期刊
MOLECULAR CARCINOGENESIS
卷 51, 期 11, 页码 861-868出版社
WILEY
DOI: 10.1002/mc.20854
关键词
breast cancer; IL-8; stromal cell; stem cell; tumor invasion; microarray
资金
- Department of Defense Breast Cancer Research Program [W81XWH-08-1-0523 01]
- Alliance of Cardiovascular Researchers
The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, alpha-smooth muscle actin and PDGFR-alpha migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion. (C) 2011 Wiley Periodicals, Inc.
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