Article
Biochemistry & Molecular Biology
Verena Boschert, Jonas Teusch, Urs D. A. Mueller-Richter, Roman C. Brands, Stefan Hartmann
Summary: PKM2 is commonly phosphorylated at Tyr105 in HNSCC, and its levels depend on tyrosine kinase activity. It is also correlated with the expression of CD44 and has an impact on the metabolism of HNSCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wei Chen, Xijuan Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang, Siyuan Zhang, Juan Xia, Bin Cheng, Tong Wu, Xianyue Ren
Summary: Mitochondria are key in maintaining oxidative balance and cell death regulation during cancer cell growth. TIPE3 downregulation through promoter hypermethylation is the main alteration in TIPEs during HNSCC development.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Chengcheng Liao, Jiaxing An, Zhangxue Tan, Fangping Xu, Jianguo Liu, Qian Wang
Summary: Glycosylation is a crucial posttranslational modification of proteins that plays a significant role in human cancer progression, especially in head and neck squamous cell carcinoma (HNSCC). Understanding the regulatory mechanisms of protein glycosylation is important for controlling the progression and malignant transformation of HNSCC.
Article
Oncology
Arthur Yan, Alaa Hanna, Thomas G. Wilson, Rohan Deraniyagala, Daniel J. Krauss, Vincent P. Grzywacz, Di Yan, George D. Wilson
Summary: The study identified a significant correlation between pretreatment CD44 expression and tumor volume with a DRM greater than 0.8. GLUT1 expression was associated with tumor volume with an SUV0 greater than 20, while SUVmax and DRM were found to be independent imaging parameters.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Won Jin Cho, David Kessel, Joseph Rakowski, Brian Loughery, Abdo J. Najy, Tri Pham, Seongho Kim, Yong Tae Kwon, Ikuko Kato, Harold E. Kim, Hyeong-Reh C. Kim
Summary: This study aims to understand the molecular basis of radiotherapy resistance in advanced head and neck squamous cell carcinoma (HNSCC) and found that autophagy pathway is upregulated in therapy-resistant HNSCC. Additionally, photodynamic therapy (PDT) directed at the endoplasmic reticulum (ER)/mitochondria can promote radiotoxicity by inducing programmed cell death. Furthermore, the study suggests that ER/mitochondria-targeted PDT can serve as a radiosensitizer in intrinsically radioresistant HNSCC with increased autophagic flux.
Review
Oncology
Philipp Baumeister, Jiefu Zhou, Martin Canis, Olivier Gires
Summary: Head and neck squamous cell carcinomas (HNSCC) are common malignancies with resistance to multi-modal therapy modalities, leading to metastasis, local recurrence, and poor survival. Understanding the molecular heterogeneity of HNSCC and its impact on treatment response is crucial for improving patient stratification and developing new therapeutic approaches to overcome therapy resistance.
Article
Biochemistry & Molecular Biology
Cheng-Ming Hsu, Ming-Yu Yang, Ming-Shao Tsai, Geng-He Chang, Yao-Hsu Yang, Yao-Te Tsai, Ching-Yuan Wu, Shun-Fu Chang
Summary: HNSCCs, the most common cancers of the head and neck, present a clinical challenge due to high recurrence rates and treatment resistance. This study explored the potential anticancer effects of DT, a compound in danshen, on HNSCCs, showing promising results in inducing cell apoptosis and reducing tumor size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Usha Patel, Sadhana Kannan, Swapnil U. Rane, Neha Mittal, Poonam Gera, Asawari Patil, Subhakankha Manna, Vishwayani Shejwal, Vanita Noronha, Amit Joshi, Vijay M. Patil, Kumar Prabhash, Manoj B. Mahimkar
Summary: This study identifies CD44 and CD44v6 as potential predictive biomarkers for NCRT response in HPV-negative LA-HNSCC patients, and CD98hc as an independent negative prognostic biomarker. These findings can help identify which HNSCC patients are most suitable for specific treatments.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Tong Tong, Xing Qin, Yingying Jiang, Haiyan Guo, Xiaoning Wang, Yan Li, Fei Xie, Hao Lu, Peisong Zhai, Hailong Ma, Jianjun Zhang
Summary: The study identified the role of the CREB5/TOP1MT axis in conferring cisplatin resistance in HNSCC, and provided a new basis for overcoming this resistance.
Article
Cell Biology
Peng Zhou, Caiyun Zhang, Xianmin Song, Dadong Zhang, Minhui Zhu, Hongliang Zheng
Summary: We found that Delta Np63 alpha may be a key factor in the resistance of HNSCC cells to Bortezomib, and CYGB plays a crucial role in this process. Delta Np63 alpha regulates the expression of CYGB, which is involved in clearing excessive ROS induced by Bortezomib, thus affecting apoptosis and drug resistance in HNSCC cells.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Taichi Nyui, Hironori Yoshino, Tetsuya Nunota, Yoshiaki Sato, Eichi Tsuruga
Summary: cGAS has a role in promoting radioresistance in HNSCC cells, as its knockdown enhances radiosensitivity and increases radiation-induced cell death and senescence.
Article
Plant Sciences
Kyung-Ran Park, Hanna Lee, Soo Hyun Kim, Hyung-Mun Yun
Summary: Paonia suffruticosa has been used as a medicinal plant in Asian countries. This study investigated the anti-cancer effects of a compound isolated from P. suffruticosa on head and neck squamous cell carcinomas (HNSCCs). The compound inhibited cell proliferation and induced apoptotic cell death in HNSCC cells, and also affected necroptosis and autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Dominic H. Moon, David J. Sher
Summary: Up to 40% of patients with metastatic head and neck squamous cell carcinoma have oligometastatic disease, which is associated with improved overall survival. Local ablative therapy and radiation therapy have shown promise in improving outcomes. Stereotactic ablative radiotherapy is a less invasive alternative to surgical resection, but more research is needed to determine its role.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ethan L. L. Morgan, Tiffany Toni, Ramya Viswanathan, Yvette Robbins, Xinping Yang, Hui Cheng, Sreenivasulu Gunti, Angel Huynh, Anastasia L. L. Sowers, James B. B. Mitchell, Clint T. T. Allen, Zhong Chen, Carter Van Waes
Summary: TNF alpha is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but several cancers display resistance to TNF alpha due to activation of the NF kappa B pro-survival pathway. In this study, we found that the expression of USP14, a proteasome-associated deubiquitinase, is increased in HNSCC and correlates with worse progression free survival. Inhibition or depletion of USP14 inhibited the proliferation and survival of HNSCC cells and reduced NF kappa B activity. Furthermore, we showed that the inhibitor b-AP15 sensitized HNSCC cells to TNF alpha-mediated cell death and radiation-induced cell death, and delayed tumor growth in vivo.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Engineering, Biomedical
Wen-Liang Lo, Yueh Chien, Guang-Yuh Chiou, Ling-Ming Tseng, Han-Shui Hsu, Yuh-Lih Chang, Kai-Hsi Lu, Chian-Shiu Chien, Mong-Lien Wang, Yi-Wei Chen, Pin-I Huang, Fang-Wei Hu, Cheng-Chia Yu, Pen-Yuan Chu, Shih-Hwa Chiou
Article
Engineering, Biomedical
Yi-Ping Yang, Yueh Chien, Guang-Yuh Chiou, Jong-Yuh Cherng, Mong-Lien Wang, Wen-Liang Lo, Yuh-Lih Chang, Pin-I Huang, Yi-Wei Chen, Yang-Hsin Shih, Ming-Teh Chen, Shih-Hwa Chiou
Article
Oncology
Yi-Wei Chen, Pin-I Huang, Donald Ming-Tak Ho, Yu-Wen Hu, Kai-Ping Chang, Shih-Hwa Chiou, Wan-Yuo Guo, Feng-Chi Chang, Muh-Lii Liang, Yi-Yen Lee, Hsin-Hung Chen, Ting-Rong Hsu, Shih-Chieh Lin, Tai-Tong Wong, Sang-Hue Yen
Review
Cell & Tissue Engineering
Pei-Ming Chu, Hsin-I Ma, Li-Hsin Chen, Ming-Teh Chen, Pin-I Huang, Shinn-Zong Lin, Shih-Hwa Chiou
CELL TRANSPLANTATION
(2013)
Article
Cell & Tissue Engineering
Yi-Yen Lee, Yi-Ping Yang, Ming-Chao Huang, Mong-Lien Wang, Sang-Hue Yen, Pin-I Huang, Yi-Wei Chen, Shih-Hwa Chiou, Yuan-Tzu Lan, Hsin-I Ma, Yang-Hsin Shih, Ming-Teh Chen
CELL TRANSPLANTATION
(2014)
Article
Clinical Neurology
Yi-Wei Chen, Pin-I Huang, Yu-Wen Hu, Donald Ming-Tak Ho, Kai-Ping Chang, Wan-Yuo Guo, Feng-Chi Chang, Yi-Yen Lee, Cheng-Ying Shiau, Tai-Tong Wong, Sang-Hue Yen
CHILDS NERVOUS SYSTEM
(2012)
Review
Genetics & Heredity
Pin-I Huang, Wen-Liang Lo, Jong-Yuh Cherng, Yueh Chien, Guang-Yuh Chiou, Shih-Hwa Chiou
CURRENT GENE THERAPY
(2012)
Review
Oncology
Yu-Wen Hu, Pin-I Huang, Tai-Tong Wong, Donald Ming-Tak Ho, Kai-Ping Chang, Wan-Yuo Guo, Feng-Chi Chang, Cheng-Yin Shiau, Muh-Lii Liang, Yi-Yen Lee, Hsin-Hung Chen, Sang-Hue Yen, Yi-Wei Chen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2012)
Article
Cell Biology
Yi-Ping Yang, Yuh-Lih Chang, Pin-I Huang, Guang-Yuh Chiou, Ling-Ming Tseng, Shih-Hwa Chiou, Ming-Hsiung Chen, Ming-Teh Chen, Yang-Hsin Shih, Chin-Hong Chang, Chuan-Chih Hsu, Hsin-I Ma, Chin-Tien Wang, Lo-Lin Tsai, Cheng-Chia Yu, Charn-Jung Chang
JOURNAL OF CELLULAR PHYSIOLOGY
(2012)
Article
Chemistry, Multidisciplinary
Guang-Yuh Chiou, Jong-Yuh Cherng, Han-Shui Hsu, Mong-Lien Wang, Chun-Ming Tsai, Kai-Hsi Lu, Yueh Chien, Shih-Chieh Hung, Yi-Wei Chen, Chiang-Ing Wong, Ling-Ming Tseng, Pin-I Huang, Cheng-Chia Yu, Wen-Huh Hsu, Shih-Hwa Chiou
JOURNAL OF CONTROLLED RELEASE
(2012)
Article
Oncology
Mei-Chun Cheng, Yu-Wen Hu, Ching-Sheng Liu, Jeun-Shenn Lee, Pin-I Huang, Sang-Hue Yen, Yuh-Lin Lee, Chun-Mei Hsieh, Cheng-Ying Shiau
Article
Biochemistry & Molecular Biology
Guang-Yuh Chiou, Chian-Shiu Chien, Mong-Lien Wang, Ming-Teh Chen, Yi-Ping Yang, Yung-Luen Yu, Yueh Chien, Yun-Ching Chang, Chiung-Chyi Shen, Chung-Ching Chio, Kai-Hsi Lu, Hsin-I Ma, Kuan-Hsuan Chen, Dean-Mo Liu, Stephanie A. Miller, Yi-Wei Chen, Pin-I Huang, Yang-Hsin Shih, Mien-Chie Hung, Shih-Hwa Chiou
Article
Oncology
Pen-Yuan Chu, Fang-Wei Hu, Cheng-Chia Yu, Lo-Lin Tsai, Chuan-Hang Yu, Buor-Chang Wu, Yi-Wei Chen, Pin-I Huang, Wen-Liang Lo
Article
Critical Care Medicine
Chorng-Kuang How, Yueh Chien, Kuang-Yao Yang, Hsin-Chin Shih, Chi-Chang Juan, Yi-Ping Yang, Guang-Yuh Chiou, Pin-I Huang, Yuh-Lih Chang, Liang-Kung Chen, Chien-Ying Wang, Han-Shui Hsu, Shih-Hwa Chiou, Chen-Hsen Lee
Article
Multidisciplinary Sciences
Yau-Hua Yu, Guang-Yuh Chiou, Pin-I Huang, Wen-Liang Lo, Chien-Ying Wang, Kai-Hsi Lu, Cheng-Chia Yu, Gil Alterovitz, Wen-Chien Huang, Jeng-Fan Lo, Han-Shui Hsu, Shih-Hwa Chiou
SCIENTIFIC REPORTS
(2012)