Article
Multidisciplinary Sciences
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylene Brunelle, Nicolas Gevry, Bruce D. Murphy
Summary: This study identifies SF-1 as a key regulator of the formation of the ovarian reserve, with its depletion leading to smaller ovaries and reduced primordial follicles. The study also identifies the dysregulated pathways and genes involved in follicle formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Meijie Chen, Xuena Li, Bulin Du, Song Chen, Yaming Li
Summary: This study investigates the role of upstream stimulatory factor 2 (USF2) and pyruvate kinase M2 (PKM2) in ferroptosis in pancreatic cancer cells and reveals that USF2 negatively regulates ferroptosis through transcriptional regulation of PKM2.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Dermatology
Isabelle Sahut-Barnola, Anne-Marie Lefrancois-Martinez, Damien Dufour, Jean-Marie Botto, Crystal Kamilaris, Fabio R. Faucz, Constantine A. Stratakis, Pierre Val, Antoine Martinez
Summary: Carney complex is a rare familial multineoplastic syndrome characterized by skin lesions. This study demonstrates that inactivation of the Prkar1a gene leads to familial skin pigmentation alterations, revealing the pathogenesis of cutaneous manifestations in Carney complex.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xufeng Wang, Dan Yuan, Yanchun Liu, Yameng Liang, Juan He, Xiaoyu Yang, Runlai Hang, Hong Jia, Beixin Mo, Feng Tian, Xuemei Chen, Lin Liu
Summary: Phosphorus is essential for plant growth, and plants adopt various strategies to improve phosphate acquisition efficiency to cope with phosphate starvation. This study found that overexpressing miR399 in maize is associated with premature senescence after pollination, while knockout of ZmPHO2, a target of miR399, resulted in a similar phenotype. Furthermore, ID1, a regulator of floral transition, was found to inhibit the transcription of ZmMIR399 genes, contributing to the maintenance of phosphate homeostasis in maize.
Article
Developmental Biology
Olivia E. Smith, Fanny Morin, Vickie Roussel, Micka C. Bertucci, Alexandre Boyer, Bruce D. Murphy
Summary: The nuclear receptor SF-1 is crucial for gene expression, cell function, and fertility in mature mouse gonads. Depletion of SF-1 in testicular steroidogenic cells affects steroidogenesis, spermatogenesis, and male fertility.
Article
Multidisciplinary Sciences
Daoxi Lei, Xiuru Zhang, Muhammad Abdul Rouf, Yoga Mahendra, Lin Wen, Yan Li, Xiaojuan Zhang, Li Li, Luming Wang, Tao Zhang, Guixue Wang, Yeqi Wang
Summary: The study revealed that par1 regulates the differentiation of lymphatic progenitors in zebrafish embryos, and its loss of function impairs lymphatic development, leading to compromised thoracic duct formation.
Article
Biochemistry & Molecular Biology
Madelen M. M. Diaz, Yanina Tsenkina, Dena Arizanovska, Patrick Mehlen, Daniel J. J. Liebl
Summary: The expression of the deleted in colorectal cancer (DCC) dependence receptor is upregulated in the traumatically injured brain, while the expression of its ligand netrin-1 is downregulated. Administration of netrin-1 can prevent oligodendrocyte cell death and improve motor function and myelin integrity after brain injury.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Virology
Riley M. Horvath, Ivan Sadowski
Summary: HIV-1 provirus expression is regulated by the Ras signaling pathway, which is associated with T cell receptor engagement. USF2 is crucial for HIV-1 expression, while the function of USF1 is uncharacterized. USF1 and USF2 have cooperative regulation on target genes in T cells.
Review
Biochemistry & Molecular Biology
Xin Wei, Yihua Liu, Weijia Li, Xu Shao
Summary: The present study found that NOD1 is related to the inflammatory response in endometriosis. The levels of NOD1 were elevated and positively correlated with inflammatory cytokines in ectopic endometrium. Inhibition of NOD1 reduced cell viability and the production of inflammatory cytokines.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yeu-Farn Lin, Gauthier Schang, Evan R. S. Buddle, Hailey Schultz, Thea L. Willis, Frederique Ruf-Zamojski, Michel Zamojski, Natalia Mendelev, Ulrich Boehm, Stuart C. Sealfon, Cynthia L. Andoniadou, Daniel J. Bernard
Summary: Inhibins control reproduction by suppressing follicle-stimulating hormone synthesis, and SF-1 directly regulates the transcription of Tgfbr3l/TGFBR3L, playing a role in gonadotrope cells.
Article
Biochemistry & Molecular Biology
Guang-Liang Chen, Rui Li, Xiao-Xiang Chen, Juan Wang, Shan Cao, Rui Song, Ming-Chun Zhao, Li-Ming Li, Nicole Hannemmann, Georg Schett, Cheng Qian, Aline Bozec
Summary: Metastatic melanoma is a challenging disease, and understanding the molecular mechanisms behind its metastasis is crucial. The downregulation of AP-1 transcription factor member Fra-2 in melanoma cells is associated with a more aggressive phenotype both in vitro and in vivo. Further research revealed that the Fra-2-Fam212b axis plays a key role in promoting melanoma metastasis by affecting cell migration, invasion, cell cycle transition, and tissue angiogenesis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Endocrinology & Metabolism
Dasan Mary Cibi, Reddemma Sandireddy, Hanumakumar Bogireddi, Nicole Tee, Siti Aishah Binte Abdul Ghani, Brijesh K. Singh, Nigel Mackman, Manvendra K. Singh, Anamika Singh
Summary: This study demonstrated an important role of TF in regulating diabetes-induced inflammation, hypertrophy, and remodeling of the heart leading to HFpEF.
Article
Medicine, Research & Experimental
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sekaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Summary: The transcription factor TCF-1 plays a crucial role in regulating the memory properties and expansion capacity of virus-specific CD8(+) T cells, which are important for controlling HIV infection. Increasing TCF-1 levels may enhance the secondary expansion capacity of HIV-specific CD8(+) T cells.
Article
Dermatology
Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wang
Summary: KGF-2 has been found to attenuate scar formation while promoting wound healing. This is achieved by inhibiting the expression of STAP-2 and reducing the accumulation of collagen fibers through cell signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Pratima Chowdary, Susan Shapiro, Mike Makris, Gillian Evans, Sara Boyce, Kate Talks, Gerard Dolan, Ulrike Reiss, Mark Phillips, Anne Riddell, Maria R. Peralta, Michelle Quaye, David W. Patch, Edward Tuddenham, Allison Dane, Marie Watissee, Alison Long, Amit Nathwani
Summary: FLT180a, a liver-directed adeno-associated virus (AAV) gene therapy, showed promising results in normalizing factor IX levels in patients with hemophilia B. This multicenter, open-label, phase 1-2 trial demonstrated sustained factor IX activity in most patients after receiving varying doses of FLT180a, with the use of glucocorticoids and tacrolimus for immunosuppression.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Genetics & Heredity
Xiuhua Xu, J. Julie Kim, Yinuo Li, Jia Xie, Changshun Shao, Jian-Jun Wei
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Article
Oncology
Oukseub Lee, Megan E. Sullivan, Yanfei Xu, Chiara Rogers, Miguel Muzzio, Irene Helenowski, Ali Shidfar, Zexian Zeng, Hari Singhal, Borko Jovanovic, Nora Hansen, Kevin P. Bethke, Peter H. Gann, William Gradishar, J. Julie Kim, Susan E. Clare, Seema A. Khan
CLINICAL CANCER RESEARCH
(2020)
Article
Endocrinology & Metabolism
Teerawat Wiwatpanit, Alina R. Murphy, Zhenxiao Lu, Margrit Urbanek, Joanna E. Burdette, Teresa K. Woodruff, J. Julie Kim
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Multidisciplinary Sciences
Alina R. Murphy, Teerawat Wiwatpanit, Zhenxiao Lu, Batzaya Davaadelger, J. Julie Kim
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Cell & Tissue Engineering
Hannes Campo, Alina Murphy, Sule Yildiz, Teresa Woodruff, Irene Cervello, J. Julie Kim
TISSUE ENGINEERING PART A
(2020)
Review
Obstetrics & Gynecology
Hilary O. D. Critchley, Elnur Babayev, Serdar E. Bulun, Sandy Clark, Iolanda Garcia-Grau, Peter K. Gregersen, Aoife Kilcoyne, Ji-Yong Julie Kim, Missy Lavender, Erica E. Marsh, Kristen A. Matteson, Jacqueline A. Maybin, Christine N. Metz, Inmaculada Moreno, Kami Silk, Marni Sommer, Carlos Simon, Ridhi Tariyal, Hugh S. Taylor, Gunter P. Wagner, Linda G. Griffith
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Tia Jackson-Bey, Jose Colina, Brett C. Isenberg, Jonathan Coppeta, Margrit Urbanek, J. Julie Kim, Teresa K. Woodruff, Joanna E. Burdette, Angela Russo
HUMAN REPRODUCTION
(2020)
Article
Obstetrics & Gynecology
Yinuo Li, Wenan Qiang, Brannan Brooks Griffin, Tingting Gao, Debabrata Chakravarti, Serdar Bulun, J. Julie Kim, Jian-Jun Wei
FERTILITY AND STERILITY
(2020)
Letter
Obstetrics & Gynecology
Tia Jackson-Bey, Jose Prime Colina, Brett C. Isenberg, Jonathan Coppeta, Margrit Urbanek, J. Julie Kim, Teresa K. Woodruff, Joanna E. Burdette, Angela Russo
HUMAN REPRODUCTION
(2021)
Article
Oncology
Oukseub Lee, Maarten C. Bosland, Minhua Wang, Ali Shidfar, Omid Hosseini, Xiaoling Xuei, Priyam Patel, Matthew J. Schipma, Irene Helenowski, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Results show that ulipristal acetate is the most effective among the selective progesterone receptor modulators studied, while mifepristone is ineffective and telapristone acetate is less effective. Ulipristal acetate reduces tumor incidence and delays tumor onset, and also affects gene expression in benign mammary glands.
Editorial Material
Biology
J. Julie Kim
Summary: A new laboratory model helps to study the role of senescent cells in fostering a uterine environment that can support an embryo.
Review
Oncology
Mary Towner, J. Julie Kim, Melissa A. Simon, Daniela Matei, Dario Roque
Summary: This review explores the survival rate disparities between black and white women in ovarian, uterine, and cervical cancers, and proposes a theoretical framework to explain how racial differences in experience of preventive strategies, implementation of screening efforts, early detection of symptomatic disease, and appropriate treatment contribute to these disparities.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T. Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Research in mouse model shows that exposure to progesterone leads to an increase in mammary stem cells and luminal mature cells, while reducing luminal progenitor cells. However, these effects can be reversed by progesterone receptor antagonists.
BREAST CANCER RESEARCH
(2021)
Article
Oncology
Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E. Clare, Seema A. Khan, J. Julie Kim
BREAST CANCER RESEARCH
(2019)
Article
Endocrinology & Metabolism
Vania Vidimar, Debabrata Chakravarti, Serdar E. Bulun, Ping Yin, Romana Nowak, Jian-Jun Wei, J. Julie Kim