Article
Oncology
Suna Zhou, Mingxin Zhang, Chao Zhou, Yinnan Meng, Haihua Yang, Wenguang Ye
Summary: Elevated expression of FLVCR1 in ESCC tissues is associated with poor survival and correlates with lymph node metastasis and late TNM stage. Knockdown of FLVCR1 inhibits cell proliferation and migration, and represses tumor growth and metastasis of ESCC cells in vivo. FLVCR1 interacts with CSE1L and plays a crucial role in ESCC cell survival, growth, and migration, making it a potential prognostic marker for ESCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xihui Chen, Shiwen Wang, Li Zhang, Shuying Yuan, Tong Xu, Feng Zhu, Yanmei Zhang, Lijun Jia
Summary: This study demonstrated for the first time that celastrol inhibits tumor growth of ESCC by inducing apoptosis through both extrinsic and intrinsic pathways. The mechanism involves the transcriptional activation of ATF4 and the involvement of the FoxO3a-Bim pathway. This highlights celastrol as a promising therapeutic strategy for ESCC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Shao-Feng Duan, Meng -Meng Zhang, Xin Zhang, Wei Liu, Shi-Hui Zhang, Bo Yang, Qian Dong, Ju-Guo Han, Hai-Lan Yu, Tao Li, Xin-Ying Ji, Dong-Dong Wu, Xiao-Ju Zhang
Summary: The novel conjugate HA-ADT, formed by connecting hyaluronic acid with a hydrogen sulfide donor, showed stronger inhibitory effects on the growth of esophageal squamous cell carcinoma compared to other H2S-releasing donors. HA-ADT promoted apoptosis and suppressed autophagy, suggesting its potential efficacy in cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Yong Fang, Jun Yin, Yaxing Shen, Hao Wang, Han Tang, Xiaosang Chen
Summary: In this study, it was found that circCDR1 regulates the progression of esophageal squamous cell cancer (ESCC) by acting as a sponge for miR-1290. CircCDR1 is low-expressed and negatively correlated with miR-1290 in ESCC. In both in vitro and in vivo experiments, circCDR1 inhibits proliferation, migration, and invasion of ESCC cells, while promoting apoptosis.
Article
Oncology
Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang, Dengke Bao
Summary: The study demonstrated that ivermectin significantly inhibits the proliferation of ESCC cells and induces apoptosis. Mechanistically, ivermectin induces mitochondrial dysfunction and apoptosis pathway, leading to apoptosis of ESCC cells.
Article
Oncology
Yuantao Cui, Ying Kang, Peng Zhang, Yuanguo Wang, Zhaoyu Yang, Chao Lu
Summary: The study found that the expression of Mig-6 protein was lower in ESCC tissues compared to normal esophageal epithelial tissues, and Mig-6 could restrain the growth of ESCC cells and induce cell apoptosis. PPAR, CAMs, and MAPK signaling pathways might be involved.
Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Review
Cell Biology
Yanguo Xin, Junli Li, Wenchao Wu, Xiaojing Liu
Summary: Cell proliferation is an essential cellular process for tissue maintenance and remodeling. Mitofusin-2 (Mfn-2) plays a crucial role in regulating cell proliferation by maintaining mitochondrial network and bioenergetics, making it a potential therapeutic target for pathological cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Changjin Lin, Yujun Wei, Xinchun Duan, Chunquan Liu, Yanlin Du, Xiaoran Wang, Yi Luo, Yong Cui
Summary: This study uncovered a novel molecular pathway in ESCC progression, which might provide potential biomarkers for ESCC diagnosis.
MOLECULAR CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Man Zhang, Xianzeng Wang, Cong Liu, Zhaoyang Zheng, Junhu Wan, Ying Yang, Shuangshuang Chen, Hongchun Liu
Summary: This study identified the dysregulation of GTSE1, a molecule involved in cell cycle regulation, in esophageal squamous cell carcinoma (ESCC). The study demonstrated that GTSE1 induces chromosomal instability and cellular oxidative stress in ESCC cells, leading to tumor development.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
M. Constanza Camargo, Minkyo Song, Hidemi Ito, Isao Oze, Yuriko N. Koyanagi, Yumiko Kasugai, Charles S. Rabkin, Keitaro Matsuo
Summary: This study examined circulating levels of inflammation- and immune-related proteins for associations with Esophageal Squamous Cell Carcinoma (ESCC). The results identified several inflammatory and immune molecules significantly associated with ESCC, suggesting the need for further replication and functional characterization.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Li, Riyue Feng, Yang Li, Xiao Yu, Yuhao Liu, Yahui Zhao, Zhihua Liu
Summary: This study identified that mutant caspase-8 exerts tumor-promoting properties and is associated with a worse prognosis in esophageal squamous cell carcinoma (ESCC). Mutant caspase-8 loses its inhibitory effect on tumor growth and gains a new function of protecting against oxidative stress via the mTOR/SQSTM1/Keap1/Nrf2 axis. Caspase-8 status may serve as a new prognostic factor for survival in ESCC patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Bo Liu, Xu Li, Jinbao Xie, Zhi Feng, Nanlong Lin, Minjie Yu
Summary: This study found that NRON may promote the development of cisplatin resistance in esophageal squamous cell carcinoma (ESCC) by downregulating the expression of miR-31.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxiong Xiao, Lei Jiang, Huoli Hu, Yunhe Huang, Lun Yang, Yang Jiao, Guangxia Wei
Summary: UAP1L1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its increased expression correlates with disease progression. Knockdown of UAP1L1 inhibits ESCC development by inducing apoptosis through the regulation of apoptosis-related proteins. Additionally, UAP1L1 promotes ESCC progression by affecting the PI3K/Akt, CCND1, and MAPK pathways.
MOLECULAR CARCINOGENESIS
(2021)
Article
Cell Biology
Tuo Zhang, Haitang Ang, Beibei Sun, Feng Yao
Summary: This study identified hub genes regulating tumor infiltration by immune cells and antitumor immunity in lung squamous cell carcinoma (LUSC) through bioinformatics analyses. It also discovered different immune subgroups in LUSC tissues based on ssGSEA and ESTIMATE analyses, showing significant differences in tumor purity.
Article
Cardiac & Cardiovascular Systems
Lei Zhao, Yang Zhao, Jin-Dong Guo, Ya Zeng, Feng Yao, Mi-Na Liu, Jia-Ming Wang, Chang-Xing Lv, Jun Liu, Xiao-Long Fu, Heng Zhao, Xu-Wei Cai
Summary: For patients with tracheobronchial ACC and microscopic positive surgical margins, postoperative radiotherapy (PORT) can help achieve similar outcomes as patients with complete resection.
ANNALS OF THORACIC SURGERY
(2021)
Letter
Oncology
Haitang Yang, Sean R. R. Hall, Beibei Sun, Feng Yao
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P. Zhou, Shu-Hai Lin, Jiong Deng
Summary: SLC1A1, a glutamate transporter, plays a crucial role in cystine uptake and GSH biosynthesis in lung cancer cells, impacting tumor development. Dysregulated SLC1A1 enhances cystine uptake, while depletion inhibits it, leading to oxidative stress-induced cell death or growth inhibition. Glutamate transporters provide additional therapeutic targets for cancer treatment beyond Xc(-) regulation.
Review
Oncology
Haitang Yang, Feng Yao, Paul F. Davis, Swee T. Tan, Sean R. R. Hall
Summary: The review highlights the association between CD73 expression and features of cellular plasticity in solid tumors, as well as the potential for CD73 to serve as a biomarker for identifying patients who may respond to targeted therapies.
Article
Respiratory System
Hao Wang, Zhexin Wang, Mengmeng Zhou, Jindong Chen, Feng Yao, Liang Zhao, Ben He
Summary: This study revealed a high incidence of post-pneumonectomy atrial fibrillation, with significant risk factors such as age over 60 years and left atrial diameter over 35 mm. POAF, along with infection and hemorrhage, may contribute to perioperative death.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Oncology
Haitang Yang, Sean R. R. Hall, Beibei Sun, Liang Zhao, Yanyun Gao, Ralph A. Schmid, Swee T. Tan, Ren-Wang Peng, Feng Yao
Summary: The study revealed that loss-of-function in the upstream regulator NF2 of the Hippo pathway is associated with aberrant activation of Hippo-YAP-independent signaling, defining distinct MPM subsets with different molecular features and prognosis. This has important clinical implications for precision oncology in MPM patients.
Article
Oncology
Tuo Zhang, Beibei Sun, Chenxi Zhong, Ke Xu, Zhexin Wang, Paul Hofman, Tatsuya Nagano, Antoine Legras, Biagio Ricciuti, Daniel Breadner, Duilio Divisi, Ralph A. Schmid, Ren-Wang Peng, Haitang Yang, Feng Yao
Summary: Ferroptosis inducers show high sensitivity in EGFR mutant lung cancer cells with resistance, while the histone deacetylase inhibitor Vorinostat can enhance the efficacy of ferroptosis inducers.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Haitang Yang, Mohammad Faisal Al-Hurani, Jianlin Xu, Liwen Fan, Ralph A. Schmid, Heng Zhao, Feng Yao
Summary: Prophylactic cranial irradiation provides survival benefits for SCLC patients with pN1 after surgery but not with pathological N0/N2 stage. Our findings may provide helpful stratifications for clinical decision-making of prophylactic cranial irradiation intervention in SCLC patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Pathology
Ruiying Zhao, Feng Yao, Chan Xiang, Jikai Zhao, Zhanxian Shang, Lianying Guo, Wenjie Ding, Shengji Ma, Anbo Yu, Jinchen Shao, Lei Zhu, Yuchen Han
Summary: Functional NTRK fusions are rare but present in early-stage LUAD. They are independent oncogenic drivers and mutually exclusive with other driver mutations. NTRK rearrangement analysis should be verified with an RNA-based assay.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2021)
Article
Oncology
Huijing Yin, Bo Jing, Dongliang Xu, Wenzheng Guo, Beibei Sun, Jie Zhang, Yueling Liao, Hongyong Song, Tong Wang, Shuli Liu, Yanbin Kuang, Min Hu, Kaimi Li, Siwei Zhang, Hongjia Zhang, Jianhua Xu, Xue Li, Jing Du, Yadi Wu, Yingli Wu, Qi Wang, Feng Yao, Yueh Eugene Chin, Binhua P. Zhou, Jiong Deng
Summary: The deletion of Gprc5a gene increases susceptibility to lung cancer, with the dysregulation of EGFR and NF-kappa B signaling pathways activating the expansion of active bronchioalveolar stem cells (BASC), which become the cell of origin for lung adenocarcinoma.
Letter
Oncology
Haitang Yang, Feng Yao, Ren-Wang Peng
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Haitang Yang, Beibei Sun, Wenyan Ma, Liwen Fan, Ke Xu, Yunxuan Jia, Jianlin Xu, Zhexin Wang, Feng Yao
Summary: By studying the response of metastatic lymph nodes and primary tumors in lung cancer patients treated with immune checkpoint inhibitors, we found significant differences in radiological, metabolic, and pathological changes between the two. The presence of invaded lymph nodes was associated with poor pathological responses in primary tumors and predicted rapid tumor relapse after treatment.
Article
Medicine, Research & Experimental
Yunfei He, Wenqian Luo, Yingjie Liu, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Yu-Shui Ma, Haitang Yang, Ke Xu, Xue Zhang, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Da Fu, Feng Yao, Guohong Hu
Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Haitang Yang, Beibei Sun, Liwen Fan, Wenyan Ma, Ke Xu, Sean R. R. Hall, Zhexin Wang, Ralph A. Schmid, Ren-Wang Peng, Thomas M. Marti, Wen Gao, Jianlin Xu, Weiwei Yang, Feng Yao
Summary: In this study, we identified a specific cancer-associated fibroblast subset in lung adenocarcinoma patients that promotes an aggressive phenotype. We found that THBS2 is a biomarker that can predict post-surgical survival and is exclusively derived from this fibroblast subset.
