Review
Cell Biology
Marina Caputo, Stella Pigni, Emanuela Agosti, Tommaso Daffara, Alice Ferrero, Nicoletta Filigheddu, Flavia Prodam
Summary: Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) play crucial roles in lifespan, growth, metabolism, and nutrient utilization. Nutrients are essential modifiers of the GH/IGF-I axis, and these hormones also regulate the utilization of nutrients in cells and tissues.
Review
Cell Biology
Pei-Chin Chen, Yung-Che Kuo, Cheng-Ming Chuong, Yen-Hua Huang
Summary: Stem cells interact harmoniously with their niches during development and tumor pathology, influencing cell fate. The modulation of IGF-1R signaling plays a crucial role in determining cell fate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Summary: This study reveals the crucial role of YAP in breast cancer stem cells. Knockdown of YAP reduces the viability and stemness of BCSCs in vitro and tumor formation in vivo. IGF-1R and IGF-1 regulate the expression and localization of YAP, and YAP overexpression increases the expression of IGF-1. Clinical analysis shows that high levels of YAP and IGF-1 are associated with shorter overall survival in basal-like breast cancer patients. In conclusion, the interplay between YAP and the IGF-1/IGF-1R pathway is clinically relevant for sustaining the properties of BCSCs.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Endocrinology & Metabolism
Lorena Gonzalez, Maria E. Diaz, Johanna G. Miquet, Ana I. Sotelo, Fernando P. Dominici
Summary: The interaction between EGFR and GH in the liver plays a significant role in the development and progression of liver tumors, with factors such as exposure to supraphysiological GH levels and the pattern of GH administration being important variables to consider.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Dongyan Song, Jose M. Adrover, Christy Felice, Lisa N. Christensen, Xue-Yan He, Joseph R. Merrill, John E. Wilkinson, Tobias Janowitz, Scott K. Lyons, Mikala Egeblad, Nicholas K. Tonks
Summary: PTP1B inhibitors have shown potential in preventing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). These inhibitors can attenuate aberrant neutrophil function, inhibit neutrophil migration, and promote an aged-neutrophil phenotype by reducing signaling through the CXCR4 chemokine receptor. Additionally, PTP1B inhibitors have therapeutic effects in sepsis models.
Article
Biochemistry & Molecular Biology
Chakrabhavi Dhananjaya Mohan, Chulwon Kim, Kodappully Sivaraman Siveen, Kanjoormana Aryan Manu, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Alan Prem Kumar, Kwang Seok Ahn
Summary: Crocetin inhibits STAT3 activation in HCC cells and affects the expression of multiple genes associated with cancer, thereby suppressing cell proliferation and invasive capacity.
Article
Endocrinology & Metabolism
Alessandra Esposito, Michael Kluppel, Brittany M. Wilson, Sai R. K. Meka, Anna Spagnoli
Summary: Non-union fractures have significant clinical and economic burdens, and this study reveals the importance of the interaction between CXCR4 and IGF-1R in maintaining bone homeostasis and promoting fracture repair. By regulating the IGF-1R signaling pathway and CXCR4 expression, improvements in fracture healing can be achieved, suggesting potential for the development of novel therapeutic interventions.
Article
Oncology
E. G. Garcia, A. Veloso, M. L. Oliveira, J. R. Allen, S. Loontiens, D. Brunson, D. Do, C. Yan, R. Morris, S. Iyer, S. P. Garcia, N. Iftimia, W. Van Loocke, F. Matthijssens, K. McCarthy, J. T. Barata, F. Speleman, T. Taghon, A. Gutierrez, P. Van Vlierberghe, W. Haas, J. S. Blackburn, D. M. Langenau
Summary: The study identifies PRL3 as a collaborating oncogenic driver in T-ALL, which synergizes with MYC to promote leukemia development and suppress apoptosis in cells. By suppressing downstream phosphorylation signaling pathways, PRL3's role in T-ALL is elucidated.
Article
Cardiac & Cardiovascular Systems
Wei Jiang, Chun Gan, Xindi Zhou, Qing Yang, Dan Chen, Han Xiao, Lujun Dai, Yaxi Chen, Mo Wang, Haiping Yang, Qiu Li
Summary: Our groundbreaking study has found that the soluble form of Klotho can effectively inhibit high glucose-induced ox-LDL deposition in podocytes affected by DKD. We further demonstrated that Klotho achieves this inhibition by reducing the expression of IGF-1R, leading to a decrease in RAC1 expression and an enhancement of mitochondrial function. Ultimately, this results in a significant reduction in OLR1 expression, thereby reducing renal ox-LDL deposition in DKD.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Oncology
Mansour Alfayez, Ghayas C. Issa, Keyur P. Patel, Feng Wang, Xuemei Wang, Nicholas J. Short, Jorge E. Cortes, Tapan Kadia, Farhad Ravandi, Sherry Pierce, Rita Assi, Guillermo Garcia-Manero, Courtney D. DiNardo, Naval Daver, Naveen Pemmaraju, Hagop Kantarjian, Gautam Borthakur
Summary: Mutations in the PTPN11 gene in adults with AML are associated with lower complete response rates and shorter overall survival. These mutations are more commonly found in the acute myelomonocytic/monocytic leukemia subtype and are often co-occurring with NPM1 and FLT3 mutations.
Article
Multidisciplinary Sciences
Jae Sung Ko, Dongjin Jeong, Jaemoon Koh, Hyeryeon Jung, Kyeong Cheon Jung, Yoon Kyung Jeon, Hye Young Kim, Eugene C. Yi, Ho Lee, Chang-Woo Lee, Doo Hyun Chung
Summary: Ssu72 regulates the fine-tuning of TCR signaling by acting as a tyrosine phosphatase for ZAP-70. Ssu72 deficiency leads to hyperresponsiveness in T cells upon TCR stimulation due to increased ZAP-70 phosphorylation, which can be restored by reducing ZAP-70 phosphorylation levels. Additionally, Cd4-CreSsu72fl/fl mice show defects in thymic development and alterations in peripheral T cell populations, with a predisposition for spontaneous inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Weronika Baszanowska, Magdalena Misiura, Ilona Oscilowska, Jerzy Palka, Wojciech Miltyk
Summary: The study demonstrates that PEPD can stimulate fibroblast proliferation and migration via activation of the EGFR downstream PI3K/Akt/mTOR signaling pathway. It also enhances the expression of proteins associated with EGFR signaling and promotes collagen biosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alex C. H. Liu, Severine Cathelin, Yitong Yang, David L. Dai, Dhanoop Manikoth Ayyathan, Mohsen Hosseini, Mark D. Minden, Anne Tierens, Steven M. Chan
Summary: STAT5 was identified as a critical mediator of resistance to IDH inhibitors, suggesting that combining STAT5 and IDH inhibitors may be an effective treatment strategy for IDH-mutated AML.
Article
Endocrinology & Metabolism
Marinna C. Okawa, Rebecca M. Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J. Brown
Summary: Insulin receptor signaling plays a role in growth. Patients with hyperinsulinemia and impaired insulin receptor function show impaired growth and lower bone mineral density, while elevated insulin receptor signaling leads to accelerated growth and higher bone mineral density. This suggests that insulin receptor influences growth through direct metabolic effects in bone and indirect effects via the growth hormone-IGF-1 axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Seung Un Seo, Seon Min Woo, Taeg Kyu Kwon
Summary: This study revealed that cathepsin K inhibition activates SHP2, a tyrosine phosphatase, which dephosphorylates OTUB1 and destabilizes Raptor, leading to mitochondrial dysfunction. The findings also identified Syk as an upstream tyrosine kinase required for SHP2 activation and showed that targeting the Syk/SHP2/Src/OTUB1 axis may be a potential therapeutic strategy for cancer management.
CELL DEATH & DISEASE
(2023)