Article
Oncology
Cheng Yi, Guangyue Li, Wenmeng Wang, Yixuan Sun, Yueling Zhang, Chen Zhong, Daniel B. Stovall, Dangdang Li, Jinming Shi, Guangchao Sui
Summary: The study revealed that synthetic peptides derived from YPB and OPB domains disrupted the interaction between YY1 and EZH2, inhibiting the proliferation of breast cancer cells and reducing tumor growth. Additionally, these peptides interfered with H3K27 trimethylation and primarily targeted the PTENP1 gene, highlighting its importance in the anticancer activity of YPB and OPB peptides.
Review
Immunology
Hirva K. Bhatt, Dana Song, Gyen Musgrave, P. S. S. Rao
Summary: Natural cannabinoids have been used for medicinal purposes by humans for thousands of years, with their anti-inflammatory effects well-documented. The pharmacological effects of cannabinoids are mediated through modulation of CB1 and CB2 receptors, while miRNA expression plays a key role in the immune system's response to cannabinoids.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Instruments & Instrumentation
Fahima Danesh Pouya, Yousef Rasmi, Maria Gazouli, Eleni Zografos, Mohadeseh Nemati
Summary: MicroRNAs play a crucial role in the development and progression of breast cancer, with their expression patterns serving as indicators of metastatic potential. The identification of key microRNAs could lead to the development of novel therapeutic molecules, while an efficient delivery system is essential for microRNA-based therapies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Henrique O. Duarte, Joana G. Rodrigues, Catarina Gomes, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Arnoud H. de Ru, Stefan Mereiter, Antonio Polonia, Elisabete Fernandes, Jose A. Ferreira, Peter A. van Veelen, Lucio L. Santos, Manfred Wuhrer, Joana Gomes, Celso A. Reis
Summary: The resistance of ErbB2-positive gastric cancer cells to trastuzumab is actively modulated by ST6Gal1-mediated aberrant alpha 2,6-sialylation, which reshapes the glycomes and sensitizes the cells to trastuzumab-induced cytotoxicity.
Article
Medicine, Research & Experimental
Shalini Gautam, Disha Marwaha, Neha Singh, Nikhil Rai, Madhu Sharma, Pratiksha Tiwari, Sandeep Urandur, Ravi Prakash Shukla, Venkatesh Teja Banala, Prabhat Ranjan Mishra
Summary: A two-tier approach was proposed for targeted combination therapy against metastatic breast cancer. It involves the development of a paclitaxel-loaded micellar system and the chemical anchoring of hyaluronic acid to achieve CD44 receptor mediated targeting. The combination of paclitaxel and betulinic acid showed significant synergy. The integrated system exhibited preferential CD44-mediated uptake and rapid release of drugs in response to higher glutathione concentrations. In vivo administration of targeted micelles resulted in improved pharmacokinetic parameters and significant tumor growth inhibition in mice.
MOLECULAR PHARMACEUTICS
(2023)
Article
Cell Biology
Yanli Bi, Longyuan Gong, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao
Summary: This study reveals a novel mechanism in which nuclear ErbB2 represses the transcription of DEPTOR, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Daniel S. S. Peiffer, Fangyuan Zhao, Nan Chen, Olwen M. M. Hahn, Rita Nanda, Olufunmilayo I. I. Olopade, Dezheng Huo, Frederick M. M. Howard
Summary: A retrospective cohort study of 1,136,016 patients with ERBB2-negative and ERBB2-low breast cancer found minimal prognostic differences between the two subtypes, indicating that ERBB2-low breast cancer should not be classified as a distinct disease entity.
Article
Multidisciplinary Sciences
Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B. Lanz, Bert W. O'Malley, Jianming Xu
Summary: This study reveals that ERα*RFP*Erbb2* cells progressively lose ERα during tumorigenesis to become highly metastatic, and these ERα*origin breast cancers are more aggressive.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Mohammed Fatih Rasul, Abbas Salihi, Soudeh Ghafouri-Fard, Hazha Jamal Hidayat, Mohammad Taheri
Summary: This article summarizes the important role of miRNA in breast tumor angiogenesis development, emphasizing the key roles of different miRNAs in disease processes, especially their overexpression in various diseases related to angiogenesis. More research is needed to reveal the relationship between miRNA expression and angiogenic pathways, immune response-related genes, and to provide more evidence for finding new therapeutic targets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Xiaoyang Liu, Sandhya Chipurupalli, Peijia Jiang, Mahtab Tavasoli, Byong Hoon Yoo, Michael McPhee, Sina Mazinani, Giulio Francia, Robert S. Kerbel, Kirill Rosen
Summary: We discovered a novel mechanism of ErbB2-driven 3D breast tumor growth mediated by ErbB2-dependent BLNK downregulation. In addition, we found that upregulating BLNK can inhibit tumor growth, and increased mRNA levels of BLNK are associated with increased relapse-free survival.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Mohammed Kaleem, Mahmood Hassan Dalhat, Lubna Azmi, Turky Omar Asar, Wasim Ahmad, Maimonah Alghanmi, Amal Almostadi, Torki A. Zughaibi, Shams Tabrez
Summary: Brain metastasis is a major cause of death in breast cancer patients, and the tendency to develop brain metastases differs by breast cancer subtype. Researchers are hopeful that studying the molecular pathways of brain metastasis will lead to effective treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Michal Kunc, Marta Popeda, Wojciech Biernat, Elzbieta Senkus
Summary: ER alpha(+)/PgR(-) phenotype is not rare in breast cancer, and loss of PgR expression may signify resistance to endocrine therapy and poorer outcomes. Different mechanisms of PgR loss have distinct consequences on cancer cell biology.
Article
Cell Biology
Mengyuan Qu, Yunhan Zhao, Xingrong Qing, Xinzong Zhang, Honggang Li
Summary: In patients with Late-onset hypogonadism (LOH) and castrated mice, supplementation of testosterone led to upregulation of miR-125a-5p in plasma, which was positively associated with testosterone concentrations. Further analysis revealed LYPLA1 as a target gene of miR-125a-5p, and testosterone deficiency resulted in decreased global protein palmitoylation level. Our findings suggest that testosterone may regulate global palmitoylation level through the miR-125a-5p/LYPLA1 signaling pathway in LOH, potentially contributing to the molecular mechanism underlying LOH symptoms.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Xinxin Liu, Wenqiang Tang, Kemin Chen, Yuxia Wang, Jie Qin, Fengrui Yang
Summary: This study reveals the cardioprotective role of circ_0002612 against myocardial ischemia/reperfusion injury (MI/RI), and identifies its mechanistic actions. circ_0002612 competitively binds to miR-30a-5p to release the expression of its target gene Ppargc1a, promoting cardiomyocyte viability and suppressing apoptosis. Furthermore, circ_0002612 inhibits the expression of NLRP3, leading to enhanced cardiomyocyte proliferation and reduced apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Nuria Chic, Francesco Schettini, Fara Braso-Maristany, Esther Sanfeliu, Barbara Adamo, Maria Vidal, Debora Martinez, Patricia Galvan, Blanca Gonzalez-Farre, Javier Cortes, Joaquin Gavila, Cristina Saura, Mafalda Oliveira, Sonia Pernas, Olga Martinez-Saez, Jesus Soberino, Eva Ciruelos, Lisa A. Carey, Montserrat Munoz, Charles M. Perou, Tomas Pascual, Meritxell Bellet, Aleix Prat
Summary: Chemotherapy has different biological effects on patients with hormone receptor-positive breast cancer with different menopausal statuses. Specific estrogen-regulated genes exhibited varied expression levels under different treatment regimens in these patients.
Article
Neurosciences
Hanna J. Kulbeth, Saki Fukuda, Lisa K. Brents
Summary: The study aimed to automate the quantification of opioid withdrawal in neonatal rat pups using the animal behavior software Ethovision (R) XT. Results showed that Ethovision (R) XT could reliably quantify opioid withdrawal with non-inferiority to manual scoring, accelerating progress in preclinical studies of NOWS.
NEUROTOXICOLOGY AND TERATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Syng-ook Lee, So Young Chun, EunHye Lee, Bomi Kim, BoHyun Yoon, Haejung Gil, Dae Hwan Kim, Byung Ik Jang, Dong Woo Lee, Eun Sang Yoo, Dong Jin Park, Jun Nyung Lee, Man-Hoon Han, Bum Soo Kim, Phil Hyun Song, Tae Gyun Kwon, Yun-Sok Ha
Summary: Pre-treatment with beluga lentils showed protective effects against ischemia/reperfusion-induced renal damage by reducing apoptosis, inflammation, and oxidative stress.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jung Ho Han, MinJeong Kim, Hee-Jin Choi, Jung Sook Jin, Syng-Ook Lee, Sung-Jin Bae, Dongryeol Ryu, Ki-Tae Ha
Summary: The water-extracted roots of Sanguisorba officinalis L. were found to reduce lactate dehydrogenase A (LDHA) activity and improve physical performance by enhancing AMPKα and PGC-1α levels, while suppressing glycolysis. This suggests that S. officinalis may be a candidate for enhancing physical performance through inhibiting LDHA and glycolysis.
Article
Biochemistry & Molecular Biology
Hyo-Seon Lee, Soo-Hyun Kim, Bo-Mi Kim, Stephen Safe, Syng-Ook Lee
Summary: The study identified broussochalcone A (BCA) as a new inhibitor of the overexpressed orphan nuclear receptor 4A1 in pancreatic cancer cells, demonstrating its ability to inhibit cell growth and induce apoptosis. This highlights BCA as a potential anticancer agent targeting NR4A1 overexpression in various human cancers.
Article
Biochemistry & Molecular Biology
Yeon-Seop Jung, So-Hee Lee, So Young Chun, Dae Hwan Kim, Byung Ik Jang, Man-Hoon Han, Syng-Ook Lee
Summary: This study found that the phenolic extract of beluga lentil (BLE) has protective effects against oxidative stress-induced hepatotoxicity. BLE can reduce intracellular reactive oxygen species (ROS) levels and enhance the expression of antioxidant genes. In animal experiments, pretreatment with BLE also significantly reduced liver injury markers and increased the activity of intracellular antioxidant enzymes. Therefore, BLE may be a potential source of nutraceuticals with hepatoprotective effects.
Meeting Abstract
Biochemistry & Molecular Biology
Brian J. Parks, Paloma Salazar, Julia Tobacyk, Lindsey L. Morrison, Michael D. Berquist, Lisa K. Brents
Article
Biochemistry & Molecular Biology
Hyo-Seon Lee, Dae Hwan Kim, In-Seon Lee, Ji-Hyun Park, Gregory Martin, Stephen Safe, Keuk-Jun Kim, Joung-Hee Kim, Byung Ik Jang, Syng-Ook Lee
Summary: The study demonstrates that tetrandrine (TTD) can act as an NR4A1 antagonist to inhibit proliferation and induce apoptosis in human pancreatic cancer cells by modulating related proapoptotic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Seop Jung, Yun-Jeong Jeong, Joung-Hee Kim, Chang-Hwan Jeon, Syng-Ook Lee
Summary: This study found that alantolactone (ALA) and Inula helenium (elecampane) root extract (IHE) simultaneously target AMPK alpha and Nur77, inhibiting adipogenic differentiation and reducing the expression of adipocyte markers. Further mechanistic studies revealed that IHE shares similar mechanisms of action with isoalantolactone (ISO), reducing mitotic clonal expansion during early adipogenic differentiation and decreasing expression of cell cycle regulators. These results suggest that IHE inhibits adipogenesis through co-regulation of AMPK alpha and Nur77, and may serve as a therapeutic option for obesity and related metabolic dysfunction.
Article
Substance Abuse
Julia Tobacyk, Brian J. Parks, Nakita Lovelady, Lisa K. Brents
Summary: This study analyzed public perceptions of kratom use and found that kratom is commonly used for various health-related purposes, including mental health, pain management, and substance use disorder. The study also highlighted potential individual-level consequences of using kratom.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Substance Abuse
Julia Tobacyk, Brian J. Parks, Paloma Salazar, Lori U. Coward, Michael D. Berquist, Gregory S. Gorman, Lisa K. Brents
Summary: Buprenorphine is the preferred treatment for opioid use disorder in pregnant women but can cause neonatal opioid withdrawal syndrome (NOWS). The metabolite Norbuprenorphine plays a key role in BUP-associated NOWS and has a greater impact on females. Therefore, reducing prenatal exposure to Norbuprenorphine may be more effective for females than males.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Food Science & Technology
Chae-Eun Park, Syng-Ook Lee
Summary: In this study, it was found that Protaetia brevitarsis larvae (PBL) protein hydrolysates, which have strong antioxidant activity, may protect liver cells from oxidative stress-induced injury. Among the hydrolysates prepared by different proteases, the PBL flavouryzme hydrolysate showed the highest protective effect against H2O2-induced cytotoxicity in liver cells. Mechanistic studies revealed that the protective effect of PFH was associated with its ability to reduce reactive oxygen species and induce antioxidant enzymes.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Venumadhav Janganati, Paloma Salazar, Brian J. Parks, Gregory S. Gorman, Paul L. Prather, Eric C. Peterson, Alexander W. Alund, Jeffery H. Moran, Peter A. Crooks, Lisa K. Brents
Summary: An active metabolite of buprenorphine called norbuprenorphine is implicated in neonatal opioid withdrawal syndrome when buprenorphine is taken during pregnancy. This study reports the synthesis and testing of deuterated buprenorphine (BUP-D2), which retains key pharmacodynamic properties of buprenorphine and resists metabolism to norbuprenorphine, making it a potential alternative to buprenorphine.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyung Jun Kwon, So Young Chun, Eun Hye Lee, BoHyun Yoon, Man-Hoon Han, Jae-Wook Chung, Yun-Sok Ha, Jun Nyung Lee, Hyun Tae Kim, Dae Hwan Kim, Tae Gyun Kwon, Bum Soo Kim, Syng-Ook Lee, Byung Ik Jang
Summary: Ulcerative colitis is characterized by inflammation in the colon, and obesity is closely related to its occurrence and progression. The connection between obesity and colitis is primarily through excessive adipogenesis-related inflammatory responses that cause mucosal dysfunction. Several etiological mechanisms, including excessive adipogenesis, lipotoxicity, pro-inflammatory adipokines/cytokines, macrophage polarization, oxidative stress, endoplasmic reticulum stress, and gut microbiota, link obesity and colitis. The resulting low-grade enteric inflammations lead to mucosal layer damage, especially goblet cell dysfunction, ultimately resulting in colitis. Inhibiting the inflammatory response is the most effective approach for treating obesity-related colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Obstetrics & Gynecology
Julia Tobacyk, Lisa K. Brents
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ji-eun Lee, Sung-Gook Cho, Seong-Gyu Ko, Syed A. Ahrmad, Alvaro Puga, Kyounghyun Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
