Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Donagh Egan, Bruce Moran, Michael Wilkinson, Miquel Pinyol, Esther Guerra, Sonia Gatius, Xavier Matias-Guiu, Walter Kolch, Carel W. le Roux, Donal J. Brennan
Summary: The elevated expression of CRABP2 in endometrial cancer patients is associated with poor clinical outcomes and functional implications. These findings provide important insights into the pathogenesis and prognosis of endometrial cancer.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Jin, Chuncao Huo, Wenhao Yang, Kaidi Jin, Shuai Cai, Yanxin Zheng, Baoyu Huang, Lei Wei, Meiwei Zhang, Yijing Han, Xuekai Zhang, Yaqiong Liu, Xiaotong Wang
Summary: This study investigates the effect of all-trans retinoic acid (ATRA) on the transcriptome of the Pacific oyster Crassostera gigas. A total of 586 differentially expressed genes (DEGs) were identified, with ATRA affecting the development, metabolism, reproduction, and immunity of C. gigas. Several tyrosinase genes and Tyr-related genes were upregulated by ATRA, and the DNA-binding activity of the RA receptors CgRAR and CgRXR, as well as their interaction with RAREs in the Tyr-2 promoter, were confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Alice Wood, Alexios Antonopoulos, Surawee Chuaiphichai, Theodosios Kyriakou, Rebeca Diaz, Abtehale Al Hussaini, Anna Marie Marsh, Manjit Sian, Mitul Meisuria, Gerry McCann, Victoria S. Rashbrook, Edward Drydale, Sally Draycott, Murray David Polkinghorne, Ioannis Akoumianakis, Charalambos Antoniades, Hugh Watkins, Keith M. Channon, David Adlam, Gillian Douglas
Summary: The aim of this study was to investigate the role of PHACTR1 in vascular function. It was found that the PHACTR1 locus was significantly associated with changes in distensibility in the ascending aorta and carotid artery. However, no association was observed in the descending aorta or in SCAD patients. Additionally, no association was found between the PHACTR1 locus and endothelial cell function. A murine model also confirmed these findings.
CARDIOVASCULAR RESEARCH
(2023)
Review
Medicine, Research & Experimental
Alayi Bolatai, Yujing He, Na Wu
Summary: This paper summarizes the mechanisms of unbalanced VEGF and receptor expression based on data from relevant literature on GDM and eclampsia. An imbalance in VEGF and its binding receptor is often associated with the occurrence of multiple pregnancy disorders. In recent years, researchers have focused on the potential role of VEGF and its receptors in the development of GDM and eclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Zhuangzhuang Yang, Miao Yu, Xuechun Li, Yuanyuan Tu, Chunyan Wang, Wei Lei, Min Song, Yong Wang, Ying Huang, Fengyue Ding, Kaili Hao, Xinglong Han, Xuan Ni, Lina Qu, Zhenya Shen, Shijun Hu
Summary: This study demonstrates that retinoic acid inhibits angiogenesis and suppresses glycolysis in human embryonic stem cell-derived endothelial cells. The inhibitory effect is mediated by upregulation of fructose-1,6-bisphosphatase 1 (FBP1), a key enzyme in gluconeogenesis, and is dependent on the retinoic acid receptor (RAR). These findings suggest that FBP1 may serve as a novel therapeutic target for pathological angiogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Jack Lawler
Summary: Considerable progress has been made in understanding angiogenesis in normal and tumor tissue. The success of anti-angiogenic treatments has been limited so far, but it is expected to improve with the development of therapies targeting other pathways and a better understanding of resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Michael G. Stencel, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
Summary: Calmodulin (CaM) is a crucial protein for multiple functions of vascular smooth muscle cells (VSMCs) and its expression and interactions with target proteins in VSMCs can be regulated by endothelial cells (ECs). In this study, it was discovered that proliferating ECs can upregulate total CaM expression and enhance Ca2+-bound CaM levels in VSMCs co-cultured with ECs. This endothelium-dependent upregulation of CaM in VSMCs is mediated by vascular endothelial growth factor receptors. These findings reveal a new role of ECs in regulating vascular functions through upregulating CaM and its interactions in VSMCs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Corinne Iampietro, Alessia Brossa, Stefano Canosa, Stefania Tritta, Glenn E. Croston, Torsten Michael Reinheimer, Filippo Bonelli, Andrea Roberto Carosso, Gianluca Gennarelli, Stefano Cosma, Chiara Benedetto, Alberto Revelli, Benedetta Bussolati
Summary: Quinagolide inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs) in endometriosis, but has no effect on their proliferation and limits their endothelial differentiation. These effects are mediated through activation of a specific dopamine receptor and are independent of VEGFR2 inhibition. The effects are more prominent in ectopic E-MSCs. These findings increase the rationale for the use of quinagolide in endometriosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shuo Wang, Yuequan Wang, Xiaoxue Lai, Jianwen Sun, Miao Hu, Meng Chen, Cong Li, Feng Xu, Chuizhong Fan, Xinrong Liu, Yanzhi Song, Guoliang Chen, Yihui Deng
Summary: Vascular disorders associated with inflammation, such as COVID-19 and atherosclerosis, can be treated by achieving vascular normalization through regulating endothelial dysfunction and inflammation. A nanoplatform containing budesonide and L-arginine was constructed to promote vascular normalization by targeting endothelial cells and enhancing nitric oxide production. This strategy demonstrated revolutionary therapeutic effects in mouse models.
Article
Pharmacology & Pharmacy
Ahmed Fathy, A. Rezk, Nahla Nosair, Mostafa Ellakany
Summary: Endometrial receptivity is important for reproductive outcomes. This study examined the relationship between endometrial vascular endothelial growth factor (VEGF) and endometrial receptivity in recurrent pregnancy loss patients. The findings suggest that VEGF may serve as a marker for endometrial receptivity and a potential cause of recurrent unexplained pregnancy loss.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Javeria Ali Khan, Arshad Hasan, Sumaiya Dossa, Batool Ali
Summary: This study compared the release of VEGF after conditioning with etidronic acid and phytic acid to EDTA on human dentin disks and cylinders. The results showed that HEDP released more VEGF compared to other conditioners, especially in dentin cylinders.
JOURNAL OF ENDODONTICS
(2021)
Review
Immunology
Diannita Kwang, Gavin Tjin, Louise E. Purton
Summary: B lymphopoiesis in adult mice involves interactions with non-hematopoietic cells in the bone marrow and spleen, which provide signals for migration, maturation, and survival. Conditional knockout and transgenic mouse models have revealed the roles of distinct microenvironment cell types in regulating B lymphopoiesis. Single cell RNA-seq studies have also identified clusters of stromal cell types in these organs, aiding in the identification of key regulators of B lymphopoiesis.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Haiying Wang, Liqian Yang, Minghui Liu, Jianyuan Luo
Summary: Posttranslational modifications (PTMs) of proteins play important roles in regulating cellular physiological and pathological processes. New modifications like succinylation, hydroxybutyrylation, and lactylation introduce a new layer to protein regulation with wide application prospects.
CANCER GENE THERAPY
(2023)
Article
Developmental Biology
Aditi Dubey, Jianshi Yu, Tian Liu, Maureen A. Kane, Jean-Pierre Saint-Jeannet
Summary: In Xenopus embryos, Zic1 regulates PPR formation by activating RA production and promoting the expression of Cyp26c1 and Pitx2c to maintain low levels of RA in the vicinity of PPR. Disruption of these genes results in defective cranial placodes, suggesting their crucial roles in PPR specification.
Article
Developmental Biology
Kenneth R. Myers, Guanglu Liu, Yue Feng, James Q. Zheng
DEVELOPMENTAL NEUROBIOLOGY
(2016)
Article
Neurosciences
Brenda Huang, WenJie Wei, Guohao Wang, Marta A. Gaertig, Yue Feng, Wei Wang, Xiao-Jiang Li, Shihua Li
Article
Neurosciences
X. Tan, Y. Chen, J. Li, X. Li, Z. Miao, N. Xin, J. Zhu, W. Ge, Y. Feng, X. Xu
Article
Clinical Neurology
Nanxin Huang, Jianqin Niu, Yue Feng, Lan Xiao
Article
Neurosciences
Xianjun Chen, Weiguo Zhang, Tao Li, Yu Guo, Yanping Tian, Fei Wang, Shubao Liu, Hai-Ying Shen, Yue Feng, Lan Xiao
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Wenqi Li, Megan E. Allen, Yanfang Rui, Li Ku, Guanglu Liu, Andrew N. Bankston, James Q. Zheng, Yue Feng
JOURNAL OF NEUROSCIENCE
(2016)
Article
Cell Biology
Kathryn R. Williams, Damian S. McAninch, Snezana Stefanovic, Lei Xing, Megan Allen, Wenqi Li, Yue Feng, Mihaela Rita Mihailescu, Gary J. Bassell
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Multidisciplinary Sciences
Takahiko Suiko, Kensuke Kobayashi, Kentaro Aono, Togo Kawashima, Kiyoshi Inoue, Li Ku, Yue Feng, Chieko Koike
Article
Cell Biology
Yilin Xu, Xin D. Gao, Jae-Hyung Lee, Huilin Huang, Haiyan Tan, Jaegyoon Ahn, Lauren M. Reinke, Marcus E. Peter, Yue Feng, David Gius, Kalliopi P. Siziopikou, Junmin Peng, Xinshu Xiao, Chonghui Cheng
GENES & DEVELOPMENT
(2014)
Article
Biochemistry & Molecular Biology
Callie P. Wigington, Jeenah Jung, Emily A. Rye, Sara L. Belauret, Akahne M. Philpot, Yue Feng, Philip J. Santangelo, Anita H. Corbett
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Mariana D. Mandler, Li Ku, Yue Feng
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Chi Bun Chan, Xia Liu, Lixia Zhao, Guanglu Liu, Chi Wai Lee, Yue Feng, Keiqang Ye
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Cell & Tissue Engineering
Gengzhen Zhu, Yujing Li, Fei Zhu, Tao Wang, Wensong Jin, Wei Mu, Wei Lin, Weiqi Tan, Wenqi Li, R. Craig Street, Siying Peng, Jian Zhang, Yue Feng, Stephen T. Warren, Qinmiao Sun, Peng Jin, Dahua Chen
Article
Neurosciences
Yanfang Rui, Stephanie L. Pollitt, Kenneth R. Myers, Yue Feng, James Q. Zheng
Article
Ophthalmology
Charles B. Wright, Micah A. Chrenek, Wei Feng, Shannon E. Getz, Todd Duncan, Machelle T. Pardue, Yue Feng, T. Michael Redmond, Jeffrey H. Boatright, John M. Nickerson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)