Article
Cell Biology
Lowell T. Edgar, Hyojin Park, Jessica R. Crawshaw, James M. Osborne, Anne Eichmann, Miguel O. Bernabeu
Summary: Angiogenesis involves the phases of spouting and remodelling, and abnormal remodelling can result in vascular malformation. The dysfunction of cell-cell adherens junctions is implicated in vascular disease and arteriovenous malformations (AVMs). Cell polarity mixture and excessive cell-cell cohesion disrupt cell migration and blood flow.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Hanxu Zhang, Shuang Zhou, Minxue Sun, Manqi Hua, Zhiyan Liu, Guangyan Mu, Zhe Wang, Qian Xiang, Yimin Cui
Summary: The review discusses the role of ferroptosis in endothelial cells in vascular diseases and explores potential therapeutic strategies for treating ferroptosis.
Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Article
Biochemistry & Molecular Biology
Grace Y. Liu, Shiau-Chi Chen, Gang-Hui Lee, Kritika Shaiv, Pin-Yu Chen, Hsuan Cheng, Shi-Rong Hong, Wen-Ting Yang, Shih-Han Huang, Ya-Chu Chang, Hsien-Chu Wang, Ching-Lin Kao, Pin-Chiao Sun, Ming-Hong Chao, Yian-Ying Lee, Ming-Jer Tang, Yu-Chun Lin
Summary: Microtubules, a crucial cellular structure, have been studied using chemo and optogenetics methods to disassemble specific types of microtubules. The results provide insights into their roles in cellular trafficking, organelle reorganization, and cell stiffness.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Review
Cell Biology
Jocelynda Salvador, M. Luisa Iruela-Arispe
Summary: Vascular cells are constantly influenced by physical forces associated with heart activities and vessel geometry, which regulate the transcriptional program and phenotype of these cells in different regions of the vascular tree. The nucleus plays a critical role as a mechanosensor, and maintaining nuclear integrity is essential for proper vascular function and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Jordan Whisler, Somayeh Shahreza, Karin Schlegelmilch, Nil Ege, Yousef Javanmardi, Andrea Malandrino, Ayushi Agrawal, Alessandro Fantin, Bianca Serwinski, Hesham Azizgolshani, Clara Park, Victoria Shone, Olukunle O. Demuren, Amanda Del Rosario, Vincent L. Butty, Natalie Holroyd, Marie-Charlotte Domart, Steven Hooper, Nicolas Szita, Laurie A. Boyer, Simon Walker-Samuel, Boris Djordjevic, Graham K. Sheridan, Lucy Collinson, Fernando Calvo, Christiana Ruhrberg, Erik Sahai, Roger Kamm, Emad Moeendarbary
Summary: Vascularization is driven by morphogen signals and mechanical cues that regulate cellular force generation, migration, and shape change. The developing vasculature actively regulates its own mechanical properties to achieve effective vascularization. Tissue stiffness increases during vascular morphogenesis resulting from interactions between endothelial cells, fibroblasts, and ECM, and correlates with enhanced vascular function. Contractile cellular forces, synergizing with ECM mechanical properties and mediated by YAP1, play a key role in emergent tissue stiffening and vascular function. Mouse embryos lacking YAP1 in fibroblasts exhibit reduced tissue stiffness and lethal vascular defects. Translating these findings through biology-inspired vascular tissue engineering approaches will have substantial implications in regenerative medicine.
Article
Medicine, Research & Experimental
Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J. Rusch, Zufeng Ding
Summary: This study demonstrates the significant impact of PCSK9 on efferocytosis in ECs and its implications in vascular aging. The findings suggest that PCSK9 deficiency can restore efferocytosis and inhibit the expression of aging markers. Treatment with a PCSK9 inhibitor shows potential in improving vascular aging and reducing inflammation.
Review
Cardiac & Cardiovascular Systems
Han Jiang, Lihua Li, Lili Zhang, Guangyao Zang, Zhen Sun, Zhongqun Wang
Summary: This study reviews the pathogenesis of vascular calcification, the role of endothelial cells, and the regulatory factors of EndMT, in order to provide new concepts for the prevention and treatment of VC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jerome Robert
Summary: Endothelial cells are crucial for vascular homeostasis and play a vital role in controlling blood flow, immune cell trafficking, and vascular growth and repair. Dysfunction of endothelial cells, characterized by impaired secretion of vasodilator molecules, increased reactive oxygen species, expression of adhesion molecules, and secretion of proinflammatory cytokines, leads to cardiovascular diseases. Sex hormones, such as estrogens, androgens, and progestogens, regulate endothelial functions. However, gender also influences endothelial cell physiology at the genetic level.
Article
Multidisciplinary Sciences
Ewa Sitarska, Silvia Dias Almeida, Marianne Sandvold Beckwith, Julian Stopp, Jakub Czuchnowski, Marc Siggel, Rita Roessner, Aline Tschanz, Christer Ejsing, Yannick Schwab, Jan Kosinski, Michael Sixt, Anna Kreshuk, Anna Erzberger, Alba Diz-Munoz
Summary: A curvature-sensing mechanism mediated by the BAR domain protein Snx33 is identified in immune-like cells for obstacle evasion. Actin polymerization at the leading edge of migrating cells is inhibited by Snx33 in regions with inward plasma membrane curvature. Genetic perturbation of this machinery reduces cells' ability to evade obstacles and increases their speed and persistence in obstacle-free environments. This study reveals how cells interpret their environment using actin and plasma membrane biophysics.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Yuliya Krasylenko, George Komis, Sofiia Hlynska, Tereza Vavrdova, Miroslav Ovecka, Tomas Pospisil, Jozef Samaj
Summary: Strigolactones regulate developmental events in roots by affecting the organization and dynamics of cortical microtubules. Chemical and genetic manipulation of strigolactone signaling impacts microtubule remodeling, especially under light conditions. The application of strigolactones in dark conditions partially alleviates cytoskeletal rearrangement, suggesting a new mechanistic connection between cytoskeletal behavior and light-dependent strigolactone signaling.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Engineering, Biomedical
Hiroyuki Ebata, Satoru Kidoaki
Summary: The study found that the prolonged fluctuation of traction stress on a whole-cell scale was significantly enhanced on single cell-size triangular stiff patterns, which was derived from the interplay between the nomadic migration of cells to regions with different degrees of stiffness and domain shape-dependent traction force dynamics. This enhancement should be an essential factor for keeping cells far from tensional equilibrium.
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Microbiology
Stephen K. Kyei, Henry Ogbomo, ShuShun Li, Martina Timm-McCann, Richard F. Xiang, Shaunna M. Huston, Anutosh Ganguly, Pina Colarusso, M. John Gill, Christopher H. Mody
Article
Immunology
Jiahuan Chen, Anutosh Ganguly, Ashley D. Mucsi, Junchen Meng, Jiacong Yan, Pascal Detampel, Fay Munro, Zongde Zhang, Mei Wu, Aswin Hari, Melanie D. Stenner, Wencheng Zheng, Paul Kubes, Tie Xia, Matthias W. Amrein, Hai Qi, Yan Shi
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Biophysics
Florian Hiess, Pascal Detampel, Carme Nolla-Colomer, Alex Vallmitjana, Anutosh Ganguly, Matthias Amrein, Henk E. D. J. ter Keurs, Raul Benitez, Leif Hove-Madsen, S. R. Wayne Chen
BIOPHYSICAL JOURNAL
(2018)
Article
Immunology
Yujia Lin, Dante Louie, Anutosh Ganguly, Dequan Wu, Peng Huang, Shan Liao
JOURNAL OF IMMUNOLOGY
(2018)
Article
Cell Biology
Henry Ogbomo, Martina Timm-McCann, Tavish Barnes, Richard F. Xiang, Khusraw Jamil, Anutosh Ganguly, Danuta Stack, Shaunna M. Huston, Shu Shun Li, Pina Colarusso, Christopher H. Mody
Article
Multidisciplinary Sciences
Pascal Detampel, Anutosh Ganguly, Sara Tehranian, Francis Green, Santiswarup Singha, Pere Santamaria, Ayodeji A. Jeje, Clifford S. Cho, Bjorn Petri, Matthias W. Amrein
Article
Biochemistry & Molecular Biology
Mohammed O. Altonsy, Anutosh Ganguly, Matthias Amrein, Philip Surmanowicz, Shu Shun Li, Gilles J. Lauzon, P. Regine Mydlarski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Microbiology
Althea Campuzano, Natalia Castro-Lopez, Amanda J. Martinez, Michal A. Olszewski, Anutosh Ganguly, Chrissy Leopold Wager, Chiung-Yu Hung, Floyd L. Wormley
Article
Oncology
Shibin Qu, Tejaswi Worlikar, Amy E. Felsted, Anutosh Ganguly, Megan V. Beems, Ryan Hubbard, Ashley L. Pepple, Alicia A. Kevelin, Hannah Garavaglia, Joe Dib, Mariam Toma, Hai Huang, Allan Tsung, Zhen Xu, Clifford Suhyun Cho
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Multidisciplinary Sciences
Jintao Xu, Lori M. Neal, Anutosh Ganguly, Jessica L. Kolbe, Jessica C. Hargarten, Waleed Elsegeiny, Christopher Hollingsworth, Xiumiao He, Mike Ivey, Rafael Lopez, Jessica Zhao, Benjamin Segal, Peter R. Williamson, Michal A. Olszewski
Article
Biotechnology & Applied Microbiology
Shibin Qu, Kunwei Niu, Jianlin Wang, Jimin Dai, Anutosh Ganguly, Chao Gao, Yuzi Tian, Zhibin Lin, Xisheng Yang, Xuan Zhang, Zhengcai Liu, Haimin Li
Summary: The study identified LINC00671 as a novel tumor suppressor in pancreatic cancer, with reduced expression associated with poor tumor differentiation, aggressiveness, and prognosis. Overexpression of LINC00671 inhibited tumor growth and metastasis, and it was involved in multiple tumor-associated signaling pathways.
CANCER GENE THERAPY
(2021)
Article
Microbiology
Khusraw Jamil, Maria J. Polyak, David D. Feehan, Philip Surmanowicz, Danuta Stack, Shu Shun Li, Henry Ogbomo, Michal Olszewski, Anutosh Ganguly, Christopher H. Mody
Article
Immunology
Kristie D. Goughenour, Jessica Zhao, Jintao Xu, Ziyin P. Zhao, Anutosh Ganguly, Christine M. Freeman, Michal A. Olszewski
Summary: This study found that iNOS plays a critical role in local anticryptococcal defenses in the kidneys, but appears to be dispensable in other organs. iNOS(-/-) mice had reduced survival time, increased kidney fungal burden, and impaired kidney function, but did not affect immune cell recruitment or T cell polarization.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Jintao Xu, Anutosh Ganguly, Jessica Zhao, Michel Ivey, Rafael Lopez, John J. Osterholzer, Clifford S. Cho, Michal A. Olszewski
Summary: Blocking the CCR2 pathway can improve the pathology in patients with cryptococcal meningoencephalitis, reducing central nervous system damage and mortality.
Article
Oncology
Mary Smithson, Regina K. Irwin, Gregory Williams, M. Chandler McLeod, E. Karen Choi, Anutosh Ganguly, Ashley Pepple, Clifford S. Cho, Christopher D. Willey, Judith Leopold, Karin M. Hardiman
Summary: Treatment of locally advanced rectal cancer involves chemoradiation and surgery, with variable patient response. Identifying mechanisms of resistance is critical for improved outcomes. In this study, we explored the potential of a DNA-PK inhibitor, M3814, to enhance treatment response. Our findings suggest that combining M3814 with standard of care treatment improves response in some rectal cancer models, but other repair mechanisms may limit its effect.