Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Review
Oncology
Rayane Dennaoui, Hridaya Shrestha, Kay-Uwe Wagner
Summary: Pancreatic cancer research has made significant progress in understanding the molecular and developmental processes involved in the genesis of this highly malignant tumor type. Various models, including chemical carcingen-induced and genetically engineered animal models, are being developed and analyzed to study the biological significance of new molecular targets and mechanisms contributing to pancreatic cancer onset and progression.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Rakesh Bhatia, Namita Bhyravbhatla, Andrew Kisling, Xiaoqi Li, Surinder K. Batra, Sushil Kumar
Summary: The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) consists of various cell types that communicate through low molecular weight signaling molecules called cytokines. These cytokines play crucial roles in PDAC initiation, progression, metastasis, and colonization by malignant cells. They regulate the expression of oncogenic regulators and contribute to the formation of preneoplastic lesions, inflammation, deposition of extracellular matrix, and immunosuppression. During metastasis, cytokines are involved in the colonization of PDAC cells in the liver and lung. Therefore, understanding the role of cytokines in PDAC is important for the development of related therapies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Mortoglou, Francesc Miralles, Elif Damla Arisan, Alwyn Dart, Stipo Jurcevic, Sigrun Lange, Pinar Uysal-Onganer
Summary: This study investigated the role of miR-21 in cancer stem cells (CSCs) and its association with the aggressiveness of PDAC. Knockout of miR-21 resulted in reversed expressions of CSC markers and suppressed cellular invasion and proliferation. These findings suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and serves as a novel functional biomarker for PDAC aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Neurosciences
Karli Mockenhaupt, Katarzyna M. Tyc, Adam McQuiston, Alexandra K. Gonsiewski, Masoumeh Zarei-Kheirabadi, Avani Hariprashad, Debolina D. Biswas, Angela S. Gupta, Amy L. Olex, Sandeep K. Singh, Michael R. Waters, Jeff L. Dupree, Mikhail G. Dozmorov, Tomasz Kordula
Summary: The transcription factor YY1 is expressed in astrocytes and plays a critical role in regulating gene expression and maturation of cerebellar astrocytes. It is also necessary for maintaining the mature phenotype of astrocytes in the adult cerebellum.
Article
Biochemistry & Molecular Biology
Sina Chen, Shunheng Zhou, Yu-e Huang, Mengqin Yuan, Wanyue Lei, Jiahao Chen, Kongxuan Lin, Wei Jiang
Summary: In this study, a method called scMetR was proposed to evaluate the metastatic risk of PDAC patients based on single-cell RNA sequencing data. The study found that tumor cells with metastatic features play an important role in disease progression, and metastasis-associated genes are up-regulated in these cells. Additionally, the study predicted candidate drugs that may reverse the expression of these metastasis-associated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hada Buhe, Ji-xin Ma, Fang-zhou Ye, Chen-yun Song, Xin-yu Chen, Yang Liu, Huang Lin, Xu Han, Li-xiang Ma, Hexige Saiyin
Summary: In non-immunogenic PDAC, IDO-1 expression does not correlate with immunosuppression or clinicopathological characteristics. IDO-1 promotes extrusion of neoplastic cells from ducts through induction of EMT. Inhibition of IDO-1 reduces tumorigenicity and distant metastasis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Richard Drexler, Mirco Kuchler, Kim C. Wagner, Tim Reese, Bernd Feyerabend, Moritz Kleine, Karl J. Oldhafer
Summary: The Hippo pathway is more active in non-metastasized patients compared to metastasized patients, with upregulation of certain components in the latter group. High pYAP expression is associated with favorable overall survival (OS) and disease-free survival (DFS).
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J. Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew, Phoebe A. Phillips
Summary: High expression of SLC7A11 in human PDAC tumor stroma, independently prognostic of poorer overall survival. The study demonstrates that PDAC-derived CAFs are highly dependent on SLC7A11 for cystine uptake and glutathione synthesis. Inhibition of SLC7A11 decreases CAF proliferation, reduces their resistance to oxidative stress, and inhibits their ability to support PDAC cell growth.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Laura Mainz, Mohamed A. F. E. Sarhan, Sabine Roth, Ursula Sauer, Katja Maurus, Elena M. Hartmann, Helen-Desiree Seibert, Andreas Rosenwald, Markus E. Diefenbacher, Mathias T. Rosenfeldt
Summary: Autophagy is a homeostatic process that regulates the development of pancreatic ductal adenocarcinoma (PDAC). In a genetically engineered mouse model, we found that blocking autophagy reduced the incidence of PDAC, but did not affect the survival time of animals with tumors. Additionally, the absence of autophagy led to changes in the structure of the pancreas and a decrease in the number of insulin-expressing cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Nami Sato, Nozomu Sakai, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Gaku Ohira, Hisahiro Matsubara, Masayuki Ohtsuka
Summary: YY1 is a transcription factor that plays an important role in CRC progression. Low expression of YY1 was found to be significantly associated with aggressive clinicopathological features, liver metastasis, recurrence, and poor patient survival. Knockdown of YY1 promoted migration and invasion of CRC cells. YY1 was found to suppress the expression of ITGAV and ITGB1, which may lead to the inhibition of CRC cell migration and invasion.
Article
Oncology
Erica S. Tsang, James T. Topham, Joanna M. Karasinska, Michael K. C. Lee, Laura M. Williamson, Shehara Mendis, Robert E. Denroche, Gun Ho Jang, Steve E. Kalloger, Richard A. Moore, Andrew J. Mungall, Oliver F. Bathe, Patricia A. Tang, Faiyaz Notta, Julie M. Wilson, Janessa Laskin, Grainne M. O'Kane, Jennifer J. Knox, Rachel A. Goodwin, Jonathan M. Loree, Steven J. M. Jones, Marco A. Marra, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf
Summary: This study analyzed genomic and transcriptomic data from a large cohort of PDAC patient samples, revealing a distinctive pattern of biallelic CDKN2A mutation and increased expression of FOXC2 in EOPC tumors. The correlation between FOXC2 and EMT pathways represents novel molecular characteristics of EOPC.
CLINICAL CANCER RESEARCH
(2021)