期刊
MOLECULAR CELL
卷 49, 期 3, 页码 427-438出版社
CELL PRESS
DOI: 10.1016/j.molcel.2012.11.025
关键词
-
资金
- National Institute of Health [GM31030]
- Deshpande Center [GM17151, P30 ES002109]
Quality control of ribosomes is critical for cellular function since protein mistranslation leads to severe physiological consequences. We report evidence of a previously unrecognized ribosome quality control system in bacteria that operates at the level of 70S to remove defective ribosomes. YbeY, a previously unidentified endoribonuclease, and the exonuclease RNase R act together by a process mediated specifically by the 30S ribosomal subunit, to degrade defective 70S ribosomes but not properly matured 708 ribosomes or individual subunits. Furthermore, there is essentially no fully matured 16S rRNA in a Delta ybeY mutant at 45 degrees C, making YbeY the only endoribonuclease to be implicated in the critically important processing of the 16S rRNA 3' terminus. These key roles in ribosome quality control and maturation indicate why YbeY is a member of the minimal bacterial gene set and suggest that it could be a potential target for antibacterial drugs.
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