4.8 Editorial Material

MicroRNA Factory: RISC Assembly from Precursor MicroRNAs

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MOLECULAR CELL
卷 46, 期 4, 页码 384-386

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CELL PRESS
DOI: 10.1016/j.molcel.2012.05.012

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  1. National Research Foundation of Korea [과06A1204, 2010-0020415] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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RNA silencing requires assembly of an effector complex, RNA-induced silencing complex (RISC), composed of a small RNA and the Ago protein. In this issue of Molecular Cell, Liu et al. (2012) provide insights of miRNP/RISC assembly pathways in mammals, using an in vitro human RISC assembly assay programmed by pre-miRNAs.

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