Article
Integrative & Complementary Medicine
Fu-zhen Feng, Wen-yan Gong, Si-yun Li, Yan-hui Deng
Summary: The renoprotective effect of resveratrol on the sphingosine kinase 1 signaling pathway in lipopolysaccharide-induced glomerular mesangial cells was investigated. The results showed that resveratrol significantly inhibited cell proliferation and TGF-beta 1 expression, possibly through direct inhibition of the sphingosine kinase 1 pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Summary: Men with NAFLD are more likely to progress to NASH and liver fibrosis than women. This study revealed a novel pathway involving estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through the anti-fibrogenic function of the S1P/S1PR3 axis.
MOLECULAR METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Zhuang-Zhuang Tang, Pan-Pan Gu, Xiao-Fei An, Ling-Shan Gou, Yao-Wu Liu
Summary: The upregulation of thrombin receptor PAR-1 is involved in chronic kidney diseases, including diabetic nephropathy, but the mechanisms are unclear. In this study, high glucose-induced PAR-1 upregulation in human mesangial cells was found to be associated with alterations in miR-17 family members. Specifically, miR-20a-5p overexpression reversed the upregulation of PAR-1 induced by high glucose, indicating a potential role of miR-17 family in PAR-1 upregulation and mesangial cell proliferation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Cell Biology
Yinghua Zhao, Bo Fu, Pu Chen, Qinggang Li, Qing Ouyang, Chuyue Zhang, Guangyan Cai, Lingling Wu, Xiangmei Chen
Summary: In anti-Thy-1 nephritis, endothelial cells (ECs) proliferation was associated with mesangial cells (MCs)-derived vascular endothelial growth factor A (VEGFA) and ECs-derived angiopoietin2 (Angpt2). In an in vitro co-culture system, VEGFA from MCs promoted ECs proliferation while inhibiting Tie2 phosphorylation, and Angpt2 expression in ECs also contributed to proliferation by inhibiting Tie2 phosphorylation. Promoting Tie2 phosphorylation could alleviate ECs proliferation in anti-Thy-1 nephritis, providing a new potential treatment approach for mesangial proliferative glomerulonephritis.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Hua Miao, Xia-Qing Wu, Yan-Ni Wang, Dan-Qian Chen, Lin Chen, Nosratola D. Vaziri, Shougang Zhuang, Yan Guo, Wei Su, Shi-Xing Ma, Huan-Qiao Zhang, You-Quan Shang, Xiao-Yong Yu, Yan-Long Zhao, Jia-Rong Mao, Ming Gao, Jin-Hua Zhang, Jin Zhao, Yuan Zhang, Li Zhang, Ying-Yong Zhao, Gang Cao
Summary: This study identified the role of 1-hydroxypyrene in mediating renal fibrosis in patients with chronic kidney disease. The findings suggest that targeting the aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yu Tao, Ramesh Kasetti, Gulab Zode, Keisa W. Mathis, Rong Ma
Summary: This study demonstrates the expression of neogenin receptor in glomerular mesangial cells and its role in regulating ECM protein production. High glucose and oxidative stress can increase neogenin expression, while antioxidant treatment can attenuate this increase. The previously unrecognized neogenin-fibronectin pathway may contribute to glomerular injury responses during the course of diabetic nephropathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jean-Philip Truman, Christian F. Ruiz, Magali Trayssac, Cungui Mao, Yusuf A. Hannun, Lina M. Obeid
Summary: This study reveals that under conditions of serine starvation, SK1 is degraded in a p53-independent manner, requiring the action of the proteasome. Overexpression of SK1 to compensate for its loss is detrimental to cell growth under serine deprivation, indicating that suppression of SK1 under these conditions is adaptive. The effects of SK1 suppression on intracellular reactive oxygen species were mimicked by D-erythro-sphingosine, suggesting that the accumulation of its substrate, sphingosine, is responsible for these effects.
Article
Nanoscience & Nanotechnology
Wen Ai, Peiyi Xie, Liting Liao, Haijin Chen, Li Ling, Yulan Gao, Lei Wang, Chen Shaoyuan, Fang Yeqing, Hongcheng Fang, Yanwei Chen
Summary: This study explored the role of Sphk1 in autophagy induction and cell survival in myocardial cells under high glucose treatment, as well as how silibinin regulates DCM. The results showed that silibinin could induce autophagy in a dose-dependent manner, and overexpression of Sphk1 increased the expression of autophagy gene markers. High glucose inhibited autophagy induction, but overexpression of Sphk1 counteracted this inhibitory effect.
Article
Biochemistry & Molecular Biology
Fabiola N. Velazquez, Jeffrey L. Stith, Leiqing Zhang, Amira M. Allam, John Haley, Lina M. Obeid, Ashley J. Snider, Yusuf A. Hannun
Summary: This study suggests that targeting sphingosine kinase 1 (SK1), a key enzyme upregulated in various types of cancer, can effectively decrease tumor growth in lymphoma without functional p53. This positions SK1 as a potential therapeutic target for tumors that lack functional p53.
Article
Multidisciplinary Sciences
Akihito Ishikita, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Ryohei Nishimura, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Yoshitomo Tsutsui, Ryo Miyake, Masataka Ikeda, Tomomi Ide, Shintaro Kinugawa, Hiroyuki Tsutsui
Summary: The molecular mechanisms of cardiac hypertrophy induced by glucose metabolism remain incompletely understood. The Hexosamine biosynthesis pathway (HBP) plays a key role in mediating cardiac hypertrophy through protein O-GlcNAcylation and Akt activation. GFAT2, a critical enzyme in the HBP pathway, is identified as a major isoform in the heart and is involved in regulating cardiomyocyte hypertrophy.
Article
Plant Sciences
Jialin Li, Jiawen Zhang, Meng Yang, Xiaocui Huang, Meng Zhang, Xiansong Fang, Suzhen Wu
Summary: Kirenol has reno-protective effects against diabetic nephropathy by downregulating the TGF-beta/Smads and NE-kappa B signal pathways.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Maria Concepcion Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, Insug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Summary: This study found that insulin resistance is associated with decreased HDL-associated S1P. Hepatic FoxO transcription factors are regulators of the ApoM/S1P pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad, Aya Hassan El-Kadem, Sally EL-Sayed Abu-Risha
Summary: This study aimed to investigate the role of Sphingosine kinase 1 in ulcerative colitis (UC) and demonstrated that metformin attenuated inflammation by inhibiting the SPHK1/S1P signaling pathway.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Review
Oncology
Eileen M. McGowan, Yiguang Lin, Size Chen
Summary: Obesity is closely associated with inflammation and increased cancer risk in the digestive system. Saturated fat diets and being overweight can cause chronic inflammation. Bioactive sphingolipids, signaling molecules made from saturated fats, play essential roles in maintaining healthy gastrointestinal immunity. Excessive levels of these molecules can lead to chronic inflammation, but drugs that block their activity have the potential to reduce gastrointestinal cancer risk.
Article
Oncology
Stefania Belli, Daniela Esposito, Alessandra Allotta, Alberto Servetto, Paola Ciciola, Ada Pesapane, Claudia M. Ascione, Fabiana Napolitano, Concetta Di Mauro, Elena Vigliar, Antonino Iaccarino, Carmine De Angelis, Roberto Bianco, Luigi Formisano
Summary: Resistance to ER antagonists in combination with CDK4/6 inhibitors in ER+ breast cancers is associated with up-regulation of MAPK and EMT pathways, with Pak1 playing a pivotal role. Inhibiting Pak1 could be a promising strategy to overcome resistance in these patients.
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Multidisciplinary
Fan-Shun Zhang, Qing-Ze He, Chengxue Helena Qin, Peter J. Little, Jian-Ping Weng, Suo-Wen Xu
Summary: Colchicine is an ancient herbal drug with unique anti-inflammatory effects and prominent cardiovascular actions. Clinical trials have confirmed its curative effect in treating cardiovascular diseases, and its anti-inflammatory mechanisms have been studied.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Meiming Su, Wenqi Zhao, Suowen Xu, Jianping Weng
Summary: Diabetes mellitus (DM) is a common chronic disease with significant complications. Resveratrol, a plant-derived compound, has shown protective effects against diabetes and its cardiovascular complications. These effects are mediated through various signaling pathways.
Editorial Material
Biochemistry & Molecular Biology
Xiaojun Feng, Suowen Xu, Jianping Weng
Summary: A recent study found that soy isoflavone genistein attenuates the cardiovascular side effects caused by marijuana by antagonizing cannabinoid receptor 1, suggesting a potential therapeutic approach for ameliorating these effects.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Iqra Ilyas, Peter J. Little, Zhiping Liu, Yanyong Xu, Danielle Kamato, Bradford C. Berk, Jianping Weng, Suowen Xu
Summary: This article reviews the current use and translational potential of mouse models in atherosclerosis research and drug discovery. Atherosclerotic cardiovascular disease is a chronic and progressive metabolic and inflammatory disease that causes premature human mortality. Despite promising preclinical studies, many drug candidates have not been translated to clinical use due to the complex disease mechanisms involved.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Xiumei Wu, Suowen Xu, Jianping Weng
Summary: In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia resulted in offspring's vulnerability to glucose intolerance due to insufficient TET3-mediated 5-methylcytosine oxidation and DNA demethylation, leading to hypermethylation and reduction of insulin-secreting genes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Chemistry, Multidisciplinary
Suo-wen Xu, Iqra Ilyas, Jian-ping Weng
Summary: This review examines the impact of COVID-19 on endothelial cell function and provides a comprehensive summary of biomarkers associated with endothelial cell activation in COVID-19. COVID-19 is considered a vascular and endothelial disease, and several drugs have shown potential in improving clinical manifestations of patients. Further research using cellular and animal models can accelerate the discovery of new drugs targeting endothelial dysfunction in COVID-19 patients.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Mengyun Xu, Xiumei Wu, Zhenghong Liu, Yu Ding, Weian Kong, Peter J. Little, Suowen Xu, Jianping Weng
Summary: This study successfully established a novel mouse model of diabetes, atherosclerosis, and fatty liver disease by injecting AAV8-PCSK9 vectors in db/db mice. The model exhibits characteristics of hyperlipidemia, aneurysm, and atherosclerotic plaque, making it suitable for studying the pathological mechanisms of cardiometabolic disease and its complications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Meiming Su, Wenqi Zhao, Yujie Li, Hong Li, Suowen Xu, Jianping Weng
Summary: Atherosclerosis is a chronic inflammatory vascular disease in which endothelial cells play a crucial role. Resveratrol, a polyphenol, prevents cardiovascular disease by regulating multiple signaling pathways. The study suggests that resveratrol may serve as a shear stress mimetic drug for combating atherosclerosis.
Article
Biochemistry & Molecular Biology
Tong Yue, Huiling Tan, Yu Shi, Mengyun Xu, Sihui Luo, Jianping Weng, Suowen Xu
Summary: This study investigated the changes in metabolism during aging using machine learning and identified biomarkers associated with aging. The findings provide insights into potential therapeutic targets for delaying the effects of aging.
Article
Biochemistry & Molecular Biology
Matthew L. Klos, Wanqing Hou, Bernard Nsengimana, Shiwang Weng, Chuyun Yan, Suowen Xu, Eric Devaney, Shuxin Han
Summary: Beta-hydroxybutyrate (beta OHB) is a liver-produced ketone body that serves as an alternative fuel source to glucose, especially during fasting or prolonged exercise. This study compared the effects of two commercial beta OHB formulations on the electrophysiology of induced pluripotent stem cell cardiac myocytes (iPS-CMs). The results showed that these formulations had different effects on the electrophysiology, possibly due to their stereoselectivity.
Article
Pharmacology & Pharmacy
Peng Jiang, Zhenghong Liu, Tingyu Fang, Zhidan Zhang, Yu Zhang, Dongdong Wang, Peter J. Little, Suowen Xu, Jianping Weng
Summary: Despite an increase in Gdf15 levels after APAP overdose, this study concluded that Gdf15 is not involved in APAP-induced liver injury. The study also suggests that genomic analysis of mRNA expression after APAP overdose is of limited relevance unless followed up by a functional analysis of candidate genes in vivo.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Qiuping Wang, Kui Chen, Hui Jiang, Cai Chen, Can Xiong, Min Chen, Jie Xu, Xiaoping Gao, Suowen Xu, Huang Zhou, Yuen Wu
Summary: This study presents a design of biomimetic cascade catalysis system, where metal sites are immobilized on the inner and outer layers of nanocapsules to enable efficient enzymatic cascade reactions. The biomimetic catalysis system exhibits higher activity enhancement compared to conventional systems and is successfully applied in glucose detection.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lijing Kang, Juanjuan Yi, Chi-Wai Lau, Lei He, Qinghua Chen, Suowen Xu, Jun Li, Yin Xia, Yuanting Zhang, Yu Huang, Li Wang
Summary: Hyperglycemia activates Yes-associated protein 1 (YAP) by suppressing AMPK activity, leading to obesity-associated endothelial dysfunction and inflammation. Metformin improves vascular dysfunction by activating AMPK and promoting YAP phosphorylation.
Review
Biochemistry & Molecular Biology
Xiumei Wu, Mengyun Xu, Mengya Geng, Shuo Chen, Peter J. Little, Suowen Xu, Jianping Weng
Summary: The increasing prevalence of noncommunicable diseases (NCDs) has become a significant global public health burden. Metabolic diseases, the most common form of NCDs, have life-threatening cardiovascular complications and affect people of all ages. Protein posttranslational modification (PTM) greatly enhances the functional diversity of proteins and plays a crucial role in common metabolic diseases such as diabetes, obesity, and fatty liver diseases. Understanding the mechanisms of PTMs in metabolic diseases will provide new insights for therapeutic intervention and improvement of therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)