Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Jing-Zhou Li, Xiao-Xia Zhou, Wei-Yin Wu, Hai-Feng Qiang, Guo-Sheng Xiao, Yan Wang, Gang Li
Summary: This study investigated the angiogenic role of Con A in endothelial cells and ischaemic hind-limb mice. Con A promoted tube formation and increased the secretion of angiogenic factors. It also enhanced cell viability and regulated cell cycle progression. The effects of Con A were mediated by the activation of the PI3K and MEK pathways. Additionally, Con A exhibited a repair effect in ischaemic hind-limb mice.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Alessandro Certelli, Paolo Valente, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Rosalinda D'Amico, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: In diabetic mouse skin, controlled co-delivery of TG-VEGF and TG-PDGF-BB recombinant proteins effectively induces angiogenesis and arteriogenesis, with similar efficacy to normal littermate control mice at therapeutically relevant doses. This approach also prevents abnormal vascular enlargement caused by high TG-VEGF levels and promotes effective arteriogenesis in the dermal layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pengcheng Zhang, Weijia Yan, Hong Yan
Summary: The changes in vitreous body after vitreous hemorrhage were observed in this study. It was found that the changes were relatively minor earlier (2-4 weeks), but irreversible later. Specifically, the degree of liquefaction increased with a decrease in viscosity, and the chemotaxis of macrophages and bFGF induction led to incomplete posterior vitreous detachment.
Review
Oncology
Fatema Tuz Zahra, Md. Sanaullah Sajib, Constantinos M. Mikelis
Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.
Article
Cell & Tissue Engineering
Rosalinda D'Amico, Camilla Malucelli, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: Chronic wounds in type-2 diabetic patients often have severe local skin ischemia despite normal blood flow. By using fibrin hydrogels decorated with engineered growth factors, wound closure and microvascular growth can be promoted.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Cell Biology
Fan Wang, CaiYan Li, Fei Han, LvAn Chen, Ling Zhu
Summary: The BMAL1 gene plays a crucial role in glioma tolerance for anti-angiogenesis therapy, as its expression is correlated with ANG2 and VEGF levels, microvascular density, and peritumoral edema. In vitro experiments show that silencing BMAL1 decreases VEGF expression, while overexpression promotes ANG2 and VEGF expression.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Biology
Klaudia Petrova, Miriam Backorova, Zuzana Demcisakova, Eva Petrovova, Michal Goga, Maria Vilkova, Richard Frenak, Martin Backor, Jan Mojzis, Martin Kello
Summary: In this study, the anti-angiogenic activities of usnic acid, a secondary metabolite isolated from Usena antarctica, were evaluated. The results showed that usnic acid inhibited the proliferation, migration, and tube formation of VEGF- and bFGF-stimulated HUVECs in vitro. The ex ovo CAM assay confirmed the inhibitory effects of usnic acid on vessel formation induced by VEGF and bFGF.
Article
Cell Biology
Hiroyuki Ogawa, Kosuke Kaji, Norihisa Nishimura, Hirotetsu Takagi, Koji Ishida, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Summary: Lenvatinib shows potential as a novel therapeutic strategy for liver fibrosis by inhibiting hepatic stellate cell proliferation and promoting apoptosis, as well as reducing protein expression levels and intrahepatic neovascularization.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch
Summary: This study comprehensively analyzed the evolutionary relationships of PDGF/VEGF growth factors and proposed a phylogenetic tree. Whole-genome duplications in vertebrates contribute to the diversity of PDGF/VEGF, but limited duplications are necessary to explain the emergence pattern. The oldest phylogenetically PDGF/VEGF-like growth factor likely had a BR3P signature in the C-terminus, similar to modern lymphangiogenic growth factors. Some younger VEGF genes are absent in specific vertebrate clades, while PDGF/VEGF gene duplications frequently occur in fish on top of fish-specific whole-genome duplications.
Article
Biochemistry & Molecular Biology
Guenaelle Levallet, Fatemeh Dubois, Arthur Leclerc, Edwige Petit, Lien Bekaert, Maxime Faisant, Christian Creveuil, Evelyne Emery, Gerard Zalcman, Emmanuele Lechapt-Zalcman
Summary: This study demonstrates that changes in miRNA expression related to angiogenesis and hypoxia occur in patients with diffuse gliomas, and these miRNAs are correlated with histology/grade of gliomas and predict patient survival and progression-free survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Roberto Ria, Francesco Prete, Assunta Melaccio, Giovanna Di Meo, Ilaria Saltarella, Antonio G. Solimando, Angela Gurrado, Valentina Ferraro, Alessandro Pasculli, Lucia I. Sgaramella, Vito Racanelli, Angelo Vacca, Mario Testini
Summary: This study found that circulating angiogenic factors levels were significantly increased in patients with papillary thyroid carcinoma and benign multinodular goiter before surgery, and decreased after total thyroidectomy. Patients with papillary thyroid carcinomas showed a more significant decrease in levels after surgery.
Article
Gastroenterology & Hepatology
Zengjie Chi, Yanyun Lin, Juanni Huang, Min-Yi Lv, Junguo Chen, Xijie Chen, Bin Zhang, Yufeng Chen, Jiancong Hu, Xiaosheng He, Ping Lan
Summary: This study aimed to identify risk factors for the recurrence of colorectal polyps and its subtypes. It found that male gender, age, obesity, multiple polyps, smoking, alcohol consumption, and family history of polyps/CRC were associated with a higher risk of polyp recurrence. Additionally, it found that smoking, alcohol consumption, and family history of polyps/CRC were risk factors for adenoma recurrence but not for serrated polyp recurrence.
GASTROENTEROLOGY REPORT
(2022)
Article
Oncology
Biao Yang, Dong Liu, Ye-Qing Ren, Yan-Qi Sun, Jian-Ping Zhang, Xiao-Gang Wang, Yong-Qiang Wu, Shu-Le Wang, Shi-Hao Guo, Geng Guo
Summary: This study found that FRAT1 may promote VEGFA secretion and angiogenesis in human glioblastoma cells via the Wnt/beta-catenin signaling pathway, suggesting the potential therapeutic use of FRAT1 as a target in human glioblastoma.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Clinical Neurology
Wei Li, Ming Ye, Alexandru Cimpoca, Hans Henkes, Honglei Wang, Xiang Xu, Yuxiang Gu, Huaizhang Shi, Hongming Ji, Feng Wang, Yuanli Zhao, Geng Guo, Hongqi Zhang, Youxiang Li
Summary: This study aimed to compare the safety and efficacy of the Avenir® and Axium™ passive mechanically detachable coil systems for treating intracranial aneurysms. The results showed no significant differences in short-term efficacy or safety between the two coil systems.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Wenyan Guo, Xiaofeng Long, Mingyi Lv, Shuling Deng, Duping Liu, Qin Yang
Summary: This study found that TQ can alleviate sepsis-induced cardiac damage by modulating inflammation, apoptosis, oxidative stress, and the PI3K/AKT pathway.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Genetics & Heredity
Chuling Hu, Du Cai, Min-Er Zhong, Dejun Fan, Cheng-Hang Li, Min-Yi Lv, Ze-Ping Huang, Wei Wang, Xiao-Jian Wu, Feng Gao
Summary: Long non-coding RNAs (lncRNAs) regulate tumor-infiltrating immune cells and reshape the tumor immune microenvironment (TIME) in colorectal cancer (CRC). A signature of CRC TIME-related lncRNAs (TRLs) was developed to predict prognosis and immunotherapy response. The TRLs signature can stratify CRC patients and provide valuable information for immunotherapy treatment.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Ren Li, Yuan-Yuan Wang, Shu-Le Wang, Xue-Peng Li, Yang Chen, Zi-Ao Li, Jian-Hang He, Zi-Han Zhou, Jia-Yu Li, Xiao-Long Guo, Xiao-Gang Wang, Yong-Qiang Wu, Ye-Qing Ren, Wen-Ju Zhang, Xiao-Man Wang, Geng Guo
Summary: GBP2 expression is increased in glioma tissues and is associated with worse prognosis in glioma patients. The expression of GBP2 is related to immune infiltration and immunomodulators. Single-cell analysis confirms the high expression of GBP2 in malignant glioma cells, which has high antigen presentation capability. Predicted regulators hsa-mir-26b-5p and hsa-mir-335-5p are validated in the experiment.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Yunping Ding, Mengmeng Yang, Min Lv, Ying Jiang, Tian Dong, Baihui Zhao, Qiong Luo
Summary: This study presents a case of antenatally diagnosed sacrococcygeal teratoma. Based on the monitoring of fetal and tumorous hemodynamics, the ex-utero intrapartum treatment with debulking was performed successfully. This approach may improve the prognosis for fetuses with heart failure.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Chuan-Jian Shi, Min-Yi Lv, Li-Qiang Deng, Wei-Qiang Zeng, Wei-Ming Fu, Jin-Fang Zhang
Summary: This study found that linc-ROR, a long intergenic non-protein-coding RNA, promotes tumorigenesis and adriamycin resistance in hepatocellular carcinoma through activating the Wnt/beta-catenin pathway. It suggests that linc-ROR could be a potential therapeutic target for adriamycin-resistant patients.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Du Cai, Wei Wang, Min-Er Zhong, Dejun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xin Duan, Xiao-Jian Wu, Feng Gao
Summary: By integrating tumor microenvironment and epithelial-mesenchymal transition, an ISE signature was proposed to predict the recurrence of stage II/III colorectal cancer and assist in treatment decision-making.
Article
Surgery
Biao Yang, Yeqing Ren, Yongqiang Wu, Wenju Zhang, Yanqi Sun, Xiaolong Guo, Ming Lv, Geng Guo
Summary: This article reports a rare case of hypoglossal canal dural arteriovenous fistulas (HCDAVF) where transvenous embolization through the internal jugular vein (IJV) was not feasible. The patient underwent successful transarterial and transvenous onyx embolization using external jugular vein (EJV) and facial vein as access points. This technique may serve as an effective alternative when trans-IJV access is not possible.
FRONTIERS IN SURGERY
(2023)
Article
Cell Biology
Xing-gang Mao, Xiao-yan Xue, Rui Lv, Ang Ji, Ting-yu Shi, Xiao-yan Chen, Xiao-fan Jiang, Xiang Zhang
Summary: Hypoxia plays a critical role in glioblastoma by regulating the hypoxia-regulated genes (HRGs) network. CEBPD is identified as a key transcription factor that regulates a large number of hypoxia-regulated proteins (HRPs) and HRGs. CEBPD is up-regulated in glioblastoma and high levels are associated with poor prognosis. CEBPD activates the EGFR/PI3K pathway through ECM, particularly FN1-mediated EGFR phosphorylation.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Tingyu Shi, Jun Zhu, Xiang Zhang, Xinggang Mao
Summary: Glioblastoma multiforme (GBM) is a highly malignant brain tumor characterized by a small population of glioblastoma stem-like cells (GSCs) that possess self-renewal, proliferative, invasive, and tumorigenic capabilities, leading to radio- and chemoresistance. Hypoxia inducible factors (HIFs) play a crucial role in the maintenance and progression of GSCs. This review summarizes the roles of hypoxia-associated GSCs in GBM development, including hypoxia-induced signatures, genes, pathways, and metabolic alterations. The concept of the hypoxic peri-arteriolar niche of GSCs is discussed. Autophagy and potential causes of therapeutic resistance in GBM are explored, along with chemotherapeutic agents to enhance the effectiveness of chemo-, radio-, or immunotherapy. Hyperbaric oxygen therapy (HBOT) is proposed as an adjuvant therapy to reverse the hypoxic microenvironment in GBM. Overall, understanding the intricate interactions between hypoxia and GSCs can lead to the development of novel therapeutic strategies to improve GBM patient survival.
Article
Engineering, Biomedical
Luge Bai, Zhiyan Hao, Sen Wang, Jiajia Zhou, Siqi Yao, Na Pei, Hui Zhu, Kun Zhang, Rui L. Reis, J. Miguel Oliveira, Jiankang He, Dichen Li, Xinggang Mao, Ling Wang
Summary: In this study, an in vitro bioprinted 3D glioma model was proposed to simulate the natural glioma. Neurons could promote the proliferation of glioma cells and induce morphological changes in glioma cells to be neuron-like. Glioma cells, on the other hand, could maintain neuronal survival and promote neurite outgrowth.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Meeting Abstract
Oncology
Chuling Hu, Du Cai, Min-Er Zhong, Dejun Fan, Cheng-Hang Li, Min-Yi Lv, Ze-Ping Huang, Wei Wang, Xiaojian Wu, Feng Gao
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mingyi Lv, X. F. Long
Summary: The objective of this study was to investigate the efficacy of amiodarone on heart failure patients with arrhythmia. The study found that the effectiveness rate of patients in the observation group, who received amiodarone in addition to regular medication, was significantly higher than that of the control group. There was no significant difference in the incidence rates of adverse reactions between the two groups. Amiodarone is safe and efficient in improving heart function and efficacy in heart failure patients with arrhythmia.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
