Article
Food Science & Technology
Jiahui Wang, Zhixin Zhang, Yan Lin, Juan Chen, Fangbin Wang, Lu Wang, Jian Liu, Xian Zhang
Summary: Dietary luteolin inhibits the lipolysis induced by 5-HT, preventing the development of obesity-related complications. In high-fat diet-fed mice, luteolin supplementation alleviates the occurrence of fatty liver. However, luteolin has no significant effect on body weight.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Edward O. List, Darlene E. Berryman, Julie Slyby, Silvana Duran-Ortiz, Kevin Funk, Elise S. Bisset, Susan E. Howlett, John J. Kopchick
Summary: By disrupting the growth hormone receptor in adipocytes, insulin sensitivity can be improved in the elderly and lifespan can be increased in mice. In male mice, adipocyte-specific disruption of the growth hormone receptor can increase lifespan, while also increasing fat mass, reducing circulating levels of insulin, adiponectin, resistin, and improving frailty scores. Comparison of lifespan data between GHRKO mice and adipocyte-specific GHRKO and muscle-specific GHRKO mice suggests that adipocyte-specific disruption contributes approximately 23% to the lifespan extension observed in male GHRKO mice.
Article
Endocrinology & Metabolism
Sandra Andreotti, Ayumi Cristina Medeiros Komino, Flaviane de Fatima Silva, Ana Paula Almeida Ramos, Noemi Lourenco Gil, Gabriela Araujo Azevedo, Rogerio Antonio Laurato Sertie, Fabio Bessa Lima, Richardt Gama Landgraf, Maristella Almeida Landgraf
Summary: This study found that intrauterine food restriction during pregnancy leads to inhibited lipogenesis and lipolysis in offspring with low birth weight at 12 weeks. Additionally, increased serum triacylglycerol content may contribute to increased synthesis and secretion of pro-inflammatory cytokines detected in the low birth weight group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Tsubame Nishikai-Shen, Tomomi Hosono-Fukao, Toyohiko Ariga, Takashi Hosono, Taiichiro Seki
Summary: In this study, it was demonstrated that cinnamon extract can improve type 2 diabetes and ACSL1 was identified as its molecular target in adipocytes and adipose tissue.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Chih-Hao Wang, Chen-Hung Wang, Pen-Jung Hung, Yau-Huei Wei
Summary: The prevalence and healthcare burden of obesity and its related metabolic disorders such as type 2 diabetes (T2D) are increasing rapidly. Mitochondria and endoplasmic reticulum (ER) play important roles in insulin resistance and T2D, and their dysfunction may contribute to the progression of these diseases. In this study, the authors found that the formation of mitochondria-associated ER membranes (MAMs) is increased during the differentiation of preadipocytes, and disruption of MAMs impairs cell differentiation and insulin signaling. Additionally, knocking down the protein GRP75, which is involved in MAMs formation, also impairs thermogenesis and glucose utilization in brown adipocytes. These findings suggest that MAMs formation is essential for the proper functioning of adipocytes and insulin signaling, and may be a potential target for therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Ho Ting Shiu, Xiaohan Pan, Qing Liu, KeKao Long, Kenneth King Yip Cheng, Ben Chi-Bun Ko, James Kar-Hei Fang, Yuyan Zhu
Summary: The health concerns of microplastics (MPs) and nanoplastics (NPs) have been increasing, but there is still a lack of key indicators to evaluate the adverse risks of MPs/NPs. This study demonstrates that fluorescent polystyrene nanoplastics (nPS) can distribute in white adipose tissue (WAT) of mice and reduce lipolysis under stimulation in vitro and ex vivo. Chronic oral exposure to nPS at relevant concentrations impairs lipid mobilization in obese mice, leading to larger adipocytes in WAT. Additionally, nPS exposure induces macrophage infiltration in the small intestine and increases lipid accumulation in the liver, disrupting systemic metabolism. These findings highlight the potential obesogenic role of nPS via diminishing lipid mobilization in WAT and suggest using lipolysis relevant parameters for evaluating the adverse effect of MPs/NPs in clinics.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Food Science & Technology
Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu
Summary: Succinate supplementation can reduce fat deposition and adipocyte size, enhance lipolysis in adipose tissue, and increase the activity of brown adipose tissue in obese mice.
Article
Biochemistry & Molecular Biology
Dandan Wu, In Hyuk Bang, Byung-Hyun Park, Eun Ju Bae
Summary: The study found that Sirt6 in adipocytes is essential for the improved glucose metabolism and metabolic profiles conferred by intermittent fasting (IF). Mice lacking Sirt6 in their fat cells exhibited features of metabolic syndrome under conditions of high-fat diet combined with intermittent fasting.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Zuzanna Tracz-Gaszewska, Adrian Sowka, Pawel Dobrzyn
Summary: This study reveals the impact of SCD1 on glucose and lipid metabolism in colorectal cancer cells and its significant role in promoting cancer development and progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biology
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Summary: The study identifies GPR183/EBI2 as the most highly expressed inhibitory G-protein-coupled receptor in brown adipose tissue, which decreases energy expenditure. Loss of Ebi2 in mice results in increased brown adipocyte energy expenditure in response to cold exposure, providing potential insights into modulating energy expenditure in humans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Food Science & Technology
Jingyu Zhao, Meijuan Bai, Siying Wei, Chenchen Li, Qi Lv, Yan Chen
Summary: The intermittent application of a FMD, with low carbohydrate/protein content and high dietary fiber, can reduce obesity and glucose intolerance induced by a high-fat high-sucrose diet in mice. It also decreases adipocyte size, increases expression of lipolysis genes and HSL protein in white adipose tissue, and reduces HFHSD-induced lipid accumulation in the liver. RNA sequencing shows elevated expression of genes involved in fatty acid oxidation with FMD intervention.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shu-Ju Wu, Wen-Chung Huang, Ming-Chin Yu, Ya-Ling Chen, Szu-Chuan Shen, Kuo-Wei Yeh, Chian-Jiun Liou
Summary: Tomatidine, derived from the leaves and green fruits of plants in the Solanaceae family, has been shown to exhibit anti-inflammatory and antitumor effects. It reduces lipid accumulation in the liver, decreases body and fat weight, and improves nonalcoholic fatty liver disease. Additionally, tomatidine regulates lipid metabolism and promotes lipolysis through the sirt1/AMPK signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum
Summary: This study examines the relationship between hepatic Activin E and adipose metabolism, suggesting that Activin E functions as part of a liver-adipose feedback loop to suppress adipose tissue lipolysis in response to elevated serum fatty acids and hepatic fatty acid exposure.
MOLECULAR METABOLISM
(2023)
Article
Food Science & Technology
Sucheewin Krobthong, Yodying Yingchutrakul, Patompon Wongtrakoongate, Hathaichanok Chuntakaruk, Thanyada Rungrotmongkol, Chartchai Chaichana, Thanisorn Mahatnirunkul, Thitikorn Chomtong, Kiattawee Choowongkomon, Chanat Aonbangkhen
Summary: Obesity is a global health concern that can be prevented by physical activities and consuming nutrient-rich functional foods. In this study, nano-liposomal encapsulated bioactive peptides (BPs) were developed to reduce cellular lipids. The nano-liposomal BPs showed potential as functional food ingredients for preventing obesity.
Article
Biochemistry & Molecular Biology
Qinrui Liu, Hu Wang, Hualin Wang, Na Li, Ruyi He, Zhiguo Liu
Summary: This study found that disruption of the Per1/Per2 genes can decrease the reproductive capacity of elderly male mice. The mechanism involves the reduction of testosterone synthesis and sperm motility through the PKA-StAR pathway, leading to decreased fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kazuhito Sakamoto, Patrick D. Radler, Barbara L. Wehde, Aleata A. Triplett, Hridaya Shrestha, Rosa-Maria Ferraiuolo, Foued Amari, Vincenzo Coppola, Apostolos Klinakis, Argiris Efstratiadis, Kay-Uwe Wagner
SCIENTIFIC REPORTS
(2020)
Review
Oncology
Rosa-Maria Ferraiuolo, Karoline C. Manthey, Marissa J. Stanton, Aleata A. Triplett, Kay-Uwe Wagner
Article
Audiology & Speech-Language Pathology
Shikha Tarang, Umesh Pyakurel, Michael D. Weston, Sarath Vijayakumar, Timothy Jones, Kay-Uwe Wagner, Sonia M. Rocha-Sanchez
Article
Multidisciplinary Sciences
Svenja Mertelmeyer, Matthias Weider, Tina Baroti, Simone Reiprich, Franziska Frob, C. Claus Stolt, Kay-Uwe Wagner, Michael Wegner
SCIENTIFIC REPORTS
(2020)
Review
Oncology
Rayane Dennaoui, Hridaya Shrestha, Kay-Uwe Wagner
Summary: Pancreatic cancer research has made significant progress in understanding the molecular and developmental processes involved in the genesis of this highly malignant tumor type. Various models, including chemical carcingen-induced and genetically engineered animal models, are being developed and analyzed to study the biological significance of new molecular targets and mechanisms contributing to pancreatic cancer onset and progression.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Gabriel B. Mpilla, Md Hafiz Uddin, Mohammed N. Al-Hallak, Amro Aboukameel, Yiwei Li, Steve H. Kim, Rafic Beydoun, Gregory Dyson, Erkan Baloglu, William T. Senapedis, Yosef Landesman, Kay-Uwe Wagner, Nerissa T. Viola, Bassel F. El-Rayes, Philip A. Philip, Ramzi M. Mohammad, Asfar S. Azmi
Summary: The study highlights the need for more effective targeted approaches to sensitize PNETs to everolimus for better treatment outcomes. The dual inhibitor KPT-9274 targeting PAK4-NAMPT, when combined with everolimus, showed promising results in inhibiting PNET growth and formation.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Hyunji Byun, Sojung Kwon, Kay-Uwe Wagner, Hyejin Shin, Hyunjung Jade Lim
Summary: Deficiency of Tsg101 in uterine epithelium causes implantation failure and may be due to epithelial defects. The study found that UECs harbor a necroptotic machinery that responds to death-inducing signals.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Patrick D. Radler, Barbara L. Wehde, Aleata A. Triplett, Hridaya Shrestha, Jonathan H. Shepherd, Adam D. Pfefferle, Hallgeir Rui, Robert D. Cardiff, Charles M. Perou, Kay-Uwe Wagner
Summary: Claudin-low breast cancer is an aggressive subtype mainly composed of triple-negative mammary tumor cells with stem cell-like and mesenchymal features. The consistent activation of oncogenic RAS signaling and regulators of EMT play crucial roles in maintaining the cellular plasticity and characteristics of claudin-low mammary cancer cells.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yunguang Sun, Ning Yang, Fransiscus E. Utama, Sameer S. Udhane, Junling Zhang, Amy R. Peck, Alicia Yanac, Katherine Duffey, John F. Langenheim, Vindhya Udhane, Guanjun Xia, Jess F. Peterson, Julie M. Jorns, Marja T. Nevalainen, Romain Rouet, Peter Schofield, Daniel Christ, Christopher J. Ormandy, Anne L. Rosenberg, Inna Chervoneva, Shirng-Wern Tsaih, Michael J. Flister, Serge Y. Fuchs, Kay-Uwe Wagner, Hallgeir Rui
Summary: A humanized prolactin mouse model was developed to establish therapy-naive ER+ breast cancer tumors and study treatment resistance mechanisms, revealing new insights into precision medicine approaches for this type of cancer.
Review
Oncology
Md. Hafiz Uddin, Mohammed Najeeb Al-Hallak, Philip A. Philip, Ramzi M. Mohammad, Nerissa Viola, Kay-Uwe Wagner, Asfar S. Azmi
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Medicine, Research & Experimental
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen
Summary: In HER2(+) breast cancer, overactivation of HER2 leads to aberrant G(i/o)-GPCR signaling, promoting cancer progression and resistance to HER2-targeted therapy. Pharmacologically deactivating GPCR signaling can block tumor growth and enhance therapeutic efficacy.
Article
Multidisciplinary Sciences
Patrick D. Radler, Kerry Vistisen, Aleata A. Triplett, Rayane Dennaoui, Yong Li, Hridaya Shrestha, Rosa-Maria Ferraiuolo, Amalraj Thangasamy, Dieter Saur, Kay-Uwe Wagner
Summary: The researchers developed a transgenic mouse line expressing an optimized Flp recombinase, demonstrating the versatile applicability of the new MMTV-Flp strain in manipulating genes in mammary gland cells. By combining two recombinases, genes can be deleted or activated in established tumors, showing the feasibility of gene manipulation in neoplastic mammary epithelial cells.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Madison N. Wicker, Kay-Uwe Wagner
Summary: Cellular plasticity, the ability of cells to change their identity, plays a crucial role in mammary gland development and breast cancer progression. This review provides a comprehensive overview of the factors and mechanisms that promote cellular plasticity in the mammary gland. It discusses changes in cell identity during normal development, the role of the gestation cycle, and highlights the importance of the microenvironment and extracellular matrix. The review also explores cellular reprogramming during mammary tumorigenesis, focusing on the origin of basal-like breast cancers and the role of oncogenic signaling networks. Additionally, recent advances in genetically engineered models to study cellular plasticity in vivo are discussed.
Article
Biochemistry & Molecular Biology
Dai Le, Soyeon Lim, Kwang Wook Min, Joon Woo Park, Youjoung Kim, Taejeong Ha, Kyeong Hwan Moon, Kay-Uwe Wagner, Jin Woo Kim
Summary: The distribution of membrane proteins in RPE varies during different developmental stages, indicating developmental regulation of protein trafficking. Deletion of Tsg101 disrupts RPE polarity, leading to irregular aggregates and non-polarized distribution of cell adhesion proteins and activation of epidermal growth factor receptor signaling, highlighting the importance of ESCRT-mediated protein trafficking for RPE cell polarity development and maintenance.
MOLECULES AND CELLS
(2021)
Article
Oncology
Hassan Mohammed Khair Ibrahim Higazi, Long He, Jing Fang, Fei Sun, Qing Zhou, Teng Huang, Xiaoyu He, Yi Wang, Fei Xiong, Ping Yang, Qilin Yu, Jinxiu Li, Kay-Uwe Wagner, Bao-Ling Adam, Shu Zhang, Cong-Yi Wang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)