期刊
MOLECULAR HUMAN REPRODUCTION
卷 15, 期 10, 页码 577-586出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gap057
关键词
animal model; endometriosis; endometrium; primate; uterine; pathologies
资金
- Eunice Kennedy Shriver NICHD/National Institutes of Health [U54 HD 40093]
- Specialized Cooperative Centers Program in Reproductive Research [T32 HL 007692]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [U54HD040093] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007692] Funding Source: NIH RePORTER
The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).
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