期刊
MOLECULAR HUMAN REPRODUCTION
卷 21, 期 1, 页码 11-22出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gau090
关键词
mitochondrial DNA; haplotype matching; mtDNA segregation; development; preventing mtDNA disease
资金
- UK Medical Research Council
- Medical Research Council [MR/J010448/1]
- Wellcome Trust [WT0948685MA]
- MRC [MR/J010448/1, MR/J013617/1] Funding Source: UKRI
- Medical Research Council [MR/J013617/1, MR/J010448/1] Funding Source: researchfish
Mitochondrial diseases are potentially severe, incurable diseases resulting from dysfunctional mitochondria. Several important mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA), the genetic material contained within mitochondria, which is maternally inherited. Classical and modern therapeutic approaches exist to address the inheritance of mtDNA disease, but are potentially complicated by the fact that cellular mtDNA populations evolve according to poorly-understood dynamics during development and organismal lifetimes. We review these therapeutic approaches and models of mtDNA dynamics during development, and discuss the implications of recent results from these models for modern mtDNA therapies. We particularly highlight mtDNA segregation-differences in proliferative rates between different mtDNA haplotypes-as a potential and underexplored issue in such therapies. However, straightforward strategies exist to combat this and other potential therapeutic problems. In particular, we describe haplotype matching as an approach with the power to potentially ameliorate any expected issues from mtDNA incompatibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据