Article
Biochemistry & Molecular Biology
Xiangpan Li, Qing Chen, Jingsheng Ao, Wenxin Lin, Liqin Qiu, Rihui Cao
Summary: A series of new 4,7-disubstituted quinoline derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Compound 10k showed the most potent antiproliferative activity and inhibited colorectal cancer growth through inducing autophagy.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sijia Zhang, Ying Zhang, Yuanji Feng, Jiayan Wu, Yingying Hu, Lin Lin, Caina Xu, Jie Chen, Zhaohui Tang, Huayu Tian, Xuesi Chen
Summary: This study explores the combination of regulating tumor glycometabolism with anti-PD-L1 therapy for tumor treatment. By using nanoparticles combined with anti-PD-L1, tumor development is significantly inhibited, increasing the survival time of mice. This strategy also has an immunological memory effect, successfully preventing tumor recurrence and metastasis.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Wuchang Zhang, Wei Liu, Lingfei Jia, Demeng Chen, Insoon Chang, Michael Lake, Laurent A. Bentolila, Cun-Yu Wang
Summary: Inhibition of KDM4A promotes heterochromatin compaction and DNA replication stress in SCC, activating tumor-cell-intrinsic cGAS-STING signaling. KDM4A inhibition collaborates with PD1 blockade to inhibit SCC growth and metastasis, efficiently eliminating cancer stem cells. Targeting KDM4A can activate anti-tumor immunity and enhance PD1 blockade immunotherapy in SCC by aggravating replication stress.
Article
Neurosciences
Xiaokun Zhou, Liang Lv, Yuan Tan, Zhongyi Zhang, Shuyang Wei, Shaowen Xiao
Summary: The study demonstrates that Tanshinone IIA enhances TRAIL-induced apoptosis in glioblastoma cells by modulating the expression of STAT3, DR4, and DR5. In vivo experiments show that cotreatment with T-IIA and TRAIL effectively inhibits tumor growth and induces apoptosis in nude mice.
Article
Nanoscience & Nanotechnology
June Yong Park, Yuseon Shin, Woong Roeck Won, Chaemin Lim, Jae Chang Kim, Kioh Kang, Patihul Husni, Eun Seong Lee, Yu Seok Youn, Kyung Taek Oh
Summary: An AE147 peptide-conjugated nanocarrier system was developed to target metastatic tumors, displaying potential and effective accumulation at tumor metastatic sites.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yuyu Cao, Huiquan Yang, Dongdong Li, Fan Li, Jing Ma, Peidang Liu
Summary: In this study, the optimal AS1411 density on PEGylated silver nanotriangles for targeting breast cancer cells was determined. The results showed that 10% AS1411 density had the highest accumulation and cellular uptake at the cellular level, while 5% AS1411 density had the highest accumulation in tumor tissues.
Article
Chemistry, Medicinal
Jingwei Zhou, Yanqing Pang, Weiwei Zhang, Fen OuYang, Haibiao Lin, Xingshu Li, Jun Yan
Summary: Microtubule targeting agents (MTAs) are effective chemotherapies for cancer treatment, but drug resistance remains a challenge. This study discovers that therapy-resistant cancers are vulnerable to ferroptosis, providing an alternative approach to overcome resistance. A compound 33, synthesized based on previous studies, displays potent activity in vitro and in vivo, mainly inducing cell death through ferroptosis rather than apoptosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Antoine Galmiche, Zuzana Saidak, Francois Ghiringhelli
Summary: In addition to various physical consequences, the coagulation cascade may play a specific role in regulating antitumor immunity. A recent study used systems biology and genomics to investigate how coagulation affects the tumor immune microenvironment.
Article
Biophysics
Runliang Feng, Li Zhu, Fangfang Teng, Min Wang, Shiyu Chen, Zhimei Song, Hongmei Li
Summary: In this study, PBA-modified nano-polymer micelles were synthesized for doxorubicin encapsulation and their effects on drug release, tumor targeting, and antitumor activity were investigated. The results showed that the formulation had acid-sensitive drug release behavior, and a higher polymer dosage improved tumor targeting and antitumor activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Medicinal
Bo Fang, Xue Chen, Xingui Zhou, Xindan Hu, Yan Luo, Zhigang Xu, Cheng-He Zhou, Jiang-Ping Meng, Zhong-Zhu Chen, Chunsheng Hu
Summary: This study presents platinum(IV) compounds with multiple-bond ligands, which exhibited superior activity against tumor cells, proliferation, and metastasis compared to cisplatin. Compounds 2 and 5 with meta-substituted groups showed excellent performance. Research further demonstrated that compounds 2 and 5 had appropriate reduction potential and outperformed cisplatin in cellular uptake, reactive oxygen species response, apoptosis regulation, DNA damage-related gene up-regulation, and drug-resistant cell activity. The title compounds displayed better antitumor potential and fewer side effects in vivo compared to cisplatin. Introduction of multiple-bond ligands improved absorption, overcame drug resistance, and exhibited potential for mitochondrial targeting and inhibition of tumor cell detoxification.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Vadim Le Joncour, Pierre-Olivier Guichet, Kleouforo-Paul Dembele, Alexandre Mutel, Daniele Campisi, Nicolas Perzo, Laurence Desrues, Romain Modzelewski, Pierre-Olivier Couraud, Jerome Honnorat, Francois-Xavier Ferracci, Florent Marguet, Annie Laquerriere, Pierre Vera, Pierre Bohn, Olivier Langlois, Fabrice Morin, Pierrick Gandolfo, Helene Castel
Summary: The study demonstrated that urotensin II induces aggressive behavior in GBM, leading to necrosis and angiogenesis through integrin activation, which can be targeted by UT biased ligands/antagonists.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Polymer Science
Tong Li, Dianwei Wang, Meng Meng, Zhiyu Yang, Zhimin Luo, Zhen Li, Fei Li, Cong Liu, Kai Hao, Xuan Pang, Huayu Tian, Xuesi Chen
Summary: Increasing infiltration of CD8(+) T cells can enhance the response rate to immune checkpoint blockade therapies. In this study, cuproptosis, induced by a newly defined Cu-coordinated covalent organic framework (COF), was shown to effectively increase CD8(+) T cell infiltration. The COF exhibited two functions: Cu2+ acted as a Fenton-like reagent to generate cytotoxicity by catalyzing the production of reactive oxygen species (ROS), and residual Cu2+ depleted cellular glutathione to enhance intracellular oxidative stress, further enhancing the Fenton-like effect. The synergy of these two functions achieved immunogenic cell death and improved anti-tumor effects.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Guanghong Luo, Xing Li, Jihui Lin, Gao Ge, Jiangli Fang, Wangze Song, Gary Guishan Xiao, Bo Zhang, Xiaojun Peng, Yanhong Duo, Ben Zhong Tang
Summary: Ions play a vital role in regulating various biological processes, including tumorigenesis and therapy. The perturbation of ion homeostasis can induce tumor cell death and evoke immune responses. This study prepared a pH-responsive nanoplatform that reprograms the tumor microenvironment and provides antitumor treatment through ion fluctuation.
Article
Biochemistry & Molecular Biology
Li Li, Yang Zhu, Manman Liu, Duo Jin, Lei Zhang, Junjie Cheng, Yangzhong Liu
Summary: In this study, oxaliplatin was modified and conjugated with a nanobody for targeted delivery to cancer cells, with investigation on the effect of PEG chain length on drug circulation. The results demonstrate that prolonging drug circulation significantly improves the in vivo drug efficiency of the oxaliplatin-nanobody conjugate.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Oncology
Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adem Ejub Sofovic, Noriko Kondo, Toshiyuki Sakai, Tsukasa Okuda
Summary: The study identified RUNX1 as a transcriptional regulator of TRAIL, showing that TRAIL expression is decreased in acute myeloid leukemia patients and inhibited by RUNX1-ETO.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biochemical Research Methods
Gi-Beom Jeon, Hyun-Jae Lee, Jong Pil Park, Kyeongsoon Park, Chang-Hyung Choi, Sun-Ki Kim
Summary: This study successfully enhanced the production yield and titer of glutathione by introducing a synthetic isozyme system into Saccharomyces cerevisiae. The expression of the novel bifunctional enzyme GshF required the assistance of Group-I HSP60 chaperonins from Escherichia coli. Through glucose-limited fed-batch fermentation, the engineered strain SKSC222 produced high levels of glutathione.
BIOTECHNOLOGY JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Zheng Li, Jianhua Zou, Xiaoyuan Chen
Summary: Subcellular targeted cancer therapy has emerged as a potent anticancer treatment, providing great opportunities for clinical application. This review summarizes two targeting strategies for four main subcellular organelles, including molecule- and nanomaterial-based targeted delivery or therapeutic strategies. Various treatment strategies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, and combination therapy are discussed in detail. The construction of specific materials based on the properties and mechanisms of organelles allows for the elimination of tumors by inducing dysfunction or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. A paradigm for organelle-targeting therapy with enhanced therapeutic efficacy is envisioned.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Zhao, Yuanwei Pan, Guocan Yu, Xing-Zhong Zhao, Xiaoyuan Chen, Lang Rao
Summary: The high stability and binding specificity of antibodies make them widely applicable in various diseases. However, there are limitations to traditional antibody-based therapeutics. Recent advances in cell membrane nanotechnology have led to the development of vesicular-antibody-based therapeutics, which offer new possibilities for disease treatment.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Jin-Ok Chu, Hye-Seon Jeong, Jong-Pil Park, Kyeongsoon Park, Sun-Ki Kim, Hyunmin Yi, Chang-Hyung Choi
Summary: A novel capsule-based colorimetric temperature monitoring system with precise and tunable temperature ranges is reported. It allows for customizable cold chain management and visual monitoring of temperature changes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Heegyeong Song, Seok Kang, Ying Yu, Sung Yun Jung, Kyeongsoon Park, Sang-Min Kim, HaK-Jun Kim, Jae Gyoon Kim, Sung Eun Kim
Summary: Inflammatory environments can provide important biochemical stimuli for triggered drug delivery in a controlled manner. pH-sensitive nanomaterials can effectively target drugs to the site of inflammation due to the altered local pH. In this study, pH-responsive nanoparticles were designed by complexing resveratrol and urocanic acid with a pH-sensitive moiety. The nanoparticles showed anti-inflammatory and antioxidant activities, reducing the expression of pro-inflammatory molecules and the generation of reactive oxygen species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hyeon Ji Kim, Yong Geun Lim, Yeong Jun Song, Kyeongsoon Park
Summary: In this study, well-dispersible, tumor targetable, TME-responsive, and hypoxia alleviating MnO2 nano-photosensitizers were developed for photodynamic cancer therapy. The nanoparticles exhibited good dispersity and stability under biological conditions and effectively alleviated hypoxia inside tumor cells, leading to enhanced phototherapeutic effects. Therefore, these nanoparticles have promising potential for enhancing hypoxia alleviation-triggered phototherapeutic effects.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yang Zhu, Yaxin Liao, Jianhua Zou, Junjie Cheng, Yuanbo Pan, Lisen Lin, Xiaoyuan Chen
Summary: Nanomaterials with enzyme-mimicking properties, known as nanozymes, have become an alternative to natural enzymes due to their advantages, such as stability, ease of preparation, and catalytic performance. Single atom nanozymes (SAzymes) have recently been developed, showing superior catalytic performance and selectivity, and have made progress in biomedical applications. This review systematically summarizes the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications, and discusses their potential challenges and prospects for future development.
Article
Multidisciplinary Sciences
Zhao Jiang, Liangrui He, Zhiwen Yang, Huibin Qiu, Xiaoyuan Chen, Xujiang Yu, Wanwan Li
Summary: The study demonstrates a multi-ion co-sensitization strategy for achieving ultrawideband-responsive photon conversion of lanthanide nanocrystals from UV to NIR. The authors show applications for low-powered white light-based bioimaging and excitation-regulated encryption.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Yucen Tao, Vivianne Jakobsson, Xiaoyuan Chen, Jingjing Zhang
Summary: This article introduces the integration of therapeutics and diagnostics, known as theranostics. It discusses the application of therapeutic radioligands in cancer treatment, as well as the use of binding substances to prolong their circulation time. The article also summarizes the structure of human serum albumin, efforts in finding new binders, and the recent progress of PSMA-targeting radioligands.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ruijie Huang, Peijie Zhou, Bo Chen, Yang Zhu, Xiaoyuan Chen, Yuanzeng Min
Summary: This study describes a nanotherapeutic platform for targeted drug release in tumors, which has significant antitumor efficacy. By activating the antitumor ability of macrophages, mobilizing T-cell immunity, and promoting the secretion of antitumor cytokines, this platform shows a synergistic effect with immune checkpoint blockers (ICBs).
Review
Chemistry, Multidisciplinary
Xiaoming Hu, Caijun Zhu, Fengwei Sun, Zejing Chen, Jianhua Zou, Xiaoyuan Chen, Zhen Yang
Summary: Near-infrared II (NIR-II) emitters have great potential for in vivo deep-tissue bioimaging and biosensing. This review summarizes the recent progress and structure-property relationships of NIR-II J-aggregates, discusses the molecular regulating strategies for achieving NIR-II J-aggregates, and outlines prospective efforts for promoting clinical applications of NIR-II J-aggregates.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Jae Won Ahn, Yeong Jun Song, Kyeongsoon Park
Summary: In this study, EGFR-targeting micelles were designed for the specific delivery of gefitinib to TNBC cells. The EGFR-targeting micelles formed nano-sized structures and released gefitinib in a sustained manner. They showed specific delivery to EGFR-positive TNBC cells (MDA-MB-468) and exhibited better therapeutic effects compared to EGFR-low or negative TNBC cells (MDA-MB-231 and MDA-MB-453).
MACROMOLECULAR RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ludan Yue, Xueyang Zhang, Chenchen Zhao, Rongchang Chen, Xiaoyuan Chen, Lang Rao
Summary: Inhaled drug delivery is an emerging route for the treatment of lung diseases, with advantages over oral and intravenous routes. However, there are physiological barriers that affect delivery efficacy in the respiratory tract. This review provides an overview of inhaled drug delivery methods, highlighting non-invasive strategies for treating lung diseases.
Article
Chemistry, Multidisciplinary
Pengfei Zhang, Sheng Yao, Yu Tang, Shanhe Wan, Xiaoyuan Chen, Li Ma
Summary: In this study, a new palliative interventional therapy, nanoparticle-mediated microknife ablation, was developed to eliminate local cancer pain and tumors. Compared to classic chemotherapeutic agents, this therapy showed higher effectiveness in pain removal without damaging the nervous, sensory, and motor capabilities.
Article
Chemistry, Multidisciplinary
Jianping Liu, Jiezhao Zhan, Ye Zhang, Lin Huang, Jing Yang, Jie Feng, Lingwen Ding, Zheyu Shen, Xiaoyuan Chen
Summary: In this study, a facile method for synthesizing ultrathin manganese-based layered double hydroxide nanosheets is proposed, which enhances the interaction between ferroptosis and immunotherapy, overcoming the obstacles in current cancer immunotherapy.
ADVANCED MATERIALS
(2023)