Review
Environmental Sciences
Frederic Dutheil, Aurelie Comptour, Roxane Morlon, Martial Mermillod, Bruno Pereira, Julien S. Baker, Morteza Charkhabi, Maelys Clinchamps, Nicolas Bourdel
Summary: Exposure to air pollutants during pregnancy is associated with an increased risk of autism spectrum disorder in newborns, with PM2.5 showing the strongest impact. The most at-risk periods seem to be during pregnancy and the postnatal period.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Caroline J. Smith, Danielle N. Rendina, Marcy A. Kingsbury, Karen E. Malacon, Dang M. Nguyen, Jessica J. Tran, Benjamin A. Devlin, Ravikiran M. Raju, Madeline J. Clark, Lauren Burgett, Jason H. Zhang, Murat Cetinbas, Ruslan I. Sadreyev, Kevin Chen, Malvika S. Iyer, Staci D. Bilbo
Summary: Environmental toxicant exposure, particularly air pollution, disproportionately affects low-income and minority communities, leading to higher levels of psychosocial stress. This study shows that combined exposure to air pollution and maternal stress during pregnancy induces social behavior deficits in male mice, accompanied by changes in microglial morphology and gene expression, as well as decreased dopamine receptor expression and dopaminergic fiber input in the nucleus accumbens. Importantly, the gut microbiome composition and intestinal epithelium structure are significantly altered in these exposed males, and shifting the gut microbiome at birth can prevent social deficits and microglial alterations. However, while social deficits can be reversed by activating dopamine neurons, modulation of the gut microbiome does not impact dopamine endpoints. These findings highlight the male-specific changes in the gut-brain axis following environmental toxicant exposure and emphasize the importance of the gut microbiome in modulating social behavior and microglia.
MOLECULAR PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Richard E. Frye, Janet Cakir, Patrick J. McCarty, Shannon Rose, Leanna M. Delhey, Raymond F. Palmer, Christine Austin, Paul Curtin, Maayan Yitshak-sade, Manish Arora
Summary: Neurodevelopmental regression (NDR) is a mysterious event associated with autism spectrum disorder (ASD) in which a child loses previously acquired skills and develops ASD symptoms. This study suggests that air pollution, specifically PM2.5, may trigger NDR, especially in children without a known trigger. Further research is needed to understand the biological mechanism behind this observation and potentially prevent NDR.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Kuen Su Lee, Won Kee Min, Yoon Ji Choi, Sejong Jin, Kyu Hee Park, Suhyun Kim
Summary: This study aimed to evaluate the effects of high levels of maternal exposure to ambient air pollution and heavy metals on risks of autism spectrum disorder (ASD) and epilepsy using South Korea's National Health Insurance claims data. The results showed that exposure to SO2 and Pb during pregnancy was more closely associated with the incidence of ASD, while exposure to Pb and Cd during pregnancy was associated with the incidence of epilepsy. This suggests that exposure to SO2, NO2, and Pb during pregnancy may affect neurodevelopment and be related to fetal development.
MEDICINA-LITHUANIA
(2023)
Article
Public, Environmental & Occupational Health
Hadas Magen-Molho, Marc G. Weisskopf, Daniel Nevo, Alexandra Shtein, Shimon Chen, David Broday, Itai Kloog, Hagai Levine, Ofir Pinto, Raanan Raz
Summary: This study assessed residual confounding in the association between air pollution and ASD using negative control exposures. The results support a hypothesized causal link with ASD that is specific to postnatal exposures to traffic-related pollution.
Article
Multidisciplinary Sciences
Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Summary: This study aimed to evaluate the behavioral patterns of children with ASD during and after the COVID-19 lockdown, and found that support in the areas of problematic behavior could mitigate future risks.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ja Hyeong Kim, Qi Yan, Karan Uppal, Xin Cui, Chenxiao Ling, Douglas I. Walker, Julia E. Heck, Ondine S. von Ehrenstein, Dean P. Jones, Beate Ritz
Summary: This study identified metabolic pathways disturbed in mothers with ASD offspring among women experiencing high exposure to traffic-related air pollution during pregnancy that were associated with mitochondrial dysfunction, providing a better understanding of metabolic disturbances involved in the development of ASD under adverse environmental conditions.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Editorial Material
Microbiology
Maude M. David
Summary: Autism spectrum disorder (ASD) is a complex disorder influenced by genetic and environmental factors. Studies have suggested a role of the gut microbiome in modulating ASD phenotype, but results remain inconsistent. Future research will require new experimental methodologies to better understand this relationship.
Article
Environmental Sciences
Lief Pagalan, Tim F. Oberlander, Gillian E. Hanley, Laura C. Rosella, Celeste Bickford, Whitney Weikum, Nancy Lanphear, Bruce Lanphear, Michael Brauer, Matilda van den Bosch
Summary: Research suggests that prenatal greenspace exposure is associated with reduced odds of ASD, but this effect is null at the population level. No mediating effect was observed through reduced air pollution, indicating that air pollution may act more as a confounder.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Psychiatry
Jifeng Wang, Yuan Cao, Weiliang Hou, Dexi Bi, Fang Yin, Yaohui Gao, Dengfeng Huang, Yingying Li, Zhan Cao, Yinmei Yan, Jianhua Zhao, Dewu Kong, Xiaoqiong Lv, Linsheng Huang, Hui Zhong, Chunyan Wu, Qiyi Chen, Rong Yang, Qing Wei, Huanlong Qin
Summary: Autism spectrum disorder (ASD) is a complex behavioral disorder characterized by difficulties in social interaction, restricted verbal communication, and repetitive behaviors. Fecal microbiota transplantation (FMT) is a safe and efficient strategy to adjust gut microbiota dysbiosis and improve ASD-related behavioral symptoms, but its mechanism is still unknown. Understanding the impact of microbiota on ASD development is crucial for developing new therapeutic strategies.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Environmental Sciences
Amir Shiani, Kiomars Sharafi, Abdullah Khalid Omer, Amir Kiani, Behzad Karamimatin, Tooraj Massahi, Gholamreza Ebrahimzadeh
Summary: This study aims to investigate the relationship between exposure to toxic metals and Autism Spectrum Disorder (ASD). Meta-analysis of qualified papers revealed that autistic individuals had higher levels of lead, mercury, arsenic, and aluminum in their bodies compared to healthy controls, while they had lower levels of lead, cadmium, and mercury in their urine. These findings contribute to a better understanding of the role of toxic metals as environmental factors in the development of ASD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Clinical Neurology
Ramkumar Aishworiya, Tatiana Valica, Randi Hagerman, Bibiana Restrepo
Summary: While behavioral interventions remain the primary treatment for autism spectrum disorder, new targeted treatments addressing the underlying neurophysiology have emerged. These treatments show promise in effectively addressing the core symptoms of autism and may also target genetic mechanisms associated with the disorder. This article provides a review of current pharmacological treatments for autism and explores upcoming targeted approaches in autism management.
Letter
Medicine, General & Internal
James T. Nugent, Christine Bakhoum, Lama Ghazi, Jason H. Greenberg
Summary: This study compares the frequency of hypertension screening at health maintenance visits between children with and without autism.
Article
Environmental Sciences
Yiran Li, Tian Xie, Raniere Dener Cardoso Melo, Maaike de Vries, Jeroen Lakerveld, Wilma Zijlema, Catharina A. Hartman
Summary: This study longitudinally examined the effects of ambient noise and air pollutants on the severity of ASD and ADHD symptoms in adolescence and early adulthood. The results showed that higher exposure to PM2.5 and PM10 was associated with more severe ASD and ADHD symptoms. However, there were no consistent associations between noise or other air pollutants and the severity of ASD and ADHD.
ENVIRONMENTAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Jeani Chang, Yujia Zhang, Sheree L. Boulet, Sara B. Crawford, Glenn E. Copeland, Dana Bernson, Russell S. Kirby, Dmitry M. Kissin, Wanda D. Barfield
Summary: This study compares trends and characteristics of assisted reproductive technology (ART) and non-ART perinatal deaths. It finds that ART is associated with a lower risk of perinatal deaths, especially before 28 weeks of gestation. This may be explained by earlier detection and management of fetal and maternal conditions in ART-conceived pregnancies.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Psychology, Developmental
Amy N. Esler, Jeannette Sample, Jennifer Hall-Lande, Bryn Harris, Catherine Rice, Jenny Poynter, Russell S. Kirby, Lisa Wiggins
Summary: This study compared the timing of autism spectrum disorder (ASD) identification in education and health settings for 8-year-old children with ASD using records-based surveillance. They also examined the types of ASD symptoms noted in special education evaluations. The results showed that children with records only from education sources were identified with ASD over a year later compared to those with records from health sources. There was a higher likelihood for black children to have records only from education sources. Restricted and repetitive behaviors were less frequently documented in educational evaluations, resulting in more developmental delay eligibility than specific ASD eligibility among children with ASD. Future research should focus on strategies to decrease the age of identification in educational settings and increase equitable access to health evaluations.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Education, Special
Acadia W. Buro, Heewon L. Gray, Russell S. Kirby, Jennifer Marshall, LaShae Rolle, Jamie Holloway
Summary: This qualitative study examined the acceptability, perceived benefits, and unintended consequences of a virtual implementation of an 8-week theory-driven nutrition intervention for adolescents with autism spectrum disorder (ASD). Based on interviews and focus groups with parents and adolescents, the study found that the virtual intervention was generally acceptable and received positive feedback. Participants reported changes in psychosocial determinants of dietary intake and diet changes as a result of the intervention. The findings suggest that virtual group interventions may benefit many adolescents with ASD. Quantitative research is needed to further examine the behavioral outcomes of this intervention.
ADVANCES IN NEURODEVELOPMENTAL DISORDERS
(2023)
Editorial Material
Developmental Biology
Russell S. Kirby, Marilyn L. Browne, Wendy N. Nembhard
BIRTH DEFECTS RESEARCH
(2023)
Article
Psychology, Developmental
Aisha S. Dickerson, Asha S. Dickerson
Summary: This article summarizes the associations between prenatal air pollutant, chemical, and occupational exposures, psychosocial stressors, and ASD and co-occurring neurodevelopmental disorders. It highlights the importance of research and prioritizing policies to improve services in vulnerable populations.
CHILD DEVELOPMENT PERSPECTIVES
(2023)
Article
Genetics & Heredity
Bailey A. Martin-Giacalone, Angela E. E. Lin, Sonja A. Rasmussen, Russell S. Kirby, Eirini Nestoridi, Rebecca F. Liberman, A. J. Agopian, John C. Carey, Janet D. Cragan, Nina Forestieri, Vinita Leedom, Aubree Boyce, Wendy N. Nembhard, Monika Piccardi, Theresa Sandidge, Xiaoyi Shan, Charles J. Shumate, Erin B. Stallings, Roger Stevenson, Philip J. Lupo
Summary: The lack of population-based data on Turner syndrome in the United States has limited assessments of its prevalence and associated characteristics. This study collected data from 2000 to 2017 from seven birth defects surveillance programs and estimated the prevalence of karyotype-confirmed Turner syndrome within the first year of life. The findings inform surveillance practices, prenatal counseling, and diagnosis, and highlight racial and ethnic disparities that require further investigation.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Environmental Sciences
Christian Hoover, Aisha S. Dickerson, Aaron J. Specht, Gabrielle Groth Hoover
Summary: The US has the highest number of firearms in the world and primarily uses lead ammunition. This study found that firearm-related lead exposure contributes significantly to elevated blood lead levels in children. The authors recommend further research and prevention efforts to address this potential health risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Chukwuemeka E. Ogbu, Chisa O. Oparanma, Russell S. Kirby
Summary: This study explored the factors associated with the use of complementary and alternative medicine/therapy (CAM) among adults with current asthma in the United States. The results showed that approximately 45.2% of US adults with asthma had ever used CAM, and 25.3% and 19.9% endorsed using one CAM and =2 CAMs, respectively. CAM use was significantly associated with age, gender, race/ethnicity, cost barriers, disease comorbidities, and asthma control, but not with insurance and income status.
Review
Public, Environmental & Occupational Health
Aisha S. Dickerson, Seth Frndak, Melissa DeSantiago, Ankita Mohan, Genee S. Smith
Summary: This review summarizes studies conducted between 2015 and 2022 on neurotoxicant exposures and neurodevelopmental differences, focusing on disparities by education, income, race/ethnicity, or immigration status. It emphasizes the importance of investigating such disparities in overburdened communities and provides recommendations for future research.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Cheryl A. Vamos, Abraham A. Salinas-Miranda, Ellen M. Daley, Russell S. Kirby, Karen D. Liller, Jennifer Marshall, William M. Sappenfield, Ronee E. Wilson, Donna J. Petersen
Summary: This article describes a graduate-level MCH leadership training program and demonstrates how an implementation science framework can inform program development and evaluation. The findings emphasize the importance of considering determinants across domains and highlight key lessons learned. Integrating implementation science into MCH training programs could enhance their rigor, adaptability, and dissemination efforts.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Environmental Sciences
Ashley Y. Song, Elizabeth M. Kauffman, Ghassan B. Hamra, Aisha S. Dickerson, Lisa A. Croen, Irva Hertz-Picciotto, Rebecca J. Schmidt, Craig J. Newschaffer, M. Daniele Fallin, Kristen Lyall, Heather E. Volk
Summary: This study assessed the associations between prenatal exposure to a mixture of persistent organic pollutants (POPs) and autism-related traits in children. The findings suggest that PBDE47, p,p'-DDE, PCB180, and PCB187 have independent effects on autism-related traits, and there may be interactions between PBDE99 and other PBDEs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Jonathan V. Lewis, Emily A. Knapp, Shivani Bakre, Aisha S. Dickerson, Theresa M. Bastain, Casper Bendixsen, Deborah H. Bennett, Carlos A. Camargo, Andrea E. Cassidy-Bushrow, Elena Colicino, Viren D'Sa, Dana Dabelea, Sean Deoni, Anne L. Dunlop, Amy J. Elliott, Shohreh F. Farzan, Assiamira Ferrara, Rebecca C. Fry, Tina Hartert, Caitlin G. Howe, Linda G. Kahn, Margaret R. Karagas, Teng-Fei Ma, Daphne Koinis-Mitchell, Debra MacKenzie, Luis E. Maldonado, Francheska M. Merced-Nieves, Jenae M. Neiderhiser, Anne E. Nigra, Zhongzheng Niu, Sara S. Nozadi, Zorimar Rivera-Nunez, Thomas G. O'Connor, Sarah Osmundson, Amy M. Padula, Alicia K. Peterson, Allison R. Sherris, Anne Starling, Jennifer K. Straughen, Rosalind J. Wright, Qi Zhao, Amii M. Kress
Summary: This study examined the relationship between preconception and prenatal exposure to arsenic violations in drinking water and birth outcomes. The results showed that continuous exposure to arsenic in drinking water was associated with higher birth weight. However, no significant associations were found between preconception or prenatal exposure to arsenic violations and other birth outcomes.
ENVIRONMENTAL RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Aisha S. Dickerson, Seth Frndak, Irena Gorski-Steiner, Zhengyi Deng, Tara E. Jenson, Ankita Mohan, Jake Kim, Verne Qaanaaq Boerner, Roland J. Thorpe Jr
Summary: The purpose of this review is to discuss the higher incidence of dementia in Black and Hispanic populations and those with less education, and the proposed risk factor of air pollution. Reports on ambient pollution and cognitive decline are examined, and the importance of investigations in marginalized populations is emphasized. Areas for future research are recommended.
CURRENT EPIDEMIOLOGY REPORTS
(2023)
Article
Pediatrics
Chisa O. Oparanma, Chukwuemeka E. Ogbu, Ebubechukwu Ezeh, Stella C. Ogbu, Otobo I. Ujah, Russell S. Kirby
Summary: This study analyzed the relationship between caregivers' self-rated general health, poor physical/mental health days, disease morbidity, and asthma control in children from the United States. Data was collected from 7522 children aged 0-17 years. The results showed that caregivers with fair general health, poor mental/physical health days, and multiple diseases were more likely to have children with uncontrolled asthma.
Article
Psychology, Developmental
Rachel R. Lee, Anthony R. Ward, David M. Lane, Michael G. Aman, Katherine A. Loveland, Rosleen Mansour, Deborah A. Pearson
Summary: There is a significant link between executive functioning deficits in children with autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD), particularly in regard to ADHD symptoms. The severity of ASD does not appear to be correlated with executive functioning deficits. Specifically, the domains of shift and emotional control seem to be relatively spared in children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
