Article
Biochemistry & Molecular Biology
Malini Rethnam, Darren Qiancheng Tan, Toshio Suda
Summary: Multiple myeloma (MM) has been shown to modulate mesenchymal stem cells (MSCs) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) plays a role in preventing MM cell migration. The study highlights the previously unreported role of the TAB1-TIMP-1 axis in the context of the MM bone marrow niche.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cell Biology
Chunfeng Xu, Mingjie Wang, Behrouz Zandieh-Doulabi, Wei Sun, Lingfei Wei, Yuelian Liu
Summary: BMP-2, while potentially useful in repairing bone defects after OS resection, has limited application due to concerns about its tumorigenicity. Studies are focusing on understanding the impact of BMSCs' response to BMP-2 on OS development to pave the way for safer and broader clinical use of BMP-2 in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
M. C. Sanmartin, F. R. Borzone, M. B. Giorello, N. Pacienza, G. Yannarelli, N. A. Chasseing
Summary: Breast cancer, a common pathology in women, often leads to bone metastases with high mortality. Research shows that breast cancer cells prepare a pre-metastatic niche for colonization in the future. While the role of different cellular components in bone metastasis is well described, studying the changes in the microenvironment before tumor cells arrive is a novel field of research.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Osama M. Ahmed, Ablaa S. Saleh, Eman A. Ahmed, Mohammed M. Ghoneim, Hasnaa Ali Ebrahim, Mohamed A. Abdelgawad, Mohammed Abdel-Gabbar
Summary: This study aimed to evaluate the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) and hesperetin in treating a rat model of Type 1 diabetes mellitus (T1DM). The results showed that the use of hesperetin and BM-MSCs significantly improved glycemic control, insulin secretion, and pancreatic islet architecture, as well as decreased hepatic glucose output in diabetic rats. These effects may be mediated through their antioxidant, anti-inflammatory, and antiapoptotic actions.
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Feng Wang, Lingchi Kong, Wenbo Wang, Li Shi, Mengwei Wang, Yimin Chai, Jia Xu, Qinglin Kang
Summary: The study demonstrates that ADM2 enhances diabetic bone regeneration by attenuating imbalances in macrophage polarization induced by AGEs, partly through the PPARγ/NF-κB signaling pathway, and by improving AGE-impaired osteogenic differentiation of BMSCs simultaneously.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Gulen Guney-Esken, Ozgur Dogus Erol, Burcu Pervin, Gulben Gurhan Sevinc, Tamer Onder, Elif Bilgic, Petek Korkusuz, Aysen Gunel-Ozcan, Duygu Uckan-Cetinkaya, Fatima Aerts-Kaya
Summary: GS-2 is a rare autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene. This study successfully generated iPSC from 3 GS-2 patients using lentiviral vectors, which expressed pluripotency markers and differentiated into cells from all three germ layers. The iPSCs can be used for future studies on novel treatments and the pathophysiology of GS-2 disease.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Long Chen, Wei Luo, Yuanzheng Wang, Xiongbo Song, Senlei Li, Jun Wu, Li Sun
Summary: This study demonstrates that glycosylation modification enhances the directional homing ability of BMSCs to bone defect sites by enabling them to express high levels of sLe(X) antigen. Results show that glycosylation-modified BMSCs can improve the repair of bone defects in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Jinhong Lu, Dongfang Dai, Jiacheng Zhang, Rong Wang, Dengshun Miao, Weiwei Sun
Summary: Bone marrow mesenchymal stem cells (BMSCs) play a crucial role in the bone marrow microenvironment and are involved in the development of osteosarcoma (OS). Inhibiting mTORC2 signaling in BMSCs can suppress OS growth and tumor-induced bone destruction. Rictor-deficient BMSCs showed reduced proliferation and osteogenic differentiation, leading to alleviated bone destruction. Additionally, decreased secretion of cytokines related to OS cell growth, migration, invasion, and tumorigenic osteogenesis was observed in Rictor-deficient BMSCs.