Article
Dentistry, Oral Surgery & Medicine
W. Cai, Y. Ji, L. Han, J. Zhang, Y. Ni, Y. Cheng, Y. Zhang
Summary: This study uncovers the potential role of METTL3 in osteogenesis, revealing its connection with glucose metabolism and m(6)A modification. It provides new insights into the understanding of the potential molecular mechanisms of epigenetic modification in stem cell applications and intervention of metabolic bone diseases.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiao Lv, Shouliang Li, Yue Liu, Zihan Sun, Dan Wang, Zhengying You, Caiying Jiang, Qing Sheng, Zuoming Nie
Summary: The acetylation modification of the Bm30K-15 protein in silkworms enhances protein stability by competing against ubiquitination, providing insight into the molecular mechanism of this process.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biology
Chunbo Zhang, Tianyu Zhong, Yuanyuan Li, Xianfeng Li, Xiaopeng Yuan, Linlin Liu, Weilin Wu, Jing Wu, Ye Wu, Rui Liang, Xinhua Xie, Chuanchuan Kang, Yuwen Liu, Zhonghong Lai, Jianbo Xiao, Zhixian Tang, Riqun Jin, Yan Wang, Yongwei Xiao, Jin Zhang, Jian Li, Qian Liu, Zhongsheng Sun, Jianing Zhong
Summary: TET1 interacts with SIRT1 to regulate hepatic gluconeogenic gene expression, and the AMPK-TET1-SIRT1 axis plays a role in promoting glucose metabolism.
Article
Cell Biology
Zilong Zheng, Guokai Yan, Xiuzhi Li, Yuke Fei, Lingling Sun, Haonan Yu, Yaorong Niu, Weihua Gao, Qing Zhong, Xianghua Yan
Summary: Lysine crotonylation is an important protein post-translational modification that regulates various cellular processes and functions, but its role in nutrient signaling pathways is not well understood. In this study, the authors found a positive correlation between global crotonylation levels and autophagy induced by leucine deprivation. They identified multiple crotonylated proteins regulated by leucine deprivation and discovered that 14-3-3 proteins play a dominant role in leucine-mediated crotonylation. Furthermore, they showed that crotonylation of 14-3-3E disrupts its interaction with binding partners and leads to the release of protein phosphatase 1B (PPM1B), which initiates autophagy. The authors also found that HDAC7 regulates the crotonylation of 14-3-3E. Overall, this study highlights the importance of the 14-3-3E-PPM1B axis regulated by crotonylation in leucine-deprivation-induced autophagy.
Review
Microbiology
Murray P. Deutscher
Summary: RNases play crucial roles in RNA metabolism, but can also be destructive enzymes, hence the need for careful regulation of their quantity, activity, and localization. Various mechanisms for regulating RNases have been identified, indicating a diversity of processes rather than a common regulatory mechanism for these enzymes.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Article
Biochemistry & Molecular Biology
Kensuke Ninomiya, Junichi Iwakiri, Mahmoud Khamis Aly, Yuriko Sakaguchi, Shungo Adachi, Tohru Natsume, Goro Terai, Kiyoshi Asai, Tsutomu Suzuki, Tetsuro Hirose
Summary: The study reveals the role of nuclear stress bodies in repressing RNA splicing during stress recovery through two distinct mechanisms involving protein sequestration and N-6-methyladenosine modification. The sequestration of m(6)A writer complex by nSBs leads to the inhibition of m(6)A-dependent splicing, highlighting the importance of nSBs in regulating temperature-dependent splicing.
Review
Oncology
Tingshan Tan, Pengfei Shi, Muhammad Nadeem Abbas, Yi Wang, Jie Xu, Yu Chen, Hongjuan Cui
Summary: Epigenetics is the study of heritable factors that are independent of phenotypic features, including DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In tumor progression and metastasis, epigenetic changes play a crucial role in cellular differentiation, function, and the process of epithelial-mesenchymal transition (EMT). Understanding the role of epigenetics in EMT not only enhances our understanding of cancer progression and spread, but also provides new opportunities for diagnosing and treating human malignancy in the clinical setting.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Weijing He, Qingguo Li, Xinxiang Li
Summary: Acetyl-CoA is an important molecule that participates in multiple intracellular metabolic reactions and affects protein post-translational modification, playing a key role in cell metabolism and epigenetic inheritance. In cancer, extensive lipid metabolism and histone acetylation are required for cancer cell growth and expression of cancer-promoting genes. Acetyl-CoA, as a raw material for lipid synthesis and histone acetylation, has a major impact on lipid metabolism and histone acetylation in cancer. Moreover, acetyl-CoA connects lipid metabolism with histone acetylation, forming a complex regulatory mechanism that influences cancer growth, proliferation, and metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Microbiology
Jackson Luu, Valerie J. Carabetta
Summary: Protein acetylation is a crucial posttranslational modification in bacteria, regulated by enzymatic and nonenzymatic mechanisms. Research on acetylation in bacterial virulence and biofilm formation is ongoing, shedding light on its impact on host-pathogen interactions and antimicrobial resistance.
Article
Neurosciences
Jiwoon Lee, Bum-Kyu Lee, Jeffrey M. Gross
Summary: The zebrafish retina has strong regenerative potential, and Muller glia play a crucial role in this process. The transcriptional regulation by members of the Bromodomain (Brd) family is important for Muller glia-dependent retinal regeneration.
Article
Biochemistry & Molecular Biology
Lina Hamouche, Leonora Poljak, Agamemnon J. Carpousis
Summary: Rifampicin treatment causes a decrease in cell size and total RNA content in E. coli, primarily due to a decrease in 23S and 16S rRNA levels. While rRNA degradation is not complete, growth can be reinitiated after removal of rifampicin. Analysis of mutant strains suggests RNase E, PNPase, and RNase R are involved in rifampicin-induced rRNA degradation, potentially impacting mRNA degradation rates as well.
Article
Psychiatry
Xingyun Xu, Junjie Wang, Wenjuan Wang, Yutong Zhang, Bo Wan, Zhigang Miao, Xingshun Xu
Summary: In this study, it was found that chronic restraint stress increased R-loop accumulation and decreased 5hmC modification in the prefrontal cortex of stressed mice. The increase of DNA 5hmC modification by vitamin C was accompanied by the decrease of R-loop levels, indicating that 5hmC modification inversely regulates R-loop accumulation. Tet proteins and NONO proteins formed a complex to inhibit R-loop formation, and the administration of antidepressant fluoxetine effectively decreased R-loop accumulation and DNA damage by increasing NONO protein levels.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Mohammed G. Dorgham, Brittany A. Elliott, Christopher L. Holley, Kyle D. Mansfield
Summary: This study investigates the role of mRNA modification N6-methyladenosine (m6A) in breast cancer progression. The results indicate that manipulating m6A levels has different effects on proliferation and migration depending on the stage of disease progression. Knocking down the main m6A RNA methyltransferase at different stages of breast cancer progression results in unique effects, suggesting a dynamic role of m6A in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hye-Jin Kim, Eunmi Kim, Haesong Lee, Jae Woo Jung, Ji Eon Kim, Chan-Gi Pack, Jung Weon Lee
Summary: This study showed that cell adhesion to fibronectin can enhance the translocation of TM4SF5 vesicles to the leading edges, while microtubule acetylation plays a regulatory role in this process. The coordinated actions of paxillin, SLAC2B, and HDAC6 are essential for controlling the intracellular traffic of TM4SF5 vesicles towards the leading edges, leading to TM4SF5-dependent cell migration.
Article
Biochemistry & Molecular Biology
Zihan Sun, Yafei Ma, Yue Liu, Jiao Lv, Dan Wang, Zhengying You, Caiying Jiang, Qing Sheng, Zuoming Nie
Summary: This study reveals the mechanism of acetylation regulating the stability of silkworm SP1 protein, thereby affecting the nutrient storage and utilization of silkworm.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sk Tofajjen Hossain, Arun Malhotra, Murray P. Deutscher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Fenghua Yuan, Tanmay Dutta, Ling Wang, Lei Song, Liya Gu, Liangyue Qian, Anaid Benitez, Shunbin Ning, Arun Malhotra, Murray P. Deutscher, Yanbin Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Sk Tofajjen Hossain, Arun Malhotra, Murray P. Deutscher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Limin Song, Guangyuan Wang, Arun Malhotra, Murray P. Deutscher, Wenxing Liang
NUCLEIC ACIDS RESEARCH
(2016)
Article
Cell Biology
Douglas R. Boettner, Veronica A. Segarra, Balaji T. Moorthy, Nagore de Leon, John Creagh, John R. Collette, Arun Malhotra, Sandra K. Lemmon
Article
Medicine, Research & Experimental
Lily Liu-Shin, Adam Fung, Arun Malhotra, Gayathri Ratnaswamy
Article
Biochemistry & Molecular Biology
Tanmay Dutta, Arun Malhotra, Murray P. Deutscher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Tanmay Dutta, Arun Malhotra, Murray P. Deutscher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Brad J. Schmier, Jayaraman Seetharaman, Murray P. Deutscher, John F. Hunt, Arun Malhotra
JOURNAL OF MOLECULAR BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Caleb B. McDonald, Laura Buffa, Tomer Bar-Mag, Zaidoun Salah, Vikas Bhat, David C. Mikles, Brian J. Deegan, Kenneth L. Seldeen, Arun Malhotra, Marius Sudol, Rami I. Aqeilan, Zafar Nawaz, Amjad Farooq
JOURNAL OF MOLECULAR BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Tristan Aguero, Zhigang Jin, Dawn Owens, Arun Malhotra, Karen Newman, Jing Yang, Mary Lou King
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2018)
Article
Multidisciplinary Sciences
Brad J. Schmier, Claudiu M. Nelersa, Arun Malhotra
SCIENTIFIC REPORTS
(2017)
Article
Medicine, Research & Experimental
Anja Resemann, Lily Liu-Shin, Guillaume Tremintin, Arun Malhotra, Adam Fung, Fang Wang, Gayathri Ratnaswamy, Detlev Suckau
Article
Medicine, Research & Experimental
Lily Pei-Yao Liu-Shin, Adam Fung, Arun Malhotra, Gayathri Ratnaswamy