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Biochemistry & Molecular Biology
Omar A. Itani, Xuefei Zhong, Xiaoting Tang, Barbara A. Scott, Jun Yi Yan, Stephane Flibotte, Yiting Lim, Andrew C. Hsieh, James E. Bruce, Marc Van Gilst, C. Michael Crowder
Summary: Our study reveals an unrecognized higher-order-translation regulatory mechanism in a metazoan, where ribosome biogenesis genes communicate with genes controlling tRNA abundance to match the global rate of protein synthesis with available resources.
Review
Cell Biology
Anabela Ferreira, Flavia Pereira, Celso Reis, Maria Jose Oliveira, Maria Joao Sousa, Ana Preto
Summary: KRAS mutations play a crucial role in promoting cancer cell proliferation, inducing autophagy, and suppressing apoptosis, leading to drug resistance and poor prognosis.
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Chemistry, Multidisciplinary
Xinyue Cui, Zhaoyuan Liang, Jianqing Lu, Xuan Wang, Fan Jia, Qin Hu, Xiangqian Xiao, Xiongwei Deng, Yan Wu, Wang Sheng
Summary: This study demonstrated the construction of a nanodiamond-based nanoplatform for enhanced mild-temperature photothermal/chemo combination therapy against TNBC by inhibiting autophagy, which could weaken therapeutic resistance and improve anti-tumor efficacy both in vitro and in vivo. Additionally, the nanoplatform could be used for fluorescence and photoacoustic imaging, showing its potential as a theranostic tool.
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Biochemistry & Molecular Biology
Shuang Liu, Jiahuan Hu, Min Li, Shengyong Zhu, Shujuan Guo, Hongyun Guo, Tao Wang, Yongdong Zhang, Ji Zhang, Junlong Wang
Summary: The study revealed a positive correlation between Se content and anti-tumor effects of Se-polysaccharides, suggesting that adjusting Se content could enhance the anti-tumor activities. SeASPs showed potent anti-proliferation activities against tumor cells by inducing apoptosis and cell cycle arrest, while displaying low cytotoxicity against normal cells. This suggests that SeASPs could be a promising candidate for anti-tumor therapy with potential to be more effective than traditional treatments.
Article
Biochemistry & Molecular Biology
Ki-Tae Jung, Seon-Hee Oh
Summary: Cadmium is a highly toxic pollutant that damages kidneys, and this study shows that it promotes cell apoptosis through the polyubiquitination of p53. The study also reveals the involvement of autophagy and the polyubiquitination of SQSTM1/p62 in regulating this process.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Jinning Gao, Xiatian Chen, Pengcheng Wei, Yin Wang, Peifeng Li, Kai Shao
Summary: Cardiovascular disease is a critical threat to human life, and recent studies have shown the important roles of inflammation and pyroptosis in its progression. Noncoding RNAs are considered promising biomarkers and therapeutic targets for diagnosing and treating cardiovascular diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Review
Cell Biology
Annamaria Paolini, Rebecca Borella, Sara De Biasi, Anita Neroni, Marco Mattioli, Domenico Lo Tartaro, Cecilia Simonini, Laura Franceschini, Gerolamo Cicco, Anna Maria Piparo, Andrea Cossarizza, Lara Gibellini
Summary: Cell death mechanisms play a crucial role in maintaining a healthy cellular environment, but dysregulation of these processes during viral infections can contribute to disease pathology. In COVID-19 patients, lymphopenia and monocytopenia are important factors in immunopathogenesis, and the underlying mechanisms are still not fully understood. Further research is needed to develop new therapeutic strategies for COVID-19.
Review
Biochemistry & Molecular Biology
Omchit Surien, Siti Fathiah Masre, Dayang Fredalina Basri, Ahmad Rohi Ghazali
Summary: Cancer incidence is increasing globally, causing significant physical, mental, and financial burdens. Conventional cancer treatments have limitations such as drug resistance and side effects. Chemoprevention, including the use of natural compounds like pterostilbene, shows promise in reducing the cancer burden. Pterostilbene has various pharmacological properties and can induce apoptosis to prevent cancer progression. This review discusses pterostilbene's role as a chemopreventive agent against different types of cancer by modulating the apoptosis pathway at the molecular level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Haina Zhang, Yeling Wang, Hongbo Men, Wenqian Zhou, Shanshan Zhou, Quan Liu, Lu Cai
Summary: CARD9 is a crucial adaptor protein involved in the pathogenesis of cardiovascular diseases, including inflammation, apoptosis, and autophagy. By regulating signaling pathways and cytokine production, CARD9 plays a significant role in the development of CVDs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Yanrui Zhang, Taian Jin, Zhangqi Dou, Boxing Wei, Buyi Zhang, Chongran Sun
Summary: The binding of CD95 to CD95L triggers a cascade of signals leading to apoptosis, but most tumor cells are resistant to CD95L-induced apoptosis. In some cancers, the CD95-CD95L binding promotes tumor growth. This review summarizes the potential mechanisms of non-apoptotic signaling and the expression of CD95L in other cell types.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Andrea Urbani, Elena Prosdocimi, Andrea Carrer, Vanessa Checchetto, Ildiko Szabo
Summary: Mitochondria are vital organelles involved in cell survival and death. Ion channels in the inner membrane of mitochondria play a crucial role in regulating mitochondrial function and ultimately affecting cell fate. Understanding the regulation of mitochondrial ion channels may lead to the identification of new therapeutic targets for mitochondria-related pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Lucy May Vining, Louisa J. Zak, Simon Crawford Harvey, Katie Evelyn Harvey
Summary: Cryopreservation of gametes and embryos is crucial for assisted reproductive technology and livestock reproduction. Freezing procedures may induce cell apoptosis, and inhibiting apoptosis could improve cryosurvival.
Review
Medicine, Research & Experimental
Sina Khodakarimi, Amir Zarebkohan, Houman Kahroba, Mohammadhassan Omrani, Tina Sepasi, Gisou Mohaddes, Hanieh Beyrampour-Basmenj, Ayyub Ebrahimi, Abbas Ebrahimi-Kalan
Summary: Autoimmune diseases are chronic injuries caused by specific auto-reactive reactions, with most of their etiology not well understood. Autophagy serves as a protective response to maintain homeostasis by recycling and discrediting cell compartments, playing a crucial role in controlling immune homeostasis.MicroRNAs, on the other hand, are endogenous non-coding small RNAs that play important roles in cell processes and immune system function, with dysregulated miRNAs implicated in the pathogenesis of autoimmune diseases and the regulation of autophagy.
Article
Cell Biology
Silvia Ramirez-Peinado, Tatiana I. Ignashkova, Bram J. van Raam, Jan Baumann, Erica L. Sennott, Mathieu Gendarme, Ralph K. Lindemann, Michael N. Starnbach, Jan H. Reiling
JOURNAL OF CELL SCIENCE
(2017)
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Biochemistry & Molecular Biology
Cristina Pop, Andrew Oberst, Marcin Drag, Bram J. Van Raam, Stefan J. Riedl, Douglas R. Green, Guy S. Salvesen
BIOCHEMICAL JOURNAL
(2011)
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Biochemistry & Molecular Biology
Janna Hachmann, Scott J. Snipas, Bram J. van Raam, Erik M. Cancino, Emily J. Houlihan, Marcin Poreba, Paulina Kasperkiewicz, Marcin Drag, Guy S. Salvesen
BIOCHEMICAL JOURNAL
(2012)
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Biochemistry & Molecular Biology
Katherine Wachmann, Cristina Pop, Bram J. van Raam, Marcin Drag, Peter D. Mace, Scott J. Snipas, Christian Zmasek, Robert Schwarzenbacher, Guy S. Salvesen, Stefan J. Riedl
Review
Biochemistry & Molecular Biology
Bram J. van Raam, Guy S. Salvesen
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2012)
Article
Hematology
Bram J. van Raam, Agata Drewniak, Vincent Groenewold, Timo K. van den Berg, Taco W. Kuijpers
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Hematology
Agata Drewniak, Bram J. van Raam, Judy Geissler, Anton T. J. Tool, Olaf R. F. Mook, Timo K. van den Berg, Frank Baas, Taco W. Kuijpers
Letter
Hematology
Bram J. van Raam, Robin van Bruggen, Anton T. J. Tool, Machiel H. Jansen, Adilia Warris, Stephen Jolles, Tacow. Kuijpers
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Biochemistry & Molecular Biology
B. J. van Raam, D. E. Ehrnhoefer, M. R. Hayden, G. S. Salvesen
CELL DEATH AND DIFFERENTIATION
(2013)
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Biochemistry & Molecular Biology
Laura E. Edgington, Bram J. van Raam, Martijn Verdoes, Christoph Wierschem, Guy S. Salvesen, Matthew Bogyo
CHEMISTRY & BIOLOGY
(2012)
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Hematology
Bram J. van Raam, Taco W. Kuijpers
CURRENT OPINION IN HEMATOLOGY
(2009)
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Multidisciplinary Sciences
Bram J. Van Raam, Wim Sluiter, Elly de Wit, Dirk Roos, Arthur J. Verhoeven, Taco W. Kuijpers
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Multidisciplinary Sciences
Sonu Kumar, Bram J. van Raam, Guy S. Salvesen, Piotr Cieplak
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Multidisciplinary Sciences
Jennifer V. Lu, Brian M. Weist, Bram J. van Raam, Brett S. Marro, Long V. Nguyen, Prathna Srinivas, Bryan D. Bell, Keith A. Luhrs, Thomas E. Lane, Guy S. Salvesen, Craig M. Walsh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
