Article
Chemistry, Multidisciplinary
Sathish Rajendran, Shani Ben Zichri, Varsha Usha Vipinachandran, Raz Jelinek, Susanta Kumar Bhunia
Summary: This research presents a novel type of carbon dots that can serve as both mitochondrial labeling agents and tetracycline sensors, exhibiting a high quantum yield of fluorescence. These carbon dots have the ability to recognize cellular mitochondria and rapidly detect tetracycline in a quenching response.
Article
Chemistry, Multidisciplinary
Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda
Summary: The 14-3-3 family of proteins plays a central role in regulating signaling pathways driven by serine/threonine kinases. Although there are seven highly conserved isoforms of 14-3-3 in humans, the specific functions of each isoform are still not fully understood. This study focused on evaluating the sigma isoform of 14-3-3 and designing a fluorescent labeling agent using a natural product as a base. The results showed that the labeled agent exhibited selective fluorescent detection of 14-3-3 sigma, indicating its potential use for studying the biological roles of this isoform.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Aaron E. Chiou, Joshua A. Hinckley, Rupal Khaitan, Neta Varsano, Jonathan Wang, Henry F. Malarkey, Christopher J. Hernandez, Rebecca M. Williams, Lara A. Estroff, Steve Weiner, Lia Addadi, Ulrich B. Wiesner, Claudia Fischbach
Summary: This study introduces fluorescent silica nanoparticles (SNPs) as a robust and versatile labeling strategy to analyze tumor cells within mineralized bone. The uptake and labeling efficiency of MDA-MB-231 breast cancer cells with SNPs are characterized using cryo-scanning electron microscopy and different tissue processing methods. SNPs are demonstrated to allow visualization of labeled tumor cells in mineralized bone using various imaging modalities, suggesting their value in analyzing tumor cells within mineralized bone.
Article
Biotechnology & Applied Microbiology
Jiayi Lin, Linlin Xu, Yuling Zheng, Dalin Wu, Jun Yue
Summary: This study reports a fluorescence probe with a core-shell structure that can selectively label different types of bacteria and biofilms. The results demonstrate the potential application of this probe in bacterial research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Eric Zhang, Yanwen Liu, Chaoshan Han, Chengming Fan, Lu Wang, Wangping Chen, Yipeng Du, Dunzheng Han, Baron Arnone, Shiyue Xu, Yuhua Wei, James Mobley, Gangjian Qin
Summary: Exosomes, particularly those derived from mesenchymal stem cells (MSCs), have been shown to replicate the therapeutic activity of stem cells themselves, making them a potential alternative for the treatment of cardiovascular disorders. This study developed an in vivo model using bioorthogonal chemistry and metabolic labeling to track and quantify proteins from systemically administered MSC exosomes. The results showed that labeled exosomal proteins from MSCs could be identified, isolated, and quantified from various mouse organs, providing insights into exosome homing and the distribution of exosomal proteins in the context of myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Lars H. Andersen, Anne P. Rasmussen, Henrik B. Pedersen, Oleg B. Beletsan, Anastasia V. Bochenkova
Summary: By using time-resolved action spectroscopy of cryogenically cooled molecular ions, we have achieved high vibrational resolution in the photoresponse of the deprotonated GFP chromophore. We have identified four characteristic spectral regions and determined the energy barrier towards internal conversion. The red-shifted origin of the S-0-S-1 band suggests similar photophysics between the protein and its chromophore.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Applied
Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan
Summary: A dual-mode nanosensor using spectroscopy and fluorescence was developed for the quantitative determination of new coccine in foods. It was successfully applied to the detection of new coccine in energy drinks, carbonated beverage, gum, and ketchup.
Article
Chemistry, Applied
Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu
Summary: In this study, yellow-green fluorescent carbon dots were prepared using VB2 and citrate as precursors, and they showed great potential for detecting tartrazine and Hg2+. The N-CDs were purified and achieved excellent linear ranges and low detection limits. The quenching mechanisms of N-CDs fluorescence were also illuminated, and the nanoprobe was successfully applied to determine the content of tartrazine and Hg2+ in different samples.
Article
Environmental Sciences
Maria Carolina Robaina Vieira, Felipe Andrade Carvalho, Mathews Krambeck de Oliveira Franco, Willian Toito Suarez, Castelo Bandane Vilanculo, Marcelo Henrique dos Santos, Francisco Fernandes Gambarra-Neto
Summary: A green synthesis method for water-soluble photoluminescent carbon dots (CDs) functionalized with methimazole (MTZ) was described, with starch from rice as the natural source. The CDs were characterized using fluorescence techniques, FTIR, and UV-Vis spectroscopy, showing selective response to Hg2+ ions after MTZ functionalization. The method achieved a low detection limit of 1.8 x 10(-7) mol L-1 for Hg2+ in water samples.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Spectroscopy
Jing Ren, Wenxin Wu, Tongyao Chen, Hengyao Guo, Changlin Xu, Jing Ma, Lingna Wang, Jingfang Wang, Lin Li
Summary: Excessive uptake of Co2+ is harmful to health. A new poly-ethylenimine protected copper nanocluster can be used for specific detection of Co2+ with excellent performance and low toxicity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Multidisciplinary
Yanyun Hao, Hui Li, Xiaoyan Ge, Yang Liu, Xia Li, Yutong Liu, Hongfei Chen, Shiying Zhang, Jing Zou, Lingling Huang, Fabao Zhao, Dongwei Kang, Bruno G. De Geest, Zhiyue Zhang
Summary: In this study, a polymeric nano-immunomodulator was developed to selectively activate the immune system in tumors, enhancing T lymphocyte infiltration without causing immune-related adverse effects. It shows promising potential for safe systemic targeting delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Kishor S. Jagadhane, Ray J. Butcher, Tukaram D. Dongale, Kiran A. Nirmal, Govind B. Kolekar, Mohaseen S. Tamboli, Tae Geun Kim, Sunita Salunke-Gawali, Prashant V. Anbhule
Summary: Ethyl 2-cyano-3-(4-(1,2,2-triphenylvinyl) phenyl) acrylate (TPE-SKJ), a tetraphenylethene-based luminogen, exhibits various photophysical phenomena such as aggregation-induced emission (AIE), reversible mechanochromic, solvatochromic, organic light emitting diode (OLED), and chemical sensing. It demonstrates high selectivity and sensitivity for detecting MnO4 (-) in mixed aqueous media and shows improved efficiency in OLEDs as an emissive layer compared to traditional green OLEDs.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Spectroscopy
Urosa Latief, Shafi ul Islam, Zubair M. S. H. aKhan, Mohd Shahid Khan
Summary: This study reported an economical, easy, greener, and non-toxic synthesis method of water-soluble carbon quantum dots (CQDs), which exhibit strong blue fluorescence under UV lamp and show a sensitive response to Fe3+ ions. TEM measurements confirmed their spherical morphology and varying sizes in the range of 0.5-5 nm, with a detection limit of 0.2 μM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Optics
Sureyya Oguz Tumay
Summary: The three novel tripodal-structured polyaromatic hydrocarbon-based fluorescent sensors were synthesized and characterized, showing excellent sensitivity and selectivity for Fe3+ ions in environmental water samples. The sensors demonstrated significantly low LODs for iron ions with highly selective and sensitive fluorescence turn-off responses.
JOURNAL OF LUMINESCENCE
(2021)
Article
Chemistry, Multidisciplinary
Huanyu Xie, Yudong Lu, Ruiyun You, Wei Qian, Shan Lin
Summary: In this study, nitrogen-doped graphene quantum dots (N-GQDs) were prepared and used for the detection of tetracycline (TC) based on the internal filtration effect. The method showed greenness, rapidity, high sensitivity, and selectivity, making it suitable for real food samples.