Article
Public, Environmental & Occupational Health
Yong Chen, Haobin Huang, Xiaowei He, Weiwei Duan, Xuming Mo
Summary: The study found a negative association between blood cobalt concentration and HOMA-IR in female adults, with no significant correlation in the overall population. Participants with the lowest cobalt levels showed a 2.74% increase in HOMA-IR compared to those with the highest cobalt levels, suggesting a potential non-linear relationship between blood cobalt and HOMA-IR.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Huijie Huang, Ai Wang, Li Cong, Yingjuan Zeng
Summary: This study investigated the association between osteocalcin and insulin resistance in men with type 2 diabetes. The results showed an inverse correlation between osteocalcin and the TyG index, particularly in younger patients with lower BMI, poorer glycemic control, without hypertension or smoking.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Jonas Ellerbrock, Benthe Spaanderman, Joris van Drongelen, Eva Mulder, Veronica Lopes van Balen, Veronique Schiffer, Laura Jorissen, Robert-Jan Alers, Jeanine Leenen, Chahinda Ghossein-Doha, Marc Spaanderman
Summary: This study found that both high insulin resistance and beta cell dysfunction increase the risk of gestational diabetes mellitus (GDM) in second-trimester pregnant women. Additionally, high insulin resistance is associated with the need for additional glucose lowering medication, especially in women diagnosed with GDM who do not respond well to a low carbohydrate diet. Therefore, insulin sensitizers may be the most targeted therapeutic modality for diet-insensitive GDM patients.
Article
Environmental Sciences
Ann M. Vuong, Cai Zhang, Aimin Chen
Summary: Neonicotinoids, a new class of insecticides, may have an impact on insulin and glucose homeostasis parameters, with certain chemicals such as imidacloprid and 5-hydroxy-imidacloprid showing negative associations with insulin levels. Sex, body mass index, and age may also modulate these associations.
Article
Biochemistry & Molecular Biology
Aditya Saxena, Nitish Mathur, Pooja Pathak, Pradeep Tiwari, Sandeep Kumar Mathur
Summary: Insulin resistance (IR) is the precursor and key mechanism of type 2 diabetes (T2D) and metabolic syndrome (MetS), but the pathways shared by IR and T2D are not well understood. This study identified a set of key metagenes shared by IR and T2D using a feature selection method and found that artificial neural network (ANN) performed well in differentiating diabetics from normal glucose tolerant (NGT) persons with 73% accuracy. These key metagenes were also validated in diabetes-associated genetic studies, indicating their potential importance in the molecular pathology of both IR and T2D.
Article
Psychology, Developmental
Peiyu Chen, Ana Baylin, Joyce Lee, Galit Levi Dunietz, Alejandra Cantoral, Martha Maria Tellez Rojo, Karen E. Peterson, Erica C. Jansen
Summary: The study examined the relationship between sleep duration, timing, and insulin resistance in Mexican adolescents. Shorter sleep duration and later sleep timing were both independently associated with higher insulin resistance, particularly among girls.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Fatema Al-Reshed, Sardar Sindhu, Ashraf Al Madhoun, Fatemah Bahman, Halemah AlSaeed, Nadeem Akhter, Md. Zubbair Malik, Fawaz Alzaid, Fahd Al-Mulla, Rasheed Ahmad
Summary: This study aimed to investigate the effect of low carbohydrate intake on glucose homeostasis, inflammatory, and metabolic parameters in healthy individuals of a normal weight. The findings showed that low carbohydrate intake was significantly associated with dysregulated glucose homeostasis, metabolic acidosis, and the potential for inflammation triggered by elevated C-peptide.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Michalina Gruszczynska, Anna Sadowska-Przytocka, Weronika Szybiak, Barbara Wieckowska, Katarzyna Lacka
Summary: Insulin resistance may play a role in the development of acne vulgaris, as indicated by this cohort study and systematic review. The findings suggest that insulin resistance is more common in acne vulgaris patients and should be considered as an independent factor in diagnosis and treatment.
Article
Endocrinology & Metabolism
Yan Li, Yiwen Wang, Hai Liu, Shaodi Zhang, Cuilian Zhang
Summary: This study explored the association between insulin resistance (IR) and ovarian sensitivity to exogenous gonadotropin (Gn) in women with polycystic ovary syndrome (PCOS). It was found that IR was negatively correlated with ovarian sensitivity. This provides new insights for individualized treatment in PCOS patients with IR undergoing assisted reproductive technology (ART).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Minna F. Schleu, Beatriz Barreto-Duarte, Maria B. Arriaga, Mariana Araujo-Pereira, Ana Marice Ladeia, Bruno B. Andrade, Maria L. Lima
Summary: The study found that lower levels of VITD are strongly associated with increased insulin resistance in obese women. Different expression profiles of laboratory markers were observed according to 25(OH)D levels.
Article
Endocrinology & Metabolism
Shijun Gong, Shenglian Gan, Yuhua Zhang, Haifeng Zhou, Quan Zhou
Summary: This study found that the GGT/HDL-C ratio has a strong predictive power for MetS in patients with type 2 diabetes, and it is more effective than the TyG index and HOMA-IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mengxing Wang, Lerong Mei, Aoming Jin, Xueli Cai, Jing Jing, Suying Wang, Xia Meng, Shan Li, Tiemin Wei, Yongjun Wang, Yuesong Pan
Summary: The study found that in patients without diabetes, a high triglyceride glucose (TyG) index was associated with increased atherosclerotic burden and plaques in coronary, intra- and extracranial arteries. Compared with the homeostasis model assessment of insulin resistance (HOMA-IR), the TyG index was more strongly associated with intracranial atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Semi Zouiouich, Erikka Loftfield, Inge Huybrechts, Vivian Viallon, Panayiotis Louca, Emily Vogtmann, Philippa M. Wells, Claire J. Steves, Karl-Heinz Herzig, Cristina Menni, Marjo-Riitta Jarvelin, Rashmi Sinha, Marc J. Gunter
Summary: The study revealed that higher levels of HOMA-IR, CRP, and HbA(1c) were associated with lower gut microbiome diversity in both the NFBC1966 and TwinsUK cohorts. This association persisted even after adjusting for BMI and other variables.
Article
Endocrinology & Metabolism
Honglin Sun, Xiaona Chang, Nannan Bian, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: Adipose tissue insulin resistance was strongly associated with serum uric acid levels and hyperuricemia regardless of BMI classification. In men with normal BMI, Adipo-IR, rather than HOMA-IR, was closely associated with hyperuricemia. These findings emphasize the critical role of adipose tissue insulin resistance in serum uric acid metabolism and hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hye Min Park, Hye Sun Lee, Yong-Jae Lee, Jun-Hyuk Lee
Summary: The study demonstrates that the TyG index is more effective than HOMA-IR in predicting the prevalence and incidence of type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Stefan Kabisch, Oda Sophia Hedemann, Andreas F. H. Pfeiffer
Summary: This study aimed to predict risk factors for periodontitis in a German diabetes outpatient cohort. The study found that quality of life and lifestyle factors were associated with periodontitis in diabetes patients. Further research is needed for replication and clarification of the underlying mechanisms.
ACTA DIABETOLOGICA
(2022)
Article
Nutrition & Dietetics
Michaela Haerdrich, Anja Haase-Fielitz, Jens Fielitz, Michael Boschmann, Olga Pivovarova-Ramich, Andreas F. H. Pfeiffer, Natalia Rudovich, Karsten H. Weylandt, Christian Butter
Summary: This study found that NEFA concentrations improved within the reference range in men but not women after transcatheter aortic valve implantation (TAVI). Men also showed an increased physical performance after TAVI, while women did not. There was no association between NEFA concentrations and physical performance in both men and women after TAVI.
Meeting Abstract
Endocrinology & Metabolism
Arvid Sandforth, Karl D. Lange, Robert Wagner, Andreas F. Pfeiffer, Michael Roden, Andreas Fritsche, Reiner Jumpertz von Schwartzenberg, Andreas L. Birkenfeld
Article
Nutrition & Dietetics
Charlotte Wernicke, Anne Pohrt, Laura Pletsch-Borba, Konstantina Apostolopoulou, Silke Hornemann, Nina Meyer, Jurgen Machann, Christiana Gerbracht, Frank Tacke, Andreas F. H. Pfeiffer, Joachim Spranger, Knut Mai
Summary: This study aimed to assess the long-term effects of a dietary intervention high in protein and unsaturated fatty acids on intrahepatic lipids and metabolism. The study found that in adherent older individuals following dietary recommendations, a high-protein and unsaturated fatty acids diet can have beneficial long-term effects on liver fat and lipid metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Robert Wagner, Martin Heni, Konstantinos Kantartzis, Arvid Sandforth, Juergen Machann, Fritz Schick, Andreas Peter, Louise Fritsche, Julia Szendroedi, Andreas F. H. Pfeiffer, Annette Schuermann, Matthias Blueher, Hans Hauner, Jochen Seissler, Stefan Bornstein, Michael Roden, Norbert Stefan, Andreas L. Birkenfeld, Morris F. White, Hans-Ulrich Haering, Andreas Fritsche
Summary: The objective of this study was to examine the effects of lifestyle intervention on impaired insulin secretion in specific subphenotypes of prediabetes. Participants from the Prediabetes Lifestyle Intervention Study were divided into six prediabetes clusters and assessed for insulin secretion, glycemia, insulin sensitivity, and liver fat changes during a 1-year intervention. The lifestyle intervention improved glycemic traits in all high-risk clusters, while insulin secretion increased only in clusters 3 and 5. However, high liver fat in cluster 5 hindered the improvement of insulin secretion.
Article
Nutrition & Dietetics
Jiudan Zhang, Sylva Mareike Schaefer, Stefan Kabisch, Marta Csanalosi, Bettina Schuppelius, Margrit Kemper, Mariya Markova, Nina Marie Tosca Meyer, Olga Pivovarova-Ramich, Farnaz Keyhani-Nejad, Sascha Rohn, Andreas F. H. Pfeiffer
Summary: This study investigates the contribution of amino acids to postprandial hyper-glucagonemia in type 2 diabetes patients. The research shows that type 2 diabetes patients have excessive glucagon responses after mixed meals, while the obese control group only shows small initial and delayed greater glucagon responses. The role of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in mixed meals is unclear.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Simon I. I. Dreher, Martin Irmler, Olga Pivovarova-Ramich, Katharina Kessler, Karsten Juerchott, Carsten Sticht, Louise Fritsche, Patrick Schneeweiss, Juergen Machann, Andreas F. H. Pfeiffer, Martin Hrabe de Angelis, Johannes Beckers, Andreas L. L. Birkenfeld, Andreas Peter, Andreas M. M. Niess, Cora Weigert, Anja Moller
Summary: This study examined the response of subcutaneous adipose tissue (SAT) to exercise and compared it with skeletal muscle. The results showed that SAT responds differently to exercise, with reductions in transcripts related to lipid storage and lipogenesis, as well as modulation of the circadian rhythm, which can potentially prevent metabolic syndrome progression towards diabetes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Marina Tsoli, Kosmas Daskalakis, Maria Wedin, Anna Angelousi, Sebastian Povlsen, Raj Srirajaskanthan, George Giovos, Martin O. Weickert, Angelika Kogut, Beata Kos-Kudla, Kira Oleinikov, Simona Grozinsky-Glasberg, Gregory Kaltsas
Summary: Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but can be detected using new diagnostic tools. A retrospective analysis was performed to study the characteristics and prognostic significance of PMs in NEN patients. The presence of PMs did not have a significant negative impact on overall survival (OS) in this study.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Michael Kruse, Silke Hornemann, Anne-Cathrin Ost, Turid Frahnow, Daniela Hoffmann, Andreas Busjahn, Martin A. Osterhoff, Bettina Schuppelius, Andreas F. H. Pfeiffer
Summary: This study investigated the gene expression changes in white adipose tissue after an isocaloric high-fat diet in healthy human twins. The results showed that fatty acid transport was reduced, while fructose transport was increased, potentially leading to increased de novo lipogenesis. These gene expression changes were partially inherited.
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: The Mediterranean Diet is a plant-based diet rich in vegetables, fruit, cereals, and olive oil. It has numerous health benefits, including improved longevity, reduced risk of chronic diseases such as diabetes and obesity, and improved cognitive function. The diet also influences the gut microbiota, promoting the growth of beneficial bacteria and reducing the growth of harmful bacteria. The adoption of the Mediterranean Diet is beneficial for both health and the environment, and should be encouraged globally.
Review
Biochemistry & Molecular Biology
Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Metabolic-associated fatty liver disease (MAFLD) has become the most common cause of chronic liver disease globally, affecting one in four people. Despite only a small proportion of MAFLD patients progressing to cirrhosis, it still plays a significant role in its development. However, MAFLD faces challenges such as insidious and asymptomatic onset, lack of accurate diagnostic tests, and absence of specific therapies.
Review
Gastroenterology & Hepatology
Mona Reinshagen, Stefan Kabisch, Andreas F. H. Pfeiffer, Joachim Spranger
Summary: Nonalcoholic fatty liver disease (NAFLD) is strongly associated with metabolic syndrome and type 2 diabetes, and can independently lead to long-term complications. Direct diagnostics for NAFLD are either invasive, costly, or dependent on the examiner's expertise. Biomarkers, specifically liver fat indices, provide a cheap diagnostic alternative for NAFLD prediction, but have limited accuracy for liver fat quantification. Currently, they lack precision for individual patient monitoring but can serve as compound biomarkers in large cohorts.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Thomas Skurk, Anja Bosy-Westphal, Arthur Gruenerbel, Stefan Kabisch, Winfried Keuthage, Peter Kronsbein, Karsten Muessig, Helmut Nussbaumer, Andreas F. H. Pfeiffer, Marie-Christine Simon, Astrid Tombek, Katharina S. S. Weber, Diana Rubin
Meeting Abstract
Endocrinology & Metabolism
B. Schuppelius, R. Schueler, O. Pivovarova-Ramich, S. Hornemann, A. Busjahn, J. Machann, M. Kruse, A. F. H. Pfeiffer