期刊
SCIENCE CHINA-LIFE SCIENCES
卷 58, 期 10, 页码 958-967出版社
SCIENCE PRESS
DOI: 10.1007/s11427-015-4941-1
关键词
autism spectrum disorder; genetic architecture; genomic disorder; gene mutation; copy number variants; single nucleotide variants; genetic pathways; epigenetic influence; DNA methylation; chromatin remodeling; long non-coding RNAs; environment exposure; immune dysregulation; gastrointestinal microbiota
类别
资金
- National Basic Research Program of China (973 Program) [2010CB529601, 2013CB945404]
Autism spectrum disorder (ASD) is a spectral neurodevelopment disorder affecting approximately 1% of the population. ASD is characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Multiple factors, including genetic/genomic, epigenetic/epigenomic and environmental, are thought to be necessary for autism development. Recent reviews have provided further insight into the genetic/genomic basis of ASD. It has long been suspected that epigenetic mechanisms, including DNA methylation, chromatin structures and long non-coding RNAs may play important roles in the pathology of ASD. In addition to genetic/genomic alterations and epigenetic/epigenomic influences, environmental exposures have been widely accepted as an important role in autism etiology, among which immune dysregulation and gastrointestinal microbiota are two prominent ones.
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