Article
Multidisciplinary Sciences
Samuel V. Rasmussen, Noah E. Berlow, Lisa Hudson Price, Atiya Mansoor, Stefano Cairo, Sandra Rugonyi, Charles Keller
Summary: Preclinical cancer research can be expensive, with in vitro studies often not representative of the tumor microenvironment and mouse studies being costly at scale. Using Japanese quail in chorioallantoic membrane (CAM) assays, researchers have developed a cost-effective method to screen for anti-cancer efficacy and drug toxicity, demonstrating concordance with murine in vivo studies and suggesting potential for validating new anti-cancer agents.
SCIENTIFIC REPORTS
(2021)
Review
Agriculture, Dairy & Animal Science
Ana Patricia Alves Leao, Renata Ribeiro Alvarenga, Marcio Gilberto Zangeronimo
Summary: The study evaluated the effect of probiotic inoculation in fertilized eggs on hatching and posthatching characteristics of broilers. Probiotic inoculation did not significantly impact hatching parameters but improved weight gain and feed conversion ratio posthatching. The type of microorganism, inoculation site, and broiler strain used were found to influence the effectiveness of probiotics on posthatching performance.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cindy L. Olmos-Carreno, Maria Figueres-Onate, Gabriel E. Scicolone, Laura Lopez-Mascaraque
Summary: Clonal cell analysis reveals the ontogenic potential of retinal stem/progenitor cells and uncovers neural heterogeneity among different cell types and lineages. Using a chick embryo model, this study tracks retinal cell lineages derived from individual progenitors and shows the presence of multipotent and committed progenitor cells in the early stages of development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Joanna Pawlowska, Ewa Sosnowka-Czajka, Iwona Skomorucha
Summary: In ovo technology is a method to administer bioactive substances to eggs during bird's embryonic development, and injecting 500 mu L of saline solution into the developing chick embryo during the last days of incubation may have a positive effect on the quality of day-old chicks.
Article
Health Care Sciences & Services
Deok-Hwan Kim, Eun-Hye Yoo, Ui-Seong Hong, Jun-Hyeok Kim, Young-Heon Ko, Seung-Cheol Moon, Miju Cheon, Jang Yoo
Summary: The MotionFree algorithm was found to improve the accuracy of PET/CT images by correcting misregistrations caused by respiratory motion, with shorter CT scan times reducing misregistration frequency and natural breathing protocols decreasing misregistration lengths.
Article
Anatomy & Morphology
Sejin Choi, Kyung Hyun Kim, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee
Summary: This study successfully visualized the gross morphology of chick embryos at different developmental stages and presented the detailed structure of the caudal cell mass from HH12 to 16. It also showed the spatiotemporal relationship between the caudal cell mass, floor plate of the neural tube, and notochord, as well as described the dynamic changes during early stages of secondary neurulation.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Agriculture, Dairy & Animal Science
Ezaldeen Abdelghani, Mohamed A. Fathi, Li Zhojian, Dai Pengyuan, Yansen Li, Chunmei Li
Summary: This study aimed to evaluate the effects of in ovo injection of soy isoflavones (ISF) on hatchability, body weight, antioxidant status, and intestinal development of newly hatched broiler chicks. The results showed that the in ovo inclusion of 6 mg of ISF significantly increased hatchability and hatch weight. ISF treatments also improved antioxidant status, intestinal development, and modulated the expression of proinflammatory cytokines, tight junctions, and insulin-like growth factor.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Yanqiang Geng, Xiaoming Sun, Lin Lu, Xi Lin, Xiudong Liao, Liyang Zhang, Runlian Wang, Xugang Luo
Summary: This study aimed to investigate the effects of in ovo manganese injection on embryonic development, antioxidant capacity, and performance of offspring broilers. The results showed that in ovo manganese injection can enhance the antioxidant capacity in the chick embryonic heart, but high temperature can negatively affect the growth performance of the offspring broilers.
Article
Agriculture, Dairy & Animal Science
Ziqiang Feng, Ichraf Mabrouk, Petunia Msuthwana, Yuxuan Zhou, Yupu Song, Haizhou Gong, Shengyi Li, Changguo Min, Anqi Ju, Aoyi Duan, Jiangting Niu, Jinhong Fu, Xiaomin Yan, Xiaohui Xu, Chuanghang Li, Yongfeng Sun
Summary: This study found that activating the Wnt/beta-catenin signaling pathway can promote the morphogenesis and development of feather follicles in a chick embryo model, and increase the expression of the downstream target LEF1.
Review
Engineering, Biomedical
Andre Z. Kyme, Roger R. Fulton
Summary: Patient motion affects SPECT, PET, and CT imaging by causing projection data inconsistencies, leading to reconstruction artifacts and compromised image quality. Methods to estimate and correct for motion in these modalities have been developed over decades, with ongoing efforts to improve clinical feasibility and utility. Further developments in data-driven methods, including the use of deep learning, hold promise for enhancing clinical utility in motion estimation and correction.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joscha Maier, Sergej Lebedev, Julien Erath, Elias Eulig, Stefan Sawall, Eric Fournie, Karl Stierstorfer, Michael Lell, Marc Kachelriess
Summary: Deep PAMoCo is a method for estimating and compensating coronary artery motion, which uses a deep neural network to enhance computational performance and quality of motion-compensated reconstructions. The results demonstrate that Deep PAMoCo can effectively remove motion artifacts and improve the diagnostic value of cardiac CT scans, outperforming other approaches in terms of processing time and accuracy.
Article
Veterinary Sciences
Elahe Razeghi, Farhad Mashayekhi, Fatemeh Ghasemian, Zivar Salehi
Summary: Folate plays an important role in DNA synthesis and neurogenesis in fetal brains. The study found that in ovo administration of folic acid could increase BDNF expression and decrease gga-miR-190a-3p expression in the developing chick cerebral cortex.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Guofeng Han, Yu Ren, Dan Shen, Shangmin Li, Vishwajit S. Chowdhury, Yansen Li, Mitsuhiro Furuse, Chunmei Li
Summary: In ovo administration of L-Leucine was shown to affect embryonic growth and amino acid metabolism, leading to decreased embryo and yolk sac weight, altered plasma amino acid concentrations, and increased hepatic Lys concentration. Interestingly, the Leu concentrations in plasma and liver were not affected by L-Leu administration, suggesting that L-Leu was metabolized before embryonic day 14 and influenced embryonic growth and amino acid metabolism.
JOURNAL OF POULTRY SCIENCE
(2021)
Article
Oncology
Jessica Loeffler, Hendrik Herrmann, Ellen Scheidhauer, Mareike Wirth, Anne Wasserloos, Christoph Solbach, Gerhard Glatting, Ambros J. Beer, Volker Rasche, Gordon Winter
Summary: This study used the chorioallantoic membrane (CAM) model to assess the target-specific binding of radiopharmaceuticals and investigated the feasibility of inhibition studies in the CAM model. The results demonstrated that the CAM model can be used to detect the receptor-specific binding of radiopharmaceuticals. This study provides an alternative to mouse experiments for early evaluation of promising radiopharmaceuticals.
Article
Medicine, General & Internal
Giridhar Dasegowda, Bernardo C. Bizzo, Parisa Kaviani, Lina Karout, Shadi Ebrahimian, Subba R. Digumarthy, Nir Neumark, James M. Hillis, Mannudeep K. Kalra, Keith J. Dreyer
Summary: In this study, an artificial intelligence model was trained and tested to identify motion artifacts in CT pulmonary angiography. The model successfully identified motion artifacts in multicenter datasets.
