Article
Fisheries
Sheng Wang, Haoyang Li, Rongjian Chen, Xiewu Jiang, Jianguo He, Chaozheng Li
Summary: This study found that shrimp TAK1 can provide antibacterial protection by activating both the MAPK and NF-kappa B pathways, suggesting that the TAK1-MAPK/NF-kappa B axis could be a potential therapeutic target for enhancing antibacterial responses in crustaceans.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Chemical
Yanjun Zhang, Chunli Wang, Xiaona Li, Li Yang
Summary: The imbalance in the expression of MMPs and LOXs in SFs caused by mechanical injury and inflammatory response prevents injured ACLs from self-healing. This study found that growth factors and mechanical factors play an important role in regulating the joint-cavity microenvironment.
Article
Environmental Sciences
Ahmed G. Abd Elhameed
Summary: The study revealed that the combination of oral aspirin and krill oil could significantly alleviate silica-induced pulmonary injury by reducing inflammatory cell accumulation, decreasing oxidative stress levels, and inhibiting the expression of inflammatory and fibrotic mediators. Additionally, this combination also showed a decrease in hydroxyproline content induced by silica and a clear restoration of lung architecture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Tian Lan, Hang-fei Chen, Fang Zheng, Hui Huang, Qi Wu, Xue-yu Fan, Si-wei Wang, Feng Zhang
Summary: Cinobufacini was found to inhibit the progression of pancreatic ductal adenocarcinoma by modulating the YEATS2/TAK1/NF-kappa B pathway. The results demonstrated that cinobufacini can induce cell cycle arrest and inhibit the growth of pancreatic cancer cells, as well as suppress tumor progression in mice.
Article
Chemistry, Medicinal
Guancheng Liu, Zhe Cui, Xiaoyan Gao, Huizhe Liu, Linghe Wang, Jinyan Gong, Ao Wang, Jianxiu Zhang, Qianqian Ma, Yuan Huang, Guangchun Piao, Haidan Yuan
Summary: Corosolic acid (CA) from hawthorn has shown significant therapeutic effects on non-alcoholic steatohepatitis (NASH), ameliorating liver inflammation and fibrosis by regulating TGF-beta 1/Smad2, NF-kappa B, and AMPK signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Virology
Constanza E. Espada, Corine St Gelais, Serena Bonifati, Victoria V. Maksimova, Michael P. Cahill, Sun Hee Kim, Li Wu
Summary: SAMHD1 restricts HIV-1 replication by limiting the intracellular dNTP pool and suppresses NF-kappa B activation. This suppression is modulated by TRAF6 and TAK1, which play key roles in mediating the negative regulation of the NF-kappa B pathway by SAMHD1.
JOURNAL OF VIROLOGY
(2021)
Article
Anatomy & Morphology
Lei Wang, Mei Shao, Wei Jiang, Yangfeng Huang
Summary: This study suggests that resveratrol may protect against bleomycin-induced pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition and down-regulating the TLR4/NF-Kappa B and TGF-beta 1/smad3 signaling pathways.
Article
Medicine, Research & Experimental
Yifan Chen, Hanwei Yin, Jing Sun, Guozhou Zhang, Ying Zhang, Huihui Zeng
Summary: This study demonstrates that butaselen is a potential drug for the treatment of pulmonary fibrosis by inhibiting the NF-κB/TGF-β1/Smads signaling pathway. Additionally, butaselen and dexamethasone have a synergistic effect in inhibiting pulmonary fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Bozhi Ye, Xudong Chen, Yanghao Chen, Wante Lin, Diyun Xu, Zimin Fang, Nipon Chattipakorn, Weijian Huang, Xu Wang, Gaojun Wu, Guang Liang
Summary: This study demonstrates that Costunolide (Cos) can improve obesity cardiomyopathy by inhibiting inflammation. Through molecular docking, we confirmed that Cos targets TAK1 and inhibits NF-kappa B pathway activation by blocking the formation of the TAK1/TAB2 complex, thereby reducing inflammatory cytokine release and improving myocardial inflammation. Moreover, Cos effectively reduces cardiac hypertrophy and fibrosis caused by obesity, leading to improved cardiac function against obesity cardiomyopathy.
Article
Gastroenterology & Hepatology
Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang, Yimin Jia, Longfei Jia, Xiang Zhong, Ruqian Zhao
Summary: The study revealed the close association between m(6)A methylation, METTL3/METTL14 upregulation, and TGF-beta 1 upregulation in NASH rat liver and LPS-activated KCs. NF-kappa B acts as a transcription factor to transactivate METTL3/METTL14 genes, leading to global RNA m(6)A hypermethylation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Engineering, Biomedical
Xiangbing Wu, Shichong Qiao, Wei Wang, Yi Zhang, Junyu Shi, Xiaomeng Zhang, Wen Gu, Xiao Zhang, Yuan Li, Xinxin Ding, Jianxu Wei, Yingxin Gu, Hongchang Lai
Summary: The study demonstrates that prophylactic administration of melatonin reduces the incidence of peri-implantitis by decreasing proinflammatory cytokine levels, inhibiting osteoclastogenesis, and promoting osteogenesis. Melatonin may prevent peri-implantitis by inhibiting TLR4/NF-kappa B signaling, presenting a novel strategy for prevention in dental implantology.
ACTA BIOMATERIALIA
(2021)
Article
Cardiac & Cardiovascular Systems
Shuting Chang, Guanzhao Zhang, Lanlan Li, Haiying Li, Xiaodong Jin, Yunshan Wang, Bo Li
Summary: This study found that Sirt4 deficiency aggravates the development of atherosclerosis by activating the NF-kappa B/I kappa B/CXCL2/3 pathway. This suggests that Sirt4 may have a protective effect in atherosclerosis, providing a new strategy for clinical prevention and treatment of atherosclerosis.
Article
Chemistry, Multidisciplinary
Deng-qiu Xu, Lei Zhao, Si-jia Li, Xiao-fei Huang, Chun-jie Li, Li-xin Sun, Xi-hua Li, Lu-yong Zhang, Zhen-zhou Jiang
Summary: Catalpol can restore skeletal muscle strength and alleviate skeletal muscle damage in aged mdx mice, providing a potential novel therapy for DMD. Catalpol attenuates muscle fibrosis by inhibiting the TGF-beta 1/TAK1 signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Fisheries
Yandong Xu, Bi Zhu, Ru Zhang, Jianzhou Tang, Yang Liu, Wenjun Wang, Zuzhen Wang, Ying Mao, Guoqing Zeng, Jinpeng Yan
Summary: The study successfully cloned and characterized maTak1 in blunt snout bream, revealing its function and interaction with TAB1 in NF-kappa B activation. The results showed that maTAK1 and maTAB1 can directly combine to regulate the host's immune response to pathogen invasion by producing pro-inflammatory cytokines through the NF-kappa B signaling pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Oncology
R. J. Lurvink, L. Villeneuve, K. Govaerts, I. H. J. T. de Hingh, B. J. Moran, M. Deraco, K. Van der Speeten, O. Glehen, V Kepenekian, S. Kusamura
Summary: The article discusses the consensus statement creation process for PMP and PM, using the Delphi technique and GRADE methodology to reach consensus on treatment strategies among an international panel of experts.
Review
Oncology
Sajad Fakhri, Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Hossein Pourgholami
Summary: Angiogenesis plays a critical role in cancer progression, regulated by drugs and natural compounds. Herbal and natural compounds show potential in inhibiting VEGF and angiogenesis for developing novel anticancer drugs.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Oncology
Thomas Steffen, Lukas Haller, Lana Bijelic, Markus Glatzer, Olivier Glehen, Diane Goere, Ignace de Hingh, Yan Li, Brendan J. Moran, David L. Morris, Pompiliu Piso, Claudio A. Quadros, Beate Rau, Paul Sugarbaker, Yutaka Yonemura, Paul M. Putora
Summary: This study evaluated treatment strategies among international experts in peritoneal carcinosis, focusing on the decision-making process for HIPEC in women with ovarian cancer. The results showed that HIPEC plays a significant role in both primary and recurrent ovarian cancer, with the peritoneal cancer index (PCI) being a key criterion for decision-making.
Editorial Material
Surgery
Abbas El-Hajj Hussein, Joshua D. Lansom, Nayef A. Alzahrani, David L. Morris
ANZ JOURNAL OF SURGERY
(2021)
Article
Oncology
Raphael Shamavonian, Joshua D. Lansom, Josh B. Karpes, Nayef A. Alzahrani, David L. Morris
Summary: This study found that the presence of signet ring cell (SRC) in appendix cancer with peritoneal dissemination is associated with worse overall survival (OS) when compared to patients without SRC undergoing CRS/HIPEC. An increase in SRC count is negatively correlated with overall survival rate.
Article
Pharmacology & Pharmacy
Fatemeh Mahboobifard, Leila Dargahi, Masoumeh Jorjani, Fahimeh Ramezani Tehrani, Mohammad H. Pourgholami
Summary: ER alpha 36, a newly identified isoform of estrogen receptor, is highly expressed in the CNS and plays a role in neuroprotection, as well as maintaining bone density in postmenopausal women. Despite being considered an oncogenic molecule, ER alpha 36 paradoxically may have a protective role in certain tumors according to some studies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Virology
Javed Akhter, Gregory Queromes, Krishna Pillai, Vahan Kepenekian, Samina Badar, Ahmed H. Mekkawy, Emilie Frobert, Sarah J. Valle, David L. Morris
Summary: The study demonstrates that BromAc disrupts the spike and envelope proteins of SARS-CoV-2, reducing infectivity in host cells. This treatment shows potential for imminent clinical testing in patients with early SARS-CoV-2 infection.
Article
Surgery
Shigeki Kusamura, Francesco Barretta, Yutaka Yonemura, Paul Hendrick Sugarbaker, Brendan John Moran, Edward A. Levine, Diane Goere, Dario Baratti, Eran Nizri, David Lawson Morris, Olivier Glehen, Armando Sardi, Pedro Barrios, Francois Quenet, Laurent Villeneuve, Alberto Gomez-Portilla, Ignace de Hingh, Wim Ceelen, Joerg O. W. Pelz, Pompiliu Piso, Santiago Gonzalez-Moreno, Kurt van der Speeten, Marcello Deraco
Summary: This cohort study compared outcomes between PMP patients undergoing CRS with HIPEC and CRS alone, finding HIPEC to be associated with improved overall survival.
Article
Chemistry, Multidisciplinary
Carly J. Carter, Krishna Pillai, Samina Badar, Ahmed H. Mekkawy, Javed Akhter, Thomas Jefferies, Sarah J. Valle, David L. Morris
Summary: The study found that the combination of Bromelain and NAC, known as BromAc, had good dissolution efficacy rates of 80% and above on biofilms produced by three strains of Pseudomonas aeruginosa. The combination exhibited significant impact on all three strains, with Bromelain degrading biofilms more effectively while NAC showed growth enhancement in two strains. The results suggest that BromAc may be a promising treatment option for eradicating biofilms formed by Pseudomonas aeruginosa strains.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Ahmed H. Mekkawy, Mohammad Breakeit, Krishna Pillai, Samina Badar, Javed Akhter, Sarah J. Valle, David L. Morris
Summary: The study investigated the effect of intraperitoneal delivery of BromAc((R)) on colon-anastomosis healing in rats. The results showed that the rats treated with BromAc((R)) did not experience any interference with the healing process. The burst pressure and collagen density in the BromAc((R)) group were slightly higher compared to the control group, although not statistically significant.
Article
Respiratory System
Krishna Pillai, Ahmed H. H. Mekkawy, Javed Akhter, David L. L. Morris
Summary: In this study, the efficacy of BromAc as a mucolytic agent was tested on two gelatinous sputa models. The results showed that BromAc improved the viscosity and flow of the sputum, and had a greater effect compared to individual agents. Therefore, BromAc may be used as an effective mucolytic for clearing airway congestion caused by thick mucinous secretions.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
Article
Oncology
Kevin Ke, Krishna Pillai, Ahmed H. Mekkawy, Javed Akhter, Samina Badar, Sarah J. Valle, David L. Morris
Summary: A phase 1 clinical trial of intraperitoneal BromAc for pseudomyxoma peritonei is currently ongoing, with routine blood parameter analysis of 25 patients revealing elevated inflammatory markers and decreased serum albumin levels post-treatment, suggesting an inflammatory response. However, liver enzymes, coagulation studies, and other parameters remained unaffected, indicating no additional safety concerns were identified through routine blood parameter testing.
Article
Oncology
Farnaz Bahrami, Ahmed H. Mekkawy, Samina Badar, David L. Morris, Mohammad H. Pourgholami
Summary: Epithelial ovarian cancer is the leading cause of gynaecological malignancy-related deaths in women. Research has shown that MPL has potential as an anticancer drug by effectively suppressing growth and proliferation of ovarian cancer cells through inhibition of the mTOR/p70S6K pathway. Further studies are needed to explore the full potential of MPL in cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Samina Badar, Mohamed Azarkan, Ahmed H. Mekkawy, Javed Akhter, Krishna Pillai, Rachida El Mahyaoui, Kevin Ke, Lauren Cavanaugh, David L. Morris
Summary: This study examined the proteolytic, anticancer, and antithrombotic properties of four fractions of bromelain, finding that fraction 3 exhibited the highest activity in various aspects, especially in terms of cytotoxicity. Combination of fraction 3 with various drugs also showed better results.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Ahmed H. Mekkawy, Krishna Pillai, Samina Badar, Javed Akhter, Kevin Ke, Sarah J. Valle, David L. Morris
Summary: The combination of BromAc (R) with Gemcitabine showed potential efficacy and safety in treating colorectal cancer, while preliminary efficacy studies with Oxaliplatin and 5-Fluorouracil were negative. The study indicates that Gemcitabine in combination with BromAc (R) may have a role in future clinical applications.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)