Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jimmy Stalin, Beat A. Imhof, Oriana Coquoz, Rachel Jeitziner, Philippe Hammel, Thomas A. McKee, Stephane Jemelin, Marine Poittevin, Marc Pocard, Thomas Matthes, Rachid Kaci, Mauro Delorenzi, Curzio Rueegg, Marijana Miljkovic-Licina
Summary: OLFML3 plays a crucial role in promoting tumor vascularization and anti-tumor therapy, with potential implications for patient survival in colorectal cancer. High expression of OLFML3 may serve as a promising therapeutic target for CRC patients, enhancing the efficacy of current anti-PD-1-based therapies.
Review
Cell Biology
Ruipu Sun, Xiangzhan Kong, Xiaoyi Qiu, Cheng Huang, Ping-Pui Wong
Summary: Pericytes play a crucial role in regulating blood vessels and the formation of leaky vasculature in tumors. Recent research shows that they can also directly interact with stromal cells/cancer cells to modulate the tumor microenvironment and have immunomodulatory effects. Targeting pericyte functions may offer new strategies for cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhibao Wang, Bo Cao, Peng Ji, Fan Yao
Summary: Propofol inhibits tubular structure formation and various biological functions of tumor-associated endothelial cells, including migration, adhesion, proliferation, and survival, by suppressing the expression and secretion of multiple pro-angiogenic factors and specific signaling pathways. These findings provide preclinical evidence for the anti-cancer properties of propofol and its potential mechanisms in inhibiting tumor growth and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Jingyu Zhang, Wei Li, Wenxin Wang, Qingqing Chen, Zishan Xu, Meijing Deng, Lin Zhou, Guoyang He
Summary: This article investigates the regulatory mechanisms of Focal adhesion kinase (FAK) in endothelial cells (ECs) and pericytes on angiogenesis, with a focus on the Gas6/Axl pathway. It is found that upregulation of FAK in ECs can promote tumor initiation and progression, while FAK in pericytes has the opposite effect by inhibiting angiogenesis. Moreover, the challenges and future applications of drug-based anti-FAK targeted therapies are discussed as a theoretical basis for the development and use of FAK inhibitors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Digna Parmar, Madhavi Apte
Summary: Angiogenesis is crucial for providing oxygen and nutrients to cells, but its imbalance can lead to pathological conditions. Tumor growth relies on angiogenesis for sustenance. Angiopoietins as alternative targets for anti-angiogenic therapy show promise, especially in combination with VEGF inhibitors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryan G. Toedebusch, Christopher A. Lucchesi, Eshetu T. Debebe, Luke A. Wittenburg, Xinbin Chen, Christine M. Toedebusch
Summary: The study demonstrates that Olfml3 is a crucial regulator of gene expression in microglia under the influence of transforming growth factor-beta, facilitating migration and invasion of glioma cells and potentially impacting the progression of glioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jian Chen, Zequn Li, Xing Jia, Wenfeng Song, Hao Wu, Hai Zhu, Zefeng Xuan, Yehui Du, Xingxin Zhu, Guangyuan Song, Haijiang Dong, Suchen Bian, Shuo Wang, Yongchao Zhao, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: ANLN is a crucial cytokinesis regulator in hepatocellular carcinoma (HCC), controlling cell division and apoptosis processes, and playing a significant role in HCC development and progression.
Retraction
Biochemistry & Molecular Biology
Sarita Saraswati, Shakti Kumar, Abdulqader A. Alhaider
Summary: This article has been retracted. Please refer to the Retraction Notice for further information.
Article
Medicine, Research & Experimental
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang
Summary: This study provides the first evidence that Rab37 mediates CHI3L1 secretion in immune cells and highlights the dual properties of CHI3L1 nAbs that can target both cancer cells and the tumor microenvironment.
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Asumi Iesato, Stephanie Li, Peter M. Sadow, Mohammadreza Abbasian, Ara Nazarian, Jack Lawler, Carmelo Nucera
Summary: Anaplastic thyroid carcinoma (ATC) is a rapidly fatal cancer, and understanding the genetics and tumor microenvironment is crucial for effective management. Pericytes in the microenvironment play a key role in ATC, and the effectiveness of lenvatinib in ATC is not well understood. This study found that ATC samples have elevated levels of pericytes and lenvatinib showed inhibitory effects in the presence of pericytes.
Article
Food Science & Technology
Meihong Guo, Lei Yang, Xiaonan Zhao, Pinru Yan, Mengjiao Zhu, Weidong Ding, Dongmei Li, Xiaodong Han, Jiang Wu
Summary: This study found that Microcystin-leucine-arginine (MC-LR) reduces the fertility of female mice by affecting the construction of the vascular network in the corpus luteum and inhibiting hormone synthesis, which in turn affects embryo implantation and maintenance of early pregnancy.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuanfei Zhou, Mao Xia, Chenbin Cui, Hongkui Wei, Siwen Jiang, Jian Peng
Summary: The study revealed that exosomes from obese sows, particularly enriched with miR-221, inhibit endothelial cell migration and angiogenesis by suppressing the expression of Angptl2. This suggests that miR-221 plays a key role in mediating angiogenesis through adipocyte-secreted exosomal vesicles. The findings indicate a novel mechanism where harmful exosomes secreted from obesity adipose tissues lead to placental dysplasia during gestation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Jose Tunon, Lina Badimon, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J. Daemen, Jesus Egido, Paul C. Evans, Imo E. Hoefer, Daniel F. J. Ketelhuth, Esther Lutgens, Christian M. Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cecile Vindis, Christian Weber, Magnus Back
CARDIOVASCULAR RESEARCH
(2019)
Review
Cardiac & Cardiovascular Systems
Yvonne Alexander, Elena Osto, Arno Schmidt-Trucksass, Michael Shechter, Danijela Trifunovic, Dirk J. Duncker, Victor Aboyans, Magnus Back, Lina Badimon, Francesco Cosentino, Marco De Carlo, Maria Dorobantu, David G. Harrison, Tomasz J. Guzik, Imo Hoefer, Paul D. Morris, Giuseppe D. Norata, Rosa Suades, Stefano Taddei, Gemma Vilahur, Johannes Waltenberger, Christian Weber, Fiona Wilkinson, Marie-Luce Bochaton-Piallat, Paul C. Evans
Summary: Endothelial cells play a crucial role in cardiovascular health, and dysfunction can be caused by cardiovascular risk factors but restored once stimuli are removed. There are various methods to measure endothelial function, with each having its pros and cons. It is recommended to adopt a consensus methodology like flow-mediated dilatation and establish reference values for different populations. Future studies should explore the integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Paul C. Evans, G. Ed Rainger, Justin C. Mason, Tomasz J. Guzik, Elena Osto, Zania Stamataki, Desley Neil, Imo E. Hoefer, Maria Fragiadaki, Johannes Waltenberger, Christian Weber, Marie-Luce Bochaton-Piallat, Magnus Back
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Malgorzata Furmanik, Martijn Chatrou, Rick van Gorp, Asim Akbulut, Brecht Willems, Harald Schmidt, Guillaume van Eys, Marie-Luce Bochaton-Piallat, Diane Proudfoot, Erik Biessen, Ulf Hedin, Ljubica Perisic, Barend Mees, Catherine Shanahan, Chris Reutelingsperger, Leon Schurgers
CIRCULATION RESEARCH
(2020)
Article
Medical Laboratory Technology
Emmanuel Somm, Sophie A. Montandon, Ursula Loizides-Mangold, Nadia Gaia, Vladimir Lazarevic, Claudio De Vito, Elodie Perroud, Marie-Luce Bochaton-Piallat, Charna Dibner, Jacques Schrenzel, Francois R. Jornayvaz
Summary: The study shows that the GLP-1 receptor agonist liraglutide can prevent the accumulation of C16 and C24 ceramides/sphingomyelins species, alleviate inflammation, and inhibit the initiation of fibrosis in the liver of MCD-diet-fed mice. Additionally, liraglutide influences the composition of gut microbiota induced by the MCD-diet.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Yves Lecarpentier, Vincent Kindler, Xenophon Krokidis, Marie-Luce Bochaton-Piallat, Victor Claes, Jean-Louis Hebert, Alexandre Vallee, Olivier Schussler
Article
Biochemistry & Molecular Biology
Beat A. Imhof, Romain Ballet, Philippe Hammel, Stephane Jemelin, Sarah Garrido-Urbani, Makoto Ikeya, Thomas Matthes, Marijana Miljkovic-Licina
Article
Oncology
Jimmy Stalin, Beat A. Imhof, Oriana Coquoz, Rachel Jeitziner, Philippe Hammel, Thomas A. McKee, Stephane Jemelin, Marine Poittevin, Marc Pocard, Thomas Matthes, Rachid Kaci, Mauro Delorenzi, Curzio Rueegg, Marijana Miljkovic-Licina
Summary: OLFML3 plays a crucial role in promoting tumor vascularization and anti-tumor therapy, with potential implications for patient survival in colorectal cancer. High expression of OLFML3 may serve as a promising therapeutic target for CRC patients, enhancing the efficacy of current anti-PD-1-based therapies.
Article
Physiology
Sandrine Morel, Sabine Schilling, Mannekomba R. Diagbouga, Matteo Delucchi, Marie-Luce Bochaton-Piallat, Sylvain Lemeille, Sven Hirsch, Brenda R. Kwak
Summary: The study found that under both low and supra-high aneurysmal WSS conditions, endothelial cells adapt by changing their morphology to a more spherical shape, with differential regulation in gene expression and cell structure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Marijana Miljkovic-Licina, Nicolas Arraud, Aicha Dorra Zahra, Patricia Ropraz, Thomas Matthes
Summary: Extracellular vesicles (EVs) are lipid-bound vesicles secreted by cells. They play a crucial role in cell-to-cell communication by transporting various molecules. In the case of acute leukemia, EVs produced by cancer cells can impact the surrounding microenvironment and contribute to disease progression. Our study utilized different methods to quantify and characterize EVs from acute leukemia patients, providing insights into their functional role in leukemia development and their potential as therapy targets and disease biomarkers.
Article
Biochemistry & Molecular Biology
Priscilla Kaulanjan-Checkmodine, Sandra Oucherif, Sorilla Prey, Etienne Gontier, Sabrina Lacomme, Maya Loot, Marijana Miljkovic-Licina, Muriel Cario, Christine Leaute-Labreze, Alain Taieb, Francois Moisan, Hamid Reza Rezvani
Summary: The study reveals that the catecholamine noradrenaline plays a role in the response of infantile hemangioma (IH) to propranolol treatment. IH tissues contain a higher amount of noradrenaline compared to involuted IHs or propranolol-treated IHs. The sensitivity of IH to propranolol depends on the crosstalk between endothelial cells, pericytes, and telocytes in the presence of a high local amount of noradrenaline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Menno P. J. de Winther, Magnus Back, Paul Evans, Delphine Gomez, Isabel Goncalves, Helle F. Jorgensen, Rory R. Koenen, Esther Lutgens, Giuseppe Danilo Norata, Elena Osto, Lea Dib, Michael Simons, Konstantinos Stellos, Seppo Yla-Herttuala, Holger Winkels, Marie-Luce Bochaton-Piallat, Claudia Monaco
Summary: The advent of single-cell biology has opened up new possibilities for understanding human biological processes and diagnosing, monitoring, and treating diseases, including cardiovascular disease (CVD). By analyzing CVD samples at the single-cell level, new cell communities that play a role in disease development can be identified, leading to new therapeutic strategies. This review focuses on the single-cell analysis of atherosclerotic plaques, highlighting the current understanding of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. The clinical impact of single-cell technologies in CVD patient care is emphasized, calling for multidisciplinary and international collaborative efforts.
EUROPEAN HEART JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Tamara Melnik, Ksenia Kapitanova, Laurent Vinet, Marie-Luce Bochaton-Piallat, Olivier Jordan, Florence Delie
Summary: This study aimed to encapsulate a high payload of atorvastatin (ATV) to prevent intimal hyperplasia (IH) in vascular bypass grafts and evaluate its impact on synthetic smooth muscle cells (SMCs) involved in IH progression. Poly(lactic-co-glycolic acid) microparticles (MPs) were formulated with different drug loadings and tested for ATV release, sterilization, and effects on SMCs. The results showed sustained ATV release from 10% and 20% ATV-loaded MPs for 90 days. The ATV-loaded MPs reversed the synthetic phenotype of SMCs and attenuated their migratory and proliferative capacities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonija Sakic, Chiraz Chaabane, Noona Ambartsumian, Jorg Klingelhofer, Sylvain Lemeille, Brenda R. Kwak, Mariam Grigorian, Marie-Luce Bochaton-Piallat
Summary: This study investigates the role of extracellular S100A4 in the phenotypic transition of smooth muscle cells during atherosclerosis. The findings suggest that neutralization of extracellular S100A4 promotes the stabilization of atherosclerotic plaques and could potentially be a new target to influence plaque evolution.
CARDIOVASCULAR RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Sakic, C. Chaabane, N. Ambartsumian, J. Klingelhofer, S. Lemeille, B. Kwak, M. Grigorian, M. -L. Bochaton-Piallat