Article
Biotechnology & Applied Microbiology
Zhengliang Li, Xiaojing Liu, Nan Luo, Yali Pang, Yubin Hou, Guoxiang Jiang
Summary: The study found that lncRNA CERS6-AS1 was highly expressed in gastric cancer tissues and cells, suggesting a potential correlation with the condition of gastric cancer patients and the possibility of serving as a prognostic marker for the progression of gastric cancer. Knockdown of CERS6-AS1 was shown to reduce the proliferation, migration, and invasion abilities of gastric cancer cells, and also impact the expression levels of miR-567 in a related manner.
Article
Oncology
Hyesung Kim, Jae Kyung Myung, Seung Sam Paik, Hyunsung Kim, Hosub Park, Yeon Ju Kim, Seung Bum Lee, Heung Up Kim, Hyun Joo Song, In Ho Jeong, Suji Hong, Chul Min Park, Cheol Lee, Younghoon Kim, Bogun Jang
Summary: EPHB2 is an upregulated protein tyrosine kinase in gastric cancer that is closely correlated with intestinal stem cell markers and CDX2 expression, and acts as a tumor suppressor in gastric cancer, serving as a prognostic marker in intestinal-type gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pathology
Junliang Li, Cheng Chen, Bo Chen, Tiankang Guo
Summary: This study investigated the expression pattern of FN1 in gastric cancer and its association with clinical characteristics, survival, MMR genes, and immune checkpoints. The results showed that high E-FN1 expression predicted poor overall survival, while high S-FN1 expression was associated with gastric cancer progression. FN1 expression was not correlated with MMR genes or immune checkpoints.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Xiaojie Zhang, Heng Xu, Yunan Zhang, Chongyuan Sun, Zefeng Li, Chunfang Hu, Dongbing Zhao, Chunguang Guo
Summary: The expression of GPX8 is upregulated in stomach adenocarcinoma and is associated with poor prognosis. GPX8 expression is positively correlated with infiltrating levels of tumor-infiltrating lymphocytes. GPX8 may be involved in the development and invasion of stomach adenocarcinoma through multiple signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Tian Zheng, Mingyao Sun, Lanzai Liu, Yanfen Lan, Lihua Wang, Fan Lin
Summary: The study found that GPR116 is significantly upregulated in gastric cancer tissues and is positively correlated with tumor staging and invasion, high GPR116 expression is associated with poor overall survival in gastric cancer patients, and GPR116 overexpression is an independent prognostic indicator for poor outcomes in gastric cancer patients.
Article
Biochemical Research Methods
Tong Liang, Ming-Xu Da
Summary: This study investigated the expression of PIEZO2 and its clinical significance in gastric cancer. The protein expression levels of PIEZO2 were detected in GC tissues and adjacent normal tissues, and the relationship between PIEZO2 expression levels and clinicopathological parameters of GC patients was analyzed. The results showed that PIEZO2 expression was associated with lymph node metastasis and TNM stage in GC patients, and aberrant overexpression of PIEZO2 was related to poor prognosis. Several proteins were found to interact with PIEZO2.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Oncology
YuJian Xia, ZheWei Wei, WeiBin Huang, XiaoJing Wei, YuLong He
Summary: Trim47 is overexpressed in gastric cancer tissues and associated with tumor differentiation, staging, and patient survival. It may regulate gastric cancer through NF-KB, EMT, hypoxia, and apoptosis signaling pathways, and has the potential to serve as a novel prognostic biomarker in gastric cancer patients.
Article
Oncology
Sun Yi Park, Sang-Ho Jeong, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Taejin Park, Jiho Park, Tae-Han Kim, Miyeong Park, Jung Wook Yang, Young-Joon Lee
Summary: This study analyzed the expression of PHLPP1 in gastric cancer patients and found that overexpression of PHLPP1 was associated with better prognosis. Additionally, the study provided insights into the mechanism of chemotherapeutic drug resistance in a specific cell line.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Jun Yong Kim, Cheol Keun Park, Songmi Noh, Jae-Ho Cheong, Sung Hoon Noh, Hyunki Kim
Summary: This study evaluated the expression of ARID1A in a large series of advanced gastric cancer samples and analyzed its relationship with various factors. The results showed that loss of ARID1A expression was associated with poorer prognosis only in patients with MLH1-proficient and EBV-negative gastric cancer.
Article
Medicine, Research & Experimental
Juan Gu, Shu Zhang, Xin He, Sufang Chen, Yan Wang
Summary: High expression of PIG11 is associated with unfavorable prognosis in patients with gastric cancer, serving as a potential diagnostic and prognostic biomarker for gastric cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zhen Guo, Yu Zhang, Wenrong Xu, Xu Zhang, Jiajia Jiang
Summary: The study reveals that circDIDO1 suppresses gastric cancer progression by modulating the miR-1307-3p/SOSC2 axis, and RGD-Exo-circDIDO1 can serve as a feasible nanomedicine for gastric cancer therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yang-kun Wang, Xue-xia Lv, Zhi-qiang Wang, Yong-mei Zhou, Bo Jiang, Su-nan Wang, Xiao-dong Chen
Summary: This study aimed to investigate the relationship between microlymphangiogenesis, microangiogenesis, and combined detection of PD-1/ki67 in gastric cancer patients and their disease prognosis. Immunohistochemistry was used to detect microlymphatic density (MLD) and microvessel density (MVD) in different zones of gastric cancer tissue, as well as the expression of PD-1 and ki67. The results showed that the central zone had fewer atretic cord-like lymphatic vessels but the peripheral zone had more lymphatic vessels, and the MLD was significantly decreased in the central zone compared to the peripheral zone. The expression of PD-1 and ki67 also differed between the zones. The differences in microlymphangiogenesis, microangiogenesis, and PD-1/ki67 expression were not statistically significant among different histological types, but were significantly decreased in early-stage gastric cancer compared to advanced-stage cancer. These findings suggest that MLD, MVD, PD-1, and ki67 are important indicators for predicting the prognosis of gastric cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Article
Gastroenterology & Hepatology
Zhi-Nong Jiang, Syed Minhaj Uddin Ahmed, Qin-Chuan Wang, Hong-Fei Shi, Xiu-Wen Tang
Summary: The study found that overexpression of NQO1 is associated with significantly poor prognosis and better response to 5-FU in gastric cancer patients. NQO1 overexpression can serve as a prominent prognostic biomarker for gastric cancer patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Yanjie You, Shengjuan Hu
Summary: This study reveals that ECRG4 expression is significantly downregulated in gastric cancer, and low ECRG4 expression is associated with higher histological grade, lymph node metastasis, invasive depth, advanced tumor stage, and poor overall survival. In addition, silencing of ECRG4 expression promotes gastric cancer cell growth and invasion. The findings suggest that ECRG4 plays an important role in the pathogenesis and progression of gastric cancer and may serve as a prognostic biomarker for this disease.