Article
Medicine, Research & Experimental
Wei Bai, Zhi Lin, Jin Ye, Linshuang Zhou, Jingqiao Xi, Wenpin Cai
Summary: Polymorphisms in the 3'UTR of the HLA-G gene are associated with the development of URSA and may serve as predictors of pregnancy outcome.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jun Shuai, Qiao-li Chen, Wen-hong Chen, Wei-wei Liu, Guo-ning Huang, Hong Ye
Summary: Maternal age, BMI, number of embryos transferred, and frozen-thawed transfer were identified as independent risk factors for early spontaneous abortion (ESA) in assisted reproductive technology treatment cycles.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Chao Lou, Rong Qiang, Hanzhi Wu, Liping Zhang, Wei Li, Ting Jia, Xing Liu
Summary: This study investigated the impact mechanism of long interspersed nuclear element-1 (LINE-1) insertions on early spontaneous abortion (SA) and found that LINE-1 expression was higher in SA tissues compared to induced abortion (IA) tissues, suggesting a potential role of LINE-1 in early SA.
Article
Obstetrics & Gynecology
Haixia Duan, Xiaojuan Li, Yuan Hao, Juanzi Shi, He Cai
Summary: This study investigates whether cured chronic endometritis (CE) from antibiotic treatment is associated with a higher risk of spontaneous abortion in subsequent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Somayeh Aftabsavad, Zahra Noormohammadi, Ashraf Moini, Morteza Karimipoor
Summary: This study investigated the relationship between follicular fluid BPA concentrations and alterations in ICAM-1 and HLA-G gene and protein expressions in the cumulus cells of POR women. Results showed differential expressions between the two groups, with lifestyle habits potentially affecting methylation patterns and protein levels in cumulus cells, impacting ovulation and clinical pregnancy outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Hiroki Miura, Yoshiki Kawamura, Tamae Ohye, Fumihiko Hattori, Kei Kozawa, Masaru Ihira, Hiroshi Yatsuya, Haruki Nishizawa, Hiroki Kurahashi, Tetsushi Yoshikawa
Summary: Inherited chromosomally integrated HHV-6 (iciHHV-6) can be transmitted from parent to child and is associated with increased risk of spontaneous abortion, especially in mothers who are iciHHV-6 positive and those who are ≥40 years old at their most recent pregnancy.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Pawel Radwan, Agnieszka Tarnowska, Karolina Piekarska, Andrzej Wisniewski, Rafal Krasinski, Michal Radwan, Izabela Nowak
Summary: sHLA-G secretion by the embryo is associated with implantation and live birth, and its concentration depends on the ovarian stimulation protocol used.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Reyhane Rahnama, Ahmad-Reza Mahmoudi, Somayeh Kazemnejad, Mansour Salehi, Ataollah Ghahiri, Haleh Soltanghoraee, Sedigheh Vafaei, Abbas Rezaei, Amir Hassan Zarnani
Summary: This study found for the first time that TPO is expressed at gene and protein levels in human reproductive organs, potentially explaining the higher frequency of abortion and infertility in patients with thyroid autoimmunity.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Fie W. Paulsen, Malte M. Tetens, Cecilie V. Vollmond, Jan Gerstoft, Gitte Kronborg, Isik S. Johansen, Carsten S. Larsen, Lothar Wiese, Michael Dalager-Pedersen, Suzanne Lunding, Lars N. Nielsen, Nina Weis, Niels Obel, Lars H. Omland, Anne-Mette Lebech
Summary: According to a nationwide Danish study, women with HIV have similar rates of childbirth, pregnancy, and spontaneous abortion compared to women from the general population. However, the incidence of induced abortions is twice as high.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Peilong Li, Nan Wang, Yi Zhang, Chuanxin Wang, Lutao Du
Summary: HLA-G, a non-classic MHC class I molecule, is widely expressed in tumor environment where it plays a key role in immune escape, potentially important for cancer diagnosis and prognosis. However, due to its multiple subtypes, evaluating HLA-G expression in tumors is challenging.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hong-xia Ye, Guang-neng Liao, Ya-jun Dong, Lan Li, Xue-mei Wang, Jin Shu, Qu Zheng, Yan Jia
Summary: The down-regulation of miR-146a-5p in decidual macrophages is associated with M1/M2 polarization disorder in URSA. miR-146a-5p inhibits M1 polarization, promotes M2 polarization, and generates an anti-inflammatory microenvironment in vitro. In a murine model of URSA, intravenous injection of miR-146a-5p reduces embryo resorption rate and promotes M2 polarization of decidual macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Lei Zhang, Qian Li, Yan Su, Xinyuan Zhang, Jialin Qu, Dan Liao, Qin Zou, Hua Zou, Xiaoli Liu, Chunli Li, Junlin He
Summary: This study aimed to reveal the pathogenesis of unexplained recurrent spontaneous abortion (URSA) by analyzing differential protein expression profiles in decidual tissue. The findings highlighted the potential role of cytoskeletal remodeling disorder in the failure of decidualization and provided valuable information for further research and potential therapeutic interventions.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, Research & Experimental
Grayson Hatfield, Lioudmila Tepliakova, Jessica Tran, Huixin Lu, Michel Gilbert, Roger Y. Y. Tam
Summary: Monoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes, leading to potential allergic reactions. This study focuses on the binding of anti-a1-3-Gal IgE antibodies to the Fc region of mAbs with varying degrees of a1-3-galactosylation. The results suggest that bi-a1-3-galactosylation is a critical quality attribute for mAb-based biotherapeutics.
Article
Immunology
Yang Fu, Yan Song, Juan Zhang, Lin-ping Wei, Xiao-rong Sun
Summary: This study explored the correlation between syncytin-1 expression and the occurrence of unexplained recurrent spontaneous abortion (URSA). It was found that syncytin-1 expression was abnormally low in URSA villus tissues, and the HERV-W gene promoter was hypermethylated. Additionally, URSA villus tissue exhibited obvious abnormal apoptosis. Syncytin-1 has the potential to be a predictive and diagnostic biomarker for URSA.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yunhe Bai, Xiaowen Zhang, Xuxian Xuan, Ehsan Sadeghnezhad, Fei Liu, Tianyu Dong, Dan Pei, Jinggui Fang, Chen Wang
Summary: This study reveals the role of exogenous GA in regulating the VvmiR3633a and related genes regulatory network during grape seed embryo abortion. The findings provide novel insights into the molecular breeding of high-quality seedless grape berries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Camille Fraichard, Fideline Bonnet-Serrano, Christelle Laguillier-Morizot, Marylise Hebert-Schuster, Rene Lai-Kuen, Jeanne Sibiude, Thierry Fournier, Marie Cohen, Jean Guibourdenche
Summary: The study investigated the impact of protease inhibitors on endocrine functions and cellular mechanisms in pregnant women, showing that lopinavir significantly decreased the secretion of hCG and P4, affecting trophoblast differentiation and P4 production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Philipp Boehm-Sturm, Susanne Mueller, Nancy Freitag, Sophia Borowski, Marco Foddis, Stefan P. Koch, Sebastian Temme, Ulrich Floegel, Sandra M. Blois
Summary: Placental hypoperfusion and hypoxia play key roles in fetal complications like growth restriction and preeclampsia. This study successfully established a technique for noninvasively characterizing placental oxygen levels in mouse models of preeclampsia using F-19 MRI. Results showed a decrease in oxygenation in knockout mice under low oxygen conditions, highlighting the potential of MRI in studying placental malfunction.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Kirstin Faust, Nancy Freitag, Gabriela Barrientos, Christoph Hartel, Sandra M. Blois
Summary: This study found that galectin-1, -3, and -9 levels are elevated in preterm infants born in an inflammatory environment, such as amniotic infection syndrome (AIS) or early-onset sepsis (EOS). Galectin-1 levels were notably increased in infants born to AIS, and levels of galectin-3 were higher in infants who developed EOS compared to unaffected infants. These findings suggest a potential role for galectins in mediating inflammation-induced preterm birth and could be a target for future clinical trials.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Sandra M. Blois, Paula D. Prince, Sophia Borowski, Monica Galleano, Gabriela Barrientos
Summary: Utilizing the SHRSP model, this study investigated placental mechanisms promoting superimposed preeclampsia in women with chronic hypertension. The findings revealed sustained activation of cellular stress response in SHRSP placentas, leading to redox imbalance and significant alterations in placental glycocode. The study highlights the potential role of glycoredox balance as a promising target for interventions in hypertensive disorders of pregnancy.
Article
Immunology
Nancy Freitag, Yiran Xie, Lisa-Marie Adam, Sophia Borowski, Sandra M. Blois, Gabriela Barrientos
Summary: The study revealed the important role of alternative splicing regulator Rbfox2 in modulating trophoblast function during placental development, with implications for the pathogenesis of conditions like preeclampsia in pregnancy.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nazanin Yeganeh Kazemi, Benoit Gendrot, Ekaterine Berishvili, Svetomir N. Markovic, Marie Cohen
Summary: Ovarian cancer and pregnancy expose the immune system to novel antigens, with both tumors and placenta utilizing extracellular vesicles (EVs) for cell-to-cell communication. EVs play a crucial role in promoting cell division and invasion, immunosuppression, and angiogenesis in both cancer and pregnancy.
Article
Oncology
Isabelle Hernandez, Marie Cohen
Summary: csGRP78 is a protein that appears on the surface of cancer cells, playing a key role in cancer development by influencing intracellular signaling pathways, and thus associated with the maintenance and progression of the disease.
Article
Cell Biology
Lucile Yart, Maud Frieden, Stephane Konig, Marie Cohen, Begona Martinez de Tejada
Summary: Nifedipine, an L-type voltage-gated Ca2+ channel blocker, is effective in reducing uterine contractions, but its efficacy is limited over time and may be ineffective in preventing preterm birth. Research has shown that nifedipine has different effects on different types of myometrial tissues, with potential involvement of TRPC channels in its pro-contractile effect.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lucile Yart, Edith Roset Bahmanyar, Marie Cohen, Begona Martinez de Tejada
Summary: Placental development and function are crucial for efficient maternal-fetal exchanges, pregnancy-specific hormone secretion, and immune modulation. Incorrect placental development can lead to serious pregnancy disorders, such as preeclampsia, endangering both the mother and the infant. The role of the uteroplacental renin-angiotensin system in placental development and function may have been underestimated.
Article
Oncology
Lucile Yart, Daniel Bastida-Ruiz, Mathilde Allard, Pierre-Yves Dietrich, Patrick Petignat, Marie Cohen
Summary: This study found that cell fusion may be involved in the formation of ovarian PGCCs, and this process is promoted by paclitaxel and UPR activation. Modulating the UPR could be an interesting therapeutic strategy to prevent the formation of PGCCs and therefore limit cancer relapse and drug resistance.
Article
Multidisciplinary Sciences
Pascale Ribaux, Christine Wuillemin, Patrick Petignat, Florence Delie, Marie Cohen
Summary: Pigment epithelium-derived factor (PEDF) is a glycoprotein involved in various biological processes. Its expression decreases during ovarian carcinogenesis, but can be increased using the liposome and lipid nanoparticle delivery system for SBT-PEDF gene therapy. The combination of nanolipoplexes and paclitaxel shows synergistic and effective anti-tumor efficacy on ovarian tumors, highlighting the potential of lipid nanoparticles for SBT-PEDF gene therapy in ovarian cancer treatment.
Review
Biochemistry & Molecular Biology
Oceane Pecheux, Ana Correia-Branco, Marie Cohen, Begona Martinez de Tejada
Summary: The apelinergic system is a highly conserved pleiotropic system that plays important roles in pregnancy and placenta-related complications. It is involved in the regulation of the adipoinsular axis, cardiovascular and central nervous systems, carcinogenesis, and embryo cardiogenesis and vasculogenesis during pregnancy. However, there are inconsistencies in the expression and circulating levels of its components in human placenta-associated preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Charles-Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Lisa Perez, David Cottet-Dumoulin, Axel Andres, Domenico Bosco, Thierry Berney, Veronique Othenin-Girard, Begona Martinez De Tejada, Marie Cohen, Christina Olgasi, Antonia Follenzi, Ekaterine Berishvili
Summary: Lack of rapid revascularization and inflammatory attacks contribute to poor outcomes after clinical islet transplantation. In a study using pre-vascularized islet organoids, enhanced in vitro function, better engraftment, and improved vascularization were observed, mainly due to cross-talk between different cell types and upregulation of genes promoting angiogenesis and beta cell function.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Fanny Lebreton, Reine Hanna, Charles H. Wassmer, Kevin Bellofatto, Lisa Perez, Veronique Othenin-Girard, Begona Martinez de Tejada, Marie Cohen, Ekaterine Berishvili
Summary: Human amniotic epithelial cells possess anti-inflammatory and immunomodulatory properties which protect islets from damage induced by pro-inflammatory cytokines. This indicates that integrating hAECs in islet transplants may be a valuable strategy to inhibit inflammation-mediated islet damage and improve overall transplant success.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Summary: Global COVID-19 pandemic has led to nearly 500,000 deaths, with most fatalities attributed to ARDS caused by an excessive immune response. Current antiviral and anti-inflammatory therapies have shown limited efficacy, prompting the consideration of placenta-derived cells as a potential cell-based therapy for severe cases.
STEM CELL REVIEWS AND REPORTS
(2021)