Article
Biochemistry & Molecular Biology
Yuxian Yang, Shiliang Liu, Chunxia Xie, Qiaoqiao Li, Tiantian Gao, Mengzhong Liu, Mian Xi, Lei Zhao
Summary: This study revealed the oncogenic role of TMED3 in esophageal squamous cell carcinoma (ESCC) and identified the overexpression of a TMED3-related protein FAM60A in ESCC tissues. Functional verification experiments demonstrated the important roles of TMED3 and FAM60A in ESCC cell proliferation and tumorigenicity.
BIOMEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang, Hongbing Ma
Summary: In this study, miR-4443 was found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, providing a new perspective and clue to alleviate radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell Biology
Zhuo Bao, Ang Li, Xuebo Lu, Zitong Wang, Yin Yu, Wenjie Wu, Lili Zhao, Bo Li, Xiangyu Wu, Kyle Vaughn Laster, Chengjuan Zhang, Yanan Jiang, Zigang Dong, Kangdong Liu
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly prevalent malignant tumor, and current treatment strategies have limited efficacy. This study found that oxethazaine can inhibit ESCC proliferation and metastasis by targeting AURKA.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Lin Li, Hangyu Jiang, Yuqi Li, Xiaochong Xiang, Yueming Chu, Jie Tang, Kang Liu, Danqun Huo, Xiaofen Zhang
Summary: This study shows that chaetocin, a small molecular compound isolated from the marine fungus, exerts potent anticancer effects on esophageal squamous carcinoma (ESCC) cells. The anticancer effects of chaetocin are mediated by inhibiting cell proliferation through cell cycle arrest and activating the caspase-dependent apoptosis signaling pathway. Chaetocin also induces accumulation of cellular reactive oxygen species (ROS) and triggers the activation of the Hippo pathway in ESCC cells, leading to decreased nuclear translocation of YAP.
Article
Pharmacology & Pharmacy
Zuoquan Zhu, Jiahang Song, Junjie Gu, Bing Xu, Xinchen Sun, Shu Zhang
Summary: FL enhances the radioresistance of esophageal squamous cell carcinoma cells through promoting clone formation, increasing EdU incorporation, enhancing DNA damage repair, and inhibiting apoptosis. The significantly increased expression of Flt-3 receptor in ESCC cells after radiation may play a key role in their radioresistance.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tianxiao Wang, Pengying Zhang, Lu Chen, Huijie Qi, Haifei Chen, Yongjun Zhu, Liudi Zhang, Mingkang Zhong, Xiaojin Shi, Qunyi Li
Summary: This study found that ixazomib can effectively inhibit the proliferation and induce apoptosis of esophageal squamous cell carcinoma cells, making it a potential new strategy for the treatment of the disease.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yaxin Sun, Beibei Sha, Wenjing Huang, Miaomiao Li, Shan Zhao, Yuan Zhang, Jie Yan, Zheng Li, Jingwen Tang, Peiyan Duan, Jianxiang Shi, Pei Li, Tao Hu, Ping Chen
Summary: This study demonstrates the cytotoxic effect of ML323 on esophageal squamous cell carcinoma (ESCC) cells and elucidates its underlying mechanisms. ML323 inhibits the growth of ESCC cells by blocking the cell cycle, inducing DNA damage, and triggering apoptosis through the p53-Noxa pathway. Additionally, ML323 stimulates autophagy in cells, and co-treatment with autophagy inhibitors enhances its cytotoxicity.
Article
Oncology
Zhirui Fan, Yuanyuan Zheng, Xiaoli Li, Xiaoming Deng, Yan Ba, Kun Feng, Jin Su, Hui Wang, Zhenhe Suo, Lifeng Li
Summary: Pentraxin 3 (PTX3) plays an important role in esophageal carcinoma (ESCA) by affecting cell proliferation, migration, and sensitivity to chemotherapy and radiotherapy. Knockout of the PTX3 gene increases these cellular behaviors, while overexpression of PTX3 reduces them. Additionally, PTX3 knockout leads to decreased glycolysis and increased oxidative phosphorylation in cells, consistent with other findings.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaojun Zhang, Mengtao Xing, Yangcheng Ma, Zhuangli Zhang, Cuipeng Qiu, Xiao Wang, Zhihong Zhao, Zhenyu Ji, Jian-Ying Zhang
Summary: This study investigated the anticancer mechanism of oridonin on esophageal squamous cell carcinoma using proteomics. The results showed that oridonin induced apoptosis in ESCC cells by decreasing the protein expression of LASP1 and PDLIM1.
Article
Cell Biology
Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Chen
Summary: This study explores the role of USP8 inhibitor, DUB-IN-1, in esophageal squamous cell carcinoma (ESCC) cells. The results show that USP8 levels are higher in ESCC tissues compared to adjacent tissues. DUB-IN-1 induces DNA damage, G2/M phase block, and apoptosis through the p53 pathway. In addition, it stimulates autophagy through p53-dependent AMPK activation. These findings suggest that DUB-IN-1 may be a potential novel inhibitor for targeting USP8 in ESCC cells.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M. Hoffman, Yanmei Zhang, Lijun Jia
Summary: The study illustrated the significant growth inhibition of esophageal squamous cell carcinoma (ESCC) by fangchinoline (FCL) through inducing cell cycle arrest and activating apoptosis pathways. FCL demonstrated its potential as an anti-ESCC agent by elucidating its tumor-suppressive efficacy and mechanisms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Wenfeng Lu, Yun Dong, Qing Cui, Yuhan Wang, Xiwen Yang, Xiaoyue Cai, Ming Zhang
Summary: This study found that citron kinase (CIT) is highly expressed in esophageal squamous cell carcinoma (ESCC) tissues and knockdown of CIT can inhibit cell proliferation and promote apoptosis, as well as reduce tumorigenicity in vivo. Microarray and IPA analysis revealed that CIT interacts with PRKAA1, SQSTM1, and IL6, and upregulation of PRKAA1 and SQSTM1 and downregulation of IL6 can contribute to ESCC development. This suggests that CIT may serve as a promising therapeutic target for ESCC.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li, Lianghai Wang
Summary: DLEU1 is highly expressed in ESCC tissues and its upregulation is associated with worse prognosis. DLEU1 promotes tumor growth by inhibiting cell apoptosis and stabilizes DYNLL1 by interfering with RNF114-mediated ubiquitination and proteasomal degradation. Additionally, DLEU1 upregulation may be facilitated by promoter hypomethylation. Targeting DLEU1 may enhance sensitivity of ESCC cells to cisplatin-induced death.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yajie Zhao, Chunrui Pu, Zhenzhen Liu
Summary: This study found that the SLC7A5 to SLC7A8 Ratio (SSR) score is correlated with EAAs metabolism in breast cancer (BC), and high EAAs metabolism is associated with poor prognosis and immune suppression in BC.
Article
Oncology
Liulu Zhang, Zhi-Yong Wu, Jie Li, Ying Lin, Zhenzhen Liu, Yin Cao, Gangling Zhang, Hong-Fei Gao, Mei Yang, Ci-Qiu Yang, Teng Zhu, Min-Yi Cheng, Fei Ji, Jieqing Li, Kun Wang
Summary: In a randomized controlled trial, it was found that the addition of carboplatin to neoadjuvant chemotherapy significantly improved the pathologic complete response rate in patients with untreated stage II-III TNBC compared to anthracycline-based regimens. Despite the different treatment protocols, overall survival and event-free survival rates were comparable between the two groups after a 37-month follow-up period.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Min Yan, Quchang Ouyang, Tao Sun, Limin Niu, Jin Yang, Li Li, Yuhua Song, Chunfang Hao, Zhanhong Chen, Armando Orlandi, Naohiro Ishii, Kazuaki Takabe, Gianluca Franceschini, Francesco Ricci, Claire Verschraegen, Zhenzhen Liu, Mengwei Zhang, Huimin Lv, Liping Liu, Xiaohong Yang, Huawu Xiao, Zhichao Gao, Xiaorui Li, Fangyuan Dong, Xiuchun Chen, Jianghua Qiao, Guifang Zhang
Summary: This study investigated the activity and safety of pyrotinib plus capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases. The combination therapy showed a high intracranial objective response rate in patients who had not received radiotherapy and had acceptable safety profiles.
Article
Surgery
Tong Ren, Xuhui Guo, Jingyang Zhang, Zhenzhen Liu
Summary: Female breast cancer (BC) is the most common cancer in the world, with higher mortality in transitioning countries. Pyroptosis, a form of inflammation-dependent programmed cell death, plays an important role in the progression of BC. This study used comprehensive bioinformatics analysis to investigate the expression of pyroptosis-related genes in BC and their relationship with tumor progression. Pyroptosis-related genes may serve as new prognostic biomarkers and therapeutic targets for BC.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Guangshi Du, Jian Sun, Zhen Li, Qian Zhang, Wenjing Liu, Chuanyu Yang, Ping Zhao, Xinye Wang, Qiyan Yin, Yao Luo, Jinhuan Song, Yi Wen, Haixia Wang, Chuan-Huizi Chen, Guosheng Hu, Zhongmei Zhou, Xiaoyun Mao, Wen Liu, Zhenzhen Liu, Dewei Jiang, Ceshi Chen
Summary: This study identifies the promoting role of KPRT4 in BLBC cell proliferation and reveals the underlying mechanism of mutual regulation between KLF5 and KPRT4. Additionally, the study finds that targeting KPRT4 can attenuate tumor growth, suggesting KPRT4 as a major molecule for BLBC progression.
Article
Multidisciplinary Sciences
Mingda Zhu, Jingyang Zhang, Guangyu Li, Zhenzhen Liu
Summary: A key enhancer RNA region (ELOVL2-AS1) in breast cancer (BRCA) was identified through integrated analysis, which showed a direct regulatory interaction with ELOVL2 gene and lower expression in triple negative breast cancer (TNBC).
Article
Oncology
Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu
Summary: This study identified differentially expressed genes in DCIS and normal tissue and validated a six-core gene signature with potential for prognostic prediction in DCIS.
Article
Oncology
Dechuang Jiao, Youzhao Ma, Jiujun Zhu, Hao Dai, Yue Yang, Yajie Zhao, Xuhui Guo, Zhenzhen Liu
Summary: This study found that marital status is an independent prognostic factor for invasive breast cancer patients. Married patients have better survival rates compared to unmarried patients. Additional psychosocial and emotional support may be necessary for unmarried patients aged 35 and above in order to achieve longer survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dechuang Jiao, Benlong Yang, Jiajian Chen, Chunjian Wang, Lidan Jin, Wenhe Zhao, Xueqiang Gao, Haibo Wang, Jun Li, Haidong Zhao, Di Wu, Zhimin Fan, Shujun Wang, Zhenzhen Liu, Yongsheng Wang, Jiong Wu
Summary: This study evaluated the efficacy and safety of Mitoxantrone hydrochloride injection for tracing (MHI) in sentinel lymph node biopsy (SLNB) for breast cancer. The results showed that MHI has comparable efficacy to radionuclides and can be used alone or in combination with radioactive substances for SLNB.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xin Zhao, Liang Jin, Yujie Liu, Zhenzhen Liu, Qiang Liu
Summary: This study using bioinformatics analysis found that increased expression levels of SLC-related glutamine transporters were associated with poor prognosis in breast cancer patients, while decreased expression levels of SLC6A14 and SLC38A1 were also associated with poor prognosis. Additionally, these SLC-related proteins may regulate the polarization of tumor-associated macrophages.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jiujun Zhu, Dechuang Jiao, Chengzheng Wang, Zhenduo Lu, Xiuchun Chen, Lianfang Li, Xianfu Sun, Li Qin, Xuhui Guo, Chongjian Zhang, Jianghua Qiao, Min Yan, Shude Cui, Zhenzhen Liu
Summary: According to this study, the TCH + Py regimen has a higher pCR rate compared to the TCH regimen in neoadjuvant therapy for HER2-positive breast cancer, and a comparable pCR rate with the TCHP regimen.
Article
Surgery
Junzhao Wu, Minhao Lv, Peng Yuan, Youzhao Ma, Peiqi Tian, Lianfang Li, Chengzheng Wang, Zhenduo Lu, Min Yan, Xiuchun Chen, Zhenzhen Liu
Summary: This study found that patients with T1a,bN0M0 triple-negative breast cancer had a good prognosis with or without adjuvant chemotherapy after local therapy. Higher histologic grade and larger tumor size were associated with poorer prognosis, while the effect of age was complex. The data did not support the use of adjuvant chemotherapy in these patients.
Article
Genetics & Heredity
Shuochuan Liu, Yajie Zhao, Jiao Zhang, Zhenzhen Liu
Summary: Ferroptosis plays an important role in breast cancer, but its exploration is limited. In this study, a model related to ferroptosis activation was established using machine learning and validated to have a good prognostic capacity in breast cancer patients, providing insights into clinical treatment and preventing potential drug resistance. Furthermore, analysis of the tumor microenvironment revealed differences between high- and low-risk groups, offering molecular insights into ferroptosis in breast cancer patients.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Oncology
Youzhao Ma, Mingda Zhu, Minhao Lv, Peng Yuan, Xiuchun Chen, Zhenzhen Liu
Summary: This study aimed to determine the changes in prognostic factors following neoadjuvant therapy for HER2-positive breast cancer and the impact of clinicopathological characteristics of residual disease on prognosis. The results showed significant changes in HER2, ER, PR, and Ki-67 after neoadjuvant therapy, but these changes did not affect disease-free survival. Postoperative N stage, postoperative ER status, Miller-Payne grade, and targeted therapy were identified as independent prognostic factors for HER2-positive breast cancer after neoadjuvant therapy.
Article
Oncology
Youzhao Ma, Dechuang Jiao, Jingyang Zhang, Minhao Lv, Xiuchun Chen, Zhenzhen Liu
Summary: This study investigated the clinicopathological and prognostic characteristics of HER2-low status in a large sample of early-stage triple-negative breast cancer datasets. The findings suggest that HER2-low breast cancer is associated with better breast cancer-specific survival, especially in high-risk groups.