Article
Materials Science, Biomaterials
Emilio Satoshi Hara, Noriyuki Nagaoka, Masahiro Okada, Takayoshi Nakano, Takuya Matsumoto
Summary: This study reveals the distinct microstructures of bone apatite clusters in intramembranous ossification (IO) and endochondral ossification (EO), and how these differences impact the growth of apatite clusters. The findings offer insightful inspirations for the design of more efficient materials for bone tissue engineering and repair.
Article
Environmental Sciences
Meiru Wang, Martin Rucklin, Robert E. Poelmann, Carmen L. de Mooij, Marjolein Fokkema, Gerda E. M. Lamers, Merijn A. G. de Bakker, Ernest Chin, Lilla J. Bakos, Federica Marone, Bert J. Wisse, Marco C. de Ruiter, Shixiong Cheng, Luthfi Nurhidayat, Martina G. Vijver, Michael K. Richardson
Summary: In this study, the researchers investigated the effects of polystyrene nanoparticles on chicken embryos. They found that these nanoparticles could cross the gut wall and distribute to multiple organs in the embryo. The exposure to polystyrene nanoparticles resulted in severe malformations, including congenital heart defects, by selectively binding to neural crest cells.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
M. Sofia Ortega, Derek M. Bickhart, Kelsey N. Lockhart, Daniel J. Null, Jana L. Hutchison, Jennifer C. McClure, John B. Cole
Summary: The study presents a comprehensive framework for identification and validation of recessive alleles that represent genetic risk. Using Holstein haplotype 2 as an example, it demonstrates how the framework can be used to detect and confirm genetic defects that affect conception rate and stillbirths. The study also identifies specific variants associated with Holstein haplotype 2 and validates their function using knockout embryos.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
L. M. Rings, A. M. Kamr, H. M. Kinsella, L. D. Hostnik, J. M. Swink, T. A. Burns, K. Christie, J. B. David, R. E. Toribio
Summary: This study investigated the enteroinsular axis (EIA) in hospitalized foals by measuring serum insulin and plasma incretin concentrations, revealing differences between hospitalized/septic foals and healthy foals. The study found that certain hormone concentrations were associated with disease severity and outcome in foals, suggesting potential mechanisms contributing to reduced insulin secretion in critically ill foals.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Veterinary Sciences
Francisco Javier Mendoza, Sebastian Mejia-Moreira, Ben R. Buchanan, Ramiro E. Toribio, Alejandro Perez-Ecija
Summary: This study evaluated dynamic tests for diagnosing ID/DMS in suspected DMS donkeys, with IVGTT detecting more ID donkeys than CGIT. Recommendations for equine metabolic syndrome (EMS) could also be used for DMS diagnosis, although a baseline insulin cut-off value is needed.
EQUINE VETERINARY JOURNAL
(2022)
Article
Veterinary Sciences
Francisco J. Mendoza, Antonio Buzon-Cuevas, Ramiro E. Toribio, Alejandro Perez-Ecija
Summary: This study characterized OGTT and OSTT in healthy donkeys and assessed their plasma incretin response. The results showed differences in glucose and insulin peaks between OGTT and OSTT, suggesting endocrine differences between donkeys and horses.
EQUINE VETERINARY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Hannah M. Kinsella, Laura D. Hostnik, Hailey A. Snyder, Sarah E. Mazur, Ahmed M. Kamr, Teresa A. Burns, John C. Mossbarger, Ramiro E. Toribio
Summary: This study compared insulin sensitivity between neonatal foals and adult horses using the insulin-modified frequently sampled intravenous glucose tolerance test. The results showed that neonatal foals have higher insulin sensitivity in the first days of life.
Meeting Abstract
Biochemistry & Molecular Biology
Ibiagbani Max-Harry, Noriko Kantake, Ramiro Toribio, Craig Nunemaker, Thomas Rosol
Meeting Abstract
Biochemistry & Molecular Biology
Waleed J. Hashmi, Noriko Kantake, Shiyu Yuan, Ibiagbani Max Harry, Nathan K. Hoggard, Alex H. Fischbach, Ramiro E. Toribio, Thomas J. Roso
Article
Agriculture, Dairy & Animal Science
K. Dembek, K. Timko, C. Moore, L. Johnson, M. Frazer, B. Barr, R. Toribio
Summary: Sepsis is a significant health issue in neonatal foals, often leading to increased morbidity and mortality rates. Relative adrenal insufficiency (RAI) has been linked to sepsis and poor outcomes in newborn foals. This study aimed to evaluate the concentrations of various steroids and steroid precursors, including cortisol, aldosterone, and progestogens, in critically ill foals and their association with disease severity and mortality. The findings suggest that altered concentrations of these hormones may be associated with sepsis and poor outcomes in foals.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ibiagbani M. Max-Harry, Waleed J. Hashmi, Brian P. List, Noriko Kantake, Kathryn L. Corbin, Ramiro E. Toribio, Craig S. Nunemaker, Thomas J. Rosol
Summary: Parathyroid hormone-related protein (PTHrP) is an essential hormone involved in various physiological processes. Knockin mice lacking the C-terminal and nuclear localization sequence (NLS) of PTHrP showed stunted growth, decreased insulin and increased glucose secretion. Islets from these mice exhibited smaller size, enhanced insulin secretion, and reduced glucagon content. These findings highlight the crucial role of the C-terminus and NLS of PTHrP in glucose homeostasis and islet function.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Kaitlyn Bello, Gwendolen Lorch, Kyeongmin Kim, Ramiro E. Toribio, Liwei Yan, Zhiliang Xie, Kasey Hill, Mitch Phelps
Summary: The pharmacokinetics (PK) of multiple-day oral dosing of MMF in healthy horses were evaluated, and it was found that administration of MMF at 10 mg/kg PO q12h resulted in hematologic and clinical toxicity within 1 week of treatment. Therefore, a decreased MMF dose, frequency, or both is needed to avoid colic, and drug monitoring and strict biosecurity protocols should be implemented.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Diego Gomez, Ramiro Toribio, Benjamin Caddey, Marcio Costa, Stephanie Vijan, Katarzyna Dembek
Summary: This study investigated the impact of oral administration of antimicrobials on the intestinal microbiota of horses. The results showed significant changes in the microbiota of horses receiving erythromycin, doxycycline, and metronidazole, but not sulfadiazine/trimethoprim. These changes may lead to intestinal inflammation and predisposition to diarrhea.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Microbiology
Rory C. Chien, Lin Mingqun, Qi Yan, Nina Randolph, Weiyan Huang, Maxey Wellman, Ramiro Toribio, Yasuko Rikihisa
Summary: A study in Ohio identified strains of A. phagocytophilum that cause equine granulocytic anaplasmosis (EGA), and found that these strains are related to human isolates in the northeastern USA but distinct from those in California or Europe. The study also revealed a previously unrecognized prevalence of EGA in the region, highlighting the risk of transmission of anaplasmosis to humans and animals.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Katelyn Brusach, Sarah Lorbach, Jessica Quimby, Eline Nijveldt, Rene Paschall, Hannah Kinsella, Valerie Parker, Ramiro Toribio
Summary: This study compared plasma ghrelin concentrations in cats with and without chronic kidney disease (CKD) and found that cats with CKD had increased desacyl and total ghrelin concentrations, indicating dysregulation of appetite.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Erin F. Pinnell, Laura D. Hostnik, Mauria R. Watts, Kathryn J. Timko, Allison A. Thriffiley, Mercedes R. Stover, Lauren E. Koenig, Olivia M. Gorman, Ramiro E. Toribio, Teresa A. Burns
Summary: Combination therapy with RES, MET, and ASP did not significantly improve insulin and glucose dynamics in horses with experimentally induced ID.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Diego E. Gomez, Bettina Dunkel, David L. Renaud, Luis G. Arroyo, Angelika Schoster, Jamie J. Kopper, David Byrne, Ramiro E. Toribio
Summary: A multicentre study investigated clinicopathological findings and their association with survival in horses with acute diarrhoea. The study found that clinicopathological findings and survival rates were similar across different geographic regions. However, the development of laminitis secondary to diarrhoea was less common in Europe.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Diego E. Gomez, Luis G. Arroyo, Angelika Schoster, David L. Renaud, Jamie J. Kopper, Bettina Dunkel, David Byrne, Ramiro E. Toribio
Summary: This study provides an international description of diagnostic approaches and pathogens detected in cases of acute equine diarrhoea.
EQUINE VETERINARY JOURNAL
(2023)