Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Yeran Hwang, Kyeong-Eon Park, Mingu Kim, Ju-Tae Sohn
Summary: In this study, the researchers investigated the involvement of aortic contraction induced by dexmedetomidine in the transactivation of EGFR in endothelium-denuded rat aortas. They found that the activation of alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase mediated the contraction and subsequent JNK phosphorylation and increased calcium levels. These findings provide insights into the cellular mechanisms underlying dexmedetomidine-induced effects on aortic contraction and EGFR transactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yanlong Song, Weiting Chen, Bo Zhu, Wei Ge
Summary: Folliculogenesis is regulated by the communication between oocytes and follicle cells, with EGF signaling playing a critical role in the early stages of follicle development. Knockout mutants of Egf and Egfr in zebrafish revealed that Egfr is essential for follicle activation, while Egf mutation primarily affects fertilization rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen
Summary: In HER2(+) breast cancer, overactivation of HER2 leads to aberrant G(i/o)-GPCR signaling, promoting cancer progression and resistance to HER2-targeted therapy. Pharmacologically deactivating GPCR signaling can block tumor growth and enhance therapeutic efficacy.
Review
Pharmacology & Pharmacy
Michael Gekle, Virginie Dubourg, Gerald Schwerdt, Ralf A. Benndorf, Barbara Schreier
Summary: EGFR plays a critical role in the regulation of vascular function and pathogenesis of cardiovascular diseases through the interplay with AT1R.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J. Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J. Little
Summary: This study aimed to investigate the role of proximal G proteins in PAR-1 transactivation-dependent signaling. The findings showed that G alpha q is involved in PAR-1-mediated proteoglycan modification, while G alpha 11 has no effect. These findings are significant for the study of other GPCRs involved in vascular pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Cell Biology
Yan Zou, Le Pan, Yi Shen, Xiang Wang, Chenxing Huang, Hao Wang, Xuejuan Jin, Chao Yin, Ying Wang, Jianguo Jia, Juying Qian, Yunzeng Zou, Hui Gong, Junbo Ge
Summary: Progressive cardiac fibrosis is accelerated by elevated serum levels of Wnt5a and Wnt11 in hypertension patients, leading to diastolic dysfunction. Pressure overload increases the secretion of Wnt5a and Wnt11 from cardiomyocytes and cardiac fibroblasts, promoting cardiac fibrosis through the activation of FZD5 and EGFR crosstalk.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Qian Xiao, Yi-Hsiu Chen, Ya-Ling Chen, Yu-Shan Chien, Li-Hsuan Hsieh, Hitoshi Shirakawa, Suh-Ching Yang
Summary: This study investigated the beneficial effects of epidermal growth factor (EGF) on muscle loss in rats with chronic ethanol feeding. The findings showed that EGF supplementation inhibited muscular protein degradation, reduced liver injuries, and altered gut microbiota composition. However, further studies are needed to confirm the improvement in muscle loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Bing-Xi Yan, Xue-Yan Chen, Zhao-Yuan Wang, Ying-Zhe Cui, Lilla Landeck, Ni-Chang Fu, Xing-Yu Yang, Fan Xu, Yuan Zhou, Jia-Qi Chen, Xiao-Yong Man
Summary: In this study, the role of Isoleucyl-tRNA synthetase (IARS) inhibitor mupirocin in the treatment of psoriasis was investigated. The expression of IARS was found to be higher in psoriatic skin compared to healthy controls. Mupirocin reversed abnormal proliferation of keratinocytes and reduced the expression of inflammatory cytokines and infiltration of immune cells in a psoriasis-like mouse model and in cultured human keratinocytes. The findings suggest that inhibiting the formation of IARS may be one mechanism by which mupirocin treats psoriasis.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Aya Yamamura, Md Junayed Nayeem, Hiroyuki Muramatsu, Kogenta Nakamura, Motohiko Sato
Summary: The study revealed that the VEGFR-3 signaling pathway plays a crucial role in the proliferation, migration, and tumor growth of androgen-independent/highly metastatic prostate cancer cells, highlighting its potential as a novel therapeutic target for prostate cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Rahul V. Patel, Bhupendra M. Mistry, Akash V. Gujarati, Amit B. Patel, Divyesh K. Patel
Summary: Cancer is recognized as a major global health threat and a leading cause of human mortality due to uncontrolled cell expansion. EGFR mutations play a role in cancer development and research is being done on 4-aminoquinazolines to suppress EGFR. This patent review aims to update researchers on the latest EGFR-targeted developments using 4-aminoquinazolines, which hold promise for novel kinase-targeted cancer therapies.
Review
Cell Biology
Joanne L. Peterson, Brian P. Ceresa
Summary: Maintaining proper structure and function of the cornea is essential for clear vision. The epidermal growth factor receptor (EGFR) plays a crucial role in maintaining and restoring the corneal epithelium. Recent advances in understanding EGFR signaling and trafficking offer new strategies to overcome receptor desensitization and optimize receptor signaling for corneal health.
Article
Oncology
Johnny Rached, Zeina Nasr, Jad Abdallah, Tamara Abou-Antoun
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Review
Clinical Neurology
Tamara J. Abou-Antoun, James S. Hale, Justin D. Lathia, Stephen M. Dombrowski
Article
Oncology
Hayat Zaatiti, Jad Abdallah, Zeina Nasr, George Khazen, Anthony Sandler, Tamara J. Abou-Antoun
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Multidisciplinary Sciences
Tamara J. Abou-Antoun, Javad Nazarian, Anthony Ghanem, Stanislav Vukmanovic, Anthony D. Sandier
Review
Oncology
S. Al-Dimassi, T. Abou-Antoun, M. El-Sibai
CLINICAL & TRANSLATIONAL ONCOLOGY
(2014)
Article
Oncology
Thamara J. Abouantoun, Robert C. Castellino, Tobey J. MacDonald
JOURNAL OF NEURO-ONCOLOGY
(2011)
Review
Neurosciences
Hisham F. Bahmad, Farah Chamaa, Sahar Assi, Reda M. Chalhoub, Tamara Abou-Antoun, Wassim Abou-Kheir
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Review
Oncology
Hisham F. Bahmad, Mohamad K. Elajami, Talal El Zarif, Jolie Bou-Gharios, Tamara Abou-Antoun, Wassim Abou-Kheir
CANCER AND METASTASIS REVIEWS
(2020)
Article
Pharmacology & Pharmacy
Hisham F. Bahmad, Reda M. Chalhoub, Hayat Harati, Jolie Bou-Gharios, Sahar Assi, Farah Ballout, Alissar Monzer, Hiba Msheik, Tarek Araji, Mohamad K. Elajami, Paola Ghanem, Farah Chamaa, Humam Kadara, Tamara Abou-Antoun, Georges Daoud, Youssef Fares, Wassim Abou-Kheir
Summary: The study evaluated the potential anti-tumor effect of Tideglusib (TDG), an irreversible GSK-3 beta inhibitor drug, on three human NB cell lines. Results showed that TDG significantly reduced cell proliferation, viability, and migration of the NB cells in a dose- and time-dependent manner, while also hindering the formation of neurospheres. Additionally, TDG reduced CD133 cancer stem cell marker expression and inhibited NB tumor growth and progression in vivo, indicating its potential as an effective treatment targeting NB CSCs and overcoming therapy resistance.
PHARMACOLOGICAL REPORTS
(2021)
Article
Oncology
Reine Hanna, Jad Abdallah, Tamara Abou-Antoun
Summary: The study demonstrated that HSP90 inhibition can effectively suppress cellular proliferation, viability, and migration/invasion, while promoting apoptosis in neuroblastoma cells. The treatment also attenuated the stem-cell self-renewal potential in MYCN-amplified cells, showing a novel therapeutic mechanism to enhance therapeutic sensitivity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
AG Dayer, KM Cleaver, T Abouantoun, HA Cameron
JOURNAL OF CELL BIOLOGY
(2005)
Article
Peripheral Vascular Disease
M Dodic, T Abouantoun, A O'Connor, EM Wintour, KM Moritz