinie Diyabalanage, Eric C. Hansen, Iris Y. Zhou, Stephen C. Barrett, Mozhdeh Sojoodi, Kenneth K. Tanabe, Valerie Humblet, Alan Jasanoff, Peter Caravan, Moungi G. Bawendi
Summary: SNIO-CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with a type I collagen-binding peptide (CBP), is a promising T1-weighted MRI contrast agent for noninvasive detection of liver fibrosis. It exhibits high relaxivity and fast elimination from bloodstream, making it suitable for rapid imaging. The results suggest SNIO-CBP as a potential gadolinium-free molecular MRI probe for characterizing chronic liver disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu
Summary: Dendritic cells (DCs) play a critical role in regulating immune response and anti-tumor process. However, immunosuppressive cells and factors in the tumor microenvironment pose challenges to DC function. Therefore, designing nanomaterials to regulate DC autophagy is important for enhancing immune function.
Article
Nanoscience & Nanotechnology
Li-Hua Deng, Hai Jiang, Fu-Lin Lu, Han-Wei Wang, Yu Pu, Chang-Qiang Wu, Hong-Jie Tang, Ye Xu, Tian-Wu Chen, Jiang Zhu, Cheng-Yi Shen, Xiao-Ming Zhang
Summary: By using PEGylated SPIO nanoparticles as MRI contrast agents, different nanocrystal sizes and PEG coatings can be utilized to achieve T-1, T-2, or T-1-T-2 dual-mode imaging at different magnetic field intensities.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Immunology
Mehrdad Fathi, Simin Bahmanpour, Asal Barshidi, Hossein Rasouli, Fariba Karoon Kiani, Armin Mahmoud Salehi Khesht, Sepideh Izadi, Bentolhoda Rashidi, Shiva Kermanpour, Roya Mokhtarian, Vahid Karpisheh, Hadi Hassannia, Hamed Mohammadi, Ali Jalili, Farhad Jadidi-Niaragh
Summary: Inhibiting TIGIT and HIF-1 alpha can effectively suppress tumor growth, reduce angiogenesis, and significantly impact the growth rate of cancer cells, demonstrating the potential of combination therapy targeting TIGIT and HIF-1 alpha.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Corby Fink, Michael Smith, Jeffrey M. Gaudet, Ashley Makela, Paula J. Foster, Gregory A. Dekaban
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Fink, M. Smith, O. C. Sehl, J. M. Gaudet, T. C. Meagher, N. A. Sheikh, J. D. Dikeakos, M. J. Rieder, P. J. Foster, G. A. Dekaban
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2020)
Article
Clinical Neurology
Natalie Kozyrev, Shawn Albers, Jennifer Yang, Vania F. Prado, Marco A. M. Prado, Gregory J. Fonseca, R. Jane Rylett, Gregory A. Dekaban
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Cell & Tissue Engineering
Kevin P. Robb, Laura Juignet, Pascal Morissette Martin, John T. Walker, Courtney R. Brooks, Christy Barreira, Gregory A. Dekaban, Lauren E. Flynn
Summary: The study investigated the role of donor adipose-derived stromal cells (ASCs) and host macrophages in tissue remodeling of decellularized adipose tissue (DAT) scaffolds. Results showed that exogenous ASCs indirectly enhanced tissue regeneration through multiple mechanisms including cell recruitment and immunomodulation, providing important data for soft tissue engineering.
TISSUE ENGINEERING PART A
(2021)
Article
Neurosciences
Amy L. Schranz, Gregory A. Dekaban, Lisa Fischer, Kevin Blackney, Christy Barreira, Timothy J. Doherty, Douglas D. Fraser, Arthur Brown, Jeff Holmes, Ravi S. Menon, Robert Bartha
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Critical Care Medicine
Michael R. Miller, Michael Robinson, Robert Bartha, Tanya Charyk Stewart, Lisa Fischer, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, Douglas D. Fraser
Summary: Concussions in sports can lead to significant neurological disability, with adolescents being particularly susceptible. This study found that after sports-related concussions, specific plasma glycerophospholipids (PCs) decreased significantly, with no increase observed. Combining four specific PCs could provide excellent diagnostic potential for adolescent concussions, but external validation in larger cohorts is needed.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Cell Biology
Romain Gasser, Marc Cloutier, Jeremie Prevost, Corby Fink, Eric Ducas, Shilei Ding, Nathalie Dussault, Patricia Landry, Tony Tremblay, Audrey Laforce-Lavoie, Antoine Lewin, Guillaume Beaudoin-Bussieres, Annemarie Laumaea, Halima Medjahed, Catherine Larochelle, Jonathan Richard, Gregory A. Dekaban, Jimmy D. Dikeakos, Renee Bazin, Andres Finzi
Summary: Depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This finding may have implications for designing more effective antibody-based COVID-19 therapies and explaining the increased susceptibility of autoimmune patients receiving therapies that inhibit the production of immunoglobulin M (IgM).
Article
Neurosciences
Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha, Mark Daley, Haojie Mao, Vania Prado, Marco A. M. Prado, Lisa Saksida, Tim Bussey, Arthur Brown
Summary: Research has shown that even repetitive mild traumatic brain injuries (rmTBI) that do not reach the diagnostic threshold for concussion can have long-term effects on athletes, including brain damage, behavioral deficits, metabolic changes, etc., which may only become apparent months after the initial injury.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Tim Tian Y. Han, John T. Walker, Aaron Grant, Gregory A. Dekaban, Lauren E. Flynn
Summary: The study shows that bioreactor preconditioning enhances the regenerative potential of human ASCs by altering the expression characteristics of ASCs on DAT scaffolds through in vitro culture, and also promotes the infiltration of host cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Immunology
Irfan Ullah, Jeremie Prevost, Mark S. Ladinsky, Helen Stone, Maolin Lu, Sai Priya Anand, Guillaume Beaudoin-Bussieres, Kelly Symmes, Mehdi Benlarbi, Shilei Ding, Romain Gasser, Corby Fink, Yaozong Chen, Alexandra Tauzin, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Matthias Mack, Kunho Chung, Craig B. Wilen, Gregory A. Dekaban, Jimmy D. Dikeakos, Emily A. Bruce, Daniel E. Kaufmann, Leonidas Stamatatos, Andrew T. McGuire, Jonathan Richard, Marzena Pazgier, Pamela J. Bjorkman, Walther Mothes, Andres Finzi, Priti Kumar, Pradeep D. Uchil
Summary: Neutralizing antibodies are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Real-time imaging revealed that highly potent NAbs can prevent and resolve established infections when administered within three days. Both Fab and Fc effector functions of NAbs are essential for optimal efficacy against SARS-CoV-2.
Article
Microbiology
Gyoung Nyoun Kim, Jung-ah Choi, Kunyu Wu, Nasrin Saeedian, Eunji Yang, Hayan Park, Sun-Je Woo, Gippeum Lim, Seong-Gyu Kim, Su-Kyeong Eo, Hoe Won Jeong, Taewoo Kim, Jae-Hyung Chang, Sang Hwan Seo, Na Hyung Kim, Eunsil Choi, Seungho Choo, Sangkyun Lee, Andrew Winterborn, Yue Li, Kate Parham, Justin M. Donovan, Brock Fenton, Jimmy D. Dikeakos, Gregory A. Dekaban, S. M. Mansour Haeryfar, Ryan M. Troyer, Eric J. Arts, Stephen D. Barr, Manki Song, C. Yong Kang
Summary: The COVID-19 pandemic has had unprecedented global impact. Vaccinating the majority of the world's population is crucial in preventing new infections. Developing new derivatives of current vaccines and utilizing safe vesicular stomatitis virus-based delivery vehicles have shown promise in protecting against SARS-CoV-2 infection and reducing lung damage.
Review
Immunology
Eoin N. Blythe, Lynne C. Weaver, Arthur Brown, Gregory A. Dekaban
Summary: CD11d/CD18 is a recently discovered and poorly understood β2 integrin, playing a crucial role in localizing white blood cells to inflammation sites. Although its adhesive mechanisms and signaling pathways have been investigated, further research is needed to fully understand its functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Michael R. Miller, Michael Robinson, Lisa Fischer, Alicia DiBattista, Maitray A. Patel, Mark Daley, Robert Bartha, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, Eleftherios P. Diamandis, Ioannis Prassas, Douglas D. Fraser
Summary: This study identified three protein biomarkers (ATOX1, SPARC, and NT5C3A) in plasma that, when combined, showed high accuracy in diagnosing sport concussions. These proteins may play a role in tissue inflammation modulation and regulation of the cerebral microvasculature, making them potential candidates for future screening of adolescent sport concussions. Further validation in larger cohorts is needed to confirm their utility.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia J. Gevaert, Corby Fink, Jimmy D. Dikeakos, Gregory A. Dekaban, Paula J. Foster
Summary: This study evaluates magnetic particle imaging (MPI) as a method for in vivo tracking of dendritic cells (DC) and demonstrates its potential applications in migration models.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Virology
Antony Lurie, Corby Fink, Genevieve Gosselin, Gregory A. Dekaban, Jimmy D. Dikeakos
Summary: The article explores the rationale for pharmacologically targeting the HIV-1 accessory protein Nef and reviews the progress in the identification and development of Nef inhibitors.
