Article
Biochemistry & Molecular Biology
Hyejung Jo, Dahae Lee, Cheolhyeon Go, Yoojin Jang, Suhyun Bae, Tomoyo Agura, Jiye Hong, Dongmin Kang, Yejin Kim, Jae Seung Kang
Summary: Pancreatic cancer is a highly lethal solid tumor with limited treatment options. Recent studies have shown that upregulation of the amino acid transporter SLC6A14 is associated with glutamine metabolism in some cancers. Alloferon, a peptide derived from the insect immune system, has been found to have anti-tumoral effects, although its underlying mechanisms are not well understood. In this study, researchers investigated the effects of alloferon on pancreatic cancer cell lines and found that it downregulated SLC6A14 expression and reduced glutamine uptake. This suggests that alloferon could potentially be used as an adjuvant for chemotherapeutic drugs in pancreatic cancer treatment.
Article
Oncology
Yifan Feng, Ye Wang, Yangqin Xie, Shuwei Wu, Yuyang Li, Min Li
Summary: Factors affecting the prognosis of patients with stage IIIC1 cervical cancer were analyzed to establish nomogram models for predicting overall survival (OS) and cancer-specific survival (CSS). Tumor size was identified as the most important prognostic factor in these models.
Article
Multidisciplinary Sciences
Kareem A. Wahid, Brennan Olson, Rishab Jain, Aaron J. Grossberg, Dina El-Habashy, Cem Dede, Vivian Salama, Moamen Abobakr, Abdallah S. R. Mohamed, Renjie He, Joel Jaskari, Jaakko Sahlsten, Kimmo Kaski, Clifton D. Fuller, Mohamed A. Naser
Summary: This data descriptor presents a dataset of head and neck cancer patients, including manually segmented CT images of skeletal muscle and adipose tissue, as well as additional clinical demographic data relevant to body composition analysis. These data are valuable for studying sarcopenia and body composition analysis in patients with head and neck cancer.
Article
Oncology
Xiang Fan, Yifei Wang, Ni Yang, Pengfeng Zhu
Summary: This study aimed to analyze the prognostic factors in patients with stage IIIC1p cervical cancer treated by surgery. Through a retrospective analysis of clinical data from 102 patients who underwent surgical treatment, it was found that no postoperative adjuvant therapy, LNR > 0.3, and NLR > 3.8 were independent risk factors for poor prognosis in patients with stage IIIC1p cervical cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer, Virna D. Leaner
Summary: Pre-treatment with INI-43 significantly enhances cisplatin sensitivity in cervical cancer cells by stabilizing p53 and reducing nuclear import of NF kappa B. The combination of nuclear import inhibition and cisplatin shows synergistic effects in enhancing DNA damage and cell death in cervical cancer cells.
Article
Oncology
Yanshan Jin, Shangdan Xie, Bo Sheng, Mei Chen, Xueqiong Zhu
Summary: This study aimed to explore the effect of propofol on the chemosensitivity of cervical cancer cells to paclitaxel. The results showed that propofol had no significant effect on the malignant behavior of the cells, but it enhanced the anti-cancer effect when used in combination with paclitaxel by reducing stathmin 1 expression.
Article
Oncology
Qunxian Rao, Xue Han, Yuan Wei, Hui Zhou, Yajie Gong, Meimei Guan, Xiaoyan Feng, Huaiwu Lu, Qingsong Chen
Summary: This study analyzed data from 1075 cervical cancer patients, identified clinicopathological characteristics associated with prognosis, and established nomogram models for predicting disease-free survival (DFS) and overall survival (OS). The nomograms showed high performance in terms of discrimination, calibration, and clinical applicability.
Article
Oncology
Biniyam Tefera Deressa, Mathewos Assefa, Ephrem Tafesse, Eva Johanna Kantelhardt, Ivan Soldatovic, Nikola Cihoric, Daniel Rauch, Ahmedin Jemal
Summary: The survival rate for cervical cancer patients in Ethiopia is low due to late presentation and delays in receiving radiotherapy, leading to stage migration. Only a small percentage of patients received concurrent chemotherapy, with lower survival rates.
Article
Multidisciplinary Sciences
Shirley H. F. Lee, Nurlaylasahira Abdul Rahim, Sok King Ong, Hanif Abdul Rahman, Lin Naing
Summary: This study aimed to investigate the survival rate of cervical cancer patients in Brunei Darussalam between 2002 and 2017, compare the survival rate between two periods, and identify prognostic factors. The results showed that the 5-year survival rate was 72.5%, with increased mortality among elderly patients and those diagnosed with advanced stage cervical cancer. Therefore, public health efforts should focus on raising awareness and early detection among these groups.
Review
Oncology
Ling Han, Yali Chen, Ai Zheng, Hengxi Chen
Summary: This study conducted a systematic review and meta-analysis to compare the clinical outcomes of cervical cancer patients who underwent hysterectomy with or without preoperative cervical conization. The analysis included 11 studies with 4184 participants and showed that preoperative conization improved disease-free survival and overall survival, with a lower risk of recurrence. Especially for early-stage cervical cancer patients who underwent minimally invasive surgery, had smaller tumor size, and no lymph node involvement, preoperative conization may have a better therapeutic effect.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Fiona J. Ruiz, Matthew Inkman, Ramachandran Rashmi, Naoshad Muhammad, Nishanth Gabriel, Christopher A. Miller, Michael D. McLellan, Michael Goldstein, Stephanie Markovina, Perry W. Grigsby, Jin Zhang, Julie K. Schwarz
Summary: Persistent HPV infection is the main cause of cervical cancer, and patients with cervical tumors containing HPV genotypes other than HPV 16 have worse survival outcomes after CRT. High levels of E6*I and E6 expression may represent novel biomarkers of CRT efficacy.
Article
Oncology
Lixia Ju, Juan Yang, Changyun Zhai, Shuizhen Chai, Zhiyi Dong, Minghua Li
Summary: The prognosis for small cell lung cancer (SCLC) patients receiving later-line treatment is very poor, and using CTCs cultured in vitro for drug susceptibility testing may not benefit the improvement of therapeutic regimen for SCLC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Le Qin, Yixin Heng, Shenghe Deng, Junnan Gu, Fuwei Mao, Yifan Xue, Zhenxing Jiang, Jun Wang, Denglong Cheng, Ke Wu, Yinghao Cao, Kailin Cai
Summary: This retrospective study evaluated the impact of tumour perineural invasion (PNI) on the prognosis of patients with colorectal cancer (CRC). The results showed that PNI significantly affected the long-term survival and prognosis of patients with CRC undergoing surgery and was an independent prognostic factor. Furthermore, postoperative chemotherapy improved the overall survival of PNI(+) patients.
Article
Oncology
Xiangdi Meng, Yingxiao Jiang, Xiaolong Chang, Yan Zhang, Yinghua Guo
Summary: This study used conditional survival analysis to assess the improvement of survival over time in long-term survived cervical cancer patients and developed a novel conditional survival nomogram for individualized and real-time prognostic information.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jing-Ying Xu, Jun-Ni Chen, Jian Lei, Min Hu, San-Gang Wu, Juan Zhou
Summary: This study evaluated the value of local treatment in stage IVB cervical cancer patients and found that the addition of local surgery or radiotherapy to chemotherapy can improve survival outcomes.
GYNECOLOGIC ONCOLOGY
(2022)