Review
Biochemistry & Molecular Biology
Pinghan Wang, Fangyi Long, Hong Lin, Ting Wang
Summary: Breast cancer, accounting for 11.7% of all newly diagnosed cancer cases, has become the leading cause of cancer worldwide. Naturally occurring dietary phytochemical compounds, such as curcumin and resveratrol, are considered promising agents for breast cancer prevention. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key regulatory role in suppressing the accumulation of carcinogens, and its modulation by dietary phytochemicals appears to be a promising approach for breast cancer prevention.
Article
Cell Biology
Adilene Acosta-Casique, Jose B. Montes-Alvarado, Minuet Barragan, Karen A. Larrauri-Rodriguez, Andrea Perez-Gonzalez, Alam Delgado-Magallon, Lourdes Millan-Perez-Pena, Nora H. Rosas-Murrieta, Paola Maycotte
Summary: In this study, the researchers found that TNBC cell lines had increased ERK phosphorylation, which played an important role in cell migration. The increase in ERK phosphorylation upon antioxidant treatment suggested an enhanced invasive potential. Interestingly, MEK inhibitor PD0325901 (PD) treatment reduced ROS levels and decreased mitochondrial fragmentation in TNBC cells, indicating the important role of MEK/ERK in regulating cellular migration, mitochondrial dynamics, and ROS production in this breast cancer subtype.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Adilene Acosta-Casique, Jose B. Montes-Alvarado, Minuet Barragan, Karen A. Larrauri-Rodriguez, Andrea Perez-Gonzalez, Alam Delgado-Magallon, Lourdes Millan-Perez-Pena, Nora H. Rosas-Murrieta, Paola Maycotte
Summary: In this study, we observed increased ERK phosphorylation in TNBC cell lines, indicating a crucial role for ERK in sustaining TNBC cell migration. Additionally, antioxidant treatment paradoxically increased ERK phosphorylation, suggesting a potential link between increased invasion and ROS production. Interestingly, treatment with a MEK inhibitor decreased ROS levels and mitochondrial fragmentation in TNBC cells, highlighting the involvement of MEK/ERK in regulating migration, mitochondrial dynamics, and ROS production in this breast cancer subtype.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Multidisciplinary
Chang Min Lee, Jongsung Lee, Mi-Ae Kang, Hee Taek Kim, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, See-Hyoung Park
Summary: Linifanib has been shown to efficiently inhibit receptor tyrosine kinases, and in this study, its anti-cancer effects in ovarian cancer were investigated. Linifanib was found to inhibit proliferation and induce apoptosis in SKOV3 cells, as well as cause DNA damage and increase intracellular ROS levels.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Mohd Farhan, Asim Rizvi, Ferasat Ali, Aamir Ahmad, Mohammad Aatif, Arshi Malik, Mir Waqas Alam, Ghazala Muteeb, Saheem Ahmad, Awal Noor, Farhan Asif Siddiqui
Summary: Anthocyanidins can induce DNA damage and inhibit cell proliferation in cancer cells by reacting with intracellular copper. Copper supplementation increases the sensitivity of normal cells to anthocyanidins and decreases cell proliferation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Robert B. Rosenblatt, Joseph A. Frank, Scott R. Burks
Summary: The study found that non-ablative pulsed focused ultrasound (pFUS) directly induces DNA damage in various tumor cell types by triggering superoxide and subsequent H2O2 formation through cytosolic calcium transients. These results support the potential clinical utility of pFUS.
Review
Biochemistry & Molecular Biology
Yedi Herdiana, Sriwidodo Sriwidodo, Ferry Ferdiansyah Sofian, Gofarana Wilar, Ajeng Diantini
Summary: Breast cancer is characterized by oxidative stress, which is an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. ROS is involved in BC development and progression by causing DNA damage, inflammation, and angiogenesis. Plants contain antioxidants that regulate stress signaling and programmed cell death (PCD) in BC. Combining different antioxidants shows promise in enhancing BC treatment effectiveness. Antioxidant nanoparticles effectively target breast cancer cells, induce PCD, and sensitize them to chemotherapy. This review explores how nanotechnology can modulate stress signaling and PCD in breast cancer.
Article
Toxicology
Carlos Angele-Martinez, Fathima S. Ameer, Yash S. Raval, Guohui Huang, Tzuen-Rong J. Tzeng, Jeffrey N. Anker, Julia L. Brumaghim
Summary: Polyphenolic antioxidants have varying effects on preventing DNA damage and cytotoxicity induced by (CuO)-Cu-NP and H2O2, with some being protective, some having no effect, and some even increasing DNA damage. Additionally, polyphenols can modulate levels of reactive oxygen species (ROS) generated, and protect DNA under oxidative stress conditions.
TOXICOLOGY IN VITRO
(2022)
Article
Biochemistry & Molecular Biology
Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang
Summary: The study confirmed that mitochondria are the main source of ROS induced by 6c, leading to mitochondrial dysfunction and lysosomal destabilization. Moreover, ROS regulated the expression of 6c-mediated proteins, promoted the formation of autophagosomes, and caused DNA damage, ultimately resulting in cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shan Zhang, Yue Zhao, Xueqi Wang, Ce Qi, Jialiang Tian, Zhihua Zou
Summary: In this study, we investigated the synergistic anticancer effect between ATR inhibition and oxidative DNA damage induced by the thioredoxin reductase inhibitor auranofin. Our findings suggest that auranofin can induce oxidative DNA damage selectively in cancer cells by increasing reactive oxygen species (ROS) levels, which leads to activation of the ATR DNA damage response pathway. Inhibition of ATR in auranofin-treated cancer cells results in replication catastrophe and potent synergistic lethality.
Article
Pharmacology & Pharmacy
Rahul Checker, H. N. Bhilwade, Shivani R. Nandha, Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur
Summary: A plant compound called Withaferin A (WA) has been found to protect normal lymphocytes from radiation-induced apoptosis, demonstrating its radioprotective potential. WA inhibits caspase-3 activation, reduces DNA damage, and decreases intracellular ROS and GSH levels. It also induces the expression of cytoprotective genes via the ERK pathway. Animal experiments further confirm the radioprotective efficacy of WA. Overall, this study highlights that WA selectively protects normal cells from radiation-induced apoptosis through the activation of the cytoprotective Nrf-2 pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Birandra K. Sinha, Erik J. Tokar, Carl D. Bortner
Summary: NCX4040 exhibits cytotoxicity against ovarian tumor cells and induces apoptosis and oxidative stress. Sensitivity to NCX4040 and DNA damage repair efficiency vary among different cell lines, and the cytotoxicity may be mediated by peroxynitrite.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Kuiyang Zuo, Qi Xu, Yujie Wang, Yutong Sui, Ye Niu, Zinan Liu, Mingsheng Liu, Xinpeng Liu, Dan Liu, Wei Sun, Ziyu Wang, Xiaomei Liu, Jinyu Liu
Summary: Methylmercury (MeHg) is a toxic substance that causes oxidative damage to neurons. Vitamin C, a well-known antioxidant, can protect neurons from oxidative damage. In this study, we found that supplementation with L-ascorbic acid 2-phosphate (AA2P) could attenuate MeHg-induced apoptosis by reducing reactive oxygen species (ROS)-mediated DNA damage. AA2P also increased cell viability and decreased MeHg-induced apoptosis. Furthermore, it regulated gene expression in a contrary manner compared to MeHg. This study suggests that AA2P may be a potential treatment for MeHg neurotoxicity.
Review
Plant Sciences
Dandan Huang, Guangqin Jing, Lili Zhang, Changbao Chen, Shuhua Zhu
Summary: NO, H2S, and ROS play essential signaling roles in cells through oxidative post-translational modification within suitable ranges of concentration to maintain redox balance and regulate DNA repair pathways, including mtDNA. The interactions among them are intricate, influencing their generation, elimination, and signaling actions. Additionally, NO and H2S may be involved in epigenetic variations in DNA damage repair of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Cell Biology
Chia-Hung Chien, Wei-Ting Hsueh, Jian-Ying Chuang, Kwang-Yu Chang
Summary: Glioblastoma is considered fatal due to its development of resistance, with temozolomide being effective in disease control but recurrence eventually occurring. The main factor determining drug susceptibility is aberrations in O-6-methylguanine-DNA methyltransferase, while alterations in other DNA repair genes also impact drug effect. Recent identification of specific cellular subsets with features of stem-like cells may play a role in evading cancer treatment.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lenora Ann Pluchino, Amethyst Kar-Yin Liu, Hwa-Chain Robert Wang
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Review
Microbiology
Jun-Da Zhu, Wen Meng, Xiao-Jia Wang, Hwa-Chain R. Wang
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Oncology
Lenora Ann Pluchino, Shambhunath Choudhary, Hwa-Chain Robert Wang
Article
Radiology, Nuclear Medicine & Medical Imaging
Bincy Anu John, Tingting Xu, Steven Ripp, Hwa-Chain Robert Wang
MOLECULAR IMAGING AND BIOLOGY
(2017)
Article
Virology
Wen Meng, Shi-Chong Han, Cui-Cui Li, Hui-Jun Dong, Jian-Yu Chang, Hwa-Chain Robert Wang, Xiao-Jia Wang
Article
Environmental Sciences
Abdul-Fattah Salah Fararjeh, Shih-Hsin Tu, Li-Ching Chen, Tzu-Chun Cheng, Yun-Ru Liu, Hang-Lung Chang, Hui-Wen Chang, Chi-Cheng Huang, Hwa-Chain Robert Wang, Wendy W. Hwang-Verslues, Chih-Hsiung Wu, Yuan-Soon Ho
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shambhunath Choudhary, Shilpa Sood, Hwa-Chain Robert Wang
MOLECULAR CARCINOGENESIS
(2014)
Article
Multidisciplinary Sciences
Lenora Ann Pluchino, Hwa-Chain Robert Wang
Review
Microbiology
Wen Meng, Xiao-Jia Wang, Hwa-Chain Robert Wang
CRITICAL REVIEWS IN MICROBIOLOGY
(2019)
Article
Oncology
Yan-Hong Yong, Ping Wang, Ru-Min Jia, Ravi Gooneratne, Hwa-Chain Robert Wang, Ming Liao, Xiang-Hong Ju
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)
Review
Pharmacology & Pharmacy
Cui-Cui Li, Xiao-Jia Wang, Hwa-Chain Robert Wang
DRUG DISCOVERY TODAY
(2019)
Article
Oncology
Pawat Pattarawat, Shelby Wallace, Bianca Pfisterer, Agricola Odoi, Hwa-Chain Robert Wang
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Article
Oncology
Pawat Pattarawat, Hong Tian, Shelby Wallace, Hu Yanchun, Robert Donnell, Wang Tzu-Hao, Tsai Chia-Lung, Wang Jinquan, Hwa-Chain Robert Wang
BRITISH JOURNAL OF CANCER
(2020)
Article
Oncology
Pawat Pattarawat, Jessica T. Hunt, Jacob Poloway, Collin J. Archibald, Hwa-Chain Robert Wang
Summary: The study demonstrated the efficacy of gemcitabine plus romidepsin + cisplatin regimen in controlling TNBC tumor development, recurrence, and metastasis in animal models, showing significant inhibition effects in reducing tumor growth and metastatic nodules.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Meeting Abstract
Oncology
Hwa-Chain Robert Wang, Lenora Ann Pluchino
ANTICANCER RESEARCH
(2014)