期刊
MOLECULAR CELL
卷 31, 期 3, 页码 309-312出版社
CELL PRESS
DOI: 10.1016/j.molcel.2008.07.008
关键词
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资金
- NIGMS NIH HHS [R01 GM072830-04, R01 GM072830] Funding Source: Medline
Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.
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